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Cellular responses of aniline oligomers: a preliminary study
2012
Toxicology Research
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Underwater Acoustic Sensor Networks Node Localization Based on Compressive Sensing in Water Hydrology
2019
Sensors
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Groundwater is an important source of human activities, agriculture and industry. Underwater Acoustic Sensor Networks (UASNs) is one of the important technologies for marine environmental monitoring. Therefore, it is of great significance to study the node self- localization technology of underwater acoustic sensor network. This paper mainly studies the node localization algorithm based on range-free. In order to save cost and energy consumption, only a small number of sensing nodes in sensor
doi:10.3390/s19204552
fatcat:3fm2k5ydqjdi5mu5ivfam4a5me
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... tworks usually know their own location. How to locate all nodes accurately through these few nodes is the focus of our research. In this paper, combined with the compressive sensing algorithm, a range-free node localization algorithm based on node hop information is proposed. Aiming at the problem that connection information collected by the algorithm is an integer, the hop is modified to further improve the localization performance. The simulation analysis shows that the improved algorithm is effective to improve the localization accuracy without additional cost and energy consumption compared with the traditional method.
A Node Self-Localization Algorithm with A Mobile Anchor Node in Underwater Acoustic Sensor Networks
2019
IEEE Access
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HONGXU TAO received the B.S degree in communication engineering from Harbin Engineering University, Harbin, China, in 2017, where he is currently pursuing the M.S. degree in information and communication ...
doi:10.1109/access.2019.2904725
fatcat:dt5idml3q5hm5ne43kqd2gazgm
Reduced miR-125a-5p level in non-small-cell lung cancer is associated with tumour progression
2018
Open Biology
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Emerging evidence suggests that microRNAs (miRNAs) serve an important role in tumourigenesis and development. Although the low expression of miR-125a-5p in non-small-cell lung cancer (NSCLC) has been reported, the underlying mechanism remains unknown. In the current study, the low expression of miR-125a-5p in NSCLC was verified in paired cancer tissues and adjacent non-tumour tissues. Furthermore, the CpG island in the miR-125a-5p region was hypermethylated in the tumour tissues, and the
doi:10.1098/rsob.180118
pmid:30305431
pmcid:PMC6223209
fatcat:xmyvv77xgjdjlfgbifcqv4ahwi
more »
... thylation was negatively correlated with miR-125a-5p expression. Target gene screening showed that the histone methyltransferase Suv39H1 was one of the potential target genes. In vitro studies showed that miR-125a-5p could directly suppress Suv39H1 expression and decrease the H3K9me3 levels. On the other hand, Suv39H1 could induce demethylation of miR-125a-5p, resulting in re-activation of miR-125a-5p. What is more, overexpessing miR-125a-5p could also self-activate the silenced miR-125a-5p in NSCLC cells, which suppressed cell migration, invasion and proliferation in vitro and inhibited cancer progression in vivo Thus, we found that the epigenetic silenced miR-125a-5p could be self-activated through targeting Suv39H1 in NSCLC, suggesting that miR-125a-5p might not only have the potential prognostic value as a tumour biomarker but also be a potential therapeutic target in NSCLC.
A Novel and Reasonable Approach for in vivo Liver Gene Transfection in Rats
2012
Journal of Animal and Veterinary Advances
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Large scale synthesis of photoluminescent carbon nanodots and their application for bioimaging
2013
Nanoscale
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Supplemental Table 3-Target prediction via PicTar.pdf from Reduced miR-125a-5p level in non-small-cell lung cancer is associated with tumour progression
2018
Figshare
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Emerging evidence suggests that microRNAs (miRNAs) serve an important role in tumourigenesis and development. Although the low expression of miR-125a-5p in non-small-cell lung cancer (NSCLC) has been reported, the underlying mechanism remains unknown. In the current study, the low expression of miR-125a-5p in NSCLC was verified in paired cancer tissues and adjacent non-tumour tissues. Furthermore, the CpG island in the miR-125a-5p region were hypermethylated in the tumour tissues. And the
doi:10.6084/m9.figshare.7110188
fatcat:cwxhlp3n2vhxrb7gz6eoivhfhi
more »
... ethylation was negatively correlated with the miR-125a-5p expression. Target gene screening showed that the histone methyltransferase Suv39H1 was one of the potential target genes. In vitro studies showed that miR-125a-5p could directly suppress the Suv39H1 expression and decrease the H3K9me3 levels. On the other hand, the Suv39H1 could induce demethylation of miR-125a-5p, resulting in re-activation of miR-125a-5p. What is more, overexpessing miR-125a-5p could also self-activate the silenced miR-125a-5p in NSCLC cells, which suppressed cell migration, invasion and proliferation in vitro and inhibited cancer progression in vivo. Thus, we uncovered here that the epigenetic silenced miR-125a-5p could be self-activated through targeting Suv39H1 in NSCLC, suggesting that miR-125a-5p might not only have the potential prognostic value as a tumour biomarker but also be potential therapeutic targets in NSCLC.
Supplemental Table 1-Target prediction via miRDB.pdf from Reduced miR-125a-5p level in non-small-cell lung cancer is associated with tumour progression
2018
Figshare
Preserved Fulltext
A copy of this work was available on the public web and has been preserved in the Wayback Machine. The capture dates from 2020; you can also visit the original URL.
The file type is application/pdf.
Emerging evidence suggests that microRNAs (miRNAs) serve an important role in tumourigenesis and development. Although the low expression of miR-125a-5p in non-small-cell lung cancer (NSCLC) has been reported, the underlying mechanism remains unknown. In the current study, the low expression of miR-125a-5p in NSCLC was verified in paired cancer tissues and adjacent non-tumour tissues. Furthermore, the CpG island in the miR-125a-5p region were hypermethylated in the tumour tissues. And the
doi:10.6084/m9.figshare.7110185.v1
fatcat:22w4vyknrzhajpzvzfml6iyghq
more »
... ethylation was negatively correlated with the miR-125a-5p expression. Target gene screening showed that the histone methyltransferase Suv39H1 was one of the potential target genes. In vitro studies showed that miR-125a-5p could directly suppress the Suv39H1 expression and decrease the H3K9me3 levels. On the other hand, the Suv39H1 could induce demethylation of miR-125a-5p, resulting in re-activation of miR-125a-5p. What is more, overexpessing miR-125a-5p could also self-activate the silenced miR-125a-5p in NSCLC cells, which suppressed cell migration, invasion and proliferation in vitro and inhibited cancer progression in vivo. Thus, we uncovered here that the epigenetic silenced miR-125a-5p could be self-activated through targeting Suv39H1 in NSCLC, suggesting that miR-125a-5p might not only have the potential prognostic value as a tumour biomarker but also be potential therapeutic targets in NSCLC.
Overexpression of MzASMT 1, a Gene From Malus zumi Mats, Enhances Salt Tolerance in Transgenic Tobacco
2020
Frontiers in Plant Science
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Melatonin, widely found in various plants as a new antioxidant, could protect plants from various biotic and/or abiotic stresses, including salt stress. MzASMT 1 (KJ123721), a gene from Malus zumi Mats, is a key enzyme required for melatonin synthesis. However, whether the overexpression of MzASMT 1 could regulate the synthesis of melatonin and improve the salt tolerance in tobacco remains unknown. In this study, the overexpression of MzASMT 1 in tobacco increased the melatonin content, and the
doi:10.3389/fpls.2020.561903
pmid:33193488
pmcid:PMC7649149
fatcat:s46x7ixvafgm7awajxianveiwa
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... transgenic lines owned higher salt tolerance capacity. The transgenic lines overexpressing MzASMT 1 exhibited lower degree of leaf wilting; much more fresh weight; higher plant height; longer root; higher relative water content (RWC) of leaves, stem, and root; and higher chlorophyll content and Fv/Fm, which makes transgenic lines better adapt to salt stress. The transgenic lines also had higher accumulation of proline, lower accumulation of malondialdehyde (MDA), and improved antioxidant systems, which protected plants from cell damage and oxidative stress due to excess reactive oxygen species (ROS) accumulation under salt treatment. The transcription of salt response genes was much more highly activated in transgenic lines than in wild type under salt stress. The above results contributed to the understanding of functions for MzASMT 1 in tobacco under salt stress and provided a new choice for the application of MzASMT 1 in improving plant salt tolerance.
Integrated physiological and genomic analysis reveals structural variations and expression patterns of candidate genes for colored- and green-leaf poplar
2019
Scientific Reports
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Author Contributions Weibing Zhuang and Henghua Zhai conceived and designed the experiments; Hongxue Wang and Tianyu Liu performed the experiments; Xiaochun Shu, Fengjiao Zhang and Tao Wang analyzed the ...
doi:10.1038/s41598-019-47681-9
pmid:31371772
pmcid:PMC6673700
fatcat:ptbomguypvbblfij4lz6x3wht4
Supplemental Table 2-Target prediction via TargetscanHuman 7.1.pdf from Reduced miR-125a-5p level in non-small-cell lung cancer is associated with tumour progression
2018
Figshare
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THRA
ENST00000450525.2 thyroid hormone receptor, alpha
547
Sites in UTR 1
0
1
0
3
0
TLK2
ENST00000582809.1 tousled-like kinase 2
5
Sites in UTR 1
0
1
0
1*
0
TAOK1
ENST00000261716.3 TAO ...
doi:10.6084/m9.figshare.7110182
fatcat:joyuuw6i7jfnloywdw4mbguiye
Cancer antigen 15-3, platelet distribution width, and fibrinogen in combination to distinguish breast cancer from benign breast disease in non-conclusive mammography patients
2017
OncoTarget
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Breast cancer is the most frequently diagnosed cancer and the leading cause of cancer death among females. However, mammographic diagnosis is sometimes nonconclusive with a Breast imaging Reporting and Data System (Bi-RaDS) result of 0. Cancer antigen 15-3 (CA15-3) is the most widely used serum tumor marker for breast cancer screening. Platelet distribution width (PDW) is an early indicator of platelet activation. Fibrinogen contributed to angiogenesis and distant metastasis. The aim of this
doi:10.18632/oncotarget.18870
pmid:28978076
pmcid:PMC5620216
fatcat:piwwttvoe5d3dfn2apirpjcpbi
more »
... dy was to investigate the ability of CA15-3, PDW, and fibrinogen individually or in combination, to distinguish breast cancer from benign breast disease. 200 consecutive patients with breast cancer and 187 patients with benign breast disease were included in this retrospective study. Patients' characteristics and hematologic tests data at initial diagnosis were collected. The benefit of adding PDW and fibrinogen to a model with only CA15-3 was evaluated as an increased in the area under the curve (AUC) obtained by receiver operating curve (ROC). CA15-3, PDW and fibrinogen are higher in breast cancer patients than in patients with benign breast disease. Single biomarkers had AUC values ranging from 0.687 for fibrinogen to 0.810 for CA15-3. In addition, the combination of PDW, CA15-3, and fibrinogen increased the AUC to 0.900 (0.866-0.928) (p<0.0001), significantly higher than those of any single marker. In conclusion, the combined use of CA15-3, PDW and fibrinogen may be clinically useful in discriminating between breast cancer and benign breast disease in non-conclusive mammography patients.
Overexpression of lysine-specific demethylase 1 promotes androgen-independent transition of human prostate cancer LNCaP cells through activation of the AR signaling pathway and suppression of the p53 signaling pathway
2015
Oncology Reports
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Lysine-specific demethylase 1 (LSD1) is the first defined histone demethylase, and was found to be closely correlated with the development and progression of various types of cancers, including prostate cancer (PCa). Previous research suggests that LSD1 is closely related with cell proliferation, angiogenesis, migration and invasion in PCa. However, it remains to be elucidated whether LSD1 is correlated with androgen-independent (AI) transition of PCa under androgen-ablated conditions. The
doi:10.3892/or.2015.4362
pmid:26534764
fatcat:3a66uoxmardm7catgoii4c5gpm
more »
... nt study aimed to investigate the correlation of LSD1 expression with AI transition of human androgen-dependent PCa LNCaP cells. Our data showed that LSD1 was overexpressed in human PCa specimens and in AI PCa LNCaP-AI cells, which were established through a three-month continuous culture of LNCaP cells in androgen-deprived medium. Under androgen-deprived conditions, LNCaP-AI cells grew perfectly with less apoptosis and G 0 /G 1 cell cycle arrest. Overexpression of LSD1 protected the LNCaP cells from androgen deprivation-induced apoptosis and G 0 /G 1 arrest, while knockdown of LSD1 drove LNCaP-AI cells into a higher rate of apoptosis and G 0 /G 1 arrest. Furthermore, LSD1 was found to regulate the androgen receptor (AR) and p53 signaling pathways via demethylation, subsequently influencing apoptosis and cell cycle progression. These findings revealed that overexpression of LSD1 promoted AI transition of PCa LNCaP cells under androgen-ablated conditions via activation of the AR signaling pathway and suppression of the p53 signaling pathway. Abbreviations: PCa, prostate cancer; AIPC, androgen-independent prostate cancer; AI, androgen-independent; LSD1, lysine-specific demethylase 1; AR, androgen receptor; PSA, prostate-specific antigen
Association of total homocysteine with blood pressure in a general population of Chinese adults: a cross-sectional study in Jiangsu province, China
2018
BMJ Open
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Contents
2021
Heterocycles
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Yang, Guang-Yu 1167 Yang, Wen-Wu 1194 Yu, Li-Fang 1175 Yuan, Jin-Fang 1175 Zhang, Chuan-Bao 1159 Zhang, Huan 1167 Zhang, Jian-Duo 1159 Zhang, Shunguang 1194 Zhang, Ying 1159 Zhang, Youlai 1167 Zhou, Tao ...
Hiroki Mandai,* Kosuke Ashihara, Koichi Mitsudo,
and Seiji Suga*
■ COMMUNICATION
Organocatalyst
DMAP
Desymmetrization
Glycerol
Nucleophilic Catalyst
Tianlong Wei, Haiying Tian, Fang Guo,* Hongxue ...
doi:10.3987/contents-21-10206
fatcat:4p25ju2m6zdopaepewo4uoa5sy
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