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Navigating Multi-scale Cancer Systems Biology towards Model-driven Personalized Therapeutics [article]

Mahnoor Naseer Gondal, Safee Ullah Chaudhary
2021 bioRxiv   pre-print
Here, we have systematically reviewed the emergence and evolution of (i) repositories with scale-specific and multiscale biomolecular cancer data, (ii) systems biology models developed using this data,  ...  (iii) associated simulation software for development of personalized cancer therapeutics, and (iv) translational attempts to pipeline multi-scale panomics data for data-driven in silico clinical oncology  ...  The portal has an intuitive graphical user interface (GUI) with an integrated workbench application for integrating information from clinical practices, histopathological imaging, treatment and omics data  ... 
doi:10.1101/2021.05.17.444410 fatcat:vbfvmtb5irdapglgkmh5na73je

Navigating Multi-Scale Cancer Systems Biology Towards Model-Driven Clinical Oncology and Its Applications in Personalized Therapeutics

Mahnoor Naseer Gondal, Safee Ullah Chaudhary
2021 Frontiers in Oncology  
Furthermore, the annotation of these single- and multi-scale models with patient data can additionally assist in designing personalized therapeutic interventions as well as aid in clinical decision-making  ...  , (iii) associated simulation software for the development of personalized cancer therapeutics, and (iv) translational attempts to pipeline multi-scale panomics data for data-driven in silico clinical  ...  Zasada SJ, Wang T, Haidar A, Liu E, Graf N, Clapworthy G, et al. IMENSE: An E-Infrastructure Environment for Patient Specific Multiscale Data Integration, Modelling and Clinical Treatment.  ... 
doi:10.3389/fonc.2021.712505 pmid:34900668 pmcid:PMC8652070 fatcat:4lnicclqwjhhta5djbfjo3ctui

Converging Technologies for Improving Human Performance NANOTECHNOLOGY, BIOTECHNOLOGY, INFORMATION TECHNOLOGY AND COGNITIVE SCIENCE NSF/DOC-sponsored report

Mihail Roco, William Sims Bainbridge
unpublished
Acknowledgements This es say i s bas ed on th e k eynote lect ure at th e Annual Meeting of th e S wiss Scientific Academies (C ASS), B ern, S witzerland, on Nov ember 30 -Dece mber 2, 2000.  ...  It includes personal opinions and does not necessarily represent the position of the National Science and Technology Council or the National Science Foundation. McKhann, G.M. 2001.  ...  Especially demanding will be th e development of a hierarchical architecture for integrating sciences acr oss many scale s, d imensions, an d data modalities.  ... 
fatcat:kowkghk4xbbknmwqitcyreyxo4