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SkyPy: A package for modelling the Universe [article]

Adam Amara, Lucia F. de la Bella, Simon Birrer, Sarah Bridle, Juan Pablo Cordero, Ginevra Favole, Ian Harrison, Ian W.Harry, William G. Hartley, Coleman Krawczyk, Andrew Lundgren, Brian Nord (+9 others)
2021 arXiv   pre-print
SkyPy is an open-source Python package for simulating the astrophysical sky. It comprises a library of physical and empirical models across a range of observables and a command-line script to run end-to-end simulations. The library provides functions that sample realisations of sources and their associated properties from probability distributions. Simulation pipelines are constructed from these models using a YAML-based configuration syntax, while task scheduling and data dependencies are
more » ... ed internally and the modular design allows users to interface with external software. SkyPy is developed and maintained by a diverse community of domain experts with a focus on software sustainability and interoperability. By fostering development, it provides a framework for correlated simulations of a range of cosmological probes including galaxy populations, large scale structure, the cosmic microwave background, supernovae and gravitational waves. Version 0.4 implements functions that model various properties of galaxies including luminosity functions, redshift distributions and optical photometry from spectral energy distribution templates. Future releases will provide additional modules, for example, to simulate populations of dark matter halos and model the galaxy-halo connection, making use of existing software packages from the astrophysics community where appropriate.
arXiv:2109.06172v1 fatcat:diz2atrhjbgzhda2lshy4a2hk4

Freshwater Megafauna: Flagships for Freshwater Biodiversity under Threat

Savrina F. Carrizo, Sonja C. Jähnig, Vanessa Bremerich, Jörg Freyhof, Ian Harrison, Fengzhi He, Simone D. Langhans, Klement Tockner, Christiane Zarfl, William Darwall
2017 BioScience  
Photographs: Peter Haase, F. David Carmona, and William Darwall.  ...  F reshwater ecosystems cover less than one percent of the planet, but they are among the most diverse and dynamic systems globally (Strayer and Dudgeon 2010) .  ... 
doi:10.1093/biosci/bix099 pmid:29599539 pmcid:PMC5862257 fatcat:fvjzh2xn65bblil3n7ko2s2e3q

A new multivariable benchmark for Last Glacial Maximum climate simulations

Sean F. Cleator, Sandy P. Harrison, Nancy K. Nichols, I. Colin Prentice, Ian Roulstone
2020 Climate of the Past  
F.  ...  Sean F. Cleator was supported by a UK Natural Environment Research Council (NERC) scholarship as part of the SCENARIO Doctoral Training Partnership. Sandy P.  ... 
doi:10.5194/cp-16-699-2020 fatcat:b243no5xpvhipdcbodhanwkrra

Propagation of tau and α-synuclein in the brain: therapeutic potential of the glymphatic system

Douglas M. Lopes, Sophie K. Llewellyn, Ian F. Harrison
2022 Translational Neurodegeneration  
Tunnelling nanotubes, F-actin containing membranous bridges which connect the cytoplasm of remote cells with one another, can also facilitate cell-to-cell exchange (e).  ...  Lastly, protein species have also been shown to be exchanged directly between 'donor' and 'recipient' cells via tunnelling nanotubes (Fig. 2e ), which are F-actin-containing membranous bridges that connect  ... 
doi:10.1186/s40035-022-00293-2 pmid:35314000 pmcid:PMC8935752 fatcat:ioabnxg25fenroeopsja6hkbkm

Genomic characterisation of Almpiwar virus, Harrison Dam virus and Walkabout Creek virus; three novel rhabdoviruses from northern Australia

Jane McAllister, Penelope J. Gauci, Ian R. Mitchell, David B. Boyle, Dieter M. Bulach, Richard P. Weir, Lorna F. Melville, Steven S. Davis, Aneta J. Gubala
2014 Virology Reports  
Acknowledgments We gratefully acknowledge many years of dedicated and expert work of Harry Standfast and colleagues, who isolated Almpiwar virus, and likewise Dr Toby St George and colleagues, who isolated Harrison  ...  Harrison Dam virus (HARDV), Walkabout Creek virus (WACV) and Almpiwar virus (ALMV) were all isolated during various Australian arbovirus monitoring programmes.  ... 
doi:10.1016/j.virep.2014.09.001 fatcat:cjgrcxhh6jhjvinpzhfwnzlwkq

Impaired brain glymphatic flow in experimental hepatic encephalopathy

Anna Hadjihambi, Ian F. Harrison, Marta Costas-Rodríguez, Frank Vanhaecke, Natalia Arias, Rocío Gallego-Durán, Svetlana Mastitskaya, Patrick S. Hosford, Steven W.M. Olde Damink, Nathan Davies, Abeba Habtesion, Mark F. Lythgoe (+2 others)
2018 Journal of Hepatology  
Mark F. Lythgoe: Contributed funding to the study, developed the MRI methods, and supervised research staff. Alexander V. Gourine and Rajiv Jalan: Led and funded the study.  ...  Mark F.  ...  thalamus, (E) temporalis muscle, acting as negative control with lack of contrast agent in the temporalis muscle representing a sealed system and no CSF leakage due to the cannula implantation, and (F)  ... 
doi:10.1016/j.jhep.2018.08.021 pmid:30201461 fatcat:miohfwjnizgexowwia2jmlyaxq

Pharmacological MRI with Simultaneous Measurement of Cerebral Perfusion and Blood-Cerebrospinal Fluid Barrier Function using Interleaved Echo-Time Arterial Spin Labelling

Charith Perera, Ian F. Harrison, Mark F. Lythgoe, David L. Thomas, Jack A. Wells
2021 NeuroImage  
I.F.H. is supported by research fellowship awards from Alzheimer's Research UK (ARUK-RF2019A-003) and Parkinson's UK (F-1902). M. F.  ...  Ian F. Harrison: Conceptualization, Writing -review & editing. Mark F. Lythgoe: Conceptualization, Resources, Writing -review & editing. David L.  ...  Fig. 2 (e, f) shows the simultaneous response of cortical blood flow and the BCSFB-ASL signal in response to a hypercapnia challenge.  ... 
doi:10.1016/j.neuroimage.2021.118270 pmid:34144160 fatcat:jm3zvshh5rfzjgns3rx3ecy57y

A new multi-variable benchmark for Last Glacial Maximum climate simulations

Sean F. Cleator, Sandy P. Harrison, Nancy K, Nichols, Iain Colin Prentice, Ian Roulstone
2019 Climate of the Past Discussions  
2016; Harrison et al., 2016) .  ...  ) moisture index (MI), (b) mean annual precipitation (MAP), (c) mean annual temperature (MAT), (d) mean temperature of the coldest month (MTCO), (e) mean temperature of the warmest month (MTWA), and (f)  ... 
doi:10.5194/cp-2019-55 fatcat:wh7p5mwwqjgmlkfe2fwwlfufhi

Pathological histone acetylation in Parkinson's disease: Neuroprotection and inhibition of microglial activation through SIRT 2 inhibition

Ian F. Harrison, Andrew D. Smith, David T. Dexter
2018 Neuroscience Letters  
Harrison et al. Table 1 1 Results of Regression Analyses Performed Between TH, HLA-DPα, SIRT2 Expression and Braak Stage and AcH3-Lys9 Expression.  ... 
doi:10.1016/j.neulet.2017.12.037 pmid:29273397 pmcid:PMC5821898 fatcat:fhrdr3bmdrao5b2wopp57zkxo4

The histone deacetylase inhibitor nicotinamide exacerbates neurodegeneration in the lactacystin rat model of Parkinson's disease

Ian F. Harrison, Nicholas M. Powell, David T. Dexter
2018 Journal of Neurochemistry  
These data are consistent with prior observations in this model (Vernon et al. 2011; Harrison et al. 2015) .  ...  Appropriately, inhibitors of a number of these classes and sub-classes of HDACs have shown to produce a neuroprotective effect in cell and animal models of PD (for reviews see Harrison and Dexter 2013  ... 
doi:10.1111/jnc.14599 pmid:30269333 pmcid:PMC6487684 fatcat:gjuvnzo2u5aixes6ytzmy4bkzu

Actomyosin II contractility expels von Willebrand factor from Weibel–Palade bodies during exocytosis

Thomas D. Nightingale, Ian J. White, Emily L. Doyle, Mark Turmaine, Kimberly J. Harrison-Lavoie, Kathleen F. Webb, Louise P. Cramer, Daniel F. Cutler
2011 Journal of Cell Biology  
Nightingale, 1, 2, 3 Ian J. White, 1,2 Emily L. Doyle, 1,2,3 Mark Turmaine, 3 Kimberly J. Harrison-Lavoie, 1,2,3 Kathleen F. Webb, 1,2 Louise P. Cramer, 1, 3 and Daniel F. Cutler 1,2,3 Figure 1 .  ...  Mean fluorescence The C terminal-tagged P-selectinLum-mCherry fusion construct was generated by amplification from a P-selectin luminal PRK5 construct (Harrison-Lavoie et al., 2006) using primers encoding  ... 
doi:10.1083/jcb.201011119 pmid:21844207 pmcid:PMC3160584 fatcat:zwvrnjohdnet3pbl74y5msnmuu

Impaired glymphatic function and clearance of tau in an Alzheimer's disease model

Ian F Harrison, Ozama Ismail, Asif Machhada, Niall Colgan, Yolanda Ohene, Payam Nahavandi, Zeshan Ahmed, Alice Fisher, Soraya Meftah, Tracey K Murray, Ole P Ottersen, Erlend A Nagelhus (+3 others)
2020 Brain  
F. Harrison et al.Downloaded from by guest on 28 July 2020 | BRAIN : Page 4 of 18 I. F.  ...  Harrison et al.Downloaded from by guest on 28 July 2020 | BRAIN : Page 6 of 18 I. F.  ... 
doi:10.1093/brain/awaa179 pmid:32705145 fatcat:va7pgbjgybf6lm2carjlss7xjq

Increased blood-brain barrier permeability to water in the aging brain detected using noninvasive multi-TE ASL MRI

Yolanda Ohene, Ian F Harrison, Phoebe G Evans, David L Thomas, Mark F Lythgoe, Jack A Wells
2020 Magnetic Resonance in Medicine  
The intravascular fraction F I G U R E 2 Cortical blood-brain barrier permeability to water.  ...  F I G U R E 1 Processing pipeline to measure the exchange time (T w ) as an index of blood-brain barrier permeability to water using control data to determine extravascular tissue T 2 (T2 EV ), multiple-echo-time  ... 
doi:10.1002/mrm.28496 pmid:32910547 pmcid:PMC8432141 fatcat:5f52klxfqncifbhoolcklqs7wi

Imaging of X-Ray-Excited Emissions from Quantum Dots and Biological Tissue in Whole Mouse

Sean G. Ryan, Matthew N. Butler, Segun S. Adeyemi, Tammy Kalber, P. Stephen Patrick, May Zaw Thin, Ian F. Harrison, Daniel J. Stuckey, Martin Pule, Mark F. Lythgoe
2019 Scientific Reports  
It was fitted with an unfiltered 35 mm focal length, f/1.4 lens (Nikon Nikkor) for Fig. 1 , and a 28 mm focal-length, f/1.4 NIR lens (Edmund Optics) with a narrow bandpass filter (λ c = 700 nm, FWHM =  ... 
doi:10.1038/s41598-019-55769-5 pmid:31844147 pmcid:PMC6915766 fatcat:czmm6pej2zg65i7l27t45z5anq

Impaired brain glymphatic flow in a rodent model of chronic liver disease and minimal hepatic encephalopathy [article]

Anna Hadjihambi, Ian Harrison, Natalia Arias, Rocio Gallego-Duran, Patrick S. Hosford, Nathan Davies, Abeba Habtesion, Mark F. Lythgoe, Alexander V. Gourine, Rajiv Jalan
2017 bioRxiv   pre-print
Mark F. Lythgoe: Contributed funding to the study, developed the MRI methods, and supervised research staff. Alexander V. Gourine and Rajiv Jalan: Led and funded the study.  ... 
doi:10.1101/173526 fatcat:m5beaymcrzeldkpwjktj5ugxg4
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