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Generalized Primary Amyloid Lymphadenopathy

Jin Hyun Park, Ji Hyun Kwon, Ji Won Kim, Hyeon Jin Cho, Ki Hwan Kim, Doo Hyun Chung, Inho Kim, Sung-Soo Yoon, Seonyang Park, Byoung Kook Kim
2009 The Korean Journal of Hematology  
Systemic amyloidosis is a disease that displays deposition of insoluble polymeric protein fibrils in tissues and organs. We report here on a case of a 64-year-old woman who initially presented with multiple enlarged lymph nodes. Computed tomography showed multiple enlarged lymph nodes in the mediastinal, lower cervical, supraclavicular, axillary and abdominal areas. Excision biopsy of the cervical lymph nodes and the subsequent histopathology showed amorphous eosinophilic material deposits, and
more » ... these revealed apple-green birefringence on a polarizing microscopic examination on the Congo-red stained slide. The patient was diagnosed with amyloidosis and she received chemotherapy consisting of melphalan and dexamethasone. During chemotherapy, she was diagnosed with breast cancer. After modified unilateral radical mastectomy, the dexamethasone was restarted and this therapy resulted in stable disease. (Korean J Hematol 2009;44:320-324.)
doi:10.5045/kjh.2009.44.4.320 fatcat:dz7tydwdczguzcb6qcthaipjou

Pressure-wire based assessment of microvascular resistance using calibrated upstream balloon obstruction

June-Hong Kim, Ju-Hyun Park, Kiseok Choo, Sung-Kook Song, Jung-Su Kim, Young-Hyun Park, Jun Kim, Kook-Jin Chun, Dongcheul Han, Anthony Z. Faranesh, Robert J. Lederman
2011 Catheterization and cardiovascular interventions  
Objectives-We assess microvascular integrity as a marker of myocardial viability after coronary stenting, using only a pressure guidewire. Background-Microvascular integrity generally is not assessed using pressure-only guidewires because the transducer lies upstream of microvasculature. We partially inflate a balloon inside a coronary stent to achieve a specific normalized pressure drop at rest (distal coronary/aortic pressure=0.8) and then infuse a vasodilator, to render the wire sensitive to
more » ... microvascular function. We hypothesize that the further decline in presssure (ΔFFR 0.8 ) predicts MRI myocardial viability. Methods-We studied 29 subjects with acute coronary syndrome including myocardial infarction. After successful culprit stenting, the resting coronary/aortic pressure was set to 0.8 using temporary balloon obstruction. ΔFFR 0.8 was defined as 0.8-(distal coronary/aortic pressures) during adenosine-induced hyperemia. The average transmural extent of infarction was defined as the average area of MRI late gadolinium enhancement (after 2.8±1.5 days) divided by the corresponding full thickness of the gadolinium enhanced sector in short axis slices, and was compared with ΔFFR 0.8 . Results-ΔFFR 0.8 corresponded inversely and linearly with the average transmural extent of infarction (r 2 =0.65, p<0.001). We found that a transmural extent of infarction of 0.50 corresponded to a ΔFFR 0.8 threshold of 0.1, and had high sensitivity and specificity (100% and 94.4%, respectively). Conclusions-Using only an upstream pressure-sensitive guidewire and a partially obstructing balloon during pharmacologic hyperemia, we were able to predict MRI myocardial viability with high accuracy after relief of epicardial stenosis. With further validation, this may prove a useful clinical prognostic tool after percutaneous intervention.
doi:10.1002/ccd.23277 pmid:21805603 pmcid:PMC3448879 fatcat:zet3ypkrzrh4vbhd5h6zmvr5ke

P300/CBP-Associated Factor Activates Cardiac Fibroblasts by SMAD2 Acetylation

Yongwoon Lim, Anna Jeong, Duk-Hwa Kwon, Yeong-Un Lee, Young-Kook Kim, Youngkeun Ahn, Taewon Kook, Woo-Jin Park, Hyun Kook
2021 International Journal of Molecular Sciences  
Various heart diseases cause cardiac remodeling, which in turn leads to ineffective contraction. Although it is an adaptive response to injury, cardiac fibrosis contributes to this remodeling, for which the reactivation of quiescent myofibroblasts is a key feature. In the present study, we investigated the role of the p300/CBP-associated factor (PCAF), a histone acetyltransferase, in the activation of cardiac fibroblasts. An intraperitoneal (i.p.) injection of a high dose (160 mg/kg) of
more » ... renol (ISP) induced cardiac fibrosis and reduced the amount of the PCAF in cardiac fibroblasts in the mouse heart. However, the PCAF activity was significantly increased in cardiac fibroblasts, but not in cardiomyocytes, obtained from ISP-administered mice. An in vitro study using human cardiac fibroblast cells recapitulated the in vivo results; an treatment with transforming growth factor-β1 (TGF-β1) reduced the PCAF, whereas it activated the PCAF in the fibroblasts. PCAF siRNA attenuated the TGF-β1-induced increase in and translocation of fibrosis marker proteins. PCAF siRNA blocked TGF-β1-mediated gel contraction and cell migration. The PCAF directly interacted with and acetylated mothers against decapentaplegic homolog 2 (SMAD2). PCAF siRNA prevented TGF-β1-induced phosphorylation and the nuclear localization of SMAD2. These results suggest that the increase in PCAF activity during cardiac fibrosis may participate in SMAD2 acetylation and thereby in its activation.
doi:10.3390/ijms22189944 pmid:34576109 fatcat:mqe4e4gwyfb3lppvgzmqwueyty

Identification of long noncoding RNAs involved in muscle differentiation

Yeong-Hwan Lim, Duk-Hwa Kwon, Jaetaek Kim, Woo Jin Park, Hyun Kook, Young-Kook Kim, Seungil Ro
2018 PLoS ONE  
Long noncoding RNAs (lncRNAs) are a large class of regulatory RNAs with diverse roles in cellular processes. Thousands of lncRNAs have been discovered; however, their roles in the regulation of muscle differentiation are unclear because no comprehensive analysis of lncRNAs during this process has been performed. In the present study, by combining diverse RNA sequencing datasets obtained from public database, we discovered lncRNAs that could behave as regulators in the differentiation of smooth
more » ... r skeletal muscle cells. These analyses confirmed the roles of previously reported lncRNAs in this process. Moreover, we discovered dozens of novel lncRNAs whose expression patterns suggested their possible involvement in the phenotypic switch of vascular smooth muscle cells. The comparison of lncRNA expression change suggested that many lncRNAs have common roles during the differentiation of smooth and skeletal muscles, while some lncRNAs may have opposite roles in this process. The expression change of lncRNAs was highly correlated with that of their neighboring genes, suggesting that they may function as cis-acting lnc RNAs. Furthermore, within the lncRNA sequences, there were binding sites for miRNAs with expression levels inversely correlated with the expression of corresponding lncRNAs during differentiation, suggesting a possible role of these lncRNAs as competing endogenous RNAs. The lncRNAs identified in this study will be a useful resource for future studies of gene regulation during muscle differentiation.
doi:10.1371/journal.pone.0193898 pmid:29499054 pmcid:PMC5834194 fatcat:wc3s4ia6vbfbjajjzzxosuteie

Sleep and cognitive problems in patients with attention-deficit hyperactivity disorder

Jong-Hyun Jeong, Hae Kook Lee, Na-Young Kim, Min-Hyeon Park, Tae-Won Kim, Ho-Jun Seo, Hyun-Kook Lim, Seung-Chul Hong, Jin-Hee Han
2014 Neuropsychiatric Disease and Treatment  
Objectives: Attention-deficit hyperactivity disorder (ADHD) is characterized by inattentive and impulsive behavior. Many ADHD patients reportedly have cognitive dysfunction and sleep problems, including longer sleep latency, lower sleep efficiency, and shorter total sleep time. The purpose of this study was to examine neurocognitive functions and nocturnal sleep parameters in patients with ADHD, using a cognitive function test and actigraphy. Methods: Subjects included 37 male patients with
more » ... and 32 controls (7-12 years of age). For each participant, we determined intelligence quotient (IQ) and administered the Matching Familiar Figures Test (MFFT) and 72-hour actigraphy. The relationships between sleep parameters and cognitive functions were assessed. Results: ADHD patients significantly differed from controls in several cognitive functions and sleep variables. In the MFFT, response error rate (P0.001) and error counts (P=0.003) were significantly increased in ADHD patients compared with control children. MFFT response latency was significantly shorter in ADHD patients than in controls (P0.001). In addition, sleep latency (P=0.01), wake after sleep onset (WASO) (P0.001), and fragmentation index (P0.001) were evaluated by actigraphy and found to be significantly increased in patients with ADHD compared with controls. However, no significant differences in total sleep time or sleep efficiency were observed. WASO and response error rates were positively correlated in patients with ADHD (rho =0.52, P=0.012). Furthermore, fragmentation index sleep variables were significantly positively correlated with response error (rho =0.44, P=0.008) and response latency rates (rho =0.4, P=0.018) in the MFFT. Reaction error rate was significantly associated with the fragmentation index (beta =0.94, P=0.024). Conclusion: Patients with ADHD had more sleep problems, including significantly increased sleep latency, WASO, and fragmentation index, and poorer cognitive function, compared with controls. Some of these sleep problems, including WASO and the fragmentation index, were positively correlated with impulsivity, illustrated by the cognitive function tests in patients with ADHD. However, further studies with large sample sizes and the addition of polysomnography and determination of ADHD subtypes should be performed to confirm our results regarding sleep and cognitive problems in patients with ADHD.
doi:10.2147/ndt.s69562 pmid:25258537 pmcid:PMC4172104 fatcat:zx2qukuibvfdpj5rba34mvqpom

Complications and management of forgotten long-term biliary stents

Se Hoon Sohn, Jae Hyun Park, Kook Hyun Kim, Tae Nyeun Kim
2017 World Journal of Gastroenterology  
Sohn SH, Park JH, Kim KH, Kim TN. Complications and management of forgotten long-term biliary stents.  ... 
doi:10.3748/wjg.v23.i4.622 pmid:28216968 pmcid:PMC5292335 fatcat:jo43hb4msrdzzbwlplb6lj4lde

Biodistribution of99mTc Tricarbonyl Glycine Oligomers

Beom-Su Jang, Joo-Sang Lee, Jong Kook Rho, Sang Hyun Park
2012 Toxicological Research  
Many attempts have been made for the labeling of small peptides with 99m Tc (Park et al., 2005; Reubi, 1995; Fischman et al., 1993; McAfee and Neumann, 1996; Lee et al., 2010) .  ...  A 99m Tc-tricarbonyl precursor was successfully prepared using Log p = Octanol cpm ( ) Water cpm ( ) ------------------------------------ ⎝ ⎠ ⎛ ⎞ log a procedure described (Park et al., 2005) .  ... 
doi:10.5487/tr.2012.28.4.235 pmid:24278615 pmcid:PMC3834432 fatcat:ujyjbuz3rnbqtoadlumv7uqi24

Single Oral Dose Toxicity Test of Blue Honeysuckle Concentrate in Mice

Hyung-Soo Kim, Sang-In Park, Seung-Hoon Choi, Chang-Hyun Song, Soo-Jin Park, Yong-Kook Shin, Chang-Hyun Han, Young Joon Lee, Sae-Kwang Ku
2015 Toxicological Research  
The objective of this study was to obtain single oral dose toxicity information for concentrated and lyophilized powder of blue honeysuckle (Lonicera caerulea L., Caprifoliaceae; BHcL) in female and male ICR mice to aid in the process of developing natural origin medicinal ingredients or foods following proximate analysis and phytochemical profile measurement. The proximate analysis revealed that BHcL had an energy value of 3.80 kcal/g and contained 0.93 g/g of carbohydrate, 0.41 g/g of sugar,
more » ... .02 g/g of protein, and 0.20 mg/g of sodium. BHcL did not contain lipids, including saturated lipids, trans fats, or cholesterols. Further, BHcL contained 4.54% of betaine, 210.63 mg/g of total phenols, 159.30 mg/g of total flavonoids, and 133.57 mg/g of total anthocyanins. Following administration of a single oral BHcL treatment, there were no treatment-related mortalities, changes in body weight (bw) or organ weight, clinical signs, necropsy or histopathological findings up to 2,000 mg/kg bw, the limited dosage for rodents of both sexes. We concluded that BHcL is a practically non-toxic material in toxicity potency.
doi:10.5487/tr.2015.31.1.061 pmid:25874034 pmcid:PMC4395656 fatcat:lmoa3dj4a5gidnfummnpad4224

Survival analysis of spinal muscular atrophy type I

Hyun Bin Park, Soon Min Lee, Jin Sung Lee, Min Soo Park, Kook In Park, Ran Namgung, Chul Lee
2010 Korean Journal of Pediatrics  
doi:10.3345/kjp.2010.53.11.965 pmid:21218019 pmcid:PMC3012277 fatcat:ipm2mk5jf5d2tnnfagxb2tkviq

Engorged Serpentine Veins Across Pacemaker Scar

Jun Kim, Jeong Su Kim, Yong Hyun Park, June Hong Kim, Kook Jin Chun
2011 Korean Circulation Journal  
The authors have no financial conflicts of interest. cc This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. A 79-year-old man presented with swelling of the left arm. He had undergone implantation of single chamber ventricular pacemaker for
more » ... ment of atrial fibrillation with slow ventricular response 34 months before presentation. Physical examination was notable for multiple serpentine veins across the pacemaker incision scar (Fig. 1) . Venography of the left arm showed occlusion of the left subclavian vein and tortuous collateral veins (Fig. 2) . The patient declined further investigation or invasive treatment. Subclavian vein occlusion occurs from 3.6 to 9.0% after implantation of a cardiac rhythm device. 1)2) Engorged veins over the anterior chest wall can be caused by stenosis or oc-clusion of the superior vena cava or subclavian vein. Engorged veins over anterior chest wall should raise the possibility of subclavian vein occlusion especially in patients with preexisting cardiac rhythm device. REFERENCES 1) Korkeila P, Nyman K, Ylitalo A, et al. Venous obstruction after pacemaker implantation. Pacing Clin Electrophysiol 2007;30:199-206. 2) Haghjoo M, Nikoo MH, Fazelifar AF, Alizadeh A, Emkanjoo Z, Sadr-Ameli MA. Predictors of venous obstruction following pacemaker or implantable cardioverter-defibrillator implantation: a contrast venographic study on 100 patients admitted for generator change, lead revision, or device upgrade. Europace 2007;9:328-32. Fig. 2. Venography of the left arm shows total occlusion of the left subclavian vein with multiple collateral veins together with a single lead pacemaker. Fig. 1. Multiple engorged veins with serpentine course are seen from the left axilla to the medial portion of the clavicle across the pacemaker incision scar.
doi:10.4070/kcj.2011.41.9.563 pmid:22022336 pmcid:PMC3193052 fatcat:dlbw6yjs45exzgpjemisbx5u2y

Iatrogenic Intraspinal Epidermoid Cyst

Min Ho Park, Tach Geun Cho, Jae Gon Moon, Chang Hyun Kim, Ho Kook Lee
2014 Korean Journal of Spine  
Park MH et al.  ... 
doi:10.14245/kjs.2014.11.3.195 pmid:25346768 pmcid:PMC4206976 fatcat:rvtxqbmykbafzimddn3seh674a

Traffic Light Recognition Based on Binary Semantic Segmentation Network

Hyun-Koo Kim, Kook-Yeol Yoo, Ju H. Park, Ho-Youl Jung
2019 Sensors  
A traffic light recognition system is a very important building block in an advanced driving assistance system and an autonomous vehicle system. In this paper, we propose a two-staged deep-learning-based traffic light recognition method that consists of a pixel-wise semantic segmentation technique and a novel fully convolutional network. For candidate detection, we employ a binary-semantic segmentation network that is suitable for detecting small objects such as traffic lights. Connected
more » ... nts labeling with an eight-connected neighborhood is applied to obtain bounding boxes of candidate regions, instead of the computationally demanding region proposal and regression processes of conventional methods. A fully convolutional network including a convolution layer with three filters of (1 × 1) at the beginning is designed and implemented for traffic light classification, as traffic lights have only a set number of colors. The simulation results show that the proposed traffic light recognition method outperforms the conventional two-staged object detection method in terms of recognition performance, and remarkably reduces the computational complexity and hardware requirements. This framework can be a useful network design guideline for the detection and recognition of small objects, including traffic lights.
doi:10.3390/s19071700 fatcat:cueykkmfqnhprmdfy33l6wk4xq

PP2A negatively regulates the hypertrophic response by dephosphorylating HDAC2 S394 in the heart

Somy Yoon, Taewon Kook, Hyun-Ki Min, Duk-Hwa Kwon, Young Kuk Cho, Mira Kim, Sera Shin, Hosouk Joung, Seung Hoon Jeong, Sumin Lee, Gaeun Kang, Yunchul Park (+11 others)
2018 Experimental and Molecular Medicine  
Cardiac hypertrophy occurs in response to increased hemodynamic demand and can progress to heart failure. Identifying the key regulators of this process is clinically important. Though it is thought that the phosphorylation of histone deacetylase (HDAC) 2 plays a crucial role in the development of pathological cardiac hypertrophy, the detailed mechanism by which this occurs remains unclear. Here, we performed immunoprecipitation and peptide pull-down assays to characterize the functional
more » ... of HDAC2. Protein phosphatase (PP) 2 A was confirmed as a binding partner of HDAC2. PPP2CA, the catalytic subunit of PP2A, bound to HDAC2 and prevented its phosphorylation. Transient overexpression of PPP2CA specifically regulated both the phosphorylation of HDAC2 S394 and hypertrophyassociated HDAC2 activation. HDAC2 S394 phosphorylation was increased in a dose-dependent manner by PP2A inhibitors. Hypertrophic stresses, such as phenylephrine in vitro or pressure overload in vivo, caused PPP2CA to dissociate from HDAC2. Forced expression of PPP2CA negatively regulated the hypertrophic response, but PP2A inhibitors provoked hypertrophy. Adenoviral delivery of a phosphomimic HDAC2 mutant, adenovirus HDAC2 S394E, successfully blocked the anti-hypertrophic effect of adenovirus-PPP2CA, implicating HDAC2 S394 phosphorylation as a critical event for the anti-hypertrophic response. PPP2CA transgenic mice were protected against isoproterenolinduced cardiac hypertrophy and subsequent cardiac fibrosis, whereas simultaneous expression of HDAC2 S394E in the heart did induce hypertrophy. Taken together, our results suggest that PP2A is a critical regulator of HDAC2 activity and pathological cardiac hypertrophy and is a promising target for future therapeutic interventions.
doi:10.1038/s12276-018-0121-2 pmid:30050113 pmcid:PMC6062565 fatcat:by435vxtrvdmncunkxnebqlqri

Adaptive mammographic image enhancement using first derivative and local statistics

Jong Kook Kim, Jeong Mi Park, Koun Sik Song, Hyun Wook Park
1997 IEEE Transactions on Medical Imaging  
This paper proposes an adaptive image enhancement method for mammographic images, which is based on the first derivative and the local statistics. The adaptive enhancement method consists of three processing steps. The first step is to remove the film artifacts which may be misread as microcalcifications. The second step is to compute the gradient images by using the first derivative operators. The third step is to enhance the important features of the mammographic image by adding the
more » ... weighted gradient images. Local statistics of the image are utilized for adaptive realization of the enhancement, so that image details can be enhanced and image noises can be suppressed. The objective performances of the proposed method were compared with those by the conventional image enhancement methods for a simulated image and the seven mammographic images containing real microcalcifications. The performance of the proposed method was also evaluated by means of the receiver operating-characteristics (ROC) analysis for 78 real mammographic images with and without microcalcifications. Index Terms-Adaptive image enhancement, contrast improvement ratio, first derivative, local statistics, mammographic image, receiver operating-characteristics analysis.
doi:10.1109/42.640739 pmid:9368105 fatcat:4miw27q4kffazaf7cg5h4tucv4

Severe pulmonary artery stenosis by a calcified pericardial ring☆

Yeo-Ju Hwang, Chul-Hyun Park, Yang-Bin Jeon, Kook-Yang Park
2006 European Journal of Cardio-Thoracic Surgery  
We present a rare case of a 44-year-old man with acquired pulmonary stenosis caused by a calcified pericardial ring. Chest computer tomography and cardiac angiography showed external compression of the main pulmonary artery by a calcified pericardial ring. A calcified pericardial ring was removed and the pulmonary artery angioplasty was performed for the stenotic pulmonary artery. The patient's condition improved dramatically thereafter. #
doi:10.1016/j.ejcts.2005.12.047 pmid:16495066 fatcat:lcksccy3gbg65mxl4y5zldauoe
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