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Randomness in the hybrid modeling and simulation of insulin secretion pathways in pancreatic islets
2015
Tsinghua Science and Technology
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Insulin secreted by pancreatic isletˇ-cells is the principal regulating hormone of glucose metabolism. ...
The first step in this direction presented here is a hybrid model of the insulin secretion pathway, in which the delayed rectifying K C channels are treated as stochastic events. ...
Acknowledgements This work was supported by the National Science Foundation under award DMS-1225160, CCF-0726763, and CCF-0953590, and the National Institutes of Health under award GM078989. ...
doi:10.1109/tst.2015.7297743
fatcat:oiqr2jjrofea3nsjgxgfztpx6u
Functional Genomics of the β-Cell: Short-Chain 3-Hydroxyacyl-Coenzyme A Dehydrogenase Regulates Insulin Secretion Independent of K+Currents
2007
Molecular Endocrinology
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Computational analysis of expression profiles of several mouse and cellular models of impaired insulin secretion identified 373 candidate genes involved in regulation of insulin secretion. ...
In this study, we describe a rational and efficient approach to identifying novel regulators of insulin secretion by the pancreatic -cell. ...
Acknowledgments The authors thank Sophia Hammani and James Fulmer for maintaining our mouse colonies, John Brestelli for assistance with microarray hybridizations and data analysis, Regina Gorski for help ...
doi:10.1210/me.2006-0411
pmid:17185391
fatcat:egtbbloxmzb4to6bsgvdlbjkam
Table of Contents
2010
2010 IEEE International Conference on BioInformatics and BioEngineering
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Modeling and Simulation of Insulin Secretion Pathway in Pancreatic Islets .............................................................................................................................. ...
Thai, and Tamer Kahveci Functional Flow Simulation Based Analysis of Protein Interaction Network ...............................................144 Lei Shi, Young-Rae Cho, and Aidong Zhang How to Fold ...
doi:10.1109/bibe.2010.4
fatcat:yvd5gkaegrbdfjr6vpdf6oy2vq
Diverse roles of K(ATP) channels learned from Kir6.2 genetically engineered mice
2000
Diabetes
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in -cells require closure of the K AT P channels, 4) both glucose-and sulfonylurea-induced insulin secretions are mediated principally by the K AT P channel-dependent pathway, 5) the K AT P channels are ...
Thus, the K AT P channels are the ATP and ADP sensors in the regulation of glucose-induced insulin secretion. ...
Since the discovery of K AT P c h a n n e l s in pancreatic -cells (46) (47) (48) , a model of glucose-induced insulin secretion via a K AT P channel-dependent pathway has been proposed (3). ...
doi:10.2337/diabetes.49.3.311
pmid:10868950
fatcat:jit32mxdlngpdimpq5rqebrtnu
Immunology in the clinic review series; focus on type 1 diabetes and viruses: how viral infections modulate beta cell function
2012
Clinical and Experimental Immunology
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Type 1 diabetes mellitus (T1DM) is a multi-factorial immune-mediated disease characterized by the autoimmune destruction of insulin-producing pancreatic islet beta cells in genetically susceptible individuals ...
In fact, epidemiological data showed that T1DM incidence increases after epidemics due to enteroviruses and that enteroviral RNA can be detected in the blood of >50% of T1DM patients at the time of disease ...
Dotta is supported by the European Union [Collaborative Projects NAIMIT and PEVNET in the Framework Program 7 (FP7)]; by the Italian Ministry of Research, by the Italian Ministry of Health and by the Tuscany ...
doi:10.1111/j.1365-2249.2011.04556.x
pmid:22385233
fatcat:wajukwrixjeapmp4qj7fghocme
Therapeutic potential of VIP vs PACAP in diabetes
2012
Journal of Molecular Endocrinology
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Pancreatic islet cell death, but not the defect in new islet formation or beta-cell replication, has been blamed for the decrease in beta-cell mass observed in T2D patients. ...
Therefore, an ideal beta-cell-preserving agent is expected to protect beta cells from apoptosis and stimulate postprandial insulin secretion along with increasing beta-cell replication and/or islet neogenesis ...
In situ hybridization studies of pancreatic islets demonstrated the presence of both PAC1 and VPAC2 expressions in islets, but not VPAC1 (Inagaki et al. 1994 , Kulkarni et al. 1995 . ...
doi:10.1530/jme-12-0156
pmid:22991228
fatcat:jipjzw7pyjcuvizilpt5lgoiou
Novel Players in Pancreatic Islet Signaling: From Membrane Receptors to Nuclear Channels
2004
Diabetes
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Glucose and other nutrients regulate many aspects of pancreatic islet physiology. ...
Here we describe the role of global and local Ca 2؉ signals in insulin release, the regulation of these signals by new membrane receptors, and the generation of nuclear Ca 2؉ signals involved in gene expression ...
Diabetes, and Instituto Carlos III (RET:p G03/171, RGDM G03/212, TERCEL G03/210, RCMN C03/08). ...
doi:10.2337/diabetes.53.2007.s86
pmid:14749271
fatcat:upxgkowv4vgm3cxjchedli7qqe
3D Pancreatic Tissue Modeling in vitro: Advances and Prospects
2020
BioChip Journal
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Here, we provide an overview of three major parts of the strategies in pancreatic tissue modeling. ...
Thus, there is a great need for more effective tools to study pancreatic disease, and breakthroughs in various fields have contributed to development of in vitro tissue models to understand the pathophysiological ...
As emphasized in this review, in vitro pancreatic tissue-on-a-chip can be realized to simulate the ultrastructure of the pancreatic islets by applying dynamic and advanced engineering approaches, including ...
doi:10.1007/s13206-020-4108-4
fatcat:xiinpfscdjc7beeaorvn4hrh4i
Melatonin Promotes the Therapeutic Effect of Mesenchymal Stem Cells on Type 2 Diabetes Mellitus by Regulating TGF-β Pathway
2021
Frontiers in Cell and Developmental Biology
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hyperglycemia, insulin resistance, and liver glycogen metabolism in T2DM patients. ...
This effect depends on the binding of MLT and MLT receptors, which activates the transforming growth factor β (TGF-β) pathway and then changes the cell cycle of ADMSCs and improves the viability of ADMSCs ...
ACKNOWLEDGMENTS The authors appreciate Jiaxin Li's excellent comments and revision for this manuscript. ...
doi:10.3389/fcell.2021.722365
pmid:34722505
pmcid:PMC8554153
fatcat:mcxyieaiebdkxa4pctskqeu6tq
In Vitro Disease Models of the Endocrine Pancreas
2021
Biomedicines
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Finally, we review the current state and breakthroughs in the field of pancreatic in vitro models and conclude with some challenges that need to be addressed in the future development of in vitro models ...
This review provides an overview of in vitro models and focuses specifically on in vitro disease models of the endocrine pancreas and diabetes. ...
Conflicts of Interest: The authors declare no conflict of interest. ...
doi:10.3390/biomedicines9101415
pmid:34680532
fatcat:v5frfkxlonbgxctuyvzbjaxzky
New Insights into Beta Cell GLP-1 Receptor and cAMP Signaling
2019
Journal of Molecular Biology
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Harnessing the translational potential of the GLP-1/GLP-1R system in pancreatic beta cells has led to the development of established GLP-1R-based therapies for the long-term preservation of beta cell function ...
concepts such as signal bias, allosteric modulation, dual agonism, polymorphic receptor variants, spatial compartmentalization of cAMP signaling and new downstream signaling targets involved in the control ...
In a study with human and mouse pancreatic islets, production of interleukin 6 (IL6) by alpha cells was apparently responsible for the intra-islet production of GLP-1 and insulin, with this process being ...
doi:10.1016/j.jmb.2019.08.009
pmid:31446075
fatcat:tjmwav2bkbguxalut2kidcrqjq
Islet Biology/Insulin Secretion
2016
Diabetes
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Our model can be used to study the molecular mechanisms of ER stress and apoptosis in human β-cells in the setting of obesity, diabetes, and insulin resistance and evaluating the effi cacy of drug therapies ...
Similarly, cytokine-induced disruption to insulin secretion was increased in Cx36-/-islets and reduced in RIP-Cx36 islets compared to Cx36+/+ controls. ...
This model simulates and allows tests of mechanisms for intracellular Ca 2+ dynamics under a wide range of experimental conditions, including low and high glucose concentrations, changes in islet electrical ...
doi:10.2337/db16-2042-2114
fatcat:cenhyzdhargo5aenbbwts3tjca
Fatty Acid-Stimulated Insulin Secretion vs. Lipotoxicity
2018
Molecules
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of pancreatic β-cells. ...
Considering FAs not as mere amplifiers of glucose-stimulated insulin secretion (GSIS), but as parallel insulin granule exocytosis inductors, partly independent of the K ATP channel closure, we describe ...
Acknowledgments: An excellent technical assistance of Jana Vaicová and Ludmila Šimečková is acknowledged.
Conflicts of Interest: The authors declare no conflict of interest. ...
doi:10.3390/molecules23061483
pmid:29921789
fatcat:cklixngnurf4tptkdqhsso5wiy
Islet Biology/Insulin Secretion
2015
Diabetes
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These results implicate RAGE in h-IAPP and CML-induced β-cell oxidative stress and have important implications for the prevention of islet amyloidosis-related β-cell toxicity in T2D. ...
Thus, upregulation of MMP9 may aggravate rather than ameliorate islet amyloid deposition and β-cell apoptosis and may therefore not be a viable therapeutic target to protect islets from amyloid burden. ...
expression in human and rodent models of type 1 and type 2 diabetes mellitus, leading to altered insulin secretion, activation of ER stress pathways, and β cell death. ...
doi:10.2337/db15-2254-2373
fatcat:5inbnfelarf4vlh77dd77myleu
Stem Cells to Pancreatic β-Cells: New Sources for Diabetes Cell Therapy
2009
Endocrine reviews
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Insulin-secreting -cells in the islet of Langerhans are damaged to different extents in diabetic patients, either through an autoimmune reaction present in type 1 diabetic patients or through inherent ...
We will focus on recent progress in the understanding of signaling pathways and transcription factors during embryonic pancreas development and how this knowledge has helped to improve the methodology ...
Grace Wei, Sapna Puri, Alexandra Folias, and Limor Landsman for thoughtful comments on the manuscript. We are indebted to Jimmy Chen for expert advice with the illustration of the figures. ...
doi:10.1210/er.2009-0004
pmid:19389995
pmcid:PMC2726841
fatcat:6ppi7kcwprgs7epmipypvlxpoq
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