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Hyperstimulation of striatal D2 receptors with sleep deprivation: Implications for cognitive impairment

Nora D. Volkow, Dardo Tomasi, Gene-Jack Wang, Frank Telang, Joanna S. Fowler, Ruiliang L. Wang, Jean Logan, Christopher Wong, Millard Jayne, James M. Swanson
2009 NeuroImage  
These findings therefore suggest that hyperstimulation of D2 receptors in striatum may contribute to the impairment in visual attention during sleep deprivation.  ...  We recently reported that one night of sleep deprivation increased dopamine in striatum (measured with [ 11 C] raclopride, a PET radiotracer that competes with endogenous dopamine for binding to D2 receptors  ...  Thus striatal hyperstimulation of D2 receptors may have contributed to impairments in VA by disrupting cerebellar activation.  ... 
doi:10.1016/j.neuroimage.2009.01.003 pmid:19349237 pmcid:PMC2714585 fatcat:bwtgh7vzi5cfjmtmyn55a7lsna

How does one night of sleep deprivation affect the internal clock?

Laurence Casini, Céline Ramdani-Beauvir, Boris Burle, Franck Vidal
2013 Neuropsychologia  
One night of sleep deprivation had the same pattern of effect on explicit timing in the suprasecond range and implicit timing in the millisecond range.  ...  Twelve subjects performed two temporal tasks, one explicit (Experiment 1) and one implicit (Experiment 2) after one night of sleep deprivation and after one night of normal rest.  ...  Acknowledgments The authors warmly thank Sonia Allain for her technical help, Matthew Dyson and Sarah Winlow for their great help with English, and Jennifer Coull for her very helpful comments.  ... 
doi:10.1016/j.neuropsychologia.2012.07.041 pmid:23437440 fatcat:b2rrcbs7ozdwvovjfs27ar63ve

Sleep deprivation amplifies striatal activation to monetary reward

B. C. Mullin, M. L. Phillips, G. J. Siegle, D. J. Buysse, E. E. Forbes, P. L. Franzen
2013 Psychological Medicine  
sleep deprivation and following a night of normal sleep.  ...  Shorter total sleep time over the five nights before the sleep-deprived testing condition was associated with reduced deactivation in the mPFC during reward. Conclusions.  ...  Duryea and the Neuroscience Clinical and Translational Research Center staff for their assistance in conducting this study.  ... 
doi:10.1017/s0033291712002875 pmid:23286303 pmcid:PMC3742668 fatcat:bp3lo2afvnh73ji25pyvovjotq

Impulse control and related disorders in Parkinson's disease

Antonio Pedro Vargas, Francisco Eduardo Costa Cardoso
2018 Arquivos de Neuro-Psiquiatria  
Neuropsychiatric disorders are common among patients with Parkinson's disease and may appear in any stage of the disease.  ...  The aim of the present study was to perform a literature review on impulsivity, impulse control disorders and related conditions among patients with Parkinson's disease, with emphasis on their epidemiology  ...  C) Dopamine denervation, and potentially reduced density of D2/D3 receptors, induce increased receptor sensitivity for endogenous and exogenous dopamine.  ... 
doi:10.1590/0004-282x20180052 pmid:29972423 fatcat:dfrpqmgjx5hd3fdliimb3qtsee

Modulation of the Serotonergic Receptosome in the Treatment of Anxiety and Depression: A Narrative Review of the Experimental Evidence

Gustavo R. Villas-Boas, Stefânia N. Lavorato, Marina M. Paes, Pablinny M. G. de Carvalho, Vanessa C. Rescia, Mila S. Cunha, Manoel F. de Magalhães-Filho, Luis F. Ponsoni, Adryano Augustto Valladao de Carvalho, Roseli B. de Lacerda, Lais da S. Leite, Matheus da S. Tavares-Henriques (+18 others)
2021 Pharmaceuticals  
Of the eighteen 5-HT receptors known today, thirteen are G protein-coupled receptors (GPCRs) and represent targets for approximately 40% of drugs used in humans.  ...  targets for discovering new drugs for treating disorders ranging from migraine to neuropsychiatric upsets, such as anxiety and depression.  ...  deprivation.  ... 
doi:10.3390/ph14020148 pmid:33673205 pmcid:PMC7918669 fatcat:givbtamjcbe5lcj5mbkq3jpkwu

Chlorella Vulgaris Alleviates Lead-induced Testicular Toxicity Better than Zingiber Officinale: An Ultrastructural Study [article]

Hesham N. Mustafa
2015 Figshare  
Cemil Bilsel Congress Hall, Faculty of Science, Istanbul University, Istanbul, Turkey. Oral Presentation; 09/2015  ...  Kent Bundles and the bundle of His can be within 2mm distance.  ...  The membrane properties of the striatal projection neurons with D1 and D2 receptors, respectively, are also similar, as are those of the pallidal output neurons.  ... 
doi:10.6084/m9.figshare.1553286 fatcat:foxjxuwbnzfnlgdumwapjoqdoi

Abstracts for the XXIV International Symposium on Morphological Sciences, 2nd-6th September, 2015, Istanbul, Turkey

2015 Anatomy (International Journal of Experimental and Clinical Anatomy)  
The continuing upswing in scientific technology is providing medicine and surgery with tools of immense value; the availability of achromatic microscope, free from spherical aberration, invented by J.J  ...  and telencephalon with archipallial, paleopallial and neopallial intertwining architecture.  ...  Kent Bundles and the bundle of His can be within 2mm distance.  ... 
doi:10.2399/ana.15.075s fatcat:6lqo2gykc5favb7rzvirbkwrbq

The use of adjuvant L-arginine in schizophrenia: A behavioural and neurochemical analysis

Mary-Anne B MacKay
Despite the availability of several neuroleptic medications on the market, many patients with schizophrenia remain symptomatic.  ...  Research has shifted emphasis towards impaired glutamate signaling as a major contributor to the illness. Drug targets specific to the glutamate-nitric oxide (NO) pathway may v PREFACE  ...  Prenatal nutritional deprivation has also been implicated as a risk factor for schizophrenia.  ... 
doi:10.7939/r3zs2kq4m fatcat:j3zx2r36hzeqjif2gteou5w73i

Amino Acids in Human Nutrition and Health EDITED BY Amino Acids in Human Nutrition and Health FSC ewreratare MIX Paper ham reeponalble sources Amino Acids in Human Nutrition and Health Edited by CABI is a trading name of CAB International CABI CABI Library of Congress Cataloging-in-Publication Data

J D'mello, J D'meiio, Nosworthy Way
Given the growing need for effective cognitive enhancers with minor adverse effects, histamine H3 receptor antagonists which stimulate histamine synthesis and release are currently being evaluated for  ...  The pathological * E-mail address: implications of impaired aminotransferase metabolism is discussed, in particular their potential role in glutamate toxicity, which has been implicated  ...  It was concluded that glutamate metabolism was impaired, with the abnormal functioning of the glutamateglutamine cycle, in the prefrontal cortex of patients with schizophrenia.  ...