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Optimal screening for geriatric assessment in older allogeneic hematopoietic cell transplantation candidates

Holly M. Holmes, Jude K.A. Des Bordes, Partow Kebriaei, Sriram Yennu, Richard E. Champlin, Sergio Giralt, Supriya G. Mohile
2014 Journal of Geriatric Oncology  
Puts MT, Hardt J, Monette J, Girre V, Springall E, Alibhai SM. Use of geriatric assessment for older adults in the oncology setting: a systematic review. J Natl Cancer Inst. 2012; 104:1133-1163.  ... 
doi:10.1016/j.jgo.2014.04.004 pmid:24835889 pmcid:PMC4232495 fatcat:uyacb6dsl5fpjfxnqaxck5afbi

Regional-scale patterns in harbour porpoise occupancy of tidal stream environments

James J Waggitt, Holly K Dunn, Peter G H Evans, Jan Geert Hiddink, Laura J Holmes, Emma Keen, Ben D Murcott, Marco Piano, P E Robins, Beth E Scott, Jenny Whitmore, Gemma Veneruso
2017 ICES Journal of Marine Science  
Peer reviewed version Cyswllt i'r cyhoeddiad / Link to publication Dyfyniad o'r fersiwn a gyhoeddwyd / Citation for published version (APA): Abstract As harbour porpoises Phocoena phocoena are abundant within tidal stream environments, mitigating population-level impacts from tidal stream energy extraction is considered a conservation priority. An understanding of their spatial and temporal occupancy of these habitats at a regional-scale will help steer installations towards locations which
more » ... mize energy returns but reduce the potential for interactions with populations. This study quantifies and compares relationships between the presence of harbour porpoise and several hydrodynamic characteristics across four tidal stream environments in Anglesey, UK-a region that has been earmarked for extensive industrial development. Within sites (0.57-1.13 km2), encounters with animals were concentrated in small areas (<200 m2) and increased during certain tidal states (ebb vs. flood). In sites showing relatively high maximum current speeds (2.67-2.87 ms−1), encounters were strongly associated with the emergence of shearlines. In sites with relatively low maximum current speeds (1.70-2.08 ms−1), encounters were more associated with areas of shallow water during peak current speeds. The overall probability of encounters was higher in low current sites. It is suggested that the likelihood of interactions could be reduced by restricting developments to sites with high maximum current speeds (>2.5 ms−1), and placing turbines in areas of laminar currents therein. This study shows that a combination of local and regional hydrodynamic characteristics can partially explain variations in occupancy patterns across tidal-stream environments. However, it was found that such hydrodynamic characteristics could not comprehensively explain these occupancy patterns. Further studies into the biophysical mechanisms creating foraging opportunities within these habitats are needed to identify alternative explanatory variables that may have universal applications.
doi:10.1093/icesjms/fsx164 fatcat:zwdsbnxwpjbo7ju6ofkp2ezj4y

Anger, hostility, and aggression among Iraq and Afghanistan war veterans reporting PTSD and subthreshold PTSD

Matthew Jakupcak, Daniel Conybeare, Lori Phelps, Stephen Hunt, Hollie A. Holmes, Bradford Felker, Michele Klevens, Miles E. McFall
2007 Journal of Traumatic Stress  
E-mail: C 2007 International Society for Traumatic Stress Studies.  ...  M E T H O D Participants The sample for this retrospective review study was comprised of consecutive Iraq and Afghanistan War combat veterans (N = 117), who presented with a variety of concerns to the  ... 
doi:10.1002/jts.20258 pmid:18157891 fatcat:6qp5xhojvnce7l72jlcc44dnhy

Outpatient Minimally Invasive Parathyroidectomy Is Safe for Elderly Patients

Susanna H. Shin, Holly Holmes, Ruijun Bao, Camilo Jimenez, Spencer S. Kee, Elena Potylchansky, Jeffrey E. Lee, Douglas B. Evans, Nancy D. Perrier
2009 Journal of the American College of Surgeons  
BACKGROUND: Elderly patients with primary hyperparathyroidism (PHPT) are often not referred for surgical intervention because of concern of comorbid conditions that may increase perioperative complications. Because PHPT is more common in the elderly, we sought to compare indications and complications of minimally invasive parathyroidectomy in patients 70 years of age and older (elderly) with their younger counterparts. STUDY DESIGN: A review was conducted of a prospectively collected database
more » ... all patients undergoing parathyroidectomy on our endocrine surgery service. Data collected included patient demographic, biochemical pathologic, and operative findings. Wilcoxon rank sum and chi-square tests were used for comparisons. RESULTS: Disclosure Information: Nothing to disclose. This work has been in part generously supported by the American Geriatric Society Jahnigan Scholars Program. Abstract presented at the American College of Surgeons
doi:10.1016/j.jamcollsurg.2009.01.048 pmid:19476894 fatcat:jbdwyoctlvh65b347z4qg4c3qy

Silicone wristbands compared with traditional polycyclic aromatic hydrocarbon exposure assessment methods

Holly M. Dixon, Richard P. Scott, Darrell Holmes, Lehyla Calero, Laurel D. Kincl, Katrina M. Waters, David E. Camann, Antonia M. Calafat, Julie B. Herbstman, Kim A. Anderson
2018 Analytical and Bioanalytical Chemistry  
Holly M. Dixon was supported in part by NIEHS Fellowship T32ES007060 and the ARCS Foundation ® .  ...  Holly Dixon is a PhD candidate in toxicology at Oregon State University.  ...  She is a molecular and environmental epidemiologist at the Columbia C e n t e r f o r C h i l d r e n ' s E n v i r o n m e n t a l H e a l t h (CCCEH).  ... 
doi:10.1007/s00216-018-0992-z pmid:29607448 pmcid:PMC5910488 fatcat:oedatwcy6ranneg52za2vxb7my

Early microgliosis precedes neuronal loss and behavioural impairment in mice with a frontotemporal dementia-causing CHMP2B mutation

Emma L Clayton, Renzo Mancuso, Troels Tolstrup Nielsen, Sarah Mizielinska, Holly Holmes, Nicholas Powell, Frances Norona, Jytte Overgaard Larsen, Carmelo Milioto, Katherine M. Wilson, Mark F Lythgoe, Sebastian Ourselin (+8 others)
2017 Human Molecular Genetics  
Frontotemporal dementia (FTD)-causing mutations in the CHMP2B gene lead to the generation of mutant C-terminally truncated CHMP2B. We report that transgenic mice expressing endogenous levels of mutant CHMP2B developed late-onset † brain volume loss associated with frank neuronal loss and FTD-like changes in social behaviour. These data are the first to show neurodegeneration in mice expressing mutant CHMP2B and indicate that our mouse model is able to recapitulate neurodegenerative changes
more » ... ved in FTD. Neuroinflammation has been increasingly implicated in neurodegeneration, including FTD. Therefore, we investigated neuroinflammation in our CHMP2B mutant mice. We observed very early microglial proliferation that develops into a clear pro-inflammatory phenotype at late stages. Importantly, we also observed a similar inflammatory profile in CHMP2B patient frontal cortex. Aberrant microglial function has also been implicated in FTD caused by GRN, MAPT and C9orf72 mutations. The presence of early microglial changes in our CHMP2B mutant mice indicates neuroinflammation may be a contributing factor to the neurodegeneration observed in FTD.
doi:10.1093/hmg/ddx003 pmid:28093491 pmcid:PMC5409096 fatcat:wt7ul6tuujcdrjoqp4hsktz5ga

Importance of lethal control of invasive predators for island conservation

James C. Russell, Holly P. Jones, Doug P. Armstrong, Franck Courchamp, Peter J. Kappes, Philip J. Seddon, Steffen Oppel, Mark J. Rauzon, Phil E. Cowan, Gérard Rocamora, Piero Genovesi, Elsa Bonnaud (+3 others)
2016 Conservation Biology  
doi:10.1111/cobi.12666 pmid:26634637 fatcat:vxdawvrm5ndclon55bn3bcl524

In Vivo Imaging of Tau Pathology Using Magnetic Resonance Imaging Textural Analysis

Niall Colgan, Balaji Ganeshan, Ian F. Harrison, Ozama Ismail, Holly E. Holmes, Jack A. Wells, Nick M. Powell, James M. O'Callaghan, Michael J. O'Neill, Tracey K. Murray, Zeshan Ahmed, Emily C. Collins (+3 others)
2017 Frontiers in Neuroscience  
doi:10.3389/fnins.2017.00599 pmid:29163005 pmcid:PMC5681716 fatcat:zgpf46bewfgzpbp7wf2uyt7zni

Fully-Automated μMRI Morphometric Phenotyping of the Tc1 Mouse Model of Down Syndrome

Nick M. Powell, Marc Modat, M. Jorge Cardoso, Da Ma, Holly E. Holmes, Yichao Yu, James O'Callaghan, Jon O. Cleary, Ben Sinclair, Frances K. Wiseman, Victor L. J. Tybulewicz, Elizabeth M. C. Fisher (+3 others)
2016 PLoS ONE  
Holmes HE, Colgan N, Ismail O, Ma D, Powell NM, O'Callaghan JM, et al. (2016) Imaging the accumulation and suppression of tau pathology using multi-parametric MRI.  ...  O'Callaghan J, Wells J, Richardson S, Holmes H, Yu Y, Walker-Samuel S, et al. (2014) Is your system calibrated? MRI gradient system calibration for pre-clinical high-resolution imaging.  ... 
doi:10.1371/journal.pone.0162974 pmid:27658297 pmcid:PMC5033246 fatcat:wjr7ooarezgo7b4i4jaxekixje

Induced Pluripotent Stem Cell-Derived Neural Stem Cell Therapy Enhances Recovery in an Ischemic Stroke Pig Model

Emily W. Baker, Simon R. Platt, Vivian W. Lau, Harrison E. Grace, Shannon P. Holmes, Liya Wang, Kylee Jo Duberstein, Elizabeth W. Howerth, Holly A. Kinder, Steve L. Stice, David C. Hess, Hui Mao (+1 others)
2017 Scientific Reports  
T2-weighted FLAIR images taken at 4 weeks (E) and 12 weeks (F) post-transplant showed significant brain atrophy at the area of the infarct.  ...  Flow cytometry demonstrated that 94.8% of iNSCs were Sox1+/Nestin+ and immunocytochemistry confirmed consistent homogeneous expression ( Fig. 1A-E) .  ... 
doi:10.1038/s41598-017-10406-x pmid:28855627 pmcid:PMC5577218 fatcat:5323llpgc5bqdjknlvgzlg7cmm

Correction of the sickle cell disease mutation in human hematopoietic stem/progenitor cells

M. D. Hoban, G. J. Cost, M. C. Mendel, Z. Romero, M. L. Kaufman, A. V. Joglekar, M. Ho, D. Lumaquin, D. Gray, G. R. Lill, A. R. Cooper, F. Urbinati (+13 others)
2015 Blood  
(E) Silent mutations block ZFN recleavage. Figure 3 . 3 Transplantation of ZFN and donor-treated cells into NSG mice.  ...  (E) Engraftment in the peripheral blood as in D of cells from mice receiving either Oligo-, ZFN-, or ZFN1Oligo-treated cells.  ... 
doi:10.1182/blood-2014-12-615948 pmid:25733580 pmcid:PMC4408287 fatcat:5e57d2bdlvgavccudgsgf5zbje

PLA2G10Gene Variants, sPLA2 Activity, and Coronary Heart Disease RiskCLINICAL PERSPECTIVE

Montse Guardiola, Holly J. Exeter, Claire Perret, Lasse Folkersen, Ferdinand van't Hooft, Per Eriksson, Anders Franco-Cereceda, Gabrielle Paulsson-Berne, Jutta Palmen, KaWah Li, Jackie A. Cooper, Kay-Tee Khaw (+7 others)
2015 Circulation: Cardiovascular Genetics  
*Unadjusted B coefficient and standard error (log e scale) from additive model with P values for trend.  ...  †Age-and sex-adjusted B coefficient and standard error (log e scale) from additive model with P value for trend.  ... 
doi:10.1161/circgenetics.114.000633 pmid:25583995 fatcat:6sap4irmojfdlnosbr3eiqltpa

Galanin is an autocrine myelin and oligodendrocyte trophic signal induced by leukemia inhibitory factor

Melissa M. Gresle, Helmut Butzkueven, Victoria M. Perreau, Anna Jonas, Junhua Xiao, Stefan Thiem, Fiona E. Holmes, William Doherty, Pik-Ying Soo, Michele D. Binder, Rainer Akkermann, Vilija G. Jokubaitis (+5 others)
2015 Glia  
doi:10.1002/glia.22798 pmid:25639936 fatcat:mj6niyr2crfqfh2cpyeddvthva

Imaging the accumulation and suppression of tau pathology using multiparametric MRI

Holly E. Holmes, Niall Colgan, Ozama Ismail, Da Ma, Nick M. Powell, James M. O'Callaghan, Ian F. Harrison, Ross A. Johnson, Tracey K. Murray, Zeshan Ahmed, Morton Heggenes, Alice Fisher (+9 others)
2016 Neurobiology of Aging  
rTg4510 mice cohorts, we made 2 comparisons: first, wild-type versus doxycycline-treated rTg4510 mice ( Fig. 2B and C), and second, untreated rTg4510 versus the treated rTg4510 mice ( Fig. 2D and E)  ... 
doi:10.1016/j.neurobiolaging.2015.12.001 pmid:26923415 pmcid:PMC4782737 fatcat:x6ubseyqxzdbjfxbpv3hyuae5a

Tau reduction prevents neuronal loss and reverses pathological tau deposition and seeding in mice with tauopathy

Sarah L. DeVos, Rebecca L. Miller, Kathleen M. Schoch, Brandon B. Holmes, Carey S. Kebodeaux, Amy J. Wegener, Guo Chen, Tao Shen, Hien Tran, Brandon Nichols, Tom A. Zanardi, Holly B. Kordasiewicz (+4 others)
2017 Science Translational Medicine  
(D, E) Total tau mRNA (D) and protein (E) was measured in spinal cord and brain regions at 2 and 6 weeks post initial dose. (F) Experimental design for 5 week brain and CSF tau protein analysis.  ...  The longer six week duration showed both continued tau mRNA reduction as well as improved tau protein reduction compared to the two week duration (Fig. 6D , E).  ... 
doi:10.1126/scitranslmed.aag0481 pmid:28123067 pmcid:PMC5792300 fatcat:2nsnmhowqngglgj2cpbtqcso7q
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