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How Computational Models Enable Mechanistic Insights into Virus Infection [chapter]

Ivo F. Sbalzarini, Urs F. Greber
2018 Msphere  
We discuss how computational implementations of mathematical models can assist and enhance the quantitative measurements of infection dynamics of enveloped and non-enveloped viruses and thereby help generating  ...  We discuss how computational implementations of mathematical models can assist and enhance the quantitative measurements of infection dynamics of enveloped and non-enveloped viruses, and thereby help generating  ...  Hypothesis-driven vs. data-driven models Hypothesis-driven models are formulated based on an expectation or suspicion for which no data need be available at first.  ... 
doi:10.1007/978-1-4939-8678-1_30 pmid:30151595 fatcat:7pbezksan5cv3dm5ixkcnypymi

Are We Prepared for Simulation Based Studies in Software Engineering Yet?

Breno Bernard Nicolau de França, Guilherme Horta Travassos
2013 CLEI Electronic Journal  
CONTEXT: Simulation-based studies have been used in different research areas in order to conduct computerized experiments with distinct purposes.  ...  procedures for the verification and validation of simulation models in the Software Engineering context.  ...  Marco Antonio Araújo for his assistance as second researcher, supporting the selection stage of this work's protocol trial.  ... 
doi:10.19153/cleiej.16.1.8 fatcat:j7dkbf5yc5c5lnkecec434kwhm

Accelerating Architectural Simulation Via Statistical Techniques: A Survey

Qi Guo, Tianshi Chen, Yunji Chen, Franz Franchetti
2016 IEEE Transactions on Computer-Aided Design of Integrated Circuits and Systems  
While architectural simulation has been extensively utilized for computer performance evaluation, design space exploration, and computer architecture assessment, it still suffers from the high computational  ...  In addition to identifying the similarities and differences of state-of-the-art approaches, we further discuss insights gained from these studies as well as implications for future research.  ...  They conducted experiments on a design space that contains nearly 1 billion architectures, and by sampling 4000 architectures for training model, the mean prediction errors for performance and power are  ... 
doi:10.1109/tcad.2015.2481796 fatcat:jkrw5qd2irgj5cqdw6p4bewygq

A Conceptual Framework for Integration of Evidence-Based Design with Lighting Simulation Tools

Anahita Davoodi, Peter Johansson, Maria Henricson, Myriam Aries
2017 Buildings  
The aim of this study was to develop a conceptual framework for integrating EBD with lighting simulation tools.  ...  A framework is presented for integration of lighting simulation and EBD.  ...  Also, they would like to thank Geza Fischl for sharing insight and valuable knowledge about evidence-based design. Conflicts of Interest: The authors declare no conflict of interest.  ... 
doi:10.3390/buildings7040082 fatcat:7thqwywvfjh23dkwgbxpjqol34

Building better crime simulations: systematic replication and the introduction of incremental complexity

Michael Townsley, Daniel J. Birks
2008 Journal of Experimental Criminology  
We develop the concept of systematic replication, a method for developing simulation experiments which move towards generalisable inference that is directed, explicit and incorporates complexity incrementally  ...  Computer simulation models have changed the ways in which researchers are able to observe and study social phenomena such as crime.  ...  Acknowledgements A version of this paper was presented at a meeting of the Crime Simulation Network and feedback of numerous delegates has improved the paper.  ... 
doi:10.1007/s11292-008-9054-4 fatcat:6wc5pgiqxbhq3fjk5ni4j7fwna

Experience with evaluating human-assisted recovery processes

A.B. Brown, L. Chung, W. Kakes, C. Ling, D.A. Patterson
2004 International Conference on Dependable Systems and Networks, 2004  
We describe an approach to quantitatively evaluating human-assisted failure-recovery tools and processes in the environment of modern Internet-and enterprise-class server systems.  ...  We illustrate our methodology via a case study of a system-wide undo/redo recovery tool for e-mail services; our approach is able to expose the dependability benefits of the tool as well as point out areas  ...  Case study setup: evaluating Undo/Redo We now illustrate our approach to evaluating human-assisted recovery processes by applying it to an Undo/Redo tool designed explicitly for human-driven failure recovery  ... 
doi:10.1109/dsn.2004.1311910 dblp:conf/dsn/BrownCKLP04 fatcat:mgl2m45h3rbxhhssyi2xvseqjq

CoSMoS special issue editorial

Susan Stepney, Paul S. Andrews
2015 Natural Computing  
As part of that project, the research team developed the CoSMoS approach to assist the building and use of fit-for-purpose computational simulations of complex systems, and initiated a series of international  ...  Complex Systems Modelling and Simulation (CoSMoS) was a 4 year EPSRC funded research project at the Universities of York and Kent in the UK.  ...  All submissions received multiple reviews, and we thank the reviewers for their extensive and in-depth reviews.  ... 
doi:10.1007/s11047-015-9482-9 fatcat:bfowp5j6q5dn3jg7zkqj3ihsoy

Situation awareness assessment in critical driving situations at intersections by task and human error analysis

Marina Plavšić, Gudrunk Klinker, Heiner Bubb
2010 Human Factors and Ergonomics in Manufacturing  
To contribute to identification of such spots, situation awareness of 20 drivers in four critical intersection scenarios was explored. The study was conducted in the static-based driving simulator.  ...  The study has shown that the driving simulator environment can be successfully deployed to provoke and explore various driver errors.  ...  Also, up to recently, the conduction of such studies in driving simulators was ineffectual as prevailing simulation software were not mature enough to simulate such a conditions.  ... 
doi:10.1002/hfm.20173 fatcat:7mmlbugvjvchlbbn3hushkoeoi

Designing and implementing full immersion simulation as a research tool

Belinda Munroe, Thomas Buckley, Kate Curtis, Richard Morris
2016 Australasian Emergency Nursing Journal  
There is limited evidence available to inform the development of simulated clinical scenarios for the purpose of evaluating practice in research studies, with the majority of literature focused on designing  ...  A new scenario design template was devised to develop two standardised simulated clinical scenarios for the evaluation of a new assessment framework for emergency nurses.  ...  Research ethics statement This paper reports the findings of a research study that adhered to the National Statement on the Conduct of Human Research by the Australian National Health and Medical Research  ... 
doi:10.1016/j.aenj.2016.01.001 pmid:26917415 fatcat:e4rc6r7ftnfo5jfxdq74g27eea

Finding Out How They Find It Out: An empirical analysis of inquiry learners' need for support

Yvonne G. Mulder, Ard W. Lazonder, Ton de Jong
2009 International Journal of Science Education  
and the number of conducted experiments.  ...  The number of conducted experiments with the simulation and the number of model runs were retrieved from the log files.  ... 
doi:10.1080/09500690903289993 fatcat:v3e25jx7hveadne25fjd23qidy

Automatic Reuse, Adaption, and Execution of Simulation Experiments via Provenance Patterns [article]

Pia Wilsdorf, Anja Wolpers, Jason Hilton, Fiete Haack, Adelinde M. Uhrmacher
2021 arXiv   pre-print
Approaches for automatically reusing and generating simulation experiments can support modelers in conducting simulation studies in a more systematic and effective manner.  ...  In the case studies, we demonstrate the utility of our framework for a) the repeated sensitivity analysis of an agent-based model of migration routes, and b) the cross-validation of two models of a cell  ...  Yilmaz et al. demonstrated the potential of MDE for generating experiment designs for hypothesis testing as part of a goal-hypothesis-experiment framework Yilmaz et al. [2016] .  ... 
arXiv:2109.06776v1 fatcat:w2xujmhvebgn7ho6zztt5xja24

The five key questions of human performance modeling

Changxu Wu
2018 International Journal of Industrial Ergonomics  
Via building computational (typically mathematical and computer simulation) models, human performance modeling (HPM) quantifies, predicts, and maximizes human performance, humanmachine system productivity  ...  What the procedures and requirements in building and verifying a human performance model are; 4) How we integrate a human performance model with system design; and 5) What the possible future directions  ...  Acknowledgments We appreciate the support from National Science Foundation for this work. We also appreciate the valuable suggestions from the anonymous reviewers in improving this work.  ... 
doi:10.1016/j.ergon.2016.05.007 pmid:29531424 pmcid:PMC5844574 fatcat:z5jz7kgyofbnthneoadvjctbhi

Instructional Support for Intuitive Knowledge Acquisition When Learning with an Ecological Computer Simulation

Marc Eckhardt, Detlef Urhahne, Ute Harms
2018 Education Sciences  
the computer simulation.  ...  Instructional interventions for learning with computer simulations on the topic 'ecosystem water' were developed and tested in the two well-known categories data interpretation and self-regulation using  ...  conducting experiments with the computer simulations.  ... 
doi:10.3390/educsci8030094 fatcat:derafcwwnrdvzavveepf6j4m7u

Flipped Classroom With Simulation Assists Students Learning the Vector Knowledge

Ng Siu-Ping, Fung Chak-Him
2020 Journal of Education and Training Studies  
AbstractVectors are critically important in mathematics and physics because it forms the basis of the university curriculum, yet it is a challenging task for high-school students.  ...  In this study, test papers were distributed to 18 Grade 11 high-school students in Mainland China, while interviews were conducted on four students and one school leader.  ...  Design of Worksheets The design of worksheets involved the concept of "Scaffolding".  ... 
doi:10.11114/jets.v8i12.5093 fatcat:4ut3c3ivqzh5db3acewku2jjlu

The Research We Still Are Not Doing: An Agenda for the Study of Computer-Based Learning

David A. Cook
2005 Academic Medicine  
Media-comparative research-that is, the comparison of computer-based learning (CBL) to noncomputer instruction-is logically impossible because there are no valid comparison groups.  ...  In this article, the author updates the agenda for research in CBL (including Web-based learning).  ...  The author thanks D. M. Dupras and T. J. Beckman for their critical review of the manuscript.  ... 
doi:10.1097/00001888-200506000-00005 pmid:15917356 fatcat:xhh4hqa6uzbknanicyvhgolz2u
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