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Li, F.W. and Z.L. designed the study, collected the data, analyzed the data and wrote the manuscript. J.S., K.W., T.L. and X.L. collected the data. ... Li, G.L and Z.J. designed and developed a real-time automatic identification system. All authors read and approved the final version of the manuscript. ...doi:10.1038/s41598-021-90345-w pmid:34035389 fatcat:nczznan33bep5kwfp3okh6htue
Chinese contexts (Li & Zhou, 2015) . ... Survey Instruments To contextualise survey instruments in China, we follow Li and Zhou's (2015) recent conceptual model and used their proposed survey instruments to conduct this research. ... Honggui G. Li Dr. Honggui G. Li is an Associate Professor at School of Business Administration, Anhui University of Finance & Economics (China). Dr. ...doi:10.15678/eber.2016.040313 fatcat:46t5psusjnekpjdrdcmpok4ske
(doi:10.2165/00007256-200535090-00004) Botchlett R, Li H, Guo X, Qi T, Zhao J, Zheng J, Woo S-L, Pei Y, Liu M, Hu X, et al. 2016 Glucose and palmitate differentially regulate PFKFB3/ iPFK2 and inflammatory ... (doi:10.1007/s00394-014-0795-8) Arkan MC, Hevener AL, Greten FR, Maeda S, Li Z-W, Long JM, Wynshaw-Boris A, Poli G, Olefsky J & Karin M 2005 IKK-[beta] links inflammation to obesity-induced insulin resistance ...doi:10.1530/joe-16-0580 pmid:28400405 pmcid:PMC5511693 fatcat:mtdwicdni5ckxjreuwyxbr6doa
., 2011; Li et al., 2012; Shivaprasad et al., 2012; Fei et al., 2013) . ...doi:10.3389/fgene.2020.00460 pmid:32528522 pmcid:PMC7264425 fatcat:qetpot5xibbt3py46f6mgnb2dm
Due to the characteristics of large lag and high nonlinearity, the optimizing operation of wastewater treatment process (WWTP) is difficult to be designed. To solve this problem, a control optimization system based on hybrid intelligent technology is proposed in this paper. This system includes a feed-forward compensator, a feedback supervision module, a pre-setting module and a soft-sensor module. To obtain the minimum energy consumption (EC) under effluent standards, the set-points of thedoi:10.5755/j01.itc.46.3.16061 fatcat:3k2mkepp4vghta64im6tfotyte
more »... olved oxygen concentration and nitrate nitrogen concentration are adjusted through feed-forward compensation, feedback correction and online estimation. Finally, the proposed approach is applied on the WWTP simulation model. Compared to the proportional-integral-derivative (PID) and data-driven adaptive optimal controller (DDAOC) methods, simulation results of the method proposed in this paper show better performance.
., 2013; Li et al., 2017) . ... Bao et al. (2013) and Li et al. (2017) found that the pupillary light reflex time (constriction velocity) of sows in a confined crate environment was longer than the grouphoused sows, suggesting that ...doi:10.1093/jas/skz100 pmid:30906947 pmcid:PMC6488348 fatcat:fgtsx3jeqfh23eltchxl6htchy
Glycolysis, a simple pathway of glucose metabolism, critically regulates insulin secretion and metabolic functions of various cells. Depending on cell types, rates of glycolysis are determined at various steps of glycolysis that are subjected to the control of key metabolic and regulatory enzyme(s), which include glucokinase, 6-phosphofructo-1-kinase, and 6-phosphofructo-2-kinase/fructose-2,6bisphosphatase. These enzymes are regulated by both nutritional and hormonal signals at the levels ofdoi:10.1016/j.apsb.2012.06.002 fatcat:2vqtbj5lpbaavmjqid4w62zkru
more »... nscription, translation, and post-translational modifications. In hepatocytes, glycolysis is involved in the control of hepatic glucose production. The latter, when excessive, contributes to hyperglycemia in diabetes. In pancreatic b cells, glycolysis couples glucose-stimulated insulin secretion. Absolute or relatively low levels of circulating insulin causes hyperglycemia. In adipocytes, glycolysis generates metabolites for lipogenesis and channels fatty acids from excessive oxidation to triglyceride synthesis, thereby reducing oxidative stress. With increased proinflammatory status, adipocytes produce prohyperglycemic factors and bring about hyperglycemia and insulin resistance. In hypothalamic neurons, glycolysis conveys nutrient sensing that is related to feeding control. Dysregulation of glycolysis occurs in conditions of insulin deficiency or resistance, and is attributable to inappropriate amount and/or (Chaodong Wu). 1 These authors have equal contribution to this work. Acta Pharmaceutica Sinica B 2012;2(4):358-367 activities of metabolic and regulatory enzymes of glycolysis. Targeting key metabolic and regulatory enzymes to enhance glycolysis may offer viable approaches for treatment of diabetes.
In order to investigate the effect of gentle handling on the behavior, performance, and meat quality of pigs from weaning to slaughter, 144 6-week-old weaned hybrid Min piglets (a native breed) were selected and divided into a handling group (HG: 9 pens × 8 pigs) and a control group (CG: 9 pens × 8 pigs). After 6 weeks of handling, we observed and then evaluated the pigs' responses to a handler with behavioral scores. Moreover, we measured heart rate and production performance. Three pigs weredoi:10.3390/ani10020330 pmid:32092930 pmcid:PMC7070725 fatcat:e2mhais7bjaulpfciubiluyerq
more »... andomly selected from each of the 18 pens and divided into a handling group (HG: n = 27) and a control group (CG: n = 27), and the HG pigs were given gentle handling until slaughter. Subsequently, we evaluated meat quality and the production performance of six pigs from each group. The results show that AA test (approaching–avoidance test) scores in HG pigs, the number of contacts with the handler and absence of contact with the handler, were significantly higher than in the CG pigs (p < 0.01). The occurrences of avoidance and looking at the handler were lower in the HG than in the CG group (p < 0.01); however, heart rate was not found to be significantly different between the two groups (p = 0.63). No significant difference was found in the average daily gain, average daily feed intake, and feed conversion ratio between the two groups during the two periods (p > 0.05). The b* value was determined 45 min after slaughter, and it was significantly lower in the HG than that in the CG group (p = 0.002). Furthermore, 2 h after slaughter, the L value of the HG group was significantly higher than that of the CG group (p = 0.047), but no difference was observed in carcass quality or other meat quality indicators between the two groups (p > 0.05). The results indicate that gentle handling could reduce pigs' anxiety and increase their willingness to approach the handler, increasing the intimacy of the pigs and handlers. However, long-term gentle handling had little effect on pig performance, carcass quality, and meat quality.
Adenosine 2A receptor (A2AR) exerts a protective role in obesity-related non-alcoholic fatty liver disease. Here, we examined whether A2AR protects against non-alcoholic steatohepatitis (NASH). In C57BL/6J mice, feeding a methionine- and choline-deficient diet (MCD) resulted in significant weight loss, overt hepatic steatosis, and massive aggregation of macrophages in the liver compared with mice fed a chow diet. MCD feeding also significantly increased the numbers of A2AR-positivedoi:10.1530/joe-19-0198 pmid:31505462 pmcid:PMC7050433 fatcat:ljwjah5wjnbf5lhxw4kwyx47oa
more »... upffer cells in liver sections although decreasing A2AR amount in liver lysates compared with chow diet feeding. Next, MCD-induced NASH phenotype was examined in A2AR-disrupted mice and control mice. Upon MCD feeding, A2AR-disruptd mice and control mice displayed comparable decreases in body weight and fat mass. However, MCD-fed A2AR-disrupted mice revealed greater liver weight and increased severity of hepatic steatosis compared with MCD-fed control mice. Moreover, A2AR-disupted mice displayed increased severity of MCD-induced liver inflammation, indicated by massive aggregation of macrophages and increased phosphorylation states of Jun-N terminal kinase (JNK) p46 and nuclear factor kappa B (NFκB) p65 and mRNA levels of tumor necrosis factor alpha, interleukin-1 beta, and interleukin-6. In vitro, incubation with MCD-mimicking media increased lipopolysaccharide (LPS)-induced phosphorylation states of JNK p46 and/or NFκB p65 and cytokine mRNAs in control macrophages and RAW264.7 cells, but not primary hepatocytes. Additionally, MCD-mimicking media significantly increased lipopolysaccharide-induced phosphorylation states of p38 and NFκB p65 in A2AR-deficient macrophages, but insignificantly decreased lipopolysaccharide-induced phosphorylation states of JNK p46 and NFκB p65 in A2AR-deficient hepatocytes. Collectively, these results suggest that A2AR disruption exacerbates MCD-induced NASH, which is attributable to, in large part, increased inflammatory responses in macrophages.
Transport stress decreases weight and quality of meat and increases susceptibility to disease with tissue damage and immunity weakening Li et al., 2017; Xing et al., 2017) . ...doi:10.1016/j.psj.2020.12.036 pmid:33652541 pmcid:PMC7936215 fatcat:5gdximgbkrglhe7e4r46kv5pda
Flexible sensors are required to be lightweight, compatible with the skin, sufficiently sensitive, and easily integrated to extract various kinds of body vital signs during continuous healthcare monitoring in daily life. For this, a simple and low-cost flexible temperature and force sensor that uses only two carbon fiber beams as the sensing layer is reported in this work. This simple, flexible sensor can not only monitor skin temperature changes in real time but can also extract most pulsedoi:10.1038/s41528-020-00090-9 fatcat:jqchckhpmfhgvgq7map2rxsble
more »... s, including venous waves, from most parts of the human body. A pulse diagnostic glove containing three such flexible sensors was designed to simulate pulse diagnostic methods used in traditional Chinese medicine. Wearable equipment was also designed in which four flexible sensors were fixed onto different body parts (neck, chest, armpit, and fingertip) to simultaneously monitor body temperature, carotid pulse, fingertip artery pulse, and respiratory rate. Four important physiological indicators—body temperature (BT), blood pressure (BP), heart rate (HR), and respiratory rate (RR)—were extracted by the wearable equipment and analyzed to identify exercise, excited, tired, angry, and frightened body states.
Reducing obesity requires an elevation of energy expenditure and/or a suppression of food intake. Here we show that enhancing hepatic glycolysis reduces body weight and adiposity in obese mice. Overexpression of glucokinase or 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase is used to increase hepatic glycolysis. Either of the two treatments produces similar increases in rates of fatty acid oxidation in extrahepatic tissues, i.e., skeletal muscle, leading to an elevation of energydoi:10.1016/j.cmet.2005.07.003 pmid:16098830 fatcat:ipwjehtzhjb67knccq4ftfmx3e
more »... re. However, only 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase overexpression causes a suppression of food intake and a decrease in hypothalamic neuropeptide Y expression, contributing to a more pronounced reduction of body weight with this treatment. Furthermore, the two treatments cause differential lipid profiles due to opposite effects on hepatic lipogenesis, associated with distinct phosphorylation states of carbohydrate response element binding protein and AMP-activated protein kinase. The step at which hepatic glycolysis is enhanced dramatically influences overall whole-body energy balance and lipid profiles. 132 CELL METABOLISM : AUGUST 2005 Enhancing hepatic glycolysis reduces obesity
Vicinal trifluoromethyl azides have widespread applications in organic synthesis and drug development. However, their preparation is generally limited to transition-metal-catalyzed three-component reactions. We report a simple and metal-free method that...doi:10.1039/d0sc06473d pmid:34164089 pmcid:PMC8179360 fatcat:cxm43tbzp5bzvn5sufto3cf5sq
The first nickel(0)-catalyzed linear-selective hydroarylation of unactivated alkenes and styrenes with organoboronic acids are achieved under redox-neutral conditions.doi:10.1039/c8sc02101e pmid:30310616 pmcid:PMC6115005 fatcat:idsdsoa3ezbnrfmfs5ksq5jb7q
To discover new anti-cancer agents with multi-effect and low toxicity, a series of ligustrazine derivatives were synthesized using several effective anti-tumor ingredients of Shiquandabu Wan as starting materials. Our idea was enlightened by the "combination principle" in drug discovery. The ligustrazine derivatives' anti-tumor activities were evaluated on the HCT-8, Bel-7402, BGC-823, A-549 and A2780 human cancer cell lines. In addition the angiogenesis activities were valued by the chickdoi:10.3390/molecules17054972 pmid:22547319 pmcid:PMC6268357 fatcat:gyqvrs2zbndyfceucggyoyw6ey
more »... oallantoic membrane (CAM) assay. 1,7-bis(4-(3,5,6-Trimethylpyrazin-2-yl)-3-methoxyphenyl)-1,6-heptadiene-3,5-dione (4) and 3 α,12 α-dihydroxy-5β-dholanic acid-3,5,6-trimethylpyrazin-2-methyl ester (5) not only displayed antiproliferative activities on these cancer cells, but also dramatically suppressed normal angiogenesis in CAM. The LD₅₀ value of the compound 5 exceeded 3.0 g/kg by oral administration in mice.
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