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1984) in determining the constant of proportionality (0.015) in (33) was presented by Scott and Stephens (1966) and consists of cross-sectional average hydraulic paa July 1997, Vol. 123, No. 7 , by Hong-Yuan ... Lee, Hui-Ming Hsieh, Jinn-Chuang Yang, and Chih Ted Yang (Paper 1876). 5 Hydro., U.S. ...doi:10.1061/(asce)0733-9429(1999)125:2(206) fatcat:rj4cqyptynbgdhjpcc2fhqmhfu
Since the utilization of transarterial embolization (TAE) for hepatocellular carcinoma, TAE is used to treat bleeding hepatocellular adenomas (HCAs) and occasionally, in symptomatic HCAs with large tumors. However, the role of TAE in an elective setting is uncertain. The present review aims to evaluate the benefits and harms of TAE in bleeding and non-bleeding HCAs, especially in an elective setting. A systematic review of studies published from January 2000 to December 2016 in the EMBASE,doi:10.18632/oncotarget.16140 fatcat:djvgozla7zfinhjnkmfg5lwop4
more »... d and Scopus databases was performed. Avoidance of resection and tumor reduction after TAE were the primary outcomes measure in both bleeding and non-bleeding HCAs. Twenty-one case series involving 1481 patients with HCAs were included in the analysis. Most of them were underwent hepatic resection. Only 148 (10%) patients (involving 189 lesions) received TAE, including 93 (62.8%) patients with bleeding HCAs and 55 (37.2%) patients with non-bleeding HCAs. Based on data of 107 tumors, the rates of Complete Response and Partial Response were 10.3% and 73.8%, respectively. Hepatic resection was avoided in 72 of 148 (48.6%) TAE treated patients. Intended elective TAE was performed in 45/148 (30.4%) patients; 95.6% of them did not require further hepatic resection. No mortality or adverse side effects were reported during the hospitalization period. Therefore, Either in an elective setting or in the setting of bleeding, TAE can be considered safe in the management of HCAs. In the elective setting, TAE can be regarded as a reasonable alternative management to hepatic resection. High-quality prospective study with long-term follow-up is warranted.
Author Contributions Data curation: Yuan-Hong Deng, Chuan-Yuan Tao, Yan-Jing Liang, Su-Hao Yang, Yuan-Rui Yang. ... Resources: Jing Yuan, Su-Hao Yang, Yuan-Rui Yang, Xiao-Yi Xiong. Validation: Yan-Jing Liang. Writing -original draft: Yuan-Hong Deng, Xin-Xiao Zhang, Xiao-Yi Xiong. ...doi:10.1371/journal.pone.0259798 pmid:34780519 pmcid:PMC8592435 fatcat:lay5dixymfhhzffpkjwv3z4mia
E63, o4012 [https://doi.org/10.1107/S1600536807040202] 6,6′-Dimethoxy-2,3,2′,5′-tetranitro-1,1′-biphenyl Xue-Yang Xiao, Shao-Bin Miao, Hong-Hong Lan, Yuan-Yuan Jiang and Bao-Ming Ji S1. ... All bond lengths and angles in the title molecule ( Fig. 1 ) are in the expected range (Unver et al., 2002) and in good agreement with those reported previously (Yang et al., 2005) . ...doi:10.1107/s1600536807040202 fatcat:oq6odj4h3rfudigwxsioehmdvi
The angular spectrum theory is applied to the nonlinear harmonic generation process in optical superlattices. Several explicit and analytical structure functions are deduced to design optical superlattices for various purposes. Employing this method, nonlinear image formation is achieved during the second-harmonic generation process in a properly designed optical superlattice. This method is universal for both nonlinear beam shaping and nonlinear arbitrary image formation. The theory has beenarXiv:1511.07121v1 fatcat:b45te4zja5e65jggqijsqvcbhq
more »... perimentally validated in two-dimensional optical superlattice of LiTaO3 crystals and the results agree well with the theoretical prediction. This work not only extends the application of optical superlattices, but also opens a new area for imaging technologies.
The harms and benefits of adoptive immunotherapy (AIT) for patients with postoperative hepatocellular carcinoma (HCC) are controversial among studies. This study aims to update the current evidence on efficacy and safety of AIT for patients with HCC who have received curative therapy. Electronic databases were systematically searched to identify randomized controlled trials (RCTs) and cohort studies evaluating adjuvant AIT for patients with HCC after curative therapies. Recurrence and mortalitydoi:10.18632/oncotarget.14507 pmid:28061472 pmcid:PMC5392348 fatcat:kjkagfquevh6rkylmqb4oaz6ea
more »... were compared between patients with or without adjuvant AIT. Eight RCTs and two cohort studies involving 2,120 patients met the eligibility criteria and were meta-analyzed. Adjuvant AIT was associated with significantly lower recurrence rate than curative therapies alone at 1 year [risk ratio ( RR) 0.64, 95%CI 0.49-0.82], 3 years (RR 0.85, 95%CI 0.79-0.91) and 5 years (RR 0.90, 95%CI 0.85-0.95). Similarly, adjuvant AIT was associated with significantly lower mortality at 1 year (RR 0.64, 95%CI 0.52-0.79), 3 years (RR 0.73, 95%CI 0.65-0.81) and 5 years (RR 0.86, 95%CI 0.79-0.94). Short-term outcomes were confirmed in sensitivity analyses based on RCTs or choice of a fixed-or random-effect meta-analysis model. None of the included patients experienced grade 3 or 4 adverse events. Therefore, this update reinforces the evidence that adjuvant AIT after curative treatment for HCC lowers risk of recurrence and mortality.
., and Yang and Li [36, 37] . 2'-Deoxyadenosine was detected in C. cicadae, i.e., 28.13 µg/g in coremium and 49.56 µg/g in sclerotium. ... The price of C. cicadae was about 2,000 yuan per kilogram in 2013, which was 1/100 of that of O. sinensis. It was suggested that C. cicadae should be used as substitute for O. sinensis. ...doi:10.3390/molecules19056123 pmid:24830714 fatcat:ga2i3r32lffethifnoik6l2dhy
Compound 1a and 2a Synthesis, Characterization and Photochromic Properties of Novel Spirooxazines XIAO-LI YANG 1,2 , BAO-JIE YANG 1 , YUAN-YUAN LIU 1 and HONG-JUN ZHU 1,* 1 College of Science, Nanjing ...doi:10.14233/ajchem.2013.13846 fatcat:vm6ro25o6nd2bf2w5njuehoiv4
Yan-Hong Bao and Dr. Xiao-Wu Chen for helpful suggestions. ...arXiv:1011.5411v2 fatcat:uqsnzqnbfnffzmcharnkcasuyy
HONG-WEI YANG received the B.S. degree from the College of Electronic Information Engineering, Anhui University, China, in 2018. ... In 2004, he was the University Fellow with Hong Kong Baptist University. From 2005 to 2006, he was a Research Fellow with The Chinese University of Hong Kong. ...doi:10.1109/access.2019.2901764 fatcat:ztucd5y2mzcfloespk6dzvbtbq
Future mainstream microprocessors will likely integrate specialized accelerators, such as GPUs, onto a single die to achieve better performance and power efficiency. However, it remains a keen challenge to program such a heterogeneous multi-core platform, since these specialized accelerators feature ISAs and functionality that are significantly different from the general purpose CPU cores. In this paper, we present EXOCHI: (1) Exoskeleton Sequencer (EXO), an architecture to representdoi:10.1145/1273442.1250753 fatcat:kecpgrwcaneopjizq6iorj5wla
more »... us accelerators as ISA-based MIMD architecture resources, and a shared virtual memory heterogeneous multithreaded program execution model that tightly couples specialized accelerator cores with general purpose CPU cores, and (2) C for Heterogeneous Integration (CHI), an integrated C/C++ programming environment that supports accelerator-specific inline assembly and domain-specific languages. The CHI compiler extends the OpenMP pragma for heterogeneous multithreading programming, and produces a single fat binary with code sections corresponding to different instruction sets. The runtime can judiciously spread parallel computation across the heterogeneous cores to optimize performance and power. We have prototyped the EXO architecture on a physical heterogeneous platform consisting of an Intel R Core TM 2 Duo processor and an 8-core 32-thread Intel R Graphics Media Accelerator X3000. In addition, we have implemented the CHI integrated programming environment with the Intel R C++ Compiler, runtime toolset, and debugger. On the EXO prototype system, we have enhanced a suite of production-quality media kernels for video and image processing to utilize the accelerator through the CHI programming interface, achieving significant speedup (1.41X to 10.97X) over execution on the IA32 CPU alone.
High constitutive expression of Nrf2 has been found in many types of cancers, and this high level of Nrf2 also favors resistance to drugs and radiation. Here we investigate how isoliquiritigenin (ISL), a natural antioxidant, inhibits the Nrf2-dependent antioxidant pathway and enhances the radiosensitivity of HepG2 cells and HepG2 xenografts. Treatment of HepG2 cells with ISL for 6 h selectively enhanced transcription and expression of Keap1. Keap1 effectively induced ubiquitination andpmid:26101703 pmcid:PMC4473316 fatcat:nztitlbjmfallhh6eqr43bnghy
more »... on of Nrf2, and inhibited translocation of Nrf2 to the nucleus. Consequently, expression of Nrf2 downstream genes was reduced, and the Nrf2-dependent antioxidant system was suppressed. Endogenous ROS was higher than before ISL treatment, causing redox imbalance and oxidative stress in HepG2 cells. Moreover, pretreatment with ISL for 6 h followed by X-ray irradiation significantly increased γ-H2AX foci and cell apoptosis, and reduced clonogenic potential compared with cells irradiated with X-rays alone. In addition, HepG2 xenografts, ISL, and X-ray co-treatments induced greater apoptosis and tumor growth inhibition, when compared with X-ray treatments alone. Additionally, HepG2 xenografts, in which Nrf2 was expressed at very low levels due to ectopic expression of Keap1, showed that ISL-mediated radiosensitization was Keap1 dependent. ISL inhibited the Nrf2-antioxidant pathway by increasing the levels of Keap1 and ultimately inducing oxidative stress via disturbance of the redox status. The antioxidant ISL possessed pro-oxidative properties, and enhanced the radiosensitivity of liver cancer cells, both in vivo and in vitro. Taken together, these results demonstrated the effectiveness of using ISL to decrease radioresistance, suggesting that ISL could be developed as an adjuvant radiosensitization drug. Disturbance of redox status could be a potential target for radiosensitization.
Preclinical researches indicated a potential synergistic effect of taxanes-containing chemotherapy (TCC) and antiangiogenic agents (AAs) on the treatment of advanced nonsmall-cell lung cancer (NSCLC). The advantage of adding AA to TCC in the real world remains confusing. We summarized the current evidences from relevant phase II/III randomized controlled trials (RCTs) by performing this meta-analyses. Electronic databases were searched for eligible literatures. The primary endpoint was overalldoi:10.1097/md.0000000000001282 pmid:26252298 pmcid:PMC4616571 fatcat:7fniytvcnjbajcim5rutktpdpe
more »... urvival (OS). Pooled hazard ratios (HRs) and 95% confidence intervals (CIs) for outcomes were calculated using RevMan 5.2. A total of 14 phase II/III RCTs involving 9703 participants were included. Compared to standard TCC, the addition of AA was associated with the significant better OS (HR 0.92, 95% CI 0.87-0.97, P ¼ 0.002), prolonged progression-free survival (HR 0.79, 95% CI 0.71-0.87, P < 0.00001), superior response rate (risk ratio [RR] 1.69, 95% CI 1.47-1.95, P < 0.0001), and disease control rate (RR 1.19, 95% CI 1.08-1.32, P < 0.00001). Subgroup analyses indicated that patient treated with monoclonal antibodies (HR 0.89, 95% CI 0.82-0.96, P ¼ 0.02) as well as application in second-line (HR 0.91, 95% CI 0.85-0.96, P ¼ 0.02) acquired significant OS improvement. Other clinical factors directing significant OS improvement by the combination strategy included nonsquamous cancer (P ¼ 0.002), nonsmokers (P ¼ 0.0005), and female (P ¼ 0.02). Toxicities were greater but generally mild or moderate in the combination group, and were mostly manageable. In summary, the addition of AAs to TCC could improve prognosis of advanced NSCLC. Furthermore, proper selection of patient population and AAs is crucial for clinical trials design and clinical practice in the future. (Medicine 94(31):e1282) Abbreviations: AAs = antiangiogenic agents, CIs = confidence intervals, DCR = disease control rate, EPCs = endothelial progenitor cells, HRs = hazard ratios, MATKIs = multitargeted antiangiogenic TKIs, NSCLC = nonsmall-cell lung cancer, ORR = objective response rate, OS = overall survival, PFS = progressionfree survival, RCTs = randomized controlled trials, RRs = risk ratios, TCC = taxanes-containing chemotherapy, TKIs = tyrosine kinase inhibitors, VEGF = vascular endothelial growth factor. Editor: Liang Han. FIGURE 3. Forest plot and pooled HR and 95% CI for PFS: antiangionesis therapy plus TCC versus TCC alone. CI ¼ confidence interval, HR ¼ hazard ratio, PFS ¼ progression-free survival, TCC ¼ taxanes-containing chemotherapy. FIGURE 4 . Forest plot and pooled RR and 95% CI for ORR: antiangionesis therapy plus TCC versus TCC alone. CI ¼ confidence interval, ORR ¼ objective response rate, RR ¼ risk ratio, TCC ¼ taxanes-containing chemotherapy. FIGURE 5. Forest plot and pooled RR and 95% CI for DCR: antiangionesis therapy plus TCC versus TCC alone. CI ¼ confidence interval, DCR ¼ disease control rate, RR ¼ risk ratio, TCC ¼ taxanes-containing chemotherapy.
The incidence of cutaneous and subcutaneous metastases from atypical laryngeal carcinoids is approximately 20%. However, the pathogenesis and natural history of, and prognostic factors for, the condition remain poorly understood. We reported a 54-year-old female presented with cutaneous and subcutaneous metastases from atypical laryngeal carcinoid. Laryngoscopy revealed a 0.5 Â 1.5-cm reddish mass on the laryngeal surface of the epiglottis. Under general anesthesia, a biopsy sample was obtaineddoi:10.1097/md.0000000000002796 pmid:26886629 pmcid:PMC4998629 fatcat:kqdkbjpojfh5dbmgdtp3bxqo5e
more »... via suspension laryngoscopy. Routine pathology revealed atypical laryngeal carcinoid. Immunohistochemical staining of the sections of primary tumor was positive for cytokeratin, chromogranin A, synaptophysin, hypoxia-inducible factor-1a, P53, and CD56. GLUT-1, p-Akt, and PI3K were negative. The Ki-67 index was 15%. Supraglottic laryngectomy and selective right-neck dissection were performed. After 6 months, the patient complained of pain in the right wall of the chest; multiple cutaneous and subcutaneous nodules were evident at that site and in the abdomen. An abdominal nodule was biopsied and pathology revealed that the atypical metastatic carcinoid had metastasized to both cutaneous and subcutaneous areas of the abdomen. Chemotherapy was then prescribed. Currently, the intrathecal drug delivery system remains in place. No local recurrence has been detected. Furthermore, we systematically reviewed clinical manifestations of the disease, pathogenesis, prognostic factors, and treatment. The metastasis rate (cutaneous and subcutaneous) was approximately 12.2%. Thirty patients (62.5%) with cutaneous and subcutaneous metastases exhibited contemporaneous lymph node invasion. The 3-, 5-, and 10-year survival rates were 44.0%, 22.0%, and 13.0%, respectively. The prognosis of patients with atypical laryngeal carcinoids was poor. Relevant prognostic factors included the level of p53, human papilloma virus status, certain hypoxic markers, and distant metastasis. No optimal treatment for such metastases has yet been defined. (Medicine 95(7):e2796) Abbreviations: CMV = cytomegalovirus, EBV = Epstein-Barr virus, FDG = [18F]-fluoro-2-deoxy-D-glucose, GLUT-1 = glucose transporter-1, HIF-1a = hypoxia-inducible factor-1a, HPV = human papilloma virus, NEC = neuroendocrine carcinomas, PET/ CT = positron emission tomography/computed tomography, PI3K/ Akt = phosphatidylinositol 3-kinase/protein kinase B. Editor: Yung-Song Lin.
High speed and high precision demodulation method of fiber grating based on dispersion effectdoi:10.7498/aps.69.20191340 fatcat:4hey5yrvargtfo4meipjtfjura
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