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Highly effective photothermal chemotherapy with pH-responsive polymer-coated drug-loaded melanin-like nanoparticles

Chengwei Zhang, Xiaozhi Zhao, Suhan Guo, Tingsheng Lin, Hongqian Guo
2017 International Journal of Nanomedicine  
Similarly, Guo et al and Han et al reported that siRNA could be released in a controlled manner by means of the PAH-cit-modified gold NPs. 21, 22 In the present report, a PDA-based drug delivery system  ... 
doi:10.2147/ijn.s130539 pmid:28331308 pmcid:PMC5348077 fatcat:6wrsvd6uhnff3pzmi3quas7bse

Floating Hydrogel with Self-Generating Micro-Bubbles for Intravesical Instillation

Tingsheng Lin, Xiaozhi Zhao, Yifan Zhang, Huibo Lian, Junlong Zhuang, Qing Zhang, Wei Chen, Wei Wang, Guangxiang Liu, Suhan Guo, Jinhui Wu, Yiqiao Hu (+1 others)
2016 Materials  
Junlong Zhuang, Qing Zhang, Wei Chen, Wei Wang, Guangxiang Liu and Suhan Guo contributed reagents/materials/analysis tools; Tingsheng Lin and Yifang Zhang wrote the paper.  ... 
doi:10.3390/ma9121005 pmid:28774123 pmcid:PMC5456973 fatcat:5oksde7t5zgidk5llzoia3bf5a

Robot-Assisted versus Conventional Open Kidney Transplantation: A Meta-Analysis

Guangxiang Liu, Yongming Deng, Shenjie Zhang, Tingshen Lin, Hongqian Guo, Hiroki Ito
2020 BioMed Research International  
Background. Perioperative and follow-up outcomes for patients that received robot-assisted kidney transplant (RAKT), compared to patients that received conventional open kidney transplant (OKT), remain unknown. We performed a meta-analysis of controlled studies to compare the safety and efficacy of RAKT versus OKT. Methods. Systematic searching of PubMed, Embase, and Cochrane Library databases was performed to identify relevant randomized or nonrandomized controlled studies. Perioperative,
more » ... spital, and follow-up outcomes were summarized. A random-effect model incorporating the potential heterogeneity was used to synthesize the results. Results. Six nonrandomized controlled studies including 263 patients with RAKT and 804 patients with OKT were included. Pooled results showed that compared to those that received OKT, patients that received RAKT had significant higher rewarming time (mean difference (MD): 20.8 min, p < 0.001 ) and total ischemia time (MD: 17.8 min, p = 0.008 ) but a lower incidence of surgical site infection (SSI, risk ratio (RR): 0.22, p = 0.03 ). The incidence of delayed graft function was comparable between groups (RR: 1.10, p = 0.82 ), and the length of hospital stay was similar (MD: -2.03 days, p = 0.21 ). During a follow-up of 31 months, patients that received RAKT and OKT had similar serum creatinine levels (MD: 10.12 mmol/L, p = 0.42 ) and similar incidences of graft rejection (RR: 1.16, p = 0.53 ), graft failure (RR: 0.94, p = 0.79 ), and all-cause mortality (RR: 1.16, p = 0.77 ). Conclusion. Current evidence from nonrandomized studies suggests that RAKT is associated with a lower risk of SSI and similar midterm functional and clinical efficacy compared to OKT. Randomized studies are needed to validate these findings.
doi:10.1155/2020/2358028 pmid:33344632 pmcid:PMC7732374 fatcat:ruf2ttnbdnaqhmfvgteunslvgu

miR-138-5p contributes to cell proliferation and invasion by targeting Survivin in bladder cancer cells

Rong Yang, Minghui Liu, Hongwei Liang, Suhan Guo, Xu Guo, Min Yuan, Huibo Lian, Xiang Yan, Shiwei Zhang, Xi Chen, Feng Fang, Hongqian Guo (+1 others)
2016 Molecular Cancer  
Survivin (encoded by the gene BIRC5) plays an important role in the carcinogenesis of bladder cancer. Identifying miRNAs that target Survivin in the setting of bladder cancer will help to develop Survivin-based therapies for bladder cancer. Methods: The expression levels of miR-138-5p and Survivin protein were measured in 12 resected bladder cancer specimens. The correlation between miR-138-5p and Survivin was further examined by evaluating Survivin expression in human bladder cancer cell lines
more » ... that either overexpressed or knocked down miR-138-5p. A luciferase reporter assay was performed to test the direct binding of miR-138-5p to the target gene BIRC5. We also investigated the biological role of miR-138-5p targeting to Survivin in bladder cancer cell lines both in vivo and in vitro.
doi:10.1186/s12943-016-0569-4 pmid:27978829 pmcid:PMC5159976 fatcat:24jcsautovbbvnlyi7cuodefu4

New Stability Criteria for Event-Triggered Nonlinear Networked Control System with Time Delay

Hongqian Lu, Yue Hu, Chaoqun Guo, Wuneng Zhou
2019 Complexity  
This note focuses on the stability and stabilization problem of nonlinear networked control system with time delay. To alleviate the burden of transformation channel and shorten the dynamic process simultaneously, an improved event-triggered scheme is proposed. This paper employs an improved time delay method to enhance the performance and reduce the delay upper bound conservatism. Less conservative stability criteria related to the order N are derived by establishing an augmented
more » ... vskii functional manufactured for the use of Bessel-Legendre inequality. In addition, an event-triggered controller is designed for nonlinear networked control system with time delay. At last, numerical examples are proposed to verify the effectiveness of the new method.
doi:10.1155/2019/1648576 fatcat:4runvsl5fjervlfrsl66kb7tnu

Renal cell carcinoma with synchronous ipsilateral urothelial carcinoma of the renal pelvis

Qun Lu, Junlong Zhuang, Hongqian Guo
2017 Oncology Letters  
The simultaneous occurrence of renal cell carcinoma (RCC) and urothelial carcinoma (UC) in the same kidney is extraordinarily rare, and is also known as multiple primary malignant tumors. The present study reports the case of a 76-year-old female with synchronous ipsilateral RCC and UC of the renal pelvis, who underwent operation, chemotherapy and reoperation when recurrence of RCC or UC was identified. Cluster of differentiation 44 (CD44) is one of the promising markers for identifying cancer
more » ... tem cells in various solid tumors, along with aldehyde dehydrogenase 1 A1 (ALDH1A1). Detection of CD44 and ALDH1A1 prior to and subsequent to chemotherapy could provide useful prognostic information. New treatments against the cancer stem cells fraction should be used in combination with chemotherapy to improve the outcome for patients with overexpression of CSC markers. Abbreviations; RCC, renal cell carcinoma; UC, urothelial carcinoma; CSCs, cancer stem-like cells; ALDH1A1, aldehyde dehydrogenase 1 A1; CD44, cluster of differentiation 44; CT, computed tomography
doi:10.3892/ol.2017.5981 pmid:28588718 pmcid:PMC5452923 fatcat:natjlnh6nzf6fegjwosyrolwzu

Perioperative outcomes of zero ischemia radiofrequency ablation-assisted tumor enucleation for renal cell carcinoma: results of 182 patients

Chengwei Zhang, Xiaozhi Zhao, Suhan Guo, Changwei Ji, Wei Wang, Hongqian Guo
2018 BMC Urology  
To evaluate the perioperative outcomes of zero ischemia radiofrequency ablation-assisted tumor enucleation. Methods: Patients undergoing zero ischemia radiofrequency ablation-assisted tumor enucleation were retrospectively identified from July 2008 to March 2013. The tumor was enucleated after RFA treatment. R.E.N.A.L., PADUA and centrality index (C-index) score systems were used to assess each tumor case. We analyzed the correlation of perioperative outcomes with these scores. Postoperative
more » ... plications were graded with Clavien-Dindo system. Multivariate logistic regression analyses were used to assess risk of complications. Results: Among 182 patients assessed, median tumor size, estimated blood loss, hospital stay and operative time were 3.2 cm (IQR 2.8-3.4), 80 ml (IQR 50-120), 7 days (IQR 6-8) and 100 min (IQR 90-120), respectively. All three scoring systems were strongly correlated with estimated blood loss, hospital stay and operative time. We found 3 (1.6%) intraoperative and 23 (12.6%, 13 [7.1%] Grade 1 and 10 [5.5%] Grade 2 & 3a) postoperative complications. The median follow-up was 55.5 months . Additionally, the complexities of R.E.N.A.L., PADUA and C-index scores were significantly correlated with complication grades (P < 0.001; P < 0.001; P < 0.001; respectively). As the representative, R.E. N.A.L. score was an independent predictive factor for postoperative complications and patients with a high complexity had an over 24-fold higher risk compared to those with a low complexity (OR 24.360" P < 0.001). Conclusions: Zero ischemia radiofrequency ablation-assisted tumor enucleation is considered an effective nephron-sparing treatment. Scoring systems could be useful for predicting perioperative outcomes of radiofrequency ablation-assisted tumor enucleation.
doi:10.1186/s12894-018-0356-1 pmid:29764415 pmcid:PMC5952571 fatcat:bcamnimrpzdnjnnhairhv5iwge

Self-assembled albumin nanoparticles for combination therapy in prostate cancer

Huibo Lian, Jinhui Wu, Yiqiao Hu, Hongqian Guo
2017 International Journal of Nanomedicine  
doi:10.2147/ijn.s144634 pmid:29123392 pmcid:PMC5661507 fatcat:mx2xraqsanfrtnpoevmbkd5w3e

Xp11.2 translocation renal cell carcinomas in young adults

Linfeng Xu, Rong Yang, Weidong Gan, Xiancheng Chen, Xuefeng Qiu, Kai Fu, Jin Huang, Guancheng Zhu, Hongqian Guo
2015 BMC Urology  
Little is known about the biological behavior of Xp11.2 translocation renal cell carcinomas (RCCs) as few clinical studies have been performed using a large sample size. Methods: This study included 103 consecutive young adult patients (age ≤ 45 years) with RCC who underwent partial or radical nephrectomy at our institution from 2008 to 2013. Five patients without complete clinical data were excluded. Of the 98 remaining patients, 16 and 82 patients were included in the Xp11.2 translocation and
more » ... non-Xp11.2 translocation groups, respectively. Clinicopathologic data were collected, including age, gender, tumor size, laterality, symptoms at diagnosis, surgical procedure, pathologic stage, tumor grade, time of recurrence and death. Results: Xp11.2 translocation RCCs were associated with higher tumor grade and pathologic stage (P < 0.05, Fisher's exact test). During the median follow-up of 36 months (range: 3-71 months), the number of cancer-related deaths was 4 (4.9 %) and 3 (18.7 %) in the non-Xp11.2 translocation and Xp11.2 translocation groups, respectively. The Kaplan-Meier cancer specific survival curves revealed a significant difference between non-Xp11.2 translocation RCCs and Xp11.2 translocation RCCs in young adults (P = 0.042). Conclusions: Compared with non-Xp11.2 translocation RCCs, the Xp11.2 translocation RCCs seemingly showed a higher tumor grade and pathologic stage and have similar recurrence-free survival rates but poorer cancer-specific survival rates in young adults.
doi:10.1186/s12894-015-0055-0 pmid:26126525 pmcid:PMC4487560 fatcat:2kv5a3kcivderdz2ni5wpjhw5e

Hyaluronic Acid-IR780 Nanoparticles for Photothermal Ablation in Orthotopic Renal Cancer

Guangxiang Liu, Tingsheng Lin, Qing Zhang, Shengjie Zhang, Changwei Ji, Shiwei Zhang, Hongqian Guo
2020 Journal of Nanomaterials  
Renal cancer is one of the most common malignancies in urological tumors; it is necessary to develop a noninvasive and highly targeted thermal ablation method for the treatment of renal tumors. IR780 has been shown to be an effective photothermal agent for tumor thermal ablation. This study was designed to explore the feasibility of applying hyaluronic acid-IR780 nanoparticles (HA-IR780 NPs) for targeted thermal ablation of renal tumors using an in situ renal tumor model. The size of the
more » ... ticles was 172±8.2 nm; it showed a stable spherical nanostructure with good monodispersity. HA-IR780 NPs showed high photothermal efficiency, with the 20 μg/mL HA-IR780 NPs showing a maximum temperature increase of 24.5°C with 6 min of 808 nm laser irradiation. NIR imaging showed that the nanoparticles exhibited targeted accumulation in renal tumor tissues. The treatment efficacy of the HA-IR780 NPs showed that renal tumors treated with the HA-IR780 NPs and laser irradiation were effectively ablated. Our results showed that the HA-IR780 nanoparticles that mediated the photothermal effect could generate tumor-specific heat for the destruction of a renal tumor in a minimally invasive way, which provides a novel strategy for thermal ablation of renal tumors.
doi:10.1155/2020/2421971 fatcat:ysj6bwlqyvdcdosqctbfkp4ltu

Image-guided percutaneous renal cryoablation for stage 1 renal cell carcinoma with high surgical risk

Xiang Yan, Mingxin Zhang, Xiaoxiang Chen, Wang Wei, Rong Yang, Yang Yang, Weidong Gan, Hongqian Guo, Yang Wang, Guo-Ping Shi
2015 World Journal of Surgical Oncology  
This study was undertaken to evaluate the feasibility, safety, and therapeutic effects of percutaneous renal cryoablation under local anesthesia with conscious sedation for patients who have unresectable stage 1 (T1NoMo) renal cell carcinoma (RCC) in high surgical risk. Methods: Eighteen patients who were not candidates for surgery underwent primary cryosurgery guided by gray-scale ultrasound. Contrast-enhanced ultrasonography (CEUS) and contrast-enhanced computed tomography (CT) were performed
more » ... to evaluate treatment at completion. Results: The mean follow-up period was 26.8 months (range, 12-56 months). All tumors were biopsied before cryosurgery. Seventeen tumors remained free of enhancement during follow-up period. No major complications associated with cryoablation procedures were found though two instances of subcapsular hematomas, one of retroperitoneal errhysis and one of nausea, were seen after cryoablation. One patient had a local recurrence of tumor and received additional cryoablation. Local tumor control rate was 100 % of T1NoMo tumors including the recurrence case who underwent additional cryoablation. Conclusions: Percutaneous cryoablation can be recommended as a feasible, safe, and promising therapy for the treatment of renal tumor, especially those unresectable stage 1 RCC, with a low risk of complications.
doi:10.1186/s12957-015-0610-x pmid:26059547 pmcid:PMC4468960 fatcat:tjdq3mdttbfglg7hvscjag3wr4

Comparison of radiofrequency ablation and partial nephrectomy for tumor in a solitary kidney

Wu Xiaobing, Gong Wentao, Liu Guangxiang, Zhang Fan, Gan Weidong, Guo Hongqian, Zhang Gutian
2017 BMC Urology  
To estimate oncologic and functional outcomes for radiofrequency ablation (RFA) versus partial nephrectomy (PN) for tumors in a solitary kidney. Methods: Nineteen patients with sporadic renal cell carcinoma in a solitary kidney were treated with RFA, and 21 patients were treated with PN between November 2008 and September 2015. Basic demographic information including age, gender, operative and pathological data, complications, renal function, oncological outcomes, was obtained for each patient.
more » ... Statistical analysis was done to test for the correlation of clinical and pathological features, renal function outcomes, as well as oncological outcomes of RFA and PN. All statistical tests were 2-sided, and p-value < 0.05 was considered significant. Statistical analyses were performed using SPSS 19.0. Results: No significant differences were indicated between the RFA and PN with respect to mean patient age, tumor size, as well as intraoperative or postoperative complications. The mean length of hospitalization (P = 0.019) and mean operative time (P = 0.036) was significantly shorter in RFA, with the median estimated blood loss being greater in PN (P = 0.001). The mean serum creatinine level 24 h following operation were significantly higher than preoperative creatinine in PN (P = 0.009), but did not reach statistical significance in RFA. Local recurrence were detected in only 1 patient (5%) in PN and 3 patients (18.75%) in RFA (P = 0.4). One patient developed pulmonary metastasis and one exhibited tumor persistence in RFA, none were present in PN. Conclusions: Radiofrequency Ablation and Partial Nephrectomy for Tumors in a Solitary Kidney were all safe and effective, with each method having distinct advantages. It is the decision of the patient and urologist to pick the best approach.
doi:10.1186/s12894-017-0269-4 pmid:28877693 pmcid:PMC5588723 fatcat:43uahy2ljbheleiiceurjczyze

The miR-486-5p plays a causative role in prostate cancer through negative regulation of multiple tumor suppressor pathways

Yang Yang, Changwei Ji, Suhan Guo, Xin Su, Xiaozhi Zhao, Shiwei Zhang, Guangxiang Liu, Xuefeng Qiu, Qing Zhang, Hongqian Guo, Huimei Chen
2017 OncoTarget  
Copyright: Yang et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License 3.0 (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. ABSTRACT MicroRNAs have been broadly implicated in cancer, but their exact function and mechanism in carcinogenesis remain poorly understood. Aberrant miR-486-5p expression is frequently found in human cancers. Here we
more » ... a significant overexpression of miR-486-5p in prostate cancer compared with that in normal tissue and cells, and we proposed that altered expression of miR-486-5p in the prostate contributed to prostate cancer. Firstly, miR-486-5p inhibition expression reduced prostate cancercell proliferation, migration, and colonization in vitro and prostate tumor development in vivo. Moreover, we integrated RNA sequencing and target genes prediction, and systemically identified miR-486-5p candidate target genes. We conducted an experiment verifying that miR-486-5p drives tumorigenesis by directly targeting multiple negative regulators, which were involved in PTEN/PI3K/Akt, FOXO, and TGF-b/Smad2 signaling. Finally, we demonstrated that hypoxia-inducible factor-1a and TCF-12 are located at the miR-486-5p promoter, which stimulates the transcription of miR-486-5p itself. Collectively, our findings unveil miR-486-5p as a powerful prostate cancer driver that coordinates the activation of multiple oncogenic pathways and demonstrates some stimulators, which mediate the miR-486-5p signaling pathway and may be targeted for therapy.
doi:10.18632/oncotarget.20427 pmid:29069829 pmcid:PMC5641172 fatcat:fnip3jyzznatxca3ta3zh7mmju

The Therapeutic Effect of Adipose-Derived Mesenchymal Stem Cells for Radiation-Induced Bladder Injury

Xuefeng Qiu, Shiwei Zhang, Xiaozhi Zhao, Kai Fu, Hongqian Guo
2016 Stem Cells International  
This study was designed to investigate the protective effect of adipose derived mesenchymal stem cells (AdMSCs) against radiation-induced bladder injury (RIBI). Female rats were divided into 4 groups: (a) controls, consisting of nontreated rats; (b) radiation-treated rats; (c) radiation-treated rats receiving AdMSCs; and (d) radiation-treated rats receiving AdMSCs conditioned medium. AdMSCs or AdMSCs conditioned medium was injected into the muscular layer of bladder 24 h after radiation. Twelve
more » ... weeks after radiation, urinary bladder tissue was collected for histological assessment and enzyme-linked immunosorbent assay (ELISA) after metabolic cage investigation. At the 1 w, 4 w, and 8 w time points following cells injection, 3 randomly selected rats in RC group and AdMSCs group were sacrificed to track injected AdMSCs. Metabolic cage investigation revealed that AdMSCs showed protective effect for radiation-induced bladder dysfunction. The histological and ELISA results indicated that the fibrosis and inflammation within the bladder were ameliorated by AdMSCs. AdMSCs conditioned medium showed similar effects in preventing radiation-induced bladder dysfunction. In addition, histological data indicated a time-dependent decrease in the number of AdMSCs in the bladder following injection. AdMSCs prevented radiation induced bladder dysfunction and histological changes. Paracrine effect might be involved in the protective effects of AdMSCs for RIBI.
doi:10.1155/2016/3679047 pmid:27051426 pmcid:PMC4802014 fatcat:zrecwnqvube5jml5xqemx5u4ve

NRF‑1 directly regulates TFE3 and promotes the proliferation of renal cancer cells

Wenyuan Zhuang, Xiang Dong, Bo Wang, Ning Liu, Hongqian Guo, Chunni Zhang, Weidong Gan
2021 Oncology Letters  
The role of transcription factor binding to IGHM enhancer 3 (TFE3) in renal cell carcinoma (RCC) is not well understood. Nuclear respiratory factor 1 (NRF-1) may be the positive upstream regulatory gene of TFE3. The aim of the present study was to determine whether NRF-1 could directly regulate the expression of TFE3 and regulate tumorigenesis and progression of RCC through TFE3. Short hairpin RNA (shRNA) was used to silence the expression of NRF-1 in the 786-O human kidney adenocarcinoma cell
more » ... ine and the 293T human embryonic kidney cell line. Luciferase reporter assays were used to determine the relationship between NRF-1 and TFE3. The CHIP experiment was used to verify the actual binding of NRF-1 and TFE3 promoter regions. MitoTimer staining was used to measure mitochondrial biosynthesis. Flow cytometry was used to detect cell cycle and apoptosis. The 786-O and 293T cells were used to examine the underlying mechanism of action. The results demonstrated that NRF-1 could bind to the promoter region of the TFE3 gene and directly regulate the expression of TFE3. Following NRF-1 knockdown, the protein levels of phosphorylated (p)-AKT and p-S6 of mTOR pathway was inhibited, cell cycle progression was blocked, the levels of apoptosis increased, and mitochondrial generation was reduced. Following overexpression of TFE3, the levels of mTOR-associated markers were restored in NRF-1 knockdown cells. These findings suggest that NRF-1 may regulate the mTOR pathway through TFE3 and regulate the energy metabolism, proliferation and growth of cancer cells by directly regulating the expression of TFE3.
doi:10.3892/ol.2021.12940 fatcat:ih6fbqnnwza6tfv3nemmwqfoce
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