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Klüver-Bucy (KBS) syndrome is a rare and complicated neurobehavioral syndrome in humans resulting from damage of bilateral anterior temporal portion, especially the amygdala. It can be seen in association with a variety of etiologies. Stroke is a rarely reported. Here we present a 50-year-old right handed man who developed persistent KBS after cardioembolic stroke involving bilateral lateral temporal lobes. He exhibited all clinical features of KBS including visual agnosia, hypersexuality,pmid:18975528 fatcat:ir7rv2rcgnh6pdioxmk65mozea
more »... dity, hyperorality and hypermetamorphosis. The anatomical basis of pathophysiolgy, clinical course and possible treatment are discussed.
doi:10.1016/s1028-4559(08)60137-0 pmid:18936002 fatcat:tl72b4e2x5dchh4p6nnqfpjoge
Small cystine-stabilized proteins are desirable scaffolds for therapeutics and diagnostics. Specific folding and binding properties of the proteinaceous binders can be engineered with combinatorial protein libraries in connection with artificial molecular evolution. The combinatorial protein libraries are composed of scaffold variants with random sequence variation, which inevitably produces a portion of the library sequences incompatible with the parent structure. Here, we used artificialdoi:10.1016/j.str.2009.01.011 pmid:19368895 fatcat:4dbkeozuk5cixfcrvapfv4gqza
more »... ular evolution to elucidate structure-determining residues in a smallest cystine-stabilized scaffold. The structural determinant information was then applied to designing cystine-stabilized miniproteins binding to human vascular endothelial growth factor. This work demonstrated a general methodology on engineering artificial cystine-stabilized proteins as antibody mimetics with simultaneously enhanced folding and binding properties. Structure Molecular Evolution of Cystine-Stabilized Proteins Structure 17, 620-631, April 15,
, Yeh, & Lin, 2007) . ... environment in the health care industry from a more psychologyoriented perspective (Desselle & Holmes, 2007; Mott, Doucette, Gaither, Pedersen, & Schommer, 2004) or job-characteristics perspectives (Lin ...doi:10.1097/01.hmr.0000304504.27803.64 pmid:18360166 fatcat:cfglhshggrgiveemkpofb5lvsu
Apocrine osmidrosis (AO) is a chronic, recurrent, and disturbing disease characterized by malodorous secretion from apocrine glands. Despite various conservative and nonsurgical treatments, surgical removal of apocrine glands remains the cornerstone for AO treatment. Conventional suction-assisted cartilage shaver is effective; however, there are several risks and complications. Hence, we modified the conventional method to achieve better effectiveness and reduce complications. This paper aimsdoi:10.1155/2019/7314753 pmid:31205944 pmcid:PMC6530155 fatcat:wbplw2wbq5dp7oiqxny2usoxvu
more »... evaluate the clinical effectiveness and the complications arising from the modified suction-assisted cartilage shaver for AO. Thirty-nine patients (M/F=11/28, average age 26.3 years) received this surgical treatment for AO from 2013 to 2017 in the Department of Dermatology at Kaohsiung Chang Gung Memorial Hospital, Taiwan. A suction-assisted cartilage shaver was introduced for the ultimate removal of the subcutaneous tissue containing the apocrine glands. A 0.5 cm incision was made in the center of the identified elliptical surgical area at each axilla. After defatting, the incision was closed primarily. The defatting skin was anchored to the axillary fascia by using 4-0 sutures without drains. We then evaluated the clinical efficacy and complications. The mean duration of follow-up was 31.8 months (12–68 months). Among patients receiving the modified cartilage shaving for AO, 92.3% achieved excellent-to-good results, 5.1% had acceptable results, and 2.6% had fair results. None of them experienced poor clinical efficacy. There was no skin necrosis, hematoma, nor wound infection after the surgery. There were no recurrences in all these patients 2 years after the surgery. This modified suction-assisted cartilage shaver for AO results in good efficacy, a low complication rate, and a low recurrence rate. The method is superior to the conventional one due to tissue glue-free procedure, greater comfort in postoperative care, minimal wounds, less hematoma, and less skin necrosis. The clinical study registration number of this study is NCT03793374.
We report the selective growth of amorphous silica nanowires on nickel nanostructures created by an atomic force microscopy nanomachining and lift-off process. Successful growth of patterned nanowire bunches or single nanowires on Si substrates has been realized by thermal annealing. The growth mechanism is found to be a combination of vapour-liquid-solid and solid-liquid-solid modes. In addition, the relationship between the nanowire length and the growth time has a nonlinear dependence.doi:10.1088/0957-4484/17/1/027 fatcat:3cd7gje74feijhm3imabctswra
Previous studies suggest that an association between restless legs syndrome (RLS) and migraine exists. However, population-based data are unavailable in Asian cohorts. Our study thus aims to evaluate the association between migraine and RLS in a nationwide, populationbased cohort in Taiwan and to examine the effects of age, sex, migraine subtype, and comorbidities on RLS development. Data from the Taiwan National Health Insurance Research Database were used. Patients aged 20 years or older withdoi:10.1097/md.0000000000002646 pmid:26844484 pmcid:PMC4748901 fatcat:ayk2gerievdwneden2sj5e2nzm
more »... newly diagnosed migraine from 2000 to 2008 were included; 23,641 patients with newly diagnosed migraine and 94,564 subjects without migraine were randomly selected and followed until RLS development, withdrawal from the National Health Insurance, or until the end of 2011. A multivariate Cox proportional hazards regression model was used to explore the risk of RLS in patients with migraine after adjustment for demographic characteristics and comorbidities. Both cohorts were followed for a mean of 7.38 years. After adjustment for covariates, the risk of RLS was 1.42-fold higher (95% confidence interval ¼ 1.13-1.79) in the migraine cohort than in the nonmigraine cohort (7.19 versus 3.42 years per 10,000 person-years). The increased risk was more prominent in males in the migraine cohort (1.87-fold increased risk, 95% confidence interval 1.22-2.85). Neither comorbidity status nor migraine subtype influenced the RLS risk. This population-based study demonstrated that migraine is associated with an increased risk of RLS compared with those without migraine, particularly in male patients with migraine and regardless of the comorbidity status. (Medicine 95(5):e2646) Abbreviations: aHR = adjusted hazard ratio,
The aim of study is to determine whether chronic osteomyelitis (COM) is linked to an increased risk of head and neck cancer (HNC). We identify 17,033 patients with osteomyelitis and 68,125 subjects without osteomyelitis during 1996 to 2010 periods. Multivariable Cox proportional hazards regression analysis was used to measure the hazard ratio (HR) of head and neck cancer for the osteomyelitis cohort compared with the comparison cohort. A total of 99 patients in the COM and 228 patients in thedoi:10.1097/md.0000000000002407 pmid:26817870 pmcid:PMC4998244 fatcat:iidcvdzh75dfnounvdnbdh5xuq
more »... mparison cohort developed HNC during an average 5.12 years of follow-up period. The incidence rate of HNC in the COM cohort was 1.51-fold (95% confidence interval [CI]: 1.17-1.95) higher than that in the comparison cohort after adjusting gender, age, urbanization level, monthly income, and comorbidities. In subgroup analysis, younger (less than 45 years-old) and patients without comorbidities have greater risks (adjusted HR: 2.29 [95% CI:1.43-3.66] and 1.74 [95% CI:1.28-2.38] respectively). This study results suggested the association between COM and HNC, particularly in younger population and patients without comorbidities. (Medicine 95(3):e2407) Abbreviations: CI = confidence interval, HR = hazard ratio, NHIRD = National Health Insurance Research Database. Editor: Patrick Wall.
Collaborative design has become a research paradigm in design studies. To make effective collaborative design, an information service mechanism for helping collaborators to access related information of specific design situation is getting important. This paper presents an approach of applying data mining techniques to reveal information patterns for managing collaborative design information. A visual interface of linking design information based on revealed patterns are presented and issues are discussed. Ddoi:10.1016/j.autcon.2004.07.011 fatcat:v67ib7cvj5cuxns7wrnqzq3im4
Evidence about the efficacy and safety of statin treatment in high-risk patients with hypercholesterolemia is available for some populations, but not for ethnic Chinese. To test the hypothesis that treatment with pitavastatin (2 mg/day) is not inferior to treatment with atorvastatin (10 mg/day) for reducing lowdensity lipoprotein cholesterol (LDL-C), a 12-week multicenter collaborative randomized parallel-group comparative study of high-risk ethnic Chinese patients with hypercholesterolemia wasdoi:10.1371/journal.pone.0076298 pmid:24098467 pmcid:PMC3788128 fatcat:yie6asdgqjbvtjhkgnlx5tb5py
more »... conducted in Taiwan. In addition, the effects on other lipid parameters, inflammatory markers, insulin-resistance-associated biomarkers and safety were evaluated. Methods and Results: Between July 2011 and April 2012, 251 patients were screened, 225 (mean age: 58.7 ± 8.6; women 38.2% [86/225]) were randomized and treated with pitavastatin (n = 112) or atorvastatin (n = 113) for 12 weeks. Baseline characteristics in both groups were similar, but after 12 weeks of treatment, LDL-C levels were significantly lower: pitavastatin group = −35.0 ± 14.1% and atorvastatin group = −38.4 ± 12.8% (both: p < 0.001). For the subgroup with diabetes mellitus (DM) (n = 125), LDL-C levels (−37.1 ± 12.9% vs. −38.0 ± 13.1%, p = 0.62) were similarly lowered after either pitavastatin (n = 63) or atorvastatin (n = 62) treatment. Triglycerides, non-high density lipoprotein cholesterol, and apoprotein B were similarly and significantly lower in both treatment groups. In non-lipid profiles, HOMA-IR and insulin levels were higher to a similar degree in both statin groups. Hemoglobin A 1 C was significantly (p = 0.001) higher in the atorvastatin group but not in the pitavastatin group. Both statins were well tolerated, and both groups had a similar low incidence of treatment-emergent adverse events. Conclusion: Both pitavastatin (2 mg/day) and atorvastatin (10 mg/day) were well tolerated, lowered LDL-C, and improved the lipid profile to a comparable degree in high-risk Taiwanese patients with hypercholesterolemia. Trial Registration: ClinicalTrials.gov NCT01386853
BMC Cell Biology
Advanced glycation end products generated in the circulation of diabetic patients were reported to affect the function of vascular wall. We examined the effects of advanced glycation end products-bovine serum albumin (AGE-BSA) on endothelial connexin43 (Cx43) expression and gap-junction communication. Results: In human aortic endothelial cells (HAEC) treated with a series concentrations of AGE-BSA (0-500 μg/ml) for 24 and 48 hours, Cx43 transcript and Cx43 protein were reduced in a dosedoi:10.1186/1471-2121-12-19 pmid:21575204 pmcid:PMC3224147 fatcat:ibbgbprl6zcddpgwuijumnaqwu
more »... t manner. In addition, gapjunction communication was reduced. To clarify the mechanisms underlying the down-regulation, MAPKs pathways in HAEC were examined. Both a MEK1 inhibitor (PD98059) and a p38 MAPK inhibitor (SB203580) significantly reversed the reductions of Cx43 mRNA and protein induced by AGE-BSA. Consistently, phosphorylation of ERK and p38 MAPK was enhanced in response to exposure to AGE-BSA. However, all reversions of down-regulated Cx43 by inhibitors did not restore the functional gap-junction communication. Conclusions: AGE-BSA down-regulated Cx43 expression in HAEC, mainly through reduced Cx43 transcription, and the process involved activation of ERK and p38 MAPK.
Structural origin of substrate-enzyme recognition remains incompletely understood. In the model enzyme system of serine protease, canonical anti-parallel ␤-structure substrate-enzyme complex is the predominant hypothesis for the substrate-enzyme interaction at the atomic level. We used factor Xa (fXa), a key serine protease of the coagulation system, as a model enzyme to test the canonical conformation hypothesis. More than 160 fXa-cleavable substrate phage variants were experimentally selecteddoi:10.1074/jbc.m708843200 pmid:18296445 pmcid:PMC2430999 fatcat:u7gl4elisja6fksjijlrcdhztq
more »... from three designed substrate phage display libraries. These substrate phage variants were sequenced and their specificities to the model enzyme were quantified with quantitative enzyme-linked immunosorbent assay for substrate phage-enzyme reaction kinetics. At least three substrate-enzyme recognition modes emerged from the experimental data as necessary to account for the sequence-dependent specificity of the model enzyme. Computational molecular models were constructed, with both energetics and pharmacophore criteria, for the substrate-enzyme complexes of several of the representative substrate peptide sequences. In contrast to the canonical conformation hypothesis, the binding modes of the substrates to the model enzyme varied according to the substrate peptide sequence, indicating that an ensemble of binding modes underlay the observed specificity of the model serine protease. Serine proteases recognize peptide sequences as substrates with a spectrum of specificity (1), for which the structural origin remains largely unclear (2, 3). The enzyme family is one of the most important model families in enzymology as about onethird of proteases (coded in about 2% of human genome) can be classified as serine proteases and many of the serine proteases are involved in important physiological regulation and pathogenic dysfunction (1). Serine proteases hydrolyze peptide bond with nucleophilic Ser 195 in the catalytic triad (Asp 102 -His 57 -
Structure propensities of amino acids are important determinants in guiding proteins' local and global structure formation. We constructed a phage display library-a hexa-HIS tag upstream of a CXXC (X stands for any of the 20 natural amino acids) motif appending N-terminal to the minor capsid protein pIII of M13KE filamentous phage-and developed a novel directedevolution procedure to select for amino acid sequences forming increasingly stable b-turns in the disulfide-bridged CXXC motif. Thedoi:10.1016/j.str.2006.08.006 pmid:17027499 fatcat:7wswztbprzgizp6l3umft5hhhm
more »... nces that emerged from the directed-evolution cycles were in good agreement with type II b-turn propensities derived from surveys of known protein structures, in particular, Pro-Gly forming a type II b-turn. The agreement strongly supported the notion that b-turn formation plays an active role in initiating local structure folding in proteins.
Aim: Premenstrual dysphoric disorder (PMDD) has predictable, cyclic, psychological, and somatic symptoms, such as sleep problems. They result in functional impairment, are aggravated in the late luteal phase of the menstrual cycle, and are resolved by menstruation. The present study evaluated the insomnia, inattention, and fatigue symptoms of PMDD and their fluctuations during the menstrual cycle. Methods: A total of 100 women were diagnosed as having PMDD based on psychiatric interviews and adoi:10.3390/ijerph18126192 fatcat:lqslwo5srjaxxbhbjsztpoayde
more »... rospective investigation of three menstrual cycles. A total of 96 individuals without PMDD were recruited as controls. Their symptoms, namely insomnia, inattention, and fatigue as well as functional impairment were assessed by using the premenstrual symptoms screening tool, the Pittsburgh insomnia rating scale, the attention and performance self-assessment scale, and the fatigue-assessment scale during both premenstrual and follicular phases. Results: In both the premenstrual and follicular phases, women with PMDD experienced more severe insomnia, inattentiveness, and fatigue than did women in the control group. A paired t-test demonstrated that women with PMDD had more severe severity insomnia, inattentiveness, and fatigue in the luteal phase than in the follicular phase. A repeated-measures analysis of variance demonstrated that the interaction period of PMDD and a menstrual cycle was significantly associated with insomnia, inattentiveness, and fatigue. A further correlation analysis demonstrated that all three symptoms were positively associated with self-reported functional impairment due to PMDD. Conclusions: Our results demonstrated that women with PMDD experienced an exacerbation of insomnia, memory problems, difficulty maintaining focus, and fatigue in the premenstrual phase. These symptoms are correlated with PMDD symptoms severity and functional impairment, and as such, they should be evaluated, and interventions should be employed in the late luteal phase of women with PMDD.
., 2007; Lin et al., 2007; Gallotta et al., 2010; Wynne and Djakiew, 2010; Endo et al., 2014; Li et al., 2016) . We focused on the topscoring candidates and clinically approved antineoplastic drugs. ...doi:10.3389/fphar.2018.00778 pmid:30087612 pmcid:PMC6066584 fatcat:vf2srikjnfbd7mzldvbytkbaje
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