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Discussion of 'Correlated variables in regression: Clustering and sparse estimation' by Peter Bühlmann, Philipp Rütimann, Sara van de Geer and Cun-Hui Zhang

Rajen D. Shah, Richard J. Samworth
2013 Journal of Statistical Planning and Inference  
We would like to begin by congratulating the authors on their fine paper. Handling highly correlated variables is one of the most important issues facing practitioners in high-dimensional regression problems, and in some ways it is surprising that it has not received more attention up to this point. The authors have made substantial progress towards practical methodological proposals, however, and we are sure that the paper will stimulate considerable future research. In this discussion, we
more » ... ent a possible improvement to the cluster representative Lasso, give some further insights into the cluster group Lasso and conclude with some brief remarks on one possible new direction suggested by the work.
doi:10.1016/j.jspi.2013.05.022 fatcat:hfeb2y36afasxd7k2ovnef3t3a

Theoretical Study for High Energy Density Compounds from Cyclophosphazene [chapter]

Kun Wang, Jian-Guo Zhang, Hui-Hui Zheng, Hui-Sheng Huang, Tong-Lai Zhang
2012 Quantum Chemistry - Molecules for Innovations  
How to reference In order to correctly reference this scholarly work, feel free to copy and paste the following: Kun Wang, Jian-Guo Zhang, Hui-Hui Zheng, Hui-Sheng Huang and Tong-Lai Zhang (2012).  ... 
doi:10.5772/36062 fatcat:urxoqw3qtramzb3dmdssn6fagu

The structural, electronic and catalytic properties of Aun (n = 1–4) nanoclusters on monolayer MoS2

Hui Zhang, Jia Zhu, Hongge Zhang, Jinyan Zhang, Yongfan Zhang, Zhang-Hui Lu
2017 RSC Advances  
The structural stability, electronic and catalytic properties of Aun (n = 1–4) nanoclusters supported on monolayer MoS2 have been investigated based on first principle DFT calculation with van der Waals (vdW) corrections.
doi:10.1039/c7ra07591j fatcat:magxfvjqt5forim4pikcu2z3la

Robust Speaker Extraction Network Based on Iterative Refined Adaptation [article]

Chengyun Deng, Shiqian Ma, Yi Zhang, Yongtao Sha, Hui Zhang, Hui Song, Xiangang Li
2020 arXiv   pre-print
Speaker extraction aims to extract target speech signal from a multi-talker environment with interference speakers and surrounding noise, given the target speaker's reference information. Most speaker extraction systems achieve satisfactory performance on the premise that the test speakers have been encountered during training time. Such systems suffer from performance degradation given unseen target speakers and/or mismatched reference voiceprint information. In this paper we propose a novel
more » ... rategy named Iterative Refined Adaptation (IRA) to improve the robustness and generalization capability of speaker extraction systems in the aforementioned scenarios. Given an initial speaker embedding encoded by an auxiliary network, the extraction network can obtain a latent representation of the target speaker, which is fed back to the auxiliary network to get a refined embedding to provide more accurate guidance for the extraction network. Experiments on WSJ0-2mix-extr and WHAM! dataset confirm the superior performance of the proposed method over the network without IRA in terms of SI-SDR and PESQ improvement.
arXiv:2011.02102v1 fatcat:3qo3vlmvufektnrli6ph373kv4

SALL4 promotes gastric cancer progression via hexokinase II mediated glycolysis

Meng Shao, Jiayin Zhang, Jiahui Zhang, Hui Shi, Yu Zhang, Runbi Ji, Fei Mao, Hui Qian, Wenrong Xu, Xu Zhang
2020 Cancer Cell International  
The stem cell factor SALL4 is reactivated in human cancers. SALL4 plays diverse roles in tumor growth, metastasis, and drug resistance, but its role in tumor metabolism has not been well characterized. The glycolytic levels of gastric cancer cells were detected by glucose uptake, lactate production, lactate dehydrogenase activity, ATP level, and hexokinase activity. QRT-PCR and western blot were used to detect the changes in the expression of glycolytic genes and proteins. The downstream target
more » ... genes of SALL4 were identified by microarray. The regulation of hexokinase II (HK-2) by SALL4 was analyzed by luciferase reporter assay and chromatin immunoprecipitation assay. Transwell migration assay, matrigel invasion assay, cell counting assay and colony formation assay were used to study the roles of HK-2 regulation by SALL4 in gastric cancer cells in vitro. The effects of SALL4 on glycolysis and gastric cancer progression in vivo were determined by subcutaneous xenograft and peritoneal metastasis tumor models in nude mice. SALL4 knockdown inhibited glucose uptake, lactate production, lactate dehydrogenase activity, ATP level and hexokinase activity in gastric cancer cells, and decreased the expression of glycolytic genes and proteins. Microarray analysis showed that SALL4 knockdown affected glycolysis-related pathway. The regulation of HK-2 gene expression by SALL4 was confirmed by luciferase reporter assay and chromatin immunoprecipitation assay. HK-2 knockdown abrogated the promotion of glycolysis by SALL4 in gastric cancer cells, indicating that HK-2 acts as a downstream effector of SALL4. Moreover, HK-2 knockdown reversed the promoting role of SALL4 in gastric cancer cell proliferation, migration and invasion, suggesting that SALL4 drives gastric cancer progression by upregulating HK-2. SALL4 promotes gastric cancer progression through HK-2-mediated glycolysis, which reveals a new mechanism for the oncogenic roles of SALL4 in cancer.
doi:10.1186/s12935-020-01275-y pmid:32489324 pmcid:PMC7247129 fatcat:4oncnndwanc2xmq6uy6oh376z4

DELTA: A DEep learning based Language Technology plAtform [article]

Kun Han, Junwen Chen, Hui Zhang, Haiyang Xu, Yiping Peng, Yun Wang, Ning Ding, Hui Deng, Yonghu Gao, Tingwei Guo, Yi Zhang, Yahao He, Baochang Ma (+9 others)
2019 arXiv   pre-print
In this paper we present DELTA, a deep learning based language technology platform. DELTA is an end-to-end platform designed to solve industry level natural language and speech processing problems. It integrates most popular neural network models for training as well as comprehensive deployment tools for production. DELTA aims to provide easy and fast experiences for using, deploying, and developing natural language processing and speech models for both academia and industry use cases. We
more » ... trate the reliable performance with DELTA on several natural language processing and speech tasks, including text classification, named entity recognition, natural language inference, speech recognition, speaker verification, etc. DELTA has been used for developing several state-of-the-art algorithms for publications and delivering real production to serve millions of users.
arXiv:1908.01853v1 fatcat:nj5usvpvv5e4dh2vnb3ddkird4

Corrosion Behavior of Oxide Scale of 5Cr Steel in CO2 Flooding Environment

Yang Gu, Hui-bin Wu, Zhi-Hui Zhang, Peng-Cheng Zhang, Rui Yuan, Xin-tian Wang, Hui Guo
2022 ISIJ International  
Medium-Cr steel is considered as the most economical and effective pipeline material in a CO 2 flooding environment; however, the effects of iron oxides on the corrosion resistance of medium-Cr steel are still not clear. Therefore, in the present study, a high-temperature, high-pressure reactor was used to accelerate the corrosion of a rolled oxidized sheet of 5Cr steel. The corrosion behavior of oxide scale leaching was studied by comparing the mass loss and gain rate with bare steel, through
more » ... sing XRD, Raman, XPS, SEM, EDS, EPMA and other methods. It was found that the 5Cr steel rolled scale was composed of three layers: the innermost layer contained Fe 3 O 4 , the middle layer consisted of Fe 2 O 3 , and the outer layer contained Fe 3 O 4 and a small amount of Fe 2 O 3 . In the CO 2 environment, the oxide scale mainly dissolved in the initial stage, and corrosion products were deposited in the later stage. The oxide scale delayed the occurrence of corrosion, and eventually, similar to the bare steel, a double-layer product film was formed. Also, the possible corrosion mechanism of the medium-Cr steel with the oxide scale was given. KEY WORDS: 5Cr steel; oxide scale; CO 2 corrosion; microstructure; elemental distribution. ture (above 240°C), and the corrosion products of medium-Cr steel were composed of FeCO 3 , (Fe, Cr) 3 O 4 and Fe 2 O 3 . Moreover, (Fe, Cr) 3 O 4 was prone to crack, decreasing the corrosion resistance of the steel. Chen 6) et al. observed that at 90°C, the formation of dense Fe 2 O 3 decreased the corrosion rate and inhibit overall corrosion. Hua 7) et al. reported that Fe 3 O 4 formed at higher temperatures (250°C) had excellent corrosion resistance. Luo 8) et al. found that the introduction of O 2 in the CO 2 flooding environment resulted in the appearance of Fe 2 O 3 in various forms. Hua 9) et al. reported that in the O 2 environment, in addition to Fe 2 O 3 , FeOOH and Fe 3 O 4 were also formed; thus, uniform corrosion was inhibited, and local corrosion was aggravated. Lin 10) et al. found that in the CO 2 environment containing O 2 , the oxide film of corrosion products formed on the surface of 3Cr steel was loose and porous, and mainly consisted of FeCO 3 , Fe 3 O 4 , and Fe 2 O 3 . No obvious Cr element enrichment in corrosion products was noticed, and the 3Cr steel accelerated pitting corrosion.
doi:10.2355/isijinternational.isijint-2021-471 fatcat:zuwo6tnodvfc7mwhcdqnrylvo4

A Cul4 E3 Ubiquitin Ligase Regulates Histone Hand-Off during Nucleosome Assembly

Junhong Han, Hui Zhang, Honglian Zhang, Zhiquan Wang, Hui Zhou, Zhiguo Zhang
2013 Cell  
Nucleosome assembly also occurs following gene transcription and histone exchange in a DNA replication-independent pathway (Burgess and Zhang, 2013) .  ...  Therefore, nucleosome assembly plays an important role in various processes related to DNA transaction including DNA replication, DNA repair, gene transcription, and epigenetic memory (Burgess and Zhang  ... 
doi:10.1016/j.cell.2013.10.014 pmid:24209620 pmcid:PMC3994564 fatcat:3nfuv6kxbbacnktjb6mgprnmay

Targeting Human Telomerase Reverse Transcriptase by a Simple siRNA Expression Cassette in HepG2 Cells

Hui Xu, Xia Gong, Hui Hui Zhang, Qin Zhang, Dandan Zhao, Jian Xiong Peng
2015 Hepatitis Monthly  
Xia Gong and Hui Hui Zhang contributed to the development of the protocol and prepared the manuscript. Qin Zhang and Dandan Zhao provided administrative, technical and material support.  ...  Hui Xu abstracted and analyzed data, wrote the manuscript and revised the manuscript for important intellectual content.  ...  Zhang et al. transfected chemically synthesized siRNA directly into SiHa cells, but the efficacy of RNAi targeting hTERT was limited (15) . To achieve stable and long-term RNAi, Cheng et al.  ... 
doi:10.5812/hepatmon.24343 pmid:25861317 pmcid:PMC4385270 fatcat:yqs3hujtdjbq7a4cpbr3xq73ma

Cytotoxic indole alkaloids from Nauclea orientalis

Yan-Ping Liu, Peng-Kun Ju, Jin-Tao Long, Liang Lai, Wan-Hui Zhao, Chao Zhang, Zhi-Jie Zhang, Yan-Hui Fu
2017 Figshare  
A new indole alkaloid, nauclorienine (1), along with seven known alkaloids (2–8), were isolated from the stems and leaves of Nauclea orientalis. Among them, nauclorienine (1) was a new indole alkaloid holding a rare corynanthe-type skeleton, and the known compounds (2–8) were isolated from N. orientalis for the first time. Their structures were elucidated on the basis of extensive spectroscopic data analyses. All isolated compounds were evaluated for their cytotoxicities against five human
more » ... r cell lines: HL-60, SMMC-7721, A-549, MCF-7 and SW480 in vitro. Alkaloids 1–4 exhibited significant inhibitory effects against various human cancer cell lines with IC50 values comparable to those of cisplatin.
doi:10.6084/m9.figshare.5539927.v1 fatcat:2baigq4rkba5lmifvtkiqa35kq

Identification of microRNAs for the early diagnosis of Parkinson's disease and multiple system atrophy

Jia-Hui Yan, Ping Hua, Yong Chen, Lan-Ting Li, Cui-Yu Yu, Lei Yan, Hui Zhang, Ying He, Hao Zheng, Hui Chen, Zhao-Jing Zhang, Qi-Hui Yao (+2 others)
2020 Journal of Integrative Neuroscience  
MicroRNAs are reportedly involved in the pathogenesis of neurodegenerative diseases, including Parkinson's disease and multiple system atrophy. We previously identified 7 differentially expressed microRNAs in Parkinson's disease patients and control sera (miR-30c, miR-31, miR-141, miR-146b-5p, miR-181c, miR-214, and miR-193a-3p). To investigate the expression levels of the 7 serum microRNAs in Parkinson's disease and multiple system atrophy, 23 early Parkinson's disease patients (who did not
more » ... e any anti- Parkinson's disease drugs), 23 multiple system atrophy patients, and 24 normal controls were recruited at outpatient visits in this study. The expression levels of the 7 microRNAs in serum were detected using quantitative real-time polymerase chain reaction. A receiver operating characteristic curve was used to evaluate whether microRNAs can differentially diagnose Parkinson's disease and multiple system atrophy. Clinical scales were used to analyze the correlations between serum microRNAs and clinical features. The results indicated that miR-214 could distinguish Parkinson's disease from the controls, and another 3 microRNAs could differentiate multiple system atrophy from the controls (miR-141, miR-193a-3p, and miR-30c). The expression of miR-31, miR-141, miR-181c, miR-193a-3p, and miR-214 were lower in multiple system atrophy than in Parkinson's disease (all P < 0.05). Combinations of microRNAs accurately discriminated Parkinson's disease from multiple system atrophy (area under the receiver operating characteristic curve = 0.951). For the correlation analysis, negative correlations were discovered between the expression of miR-214 and the Hamilton Anxiety Scale and Parkinson's Disease Non-Motor Symptom scores (all P < 0.05). Our results demonstrate that the distinctive characteristics of microRNAs differentiate Parkinson's disease and multiple system atrophy patients from healthy controls and may be used for the early diagnosis of Parkinson's disease and multiple system atrophy.
doi:10.31083/j.jin.2020.03.163 pmid:33070521 fatcat:p7q263htrbaappauysf76atlfi

Compressed Counting Meets Compressed Sensing [article]

Ping Li, Cun-Hui Zhang, Tong Zhang
2013 arXiv   pre-print
Compressed sensing (sparse signal recovery) has been a popular and important research topic in recent years. By observing that natural signals are often nonnegative, we propose a new framework for nonnegative signal recovery using Compressed Counting (CC). CC is a technique built on maximally-skewed p-stable random projections originally developed for data stream computations. Our recovery procedure is computationally very efficient in that it requires only one linear scan of the coordinates.
more » ... r analysis demonstrates that, when 00 and C=pi/2 when p=0.5. In particular, when p->0 the required number of measurements is essentially M=K\log N, where K is the number of nonzero coordinates of the signal.
arXiv:1310.1076v1 fatcat:h3zwjvimkzhs3a6hbwvmu2tuju

Oroxylin A inhibits the generation of Tregs in non-small cell lung cancer

Le Shen, Lu-Lu Zhang, Hui Li, Xiao Liu, Xiao-Xuan Yu, Po Hu, Hui Hui, Qing-Long Guo, Shuai Zhang
2017 OncoTarget  
Oroxylin A (OA), a naturally occurring monoflavonoid isolated from Scutellariae radix, has previously been reported to inhibit the proliferation of several cancer cell lines. CD4 + CD25 + Foxp3 + regulatory T cells (Tregs) play an important role in maintenance of immunologic self-tolerance. Tregs also increase in cancer and take part in suppressing antitumor immune responses. Here, we explored how OA affected the Tregs in lung cancer environment and the involved underlying mechanism. It is
more » ... that OA reversed the generation of Tregs induced by H460 lung cancer cells co-culture. Furthermore, in vivo, OA reduced tumor formation rate and attenuated Foxp3 expression in tumor-infiltrating lymphocytes. We also found that transforming growth factor-β1 (TGF-β1) neutralizing antibody reversed the enhancement of Treg number and expression of p-Smad3ˎp-p38ˎp-JNKˎp-ERK1/2 in the co-culture model. Moreover, OA reduced the secretion of TGF-β1 and down-regulated the activation of NF-κB signaling in H460 cells. OA also inhibited Treg activity by a direct inhibition of the T cells' response to TGF-β1. In conclusion, our study demonstrated that OA inhibits the generation of Tregs in lung cancer environment by inhibiting the T cells' response to TGF-β1 and decreasing the secretion of TGF-β1 in lung cancer cells via NF-κB signaling. ACKNOWLEDGMENTS This work was supported by the Six talent peak project in Jiangsu Province (No.
doi:10.18632/oncotarget.17218 pmid:28472762 pmcid:PMC5564777 fatcat:pcin7o64xnaxney3e6kpo52isy

Simultaneous expression and transportation of insulin by supramolecular polysaccharide nanocluster

Yu-Hui Zhang, Ying-Ming Zhang, Qi-Hui Zhao, Yu Liu
2016 Scientific Reports  
Drug/gene transportation systems with stimuli-responsive release behaviors are becoming research hotspots in biochemical and biomedical fields. In this work, a glucose-responsive supramolecular nanocluster was successfully constructed by the intermolecular complexation of phenylboronic acid modified β-cyclodextrin with adamantane modified polyethylenimine, which could be used as a biocompatible carrier for insulin and pCMV3-C-GFPSpark-Ins DNA which could express insulin codelivery. Benefiting
more » ... om the response capability of phenylboronic acid moiety toward glucose, the encapsulated insulin could be specifically released and the corresponding targeted DNA could efficiently express insulin in HepG2 cell, accompanied by the high-level insulin release in vitro. Our results demonstrate that the simultaneous insulin drug delivery and insulin gene transfection in a controlled mode may have great potential in the clinical diabetes treatments. (PEI), a traditional non-viral gene carrier with high buffer capacity, low immunogenicity, and satisfactory DNA loading capability has been considered as the golden standard of gene transfection 36 Consequently, our designed glucose-responsive supramolecular nanocluster is considered as a potential drug and gene co-delivery system for the diabetes treatments. Results and Discussion Synthesis and complexation of PEI-Ada with PBCD. Adamantane modified polyethylenimine (PEI-Ada) was synthesized according to our previous method 37 , in which 13.7 adamantyl groups were grafted onto the PEI chain on average. Moreover, the β-CD derivative bearing phenylboronic acid group (PBCD) was prepared via "click chemistry" between 4-propargylamine-3-fluorophenylboronic acid and mono-(6-deoxyl-6-azido)-β-CD (see Supplementary Figs S1-S7). In our case, 1-adamantanemethanol (ADA) was employed as a reference guest to evaluate the complexation behavior between PEI-Ada and PBCD. As shown in Supplementary Fig. S8 , the 1 H NMR signals of adamantyl protons showed gradual downfield chemical shifts upon addition of PBCD, indicating PBCD could form inclusion complex with ADA. Moreover, the binding stability constant (K S ) between PBCD and ADA was calculated as 1.11 × 10 4 M −1 using a nonlinear least-squares curve-fitting method. Furthermore, it is also known that the binding constant of multivalent inclusion complex between CD and guest molecules was much higher than the value of monovalent complex 38 . Therefore, it is believed that our supramolecular nanocluster originating from the multivalent inclusion complexation of phenylboronic acid modified β -CD with adamantane modified polyethylenimine could ensure its stability in water. Meanwhile, the 2D ROESY spectrum showed that there was a self-inclusion complex in PBCD, whereas the phenylboronic acid moiety was expelled from the β-CD cavity upon addition of ADA as a competitive guest (see Supplementary Figs S9 and S10). These results jointly indicate that the PEI-Ada-PBCD complex could be formed through the noncovalent interactions between adamantyl groups of PEI-Ada and PBCD. Furthermore, the 11 B NMR experiments were carried out to investigate the interaction between PBCD with PEI-Ada. As expected, a weak interaction was observed between boronic acid and PEI (Fig. S11) and therefore, we can infer that this boronate-PEI interaction associated with host-guest complexation between CD and adamantane were jointly contributed to the formulation of PEI-Ada-PBCD assembly. Characterization of PEI-Ada-PBCD nanocluster. The morphological and structural features of the PEI-Ada-PBCD nanocluster were characterized by transmission electron microscopy (TEM), scanning electron microscopy (SEM), dynamic light scattering (DLS), and zeta potential experiments. As shown in Fig. 2a , TEM images showed that PEI-Ada-PBCD assembly existed as spherical nanoparticles with an average diameter of ca. 183 nm, which was consistent with the results in SEM images (see Supplementary Fig. S12a ). Considering that PEI-Ada alone could also form nanospheres around 30 nm 37 , we can infer that the complexation of PEI-Ada with PBCD could induce the formation of large-sized nanoparticles. Along with these microscopic investigation results, the DLS results demonstrated that the main size distribution of PEI-Ada-PBCD nanocluster was ca. 282 nm, accompanied by a small hydrodynamic diameter centered at 60 nm (Fig. 2b) . In comparison, a diameter
doi:10.1038/srep22654 pmid:26948978 pmcid:PMC4780080 fatcat:shkfc264xzfatacdqg4oxdhq2y

CircDIDO1 inhibits gastric cancer progression by encoding a novel DIDO1-529aa protein and regulating PRDX2 protein stability

Yu Zhang, Jiajia Jiang, Jiayin Zhang, Han Shen, Maoye Wang, Zhen Guo, Xueyan Zang, Hui Shi, Jiayan Gao, Hui Cai, Xinjian Fang, Hui Qian (+2 others)
2021 Molecular Cancer  
Acknowledgements We thank the members of Zhang lab for excellent technical assistance and helpful discussion.  ... 
doi:10.1186/s12943-021-01390-y pmid:34384442 pmcid:PMC8359101 fatcat:cab3ssxprbgnvkhnp6vanpq33y
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