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The Open Public Health Journal, 2019, Volume 12 Oh et al. The Open Public Health Journal, 2019, Volume 12 Oh et al. ... The total number of deaths by gender and age(2005)(2006)(2007)(2008)(2009)(2010)(2011)(2012)(2013)(2014)(2015).20 The Open Public Health Journal, 2019, Volume 12 Oh et al. ...doi:10.2174/1874944501912010016 fatcat:ceqz5yzafvaplht4qgcil4em7q
Apparently, the research field of sophisticated prognostic indicators such Hyo-Jung Oh, et al: Chronologic trends of cancer-related lymph node research 1988 1989 1990 1991 1992 1993 1994 1995 1996 1997 ... publication dates dates and Journal names Informetric analysis according to author locations Informetric analysis according to cancer types (such as breast, gastric, colorectal, lung, and so on) Hyo-Jung ...doi:10.4174/astr.2020.99.5.305 pmid:33163460 pmcid:PMC7606126 fatcat:xfrotrxdhfalfmd3vtur3ypx6y
Although the expression of VDR in the whole brain in rats fed highphytate diets did not increase, we previously showed that high-phytate diets increase the levels of active 1,25(OH) 2 D  , which might ... negatively affecting calcium and phosphate homeostasis through inhibiting calcium absorption while also aggravating intestinal phosphate overload, which eventually leads to high levels of PTH and active 1,25(OH ...doi:10.3390/nu13124370 pmid:34959925 pmcid:PMC8709321 fatcat:zr7iyxtw4bbrbitvbnuquw3egu
256 서 론 직접흡연은 심혈관질환 및 뇌혈관질환 등의 주요 위험요인으로 알려져 있으며, 1,2) 간접흡연도 호흡기계질환, 천식, 중이염, 영아급사 증후군, 심혈관질환의 위험을 증가시키는 것으로 알려져 있다. 3-8) 간 접흡연이란, 비흡연자가 다른 사람이 피운 담배연기를 간접적으로 흡입하는 것을 말한다. 간접흡연자는 흡연자가 태우는 담배 끝에서 나오는 생담배연기(부류연)를 주로 들이마시게 되므로, 흡연자가 들 이마신 후 내뿜는 연기(주류연)에 비해 필터를 거치지 않고 불완전 연소가 이루어진 타르, 니코틴, 발암물질이 포함된 연기를 보다 많 이 마시게 된다. 9) 따라서 이러한 간접흡연 노출을 막기 위한 여러 정 책들이 나오고 있다. 최근 WHO 2017 세계흡연실태보고서 10) 에 따르 면 우리나라는 2017년 평가에서 '담배연기로부터 보호' 항목에서 적 극적 이행 개선이 요구된다고 평가 받았다. 우리나라는 보건시설, 교육시설, 실내 사무실 및 작업장, 식당, 커피숍, 대중교통doi:10.21215/kjfp.2021.11.4.256 fatcat:xmpcsf3sgbcjpp4s4ifvc5kq6u
more »... 비교적 많은 장소를 금연구역으로 지정하고 있으나 WHO는 해당 공공장소 에서 일부 흡연구역을 허용하지 않는 전면 금연구역으로 지정할 것 을 요구하고 있다. 이러한 간접흡연 노출을 막기 위한 여러 정책들 은 직접흡연뿐만 아니라 간접흡연이 건강에 미치는 영향에 대한 관 심도를 반영한다. Background: This study aimed to investigate the association between the exposure to secondhand smoke (SHS) and dysglycemia. Methods: This cross-sectional study included a total of 4,417 adults (1,103 with SHS exposure, 3,314 without it) aged 19 years old or older, using data from the 7th Korean National Health and Nutrition Examination Survey. Exposure to SHS at home and/or at workplace and/or public space was assessed by a self-reported questionnaire and corroborated by urine cotinine levels. In addition, the SHS group subjects were subdivided into five groups according to the urine cotinine level. The associations between SHS and dysglycemia (fasting blood glucose ≥100 mg/dL or HbA1c ≥5.7%) were examined using logistic regression analyses. Results: After adjusting for covariates, the SHS group showed higher odds ratio for dysglycemia than the non-exposed SHS group, although the relationship was not significant (odds ratio, 1.176; 95% confidence interval, 0.985-1.405; P=0.074). The SHS group showed a higher fasting plasma glucose level in men than the non-exposed group (odds ratio, 1.274; 95% confidence interval, 1.014-1.600; P=0.038). In addition, the risk of dysglycemia was high in subgroups of higher urine cotinine concentration in the SHS group. Conclusion: Dysglycemia is correlated with the degree of exposure to secondhand smoke. KJFP 록 요중 코티닌 농도가 증가한다는 가정하에 요중 코티닌 농도를 5 분위하여 로지스틱 회귀 분석을 추가로 시행하여 관련성을 살펴보 았다. 두 번째 제한점으로는 본 연구는 단면연구로 진행되어 관련성 을 살펴볼 수는 있지만, 원인과 결과의 선후관계를 명확히 할 수 없 다는 점이 있다. 마지막으로 혈당장애에 영향을 줄 수 있는 관련요 인들을 보정하였지만, 다른 잠재적인 요인들이 있을 수 있다. 이러한 제한점들을 보완하여 추후 객관적이고 전향적인 대규모 코호트 연구가 더 필요할 것으로 생각되며, 이와 함께 간접흡연의 노출을 막기 위한 공중보건 노력이 필요할 것으로 생각된다. 요 약 연구배경: 본 연구는 간접흡연 노출과 혈당 이상(dysglycemia)과의 연관성을 밝혀보고자 하였다. 방법: 본 연구는 제7차 국민건강영양조사(2016)의 데이터를 이용하 여 19세 이상의 성인 4,417명(간접흡연 노출군 1,103명, 간접흡연 비 노출군 3,314명)을 대상으로 한 단면연구로 진행되었다. 간접흡연 노 출은 가정, 직장, 공공장소에서 간접흡연에 노출이 된 적이 있는지 에 대한 설문과 요중 코티닌 농도로 확인되었다. 또한 간접흡연군을 요중 코티닌 농도에 따른 5분위로 나누어 분석하였으며, 간접흡연 노출과 혈당 이상(공복혈당≥100 mg/dL 혹은 당화혈색소≥5.7%)간의 연관성을 살펴보기 위해 로지스틱 회귀분석을 시행하였다. 결과: 본 연구에서 여러 교란변수들을 보정한 모델에서 간접흡연 노출군은 간접흡연 비노출군에 비해 혈당 이상의 오즈비가 높게 나 타났지만, 통계적으로 유의하지는 않았다(odds ratio, 1.176; 95% confidence interval, 0.985-1.405; P=0.074). 남성에서 간접흡연 노출군 은 간접흡연 비노출군에 비해 공복혈당이 더 높게 나타났다(odds ratio, 1.274; 95% confidence interval, 1.014-1.600). 간접흡연 노출군에 서 요중 코티닌 농도가 더 높은 하위그룹에서 혈당 이상의 위험성이 더 크게 나타났다. 결론: 간접흡연에 노출된 정도가 심할수록 혈당 이상의 위험성이 크게 나타나는 것으로 보인다.
The prevalence of functional constipation (FC) is 3-27%, and FC has been reported to cause discomfort in daily life and various complications. The treatment for FC depends on laxatives, and thus, effective and non-toxic alternative treatments are needed. Methods: We conducted a randomised, sham-controlled parallel-design, pilot trial. Participants with FC were randomly assigned to either the real acupuncture (RA) or sham acupuncture (SA) group. The RA consisted of eight fixed acupuncture pointsdoi:10.1186/s12906-018-2243-4 pmid:29903020 pmcid:PMC6002973 fatcat:ytau3bfuf5chrit6qgfgxxaoae
more »... (bilateral ST25, ST27, BL52 and BL25) and four additional points targeted to the individual based on Traditional Korean medicine (TKM). SA consisted of shallow acupuncture insertion at 12 non-acupuncture points. Twelve sessions were provided over 4 weeks. The outcome measures were weekly defecation frequency (DF), spontaneous complete bowel movement (SCBM), Bristol stool scale (BSS) score and constipation assessment scale (CAS) score. The participants were followed for 4 weeks after the treatment. Results: Thirty participants were enrolled (15:15). The mean DF were 5.86 ± 5.62, 5.43 ± 3.39 and 5.79 ± 3.64 in the RA group and 3.73 ± 1.62, 5.00 ± 1.77 and 5.40 ± 1.96 in the SA group at weeks 1, 5, and 9, respectively. The increases in weekly SCBMs were 2.50 ± 3.86 and 2.71 ± 4.01 with RA and 2.33 ± 2.74 and 1.93 ± 2.25 with SA at weeks 5 and 9, respectively (mean difference [MD] 0.78). The BSS scores were 0.57 ± 1.72 and 1.09 ± 1.30 with RA and 0.15 ± 1.06 and 0.14 ± 0.88 with SA at weeks 5 and 9, respectively (MD 0.95). The CAS score changes were − 3.21 ± 2.91 and − 3.50 ± 3.98 with RA and − 2.67 + ±2.82 and − 2.87 ± 2.95 with SA at weeks 5 and 9, respectively. Greater improvements were observed in subgroup analysis of participants with hard stool. The numbers of participants who developed adverse events (AEs) were equal in both groups (four in each group), and the AEs were not directly related to the intervention. Conclusions: This clinical trial shows feasibility with minor modifications to the primary outcome measure and comparator. Acupuncture showed clinically meaningful improvements in terms of SCBMs occurring more than 3 times per week and in these improvements being maintained for 4 weeks after treatment completion. As this is a pilot trial, future studies are warranted to confirm the efficacy and safety.
Fermented soybean products, such as cheonggukjang (Japanese natto), doenjang (soy paste), ganjang (soy sauce), and douchi, are widely consumed in East Asian countries and are major sources of bioactive compounds. The fermentation of cooked soybean with bacteria (Bacillus spp.) and fungi (Aspergillus spp. and Rhizopus spp.) produces a variety of novel compounds, most of which possess health benefits. This review is focused on the preventive and ameliorative potential of fermented soy foods anddoi:10.3390/foods10030636 pmid:33803607 fatcat:htqzhvb7t5hqdckwimekutxrzu
more »... eir components to manage neurodegenerative diseases, including Alzheimer's and Parkinson's diseases.
Analysis of the Empirical Effects of Contextual Matching Advertising for Online News Hyo-Jung Oh, Changki Lee, and Chung-Hee Lee Unlike in a traditional model, an additional new player is added to the ...doi:10.4218/etrij.11.0211.0171 fatcat:zruw7v4ydjcuppemgqu35f4jtm
The use of sedatives (propofol or dexmedetomidine) is common in total knee arthroplasty (TKA) or total hip arthroplasty (THA) under spinal anesthesia. Although propofol and dexmedetomidine have been reported to decrease the risk of acute kidney injury (AKI) after cardiac surgery, their effects on AKI incidence after TKA or THA are still unknown. The purpose of this study was to investigate the associations between sedative dosage (propofol and dexmedetomidine) and AKI incidence after TKA or THAdoi:10.21037/atm.2019.04.66 pmid:31317007 pmcid:PMC6603358 fatcat:frmnt3v2czfl5l2fflwuyljyvu
more »... under spinal anesthesia. This retrospective observational study analyzed medical records of adult patients aged 18 years or older who underwent unilateral TKA or THA under spinal anesthesia at a single tertiary care hospital between January 2007 and June 2018. Data were analyzed using univariable and multivariable logistic regression analyses. A total of 5,663 patients were included in the analysis (TKA: 3,570, 63.0%; THA: 2,093, 37.0%), and 147 patients (2.6%) developed AKI in postoperative days 0-3. Multivariable logistic regression analysis showed that propofol dosage (odds ratio: 0.99, 95% confidence interval: 0.94, 1.05; P=0.839) and dexmedetomidine dosage (odds ratio: 0.95, 95% confidence interval: 0.84, 1.09; P=0.461) were not significantly associated with AKI incidence. This study demonstrated no significant association between sedative uses (propofol, dexmedetomidine) and AKI incidence after THA or TKA under spinal anesthesia, and use of such sedatives does not require extreme caution.
The expression of multiple proteins and high-throughput vector assembly system are highly relevant in the field of plant genetic engineering and synthetic biology. Deployment of the self-cleaving 2A peptide that mediates polycistronic gene expression has been an effective strategy for multigene expression, as it minimizes issues in coordinated transgene regulation and trait staking in plants. However, efficient vector assembly systems optimized for 2A peptide-mediated polycistronic expressiondoi:10.3389/fpls.2020.559365 pmid:33193484 pmcid:PMC7609577 fatcat:zvsqf7grcjd37l4gjzhvdzibtq
more »... e currently unavailable. Furthermore, it is unclear whether protein expression levels are influenced by the transgene position in the polycistronic expression cassette. In this article, we present Golden Gate cloning-compatible modular systems allowing rapid and flexible construction of polycistronic expression vectors applicable for plants. The genetic modules comprised 2A peptides (T2A and P2A)-linked tricistron expression cassette and its acceptor backbones, named pGO-DV1 and pGO-DV2. While both acceptor backbones were binary T-DNA vectors, pGO-DV2 was specially designed to function as a DNA replicon enhancing gene expression levels. Using the Golden Gate cloning, a set of six tricistronic vectors was constructed, whereby three transgenes encoding fluorescent proteins (mCherry, eYFP, and eGFP) were combinatorially placed along the expression cassette in each of the binary vectors. Transient expression of the construct in tobacco leaves revealed that the expression levels of three fluorescent proteins were comparable each other regardless of the gene positions in the tricistronic expression cassette. pGO-DV2-based constructs were able to increase protein expression level by up to 71%, as compared to pGO-DV1-based constructs.
Stevens-Johnson syndrome and toxic epidermal necrolysis (SJS/TEN) are the most severe cutaneous drug hypersensitivity reactions, which are unpredictable adverse drug reactions. SJS/TEN is associated with significant mortality and morbidity; however, effective treatment is difficult. Mesenchymal stem cells (MSCs) are well-known for their anti-inflammatory and tissue regeneration properties. The purpose of the present study was to verify whether MSCs could be applied for the treatment of SJS/TEN.doi:10.3346/jkms.2020.35.e130 pmid:32301297 pmcid:PMC7167404 fatcat:crje5uyuxncindbujlkfruwepu
more »... We developed an SJS/TEN mouse model using peripheral blood mononuclear cells from a lamotrigine-induced SJS patient. MSCs were injected into the model to verify the treatment effect. In SJS model mice treated with MSCs, ocular damage rarely occurred, and apoptosis rate was significantly lower. We demonstrated a therapeutic effect of MSCs on SJS/TEN, with these cells presenting a potential novel therapy for the management of this disorder.
S Choi, JA Kim, H Li, and KO Shin performed experiments; S Choi, GT Oh, YM Lee, S Oh, and SH Suh performed analysis and interpretation of data; Y Pewzner-Jung generated CerS2 null mice; S Choi, Y Pewzner-Jung ... Animals CerS2 null mice were generated as described (Pewzner-Jung et al., 2010) , and catalase À/À /GPX1 À/À mice were generously donated by Dr. ...doi:10.1111/acel.12502 pmid:27363720 pmcid:PMC5013018 fatcat:jxhowjgsffbvpiurguh2fqnqtq
However, if we use high power transmitter to pump large amount of currents into the highly resistive ground, we can acquire similar data in repeated-measurements (Jung et al., 2000) . ...doi:10.1071/eg08111 fatcat:yvdlfju4yndorb2hamzrf6yweq
Embedding a social cause in news features: The effects of corporate sponsorship and localization on audience's attitudes toward nonprofit coverage. Abstract The current two studies, one testing college students and the other testing adults, showed nearly identical comparative effects of news features about either a nonprofit organization alone or about that same nonprofit but sponsored by a commercial company. There were two exemplars of nonprofit and commercial company pairings, and each wasdoi:10.1177/0899764012464908 fatcat:dxcceh72nbckfey45ylg6mh7kq
more »... esented as "localized." That is, the nonprofit and commercial company were located in the same city as the respondents or non-localized. Surprisingly, there was almost no indication that the commercial sponsor damaged positive responses, but there was some indication that under the localized condition, there was more negativity toward the commercial sponsorship. The ELM and attribution theory provide theoretical space for understanding these effects.
Oh et al. / Information Sciences 177 (2007) 3696-3717 ...doi:10.1016/j.ins.2007.02.038 fatcat:3j6o2hodovd77j44lquqkdtevi
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