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IMGT, the international ImMunoGeneTics database

M. Ruiz
2000 Nucleic Acids Research  
At present, IMGT includes two databases: IMGT/LIGM-DB, a comprehensive database of Ig and TcR from human and other vertebrates, with translation for fully annotated sequences, and IMGT/ HLA-DB, a database  ...  The IMGT server provides a common access to expertized genomic, proteomic, structural and polymorphic data of Ig and TcR molecules of all vertebrates.  ...  The database provides users with online tools and facilities for the retrieval and analysis of HLA sequences.  ... 
doi:10.1093/nar/28.1.219 pmid:10592230 pmcid:PMC102442 fatcat:v5oeir47tvhbzlklsmpdroce64

IMGT-ONTOLOGY and IMGT databases, tools and Web resources for immunogenetics and immunoinformatics

Marie-Paule Lefranc
2004 Molecular Immunology  
analysis (IMGT/V-QUEST, IMGT/JunctionAnalysis, IMGT/PhyloGene, IMGT/Allele-Align), for genome analysis (IMGT/GeneSearch, IMGT/GeneView, IMGT/LocusView) and for 3D structure analysis (IMGT/StructuralQuery  ...  IMGT consists of several sequence databases (IMGT/LIGM-DB, IMGT/MHC-DB, IMGT/PRIMER-DB), one genome database (IMGT/GENE-DB) and one 3D structure database (IMGT/3Dstructure-DB), interactive tools for sequence  ...  Acknowledgements I am deeply grateful to the IMGT team for its hard work, expertise, constant motivation and enthusiasm.  ... 
doi:10.1016/j.molimm.2003.09.006 pmid:14644091 fatcat:3pcslonq4zawjnygo5skyiixpu

IMGT-Kaleidoscope, the formal IMGT-ONTOLOGY paradigm

Patrice Duroux, Quentin Kaas, Xavier Brochet, Jérôme Lane, Chantal Ginestoux, Marie-Paule Lefranc, Véronique Giudicelli
2008 Biochimie  
The accuracy and consistency of IMGT data and the coherence between the different IMGT components (databases, tools and Web resources) are based on IMGT-ONTOLOGY, the first ontology for immunogenetics  ...  IMGT standardizes and manages the complex immunogenetic data which include the immunoglobulins (IG) or antibodies, the T cell receptors (TR), the major histocompatibility complex (MHC) and the related  ...  Acknowledgements We are grateful to Gérard Lefranc for helpful discussion and to the IMGT Ò team for its constant motivation and its expertise. IMGT Ò was funded by the Centre National de la Re-  ... 
doi:10.1016/j.biochi.2007.09.003 pmid:17949886 fatcat:epwhbxlop5fgddmsv2zaunirle

IMGT, the international ImMunoGeneTics database

M.-P. Lefranc
2001 Nucleic Acids Research  
IMGT provides researchers and clinicians with a common access to all nucleotide, protein, genetic and structural immunogenetics data.  ...  This information is of high value for medical and veterinary research, biotechnology related to antibody and T cell receptor engineering, genome diversity and evolution studies of the immune response.  ...  ACKNOWLEDGEMENTS I am deeply grateful to the IMGT team for its expertise and motivation.  ... 
doi:10.1093/nar/29.1.207 pmid:11125093 pmcid:PMC29797 fatcat:kxd4biblbvc4hfgpcznoiw5iue

IMGT, the international ImMunoGeneTics database(R)

M.-P. Lefranc
2003 Nucleic Acids Research  
The international ImMunoGeneTics database 1 (IMGT) (http://imgt.cines.fr), is a high quality integrated information system specializing in Immunoglobulins (IG), T cell Receptors (TR) and Major Histocompatibility  ...  Complex (MHC) of human and other vertebrates, created in 1989, by the Laboratoire d'ImmunoGé né tique Molé culaire (LIGM), at  ...  ACKNOWLEDGEMENTS IMGT is funded by the European Union's 5th PCRDT programme (QLG2-2000-01287), the Centre National de la Recherche Scientifique (CNRS), the Ministère de l'Education Nationale et de la Recherche  ... 
doi:10.1093/nar/gkg085 pmid:12520009 pmcid:PMC165532 fatcat:kptcm56y5bfg7daxk3vlm5gvqi

IMGT, the International ImMunoGeneTics database

M. Lefranc
1998 Nucleic Acids Research  
IMGT includes three databases: LIGM-DB (for Ig and TcR), MHC/HLA-DB and PRIMER-DB (the last two in development). IMGT comprises expertly annotated sequences and alignment tables.  ...  An IMGT tool, DNAPLOT, developed for Ig, TcR and MHC sequence alignments, is also available. IMGT works in close collaboration with the EMBL database.  ...  IMGT will include, in the future, analysis of genetics data and displays of physical maps. IMGT is designed to allow common access to all immunogenetics data.  ... 
doi:10.1093/nar/26.1.297 pmid:9399859 pmcid:PMC147225 fatcat:sanf6oroyver7a254e7kzhqhcu

IMGT, the international ImMunoGeneTics database

M.-P. Lefranc, V. Giudicelli, C. Ginestoux, J. Bodmer, W. Muller, R. Bontrop, M. Lemaitre, A. Malik, V. Barbie, D. Chaume
1999 Nucleic Acids Research  
IMGT comprises three databases: LIGM-DB, a comprehensive database of Ig and TcR, MHC/HLA-DB, and PRIMER-DB (the last two in development); a tool, IMGT/DNAPLOT, developed for sequence analysis and alignments  ...  ; and expertised data based on the IMGT scientific chart, the IMGT repertoire.  ...  Based on these rules, the IMGT repertoire has become the reference in immunogenetics, by providing expertised data such as Ig and TcR germline gene tables, alignments of alleles, protein displays, Colliers  ... 
doi:10.1093/nar/27.1.209 pmid:9847182 pmcid:PMC148137 fatcat:ffwpswb5pvbs3o5abgquic2xre

IMGT-Choreography for immunogenetics and immunoinformatics

Marie-Paule Lefranc, Oliver Clement, Quentin Kaas, Elodie Duprat, Patrick Chastellan, Isabelle Coelho, Kora Combres, Chantal Ginestoux, Veronique Giudicelli, Denys Chaume, Gerard Lefranc
2005 In Silico Biology  
IMGT-Choreography will further increase the IMGT leadership in immunogenetics and immunoinformatics for medical research (repertoire analysis of the IG antibody sites and of the TR recognition sites in  ...  The accuracy and the consistency of IMGT data are based on IMGT-ONTOLOGY, a semantic specification of terms to be used in immunogenetics and immunoinformatics.  ...  ACKNOWLEDGEMENTS We are grateful to Mehdi Yousfi Monod, Joumana Jabado-Michaloud and Vincent Negre for helpful discussion.  ... 
pmid:15972004 fatcat:66kgcezv6zh5vmtfyuhma4ebeq

IMGT, the international ImMunoGeneTics information system(R)

M.-P. Lefranc
2004 Nucleic Acids Research  
IMGT tools are particularly useful for the analysis of the IG and TR repertoires in normal physiological and pathological situations.  ...  IMGT data are expertly annotated according to the rules of the IMGT Scientific chart, based on the IMGT-ONTOLOGY concepts.  ...  The IMGT Scientific chart is constituted by controlled vocabulary and annotation rules for data and knowledge management of the IG, TR, MHC and RPI of all vertebrate species.  ... 
doi:10.1093/nar/gki065 pmid:15608269 pmcid:PMC540019 fatcat:7bh7zpn4lna43ehvgy5avusgvu

IMGT, the international ImMunoGeneTics database

V. Giudicelli, D. Chaume, J. Bodmer, W. Muller, C. Busin, S. Marsh, R. Bontrop, L. Marc, A. Malik, M.-P. Lefranc
1997 Nucleic Acids Research  
An IMGT tool, DNAPLOT, developed for immunoglobulins, TcR and MHC sequence alignments, is also available. IMGT works in close collaboration with the EMBL database.  ...  IMGT goals are to establish a common data access to all immunogenetics data, including sequences, oligonucleotide primers, gene maps and other genetic data of immunoglobulins, TcR and MHC molecules, and  ...  ACKNOWLEDGMENTS We thank Gérard Mennessier for the development of LIGMotif.  ... 
doi:10.1093/nar/25.1.206 pmid:9016537 pmcid:PMC146384 fatcat:loqrrrsbzfbpdjqaoi2bkecjxm

IMGT-ONTOLOGY 2012

Véronique Giudicelli, Marie-Paule Lefranc
2012 Frontiers in Genetics  
Owing to the complexity and diversity of the immune repertoire, immunogenetics represents one of the greatest challenges for data interpretation: a large biological expertise, a considerable effort of  ...  standardization and the elaboration of an efficient system for the management of the related knowledge were required.  ...  ACKNOWLEDGMENTS We are grateful to Gérard Lefranc for helpful comments. We thank the IMGT® team, and all the previous collaborators and biocurators for the expertise and constant motivation.  ... 
doi:10.3389/fgene.2012.00079 pmid:22654892 pmcid:PMC3358611 fatcat:o7ny6ofyq5amjhko6z45wvbudq

IMGT/LIGM-DB, the IMGT(R) comprehensive database of immunoglobulin and T cell receptor nucleotide sequences

V. Giudicelli
2006 Nucleic Acids Research  
For a given entry, nine types of display are available including the IMGT flat file, the translation of the coding regions and the analysis by the IMGT/V-QUEST tool.  ...  IMGT/LIGM-DB distributes expertly annotated sequences. The annotations hugely enhance the quality and the accuracy of the distributed detailed information.  ...  We are deeply grateful to the IMGT Ò team for its expertise and constant motivation and especially to our curators for their hard work and enthusiasm.  ... 
doi:10.1093/nar/gkj088 pmid:16381979 pmcid:PMC1347451 fatcat:t3ete7g72rcmtncupigehq7cea

IMGT-ONTOLOGY for immunogenetics and immunoinformatics

Marie-Paule Lefranc, Véronique Giudicelli, Chantal Ginestoux, Nathalie Bosc, Géraldine Folch, Delphine Guiraudou, Joumana Jabado-Michaloud, Séverine Magris, Dominique Scaviner, Valérie Thouvenin, Kora Combres, David Girod (+8 others)
2003 In Silico Biology  
tools for sequence analysis (IMGT/V-QUEST, IMGT/JunctionAnalysis, IMGT/PhyloGene, IMGT/Allele-Align), for genome analysis (IMGT/GeneSearch, IMGT/GeneView, IMGT/LocusView) and for 3D structure analysis  ...  complex (MHC) and related proteins of the immune system (RPI) of human and other vertebrates, created in 1989, by the Laboratoire d'ImmunoGenetique Moleculaire LIGM.  ...  We are deeply grateful to the IMGT team for its expertise and constant motivation and specially to our curators for their hard work and enthusiasm.  ... 
pmid:15089751 fatcat:7dswqqx3vvhtjmd4fbhyh4lfg4

IMGT(R), the international ImMunoGeneTics information system(R)

M.-P. Lefranc, V. Giudicelli, C. Ginestoux, J. Jabado-Michaloud, G. Folch, F. Bellahcene, Y. Wu, E. Gemrot, X. Brochet, J. Lane, L. Regnier, F. Ehrenmann (+2 others)
2009 Nucleic Acids Research  
2 and CNRS) at Montpellier, France, in order to standardize and manage the complexity of immunogenetics data.  ...  IMGT Õ consists of five databases (IMGT/ LIGM-DB, IMGT/GENE-DB, IMGT/3Dstructure-DB, etc.), fifteen interactive online tools for sequence, genome and 3D structure analysis, and more than 10 000 HTML pages  ...  IMGT Õ has received the National Bioinformatics Platform Conflict of interest statement. None declared.  ... 
doi:10.1093/nar/gkn838 pmid:18978023 pmcid:PMC2686541 fatcat:3is6vdinlbfyvjfnztqb22t7ha

IMGT, the International ImMunoGeneTics Information System

M.-P. Lefranc
2011 Cold Spring Harbor Protocols  
IMGT/GENE-DB is the international reference for the IG and TR gene nomenclature and works in close collaboration with the HUGO Nomenclature Committee, Mouse Genome Database and genome committees for other  ...  IMGT/GENE-DB allows a search of IG and TR genes by locus, group and subgroup, which are CLASSIFICATION concepts of IMGT-ONTOLOGY.  ...  We are deeply grateful to the IMGT team for its expertise and constant motivation, and specially to our curators for their hard work and enthusiasm.  ... 
doi:10.1101/pdb.top115 pmid:21632786 fatcat:pnrzssaszveyviefosh3oq753e
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