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Tsung-Jui Wu, Ying-Tang Wang, Hung Chang, Shih-Hua Lin
2012 Kidney International  
A 45-year-old Chinese man on hemodialysis for 20 years was admitted with a 1-year history of progressive bone pain. He received left-sided video-assisted thoracoscopic surgery (VATS) to remove a mediastinal parathyroid adenoma 7 years ago. His serum intact parathyroid hormone (iPTH) concentration incrementally increased to 2500 pg/ml despite aggressive medical therapy over the past year. On examination, it was observed that he was kyphotic. Laboratory studies showed total calcium 2.8 mmol/l,
more » ... rganic phosphorus 2.27 mmol/l, and alkaline phosphatase 732 U/l. Singlephoton emission CT 99m Tc sestamibi scintigraphy ( Figure 1 ) demonstrated increased uptake at the left heart border and left chest wall in the delayed phase, suggesting functioning parathyroid nodules. Chest computed tomography ( Figure 2 ) identified three well-enhancing pleural nodules at the left cardiophrenic angle and another over the left chest wall. All four pleural parathyroid nodules were successfully removed by VATS and showed typical hyperplastic parathyroid tissue with microfollicular structure and uniform nuclei, confirming the diagnosis of parathyromatosis. Despite symptomatic improvement, a decreased but still abnormally elevated postoperative iPTH level (928 pg/ml) was ascribable to the presence of orthotopic parathyroid glands and residual tiny parathyroid nests spread over the surgical bed. With the use of intravenous 1,25 (OH) 2 vitamin D 3 at a dose of 2 mg three times weekly and calcium acetate at a dose of 4 gm daily for 3 months, his serum iPTH level was still around 750 pg/ml. Parathyromatosis is characterized by multiple benignappearing and functioning parathyroid nodules and can be classified into two types. 1 The less common type 1 refers to ontogenous parathyromatosis along the embryological developmental tract. The more common type 2 refers to postsurgical parathyromatosis due to inadvertent spillage of parathyroid cells during surgical extirpation. 2 Only 40% of parathyromatosis can be diagnosed preoperatively because of its scattered distribution and small size of individual cell nests. 3 The time from previous parathyroidectomy to the identification of parathyromatosis at reoperation ranges from 5 months to 19 years. 4 Parathyromatosis is not uncommon but under diagnosed. This case illustrates the importance of avoiding rupture of parathyroid capsule during the initial parathyroidectomy.
doi:10.1038/ki.2012.257 pmid:23128122 fatcat:ka3wkeg2evdzrgvbqwxlon5lhy

8-Hydroxydaidzein, an Isoflavone from Fermented Soybean, Induces Autophagy, Apoptosis, Differentiation, and Degradation of Oncoprotein BCR-ABL in K562 Cells

Pei-Shan Wu, Jui-Hung Yen, Chih-Yang Wang, Pei-Yi Chen, Jui-Hsiang Hung, Ming-Jiuan Wu
2020 Biomedicines  
8-Hydroxydaidzein (8-OHD, 7,8,4′-trihydoxyisoflavone) is a hydroxylated derivative of daidzein isolated from fermented soybean products. The aim of this study is to investigate the anti-proliferative effects and the underlying mechanisms of 8-OHD in K562 human chronic myeloid leukemia (CML) cells. We found that 8-OHD induced reactive oxygen species (ROS) overproduction and cell cycle arrest at the S phase by upregulating p21Cip1 and downregulating cyclin D2 (CCND2) and cyclin-dependent kinase 6
more » ... (CDK6) expression. 8-OHD also induced autophagy, caspase-7-dependent apoptosis, and the degradation of BCR-ABL oncoprotein. 8-OHD promoted Early Growth Response 1 (EGR1)-mediated megakaryocytic differentiation as an increased expression of marker genes, CD61 and CD42b, and the formation of multi-lobulated nuclei in enlarged K562 cells. A microarray-based transcriptome analysis revealed a total of 3174 differentially expressed genes (DEGs) after 8-OHD (100 μM) treatment for 48 h. Bioinformatics analysis of DEGs showed that hemopoiesis, cell cycle regulation, nuclear factor-κB (NF-κB), and mitogen-activated protein kinase (MAPK) and Janus kinase/signal transducers and activators of transcription (JAK-STAT)-mediated apoptosis/anti-apoptosis networks were significantly regulated by 8-OHD. Western blot analysis confirmed that 8-OHD significantly induced the activation of MAPK and NF-κB signaling pathways, both of which may be responsible, at least in part, for the stimulation of apoptosis, autophagy, and differentiation in K562 cells. This is the first report on the anti-CML effects of 8-OHD and the combination of experimental and in silico analyses could provide a better understanding for the development of 8-OHD on CML therapy.
doi:10.3390/biomedicines8110506 pmid:33207739 pmcid:PMC7696406 fatcat:wrgo2mfaqfdlfeev4dzxtteabe

Rotating Black Holes and Coriolis Effect [article]

Xiaoning Wu and Yi Yang and Pei-Hung Yuan and Chia-Jui Cho
2015 arXiv   pre-print
In this work, we consider the fluid/gravity correspondence for general rotating black holes. By using the Petrov-like boundary condition in near horizon limit, we study the correspondence between gravitational perturbation and fluid equation. We find that the dual fluid equation for rotating black holes contains a Coriolis force term, which is closely related to the angular velocity of the black hole horizon. This can be seen as a dual effect for the frame-dragging effect of rotating black hole under the holographic picture.
arXiv:1511.08691v1 fatcat:izjghq4u4zg5xmofdywoerdfim

Plasma matrix metalloproteinase 1 improves the detection and survival prediction of esophageal squamous cell carcinoma

Yu-Kuei Chen, Chun-Wei Tung, Jui-Ying Lee, Yi-Chun Hung, Chien-Hung Lee, Shah-Hwa Chou, Hung-Shun Lin, Ming-Tsang Wu, I-Chen Wu
2016 Scientific Reports  
doi:10.1038/srep30057 pmid:27436512 pmcid:PMC4951749 fatcat:7rzqejyf55ewfdaow4gboh3saa

Efficacy of 5% Dextrose Water Injection for Peripheral Entrapment Neuropathy: A Narrative Review

Yung-Tsan Wu, Chueh-Hung Wu, Jui-An Lin, Daniel Su, Chen-Yu Hung, Stanley K. H. Lam
2021 International Journal of Molecular Sciences  
In 2017, Wu et al. [11] used a single ultrasound-guided PIT with 5 mL D5W for treating mild-to-moderate CTS in a randomized, double-blind study.  ...  Study Design Inclusion Criteria Treatment Allocation Disease Sample Size Mean Age (Years) Female (%) Symptom Duration (Months) Outcome Measurements Follow-Up Safety Outcome Single UG injection (ulnar Wu  ... 
doi:10.3390/ijms222212358 pmid:34830240 pmcid:PMC8621462 fatcat:2hyoijqc6zcvdfu4fpskhii5j4

Engineered multiwavelength conversion using nonperiodic optical superlattice optimized by genetic algorithm

Jui-Yu Lai, Yi-Jhen Liu, Hung-Yu Wu, Yen-Hung Chen, Shang-Da Yang
2010 Optics Express  
We propose and experimentally demonstrate a new scheme for flexible multiwavelength conversion that uses the genetic algorithm with two target functions to optimize the nonperiodic optical superlattice (NOS). Compared to the widely used aperiodic optical superlattice approach, our scheme can achieve ~15% higher overall conversion efficiency, better spectral fidelity, and allows for further improvement of the performances if a larger genetic pool is used. Numerical analysis also shows that the
more » ... sulting conversion efficiency spectrum is rather insensitive to typical fabrication errors, and is distorted under pump depletion in a similar scale as that of a periodic quasi-phase matching grating. Experimentally measured conversion efficiency spectra of the two fabricated NOS devices are in good agreement with the target curves.
doi:10.1364/oe.18.005328 pmid:20389546 fatcat:4kf4ujcnhja5leyzedn3xr7kge

Rotating black holes and Coriolis effect

Chia-Jui Chou, Xiaoning Wu, Yi Yang, Pei-Hung Yuan
2016 Physics Letters B  
Wu is supported by the National Natural Science Foundation of China (Grant Nos. 11475179, 11175245 and 11575286).  ... 
doi:10.1016/j.physletb.2016.08.018 fatcat:k55n4ec24nco7ffa6xtwfrejga

Multiple eruptive myxoid dermatofibromas

Jennifer Wu, Jui-Hung Ko, Pei-Han Kao, Chih-Hsun Yang
2016 Zhōnghuá Pífūkē Yīxué Zázhì  
Keywords: multiple eruptive dermatofibromas myxoid dermatofibroma systemic lupus erythematosus a b s t r a c t Multiple eruptive dermatofibromas are a rare presentation of dermatofibroma and have been associated with altered immunity. A rare case of multiple eruptive myxoid dermatofibromas (MEMDFs), characterized by marked stromal mucin deposition, is reported herein; additionally, an in-depth discussion on the implication of altered immunity is presented. Because MEMDFs can be an initial
more » ... station of systemic lupus erythematosus, it is necessary for dermatologists to perform a skin biopsy for pathological diagnosis and a comprehensive survey for autoimmunity, infectious diseases, especially human immunodeficiency virus infection, hematologic diseases, and malignancies, or other immunodeficiency conditions when the patient is diagnosed with MEMDFs.
doi:10.1016/j.dsi.2015.08.007 fatcat:7uh2lydpcngldbh3luyiwdg2hm

Effect of applying biosolids on the biodegradation of toluene and naphthalene contaminated soils

Hung Yueh Chang, Jui Min Hung, Yeong Shing Wu, Yi Ru Lin, Hung Yu Lai, Chih Jen Lu
2009 Journal of environmental biology  
Based on the result of Wu et al. (2003) and Wu et al. (2004) , there are two respiration phases in a typical 2-phases respirogram and their relationships are hyperbolic (1 st phase) and linear functions  ...  Wu et al. (2003) reported that the non-homogenous between soils and biosolids has influence on the determination of oxygen uptake by bubble respirometer.  ... 
pmid:20329392 fatcat:jmaqnbnkrrcmhnzox6ef64ohbi

Detection of proteins and nucleic acids of Newcastle disease virus inEimeria acervulina

Hung-Yi Wu, Shiow-Her Chiou, Jui-Hung Shien, Poa-Chun Chang, Happy K. Shieh
1999 Avian Pathology  
Ten-day-old speci® c pathogen free (SPF) chickens were inoculated simultaneously with Eimeria acervulina and Newcastle disease virus (NDV). By employing immuno¯uorescent staining and in situ hybridization techniques, we detected NDV proteins and nucleic acids in different life stages of E. acervulina. However, no NDV particle was found within E. acervulina by electron microscopy. Oocysts from E. acervulina that contained NDV proteins and nucleic acids could elicit antibodies against NDV after
more » ... peated inoculation into SPF chickens. Moreover, the proportion of oocysts from chickens infected with E. acervulina and NDV which could be induced to sporulate in vitro was lower than those from chickens infected with E. acervulina alone. These results indicate that nucleic acids and proteins of NDV can exist within E. acervulina, and stimulate an immune response against NDV in chickens, and that NDV may also interfere with the sporulation of oocysts.
doi:10.1080/03079459994452 pmid:26911597 fatcat:6543n7n5zrftbbc65p5vfgkkty

Machining Stability Of A Milling Machine With Different Preloaded Spindle

Jui-Pin Hung, Qiao-Wen Chang, Kung-Da Wu, Yong-Run Chen
2015 Zenodo  
As discussed in studies [11] - [13] , increasing the bearing preload can increase the bearing stiffness, but also Jui P. Hung reduces the damping ratio of the bearings.  ...  Hung, Qiao-Wen Chang, Kung-Da Wu, Yong-Run Chen T World Academy of Science, Engineering and Technology International Journal of Mechanical and Mechatronics Engineering Vol:9, No:5, 2015 894 International  ... 
doi:10.5281/zenodo.1107209 fatcat:6q5fgebgqjgqvjlnkrllkgv7ee

Enhancer regulation for induced WNT3A expression during neuronal regeneration [article]

Chu-Yuan Chang, Jui-Hung Hung, Ching-Chih Wu, Min-Zong Liang, Pei-Yuan Huang, Joye Li, Hong-I Chen, Shaw-Fang Yet, Ka Shing Fung, Cheng-Fu Kao, Linyi Chen
2019 bioRxiv   pre-print
Jin-Wu Tsai from the National Yang-Ming University, Taiwan, for providing technical consultation on brain slice culture. We thank Mr. Hsueh-Chun Chuang and Ms.  ... 
doi:10.1101/861153 fatcat:znmgussq4bfp5oqkxmddrnuhui

Regulation of coronaviral poly(A) tail length during infection is not coronavirus species- or host cell-specific

Jui-Hung Shien, Yi-Da Su, Hung-Yi Wu
2014 Virus genes  
It has been demonstrated that the length of the poly(A) tail in the bovine coronavirus (BCoV), which belongs to genus betacoronaviruses, is regulated throughout infection in human rectal tumor-18 (HRT-18) cells, and the length of the poly(A) tail is associated with the efficiency of virus translation. Here, we examined whether the regulation of viral poly(A) tail length is cell-type independent and whether it is a common feature of coronaviruses to assess the significance of the regulation. By
more » ... igating head-to-tail viral RNA positive strands and sequencing, we found that (1) the regulation pattern of coronaviral poly(A) tail length in BCoV-infected hamster kidney-21 (BHK-21) cells was similar to that in BCoVinfected HRT-18 cells and (2) the poly(A) tail length of wild-type avian infectious bronchitis virus (IBV) virulent strain IBV-TW1, which is in the genus gammacoronaviruses, varied throughout infection in primary chicken embryo kidney (CEK) cells and in the tracheas of 1-dayold chicks. Interestingly, the poly(A) tail length variation was similarly found in the avirulent IBV strain H120 in CEK cells, although the overall poly(A) tail length was shorter for this virus. The results suggest that the regulation of coronaviral poly(A) tail length during infection may be a common feature among coronaviruses and can occur in a noncancerous cell line (BHK-21 cells), primary cell culture (CEK cells), and living system (chickens), further reinforcing the biological significance of this regulation during coronavirus infection.
doi:10.1007/s11262-014-1103-7 pmid:25034371 fatcat:5mhmwtkegfhllprrnfzmkfioku

A CMMI-based approach for medical software project life cycle study

Jui-Jen Chen, Wu-Chen Su, Pei-Wen Wang, Hung-Chi Yen
2013 SpringerPlus  
In terms of medical techniques, Taiwan has gained international recognition in recent years. However, the medical information system industry in Taiwan is still at a developing stage compared with the software industries in other nations. In addition, systematic development processes are indispensable elements of software development. They can help developers increase their productivity and efficiency and also avoid unnecessary risks arising during the development process. Thus, this paper
more » ... nts an application of Light-Weight Capability Maturity Model Integration (LW-CMMI) to Chang Gung Medical Research Project (CMRP) in the Nuclear medicine field. This application was intended to integrate user requirements, system design and testing of software development processes into three layers (Domain, Concept and Instance) model. Then, expressing in structural System Modeling Language (SysML) diagrams and converts part of the manual effort necessary for project management maintenance into computational effort, for example: (semi-) automatic delivery of traceability management. In this application, it supports establishing artifacts of "requirement specification document", "project execution plan document", "system design document" and "system test document", and can deliver a prototype of lightweight project management tool on the Nuclear Medicine software project. The results of this application can be a reference for other medical institutions in developing medical information systems and support of project management to achieve the aim of patient safety.
doi:10.1186/2193-1801-2-266 pmid:23961378 pmcid:PMC3699709 fatcat:xwksf6parnfyjmw6clmzi5tcmm

Do resting brain dynamics predict oddball evoked-potential?

Tien-Wen Lee, Younger W-Y Yu, Hung-Chi Wu, Tai-Jui Chen
2011 BMC Neuroscience  
The oddball paradigm is widely applied to the investigation of cognitive function in neuroscience and in neuropsychiatry. Whether cortical oscillation in the resting state can predict the elicited oddball eventrelated potential (ERP) is still not clear. This study explored the relationship between resting electroencephalography (EEG) and oddball ERPs. The regional powers of 18 electrodes across delta, theta, alpha and beta frequencies were correlated with the amplitude and latency of N1, P2, N2
more » ... and P3 components of oddball ERPs. A multivariate analysis based on partial least squares (PLS) was applied to further examine the spatial pattern revealed by multiple correlations. Results: Higher synchronization in the resting state, especially at the alpha spectrum, is associated with higher neural responsiveness and faster neural propagation, as indicated by the higher amplitude change of N1/N2 and shorter latency of P2. None of the resting quantitative EEG indices predict P3 latency and amplitude. The PLS analysis confirms that the resting cortical dynamics which explains N1/N2 amplitude and P2 latency does not show regional specificity, indicating a global property of the brain. Conclusions: This study differs from previous approaches by relating dynamics in the resting state to neural responsiveness in the activation state. Our analyses suggest that the neural characteristics carried by resting brain dynamics modulate the earlier/automatic stage of target detection.
doi:10.1186/1471-2202-12-121 pmid:22114868 pmcid:PMC3259052 fatcat:xy4vzg44cfcuxgr5evsrdhxe6m
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