A copy of this work was available on the public web and has been preserved in the Wayback Machine. The capture dates from 2020; you can also visit the original URL.
The file type is
This letter proposes the Faster-than-Nyquist signaling (FTNS) using overlap frequency domain equalization (FDE), which compensates the inter-symbol interference (ISI) due to band limiting filters of the FTNS at the transmitter and the receiver as well as the frequency selective fading channel. Since overlap FDE does not require any guard interval (GI) at the transmitter such as cyclic prefix (CP), higher spectral efficiency can be achieved compared to FTNS scheme using the conventional FDE. InarXiv:1509.00562v1 fatcat:loc7w3xunjdkdfnqwxtgzlyxy4
more »... he proposed method, the equalizer weight is derived based on minimum mean square error (MMSE) criterion taking the colored noise due to the receiving filter into consideration. Moreover, we also give an approximated FDE weight in order to reduce the computational complexity. The performance of the proposed scheme is demonstrated via computer simulations.
Chemical Regulation of Plants
Fukumoto ， T ． Fujii and H ． ... Fukumoto ， N ． Dohmae ， K ． Takio ， T ． Fujii arld Y ． Kamiya ， Plant CeU Ph ／ ' siol． ． 39， 1169 ( 1998) H ． Sekimoto， Y ． Sone and T ． Fujii， Planta ，193， 137 ( 1994) B ． Endo， T ， Fujii， Y ． ...doi:10.18978/jscrpi.34.2_305 fatcat:ziqacbxox5ffrh5ai2ve4hpgda
Inuzuka, Satoko Yamaguchi, Emiko Fukumoto, Keigo Yoshizaki, Takashi Nakamura, Makiko Arakaki, Yuta Chiba, Masaki Ishikawa, Hideyuki Okano, Irma Thesleff, and Satoshi Fukumoto iScience 23, 101329, July ... iScience OPEN ACCESS Article iScience, Volume 23 Article Supplemental Information Sox21 Regulates Anapc10 Expression and Determines the Fate of Ectodermal Organ Kan Saito, Frederic Michon, Aya Yamada, Hiroyuki ...doi:10.1016/j.isci.2020.101329 pmid:32674056 pmcid:PMC7363706 fatcat:cvwrlooobfbjzcujj22ujakocy
In many plate girder highway bridges, fatigue cracks occur at the connections of cross beams to main girders. In this paper, the structural parameters governing the cracking at the cross-beam connections are presented. Then, the relationship between the parameters and the cracking at the cross-beam connections is investigated for the plate girder bridges on a route of the Hanshin Expressway in Osaka, and it is shown that the deformation of a concrete slab due to running vehicles has a greatdoi:10.2208/jscej.1989.410_253 fatcat:r7y7fzn5bnfptk5ossq2ldt5se
more »... uence on the cracking at the cross-beam connections.
Objective: Thoracic aortic aneurysm (TAA) reflects the local expansion of the thoracic aorta; the underlying causal molecular mechanism of TAA is not well understood. Recent studies have shown the importance of transforming growth factor beta (TGFβ) signaling in Marfan and Loeys-Dietz syndromes; however, its role in non-familial, non-syndromic TAA remains unclear. Materials and Methods: We performed histochemical and immunohistochemical analyses for activated (phosphorylated) SMAD2 (P-SMAD2) asdoi:10.3400/avd.oa.17-00114 pmid:29682117 pmcid:PMC5882351 fatcat:zevyhvrd4zgfjcqu3vk3n6ia3q
more »... an indicator of TGFβ signaling activities in the ascending TAA tissue as well as in the ascending aortic tissue with a normal diameter obtained from 7 patients without any clinical findings suggesting familial or syndromic TAA. Results: TAA samples showed a higher P-SMAD2-positive area than samples with a normal diameter. P-SMAD2 signal was higher in the outer zone of the aortic and TAA walls. Within the TAA tissue, P-SMAD2 staining showed the following two distinct patterns: layer-like staining at the border of the medial layer and the thickened intima and a spot-like staining within the medial layer surrounding the microvessels. Conclusion: These findings suggested that TGFβ signaling is activated in several distinct histopathological contexts in TAA, suggesting a complex role of TGFβ.
For example, Fukumoto et al. [4, 18] showed that the beam spread can be reduced based on the imaging magnification at the reception point. ... For example, Fukumoto et al. [4, 18] showed that the beam spread can be reduced based on the imaging magnification at the reception point. ...doi:10.3390/app9091729 fatcat:khyzirlbxza4veo2rwo2bypsca
ECS Proceedings Volumes
We prepared novel ionic liquids containing halogen-free anions. Heterocyclic anions were selected to prepare ionic liquid with low melting point and viscosity. Salts were prepared by neutralization between 1 -ethyl-3 -methylimidazolium hydroxide and corresponding heterocyclic acids. Some o f sulfide salts having heterocyclic structure became ionic liquid and showed relatively low glass transition temperature (Tg). On the other hand, the salts containing azolate anion such as triazolate, becamedoi:10.1149/200424.0346pv fatcat:bxjqniezsvderjschhjvprlqke
Asteroid hyalosis (AH) is characterized by mild vitreous-body liquefaction and a reduced likelihood of posterior vitreous detachment (PVD). Here, we report the clinical features of 2 cases of macular hole (MH) in eyes with AH. The extent of retinal vitreous adhesion at the time of vitreous surgery, the presence or absence of iatrogenic retinal breaks, and the postoperative course was examined in regard to the association with AH. Case presentation: Case 1 involved a 67-year-old female withdoi:10.1097/md.0000000000011243 pmid:29924055 pmcid:PMC6023689 fatcat:4cujqrgbz5cobfj3sxyl7f5ycy
more »... ased visual acuity in her left eye. Although preoperative optical coherence tomography examination revealed complete PVD with operculum around the fovea central region, vitreoretinal adhesion was quite strong starting at the midperiphery of the fundus, and an iatrogenic retinal break was formed at the inferior site during vitreous surgery. Endophotocoagulation was performed, and no onset of retinal detachment (RD) postsurgery was observed. Case 2 involved a 74-year-old male with metamorphopsia in his right eye. Preoperative perifoveal PVD was observed, yet vitreoretinal adhesion was strong starting at the midperiphery of the fundus and multiple iatrogenic retinal breaks had formed on the inferior, superior, and temporal sites. Moreover, RD occurred during surgery. Endophotocoagulation and gas tamponade was performed; however, postoperative RD requiring multiple reoperations occurred. Conclusion: As with normal MH, MH with AH is thought to be caused by perifoveal PVD, yet as the vitreoretinal adhesion was found to be quite strong starting at the midperiphery of the fundus, we decided to keep the artificial PVD within a range where adhesion was loose. Abbreviations: AH = asteroid hyalosis, MH = macular hole, PVD = posterior vitreous detachment, RD = retinal detachment.
Koike, and Kenichi Fukumoto are employees of Taisho Pharmaceutical Co., Ltd. ... Declaration of Conflicting Interests The author(s) declared the following potential conflicts of interest with respect to the research, authorship, and/or publication of this article: Shigeyuki Chaki, Hiroyuki ...doi:10.1177/2470547019837712 pmid:32500107 pmcid:PMC7243201 fatcat:silq2xebkje7ldobjxtlpgmqwy
The buried interface structure was found to cause faint 3×3 periodic ripples in scanning tunneling microscope (STM) at the surface of ultra-thin Ag films on the Si (111) ffiffi ffi 3 p × ffiffiffi 3 p -B substrate. The ripples were purely geometric, since they showed no bias voltage dependence. X-ray diffraction revealed that the Ag/Si lattice commensuration introduces the 3×3 periodic displacement to the bottom layer of the Ag film. The displacement was also found to be transferred to upperdoi:10.1380/vss.61.657 fatcat:jhb47tawhzbhra6vw5kgy33v54
more »... ers in the Ag film while damping. It manifests itself as the 3×3 faint ripples on top of the Ag film in STM.
Objective: Inflammatory response is central to pathogenesis of abdominal aortic aneurysm (AAA). Recently, we reported that Syk, a signaling molecule in inflammatory cells, promotes AAA development in a mouse model. In this study, we aimed to investigate the role of Syk in human AAA pathogenesis. Materials and Methods: We obtained human AAA wall samples during open surgical aortic repair at Kurume University Hospital. Immunohistochemical analyses of AAA samples were performed for Syk activationdoi:10.3400/avd.oa.20-00009 pmid:32595791 pmcid:PMC7315237 fatcat:bxawtxz5nzc7be66or4uy6hf6u
more »... nd cell type markers. Ex vivo culture of human AAA tissue was utilized to evaluate the effect of P505-15, a Syk inhibitor, on secretions of interleukin-6 (IL-6) and matrix metalloproteinases (MMPs). Results: Immunohistochemical analysis showed infiltration of B cells, T cells, and macrophages in AAA samples. Syk activation was localized mainly in B cells and part of macrophages. AAA tissue in culture secreted IL-6, MMP-9, and MMP-2 without any stimulation. The unstimulated secretions of IL-6, MMP-9, and MMP-2 were insensitive to P505-15. Secretions of IL-6 and MMP-9 were enhanced by exogenous normal human immunoglobulin G (IgG), which was suppressed by P505-15, whereas secretion of MMP-2 was insensitive to IgG or P505-15. Conclusion: These results demonstrate an important role of Syk for IgG-dependent inflammatory response in human AAA.
Cold-inducible RNA-binding protein (CIRP) and RNA-binding motif protein 3 (RBM3) are two evolutionarily conserved RNA-binding proteins that are structurally related to hnRNPs and upregulated in response to moderately low temperatures in mammalian cells. Although contributions of splicing efficiency, the gene promoters activated upon mild hypothermia and the transcription factor Sp1 to induction of CIRP have been reported, precise mechanisms by which hypothermia and other stresses induce thedoi:10.1038/s41598-017-02473-x pmid:28536481 pmcid:PMC5442135 fatcat:mveyp37ri5gtnc4ymrsfligmv4
more »... ession of mammalian cold-inducible proteins (CIPs) are poorly understood. By screening the serine/arginine-rich splicing factors (SRSFs), we report that the transcript and protein levels of SRSF5 were increased in mammalian cells cultured at 32 °C. Expression of SRSF5 as well as CIRP and RBM3 were also induced by DNA damage, hypoxia, cycloheximide and hypotonicity. Immunohistochemical studies demonstrated that SRSF5 was constitutively expressed in male germ cells and the level was decreased in human testicular germ cell tumors. SRSF5 facilitated production of p19 H-RAS, and increased sensitivity to doxorubicin in human U-2 OS cells. Induction of CIPs was dependent on transient receptor potential vanilloid 4 (TRPV4) channel protein, but seemed independent of its ion channel activity. These findings indicate a previously unappreciated role for the TRP protein in linking environmental stress to splicing. The transient receptor potential (TRP) channels are, in general, non-selective cation channels that open in response to changes in temperature, ligand binding and other alterations of the channel protein 1, 2 . They play major roles in a variety of sensory modalities such as vision, thermosensation, olfaction, hearing, taste sensation, and mechanosensation, allowing animals to perceive the external environment. Mammalian TRP channels comprise 28 members and are divided into six subfamilies: TRPC, TRPM, TRPV, TRPA, TRPP and TRPML based on their homology of amino acid sequences 3, 4 . Among TRP channels, the temperature-activated kind constitute a subgroup formed by TRPM2, 4, 5, 8, TRPC5, and TRPA1 5, 6 . All of these thermo-TRPs can be activated within specific temperature ranges and transduce inputs into chemical and electrical signals. TRPV3 and TRPV4 have been proposed to be molecular sensors that are involved in the detection of non-noxious warmth. In heterologous expression systems, these channels show a steep increase in activation in response to increases in temperature between 25 and 35 °C 6 . Interestingly, these temperatures include those known to induce mammalian cold-inducible proteins (CIPs), CIRP (Cold-inducible RNA-binding protein, also called CIRBP or A18 hnRNP) and RBM3 (RNA-binding motif protein 3) 7, 8 . Published: xx xx xxxx OPEN www.nature.com/scientificreports/ 2 Scientific RepoRts | 7: 2295 | CIRP and RBM3 are the first proteins found to be induced by mild hypothermia in mammalian cells 9 . These proteins are highly similar to each other and belong to the glycine rich RNA-binding protein family class IVa which is characterized by an RNA recognition motif (RRM, also called CS-RBD) at the N-terminus and a glycine-rich domain at the C-terminus 10 . CIRP and RBM3 are constitutively expressed in the testis the temperature of which is physiologically lower than the body cavity temperature    . In addition to mild hypothermia, CIRP is inducible by other stimuli such as UV and hypoxia, and involved in spermatogenesis, UV-resistance, anti-apoptosis, cell cycle progression and anti-senescence 9 . Furthermore, recent reports have demonstrated that CIRP is a regulator of circadian oscillator genes, including the CLOCK gene 14 , and that when present outside the cells CIRP functions as a damage-associated molecular pattern (DAMP) molecule promoting inflammatory responses and tumorigenesis 15, 16 . Like CIRP, RBM3 is inducible by mild hypothermia and hypoxia. In general, RBM3 enhances global protein translation, and is believed to be a pleiotropic regulator of miRNA and mRNAs 9 . Although possible involvement of the transcription factor Sp1, the promoters in the CIRP gene activated upon mild hypothermia, and importance of splicing efficiency in induction of CIRP have been reported 17-19 , precise mechanisms by which hypothermia and other stresses induce the expression of CIPs are poorly understood. Especially not clarified are the temperature sensors and the signaling pathways leading to the increased expression. Serine/arginine (SR)-rich proteins (also called SR splicing factors, SRSFs) and heterogeneous nuclear ribonucleoproteins (hnRNPs) are two important families of splicing factors that activate or repress splice site selection 20, 21 . SR proteins are characterized by one or two N-terminal RRMs, followed by a downstream domain rich in arginine and serine residues, the RS domain 22 . The mammalian SR protein family consists of 12 members (SRSF1-12), and that of hnRNP at least 24    . The commonalities between these factors consist of the presence of the RRM and their modular domain structure. An ancestral arginine-rich C-terminus seems to have evolved into the canonical RS domain of SR proteins, and hnRNPs contain, in many cases, RGG boxes, suggesting that SR proteins and hnRNPs have a common ancestor 23 . As both CIRP and RBM3 are structurally similar to hnRNPs with RRM and RGG domains, and associate with the spliceosome 9 , we tried to determine in this study whether there are any CIPs belonging to SR proteins. We found that SRSF5 (also called SRp40 or SFRS5) protein is inducible by mild hypothermia and other stresses like CIRP and RBM3. Furthermore, we provide evidence that TRPV4 is necessary for the induction. These findings indicate a previously unappreciated role for the TRP channel protein in linking environmental stress to splicing.
We describe a case of arteriovenous fistula (AVF) successfully treated by coil embolization with an anchor coil inserted in the varix to facilitate dense packing at the shunting site. AVF of the left anterior choroidal artery (AChoA) draining into the ipsilateral basal vein of Rosenthal was incidentally found in a newborn female. A single detachable coil was inserted as an anchor into the varix adjacent to the shunt, and the microcatheter was pulled back to the shunting point. Three moredoi:10.15274/inr-2014-10054 pmid:24976089 pmcid:PMC4178771 fatcat:p477ugfkl5anfjeomz6xp74t34
more »... ble coils were delivered at the shunting point without migration under the support of the anchor coil, and the AVF was successfully obliterated with preservation of AChoA blood flow. The anchor coil technique can reduce the risk of coil migration and the number of coils required.
« Previous Showing results 1 — 15 out of 540 results