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Aptamers offer several advantages over traditional antibodies, including ease of synthesis and modification, high stability and low cost. Aptamers can be also applied to electrochemical (1-4), colorimetric (5,6), fluorescence-based opticaldoi:10.2144/000114425 pmid:27286805 fatcat:w7svttfsprc5ji3v5d2b553g7i
hemokines facilitate leukocyte migration and positioning, as well as other processes such as cell activation and differentiation. 1 They and their receptors constitute a large set of proteins and 2 subfamilies, CXC and CC chemokines and their receptors, have been identified. 2 There is increasing evidence from both clinical and animal studies that leukocytes play a central role in restenosis after balloon angioplasty and stent implantation in patients with coronary artery disease (CAD). Plasmadoi:10.1253/circj.67.851 pmid:14578618 fatcat:7ob4axaxgfgjvn6p2lfg6sbzvu
more »... oncentrations of monocyte chemoattractant protein-1 (MCP-1), which is a ligand for CCR2, are elevated in patients with restenosis after coronary angioplasty 3 and Horvath et al reported that blockade of CCR2 effectively reduced neointimal hyperplasia after stenting in an animal model. 4 Although there is no clear evidence to show that CXC chemokines are associated with coronary stenosis in patients with CAD, recent studies have shown that they are involved in graft rejection and ischemia -perfusion injury. The interferon-inducible protein 10 (IP10) is a chemoattractant for human monocytes and lymphocytes and promotes T cell adhesion to endothelial cells. 5 The presence of CXCR3 + T cells and the CXCR3 ligand IP10 in 169 sequential human endomyocardial biopsies strongly associ-
Moreover, the recrystallized grains had the same orientation as that of Development of Recrystallization Texture in Severely Cold-rolled Pure Iron Miho TOMITA, 1, 4) * Tooru INAGUMA, 2) Hiroaki SAKAMOTO ...doi:10.2355/isijinternational.isijint-2015-567 fatcat:qk5fg6sgmrfi3eyhkf44tqkey4
doi:10.1055/s-0033-1342958 pmid:24436533 pmcid:PMC3709965 fatcat:k2ewsrm5ancqtpvxk5opgma7z4
Tomita et al. / FEBS Letters 573 (2004) 117-120 ...doi:10.1016/j.febslet.2004.07.063 pmid:15327985 fatcat:dksdmfha7fhtxdzhxrsefn5scq
Tomita et al.(2017) で論じた重み付き最尤推定法を目的変数が欠測した状況下において利用す ると，重み付き最尤推定量 θ は， θ = arg max θ U M,n (θ) ( 4 ) U M,n (θ) = 1 n n1 i=1 log f (Y i |X i ; θ) + 1 M M m=1 n i=n1+1 w(X i , Y m i , φ) log f (Y m i |X ... Statist. 47 (1) (2018), 1-16 A Bias-corrected Estimator in Multiple Imputation for Missing Response Variables Hiroaki Tomita 1 , Hironori Fujisawa 1,2,3, * and Masayuki Henmi Abstract Multiple imputation ...doi:10.5023/jappstat.47.1 fatcat:rnxhrqdwprhj7ktzupua6sxq6a
Instrumental Achievements -X -Ray Analysis-Crystal Structure of Sodium N-Acetylneuraminate Trihydrate Naokazu SUGIYAMA*, Kin-ichi SAIT0*, Motoaki GoTo*, Hideo MIzu*, Kenkichi TOMITA*, Hiroaki TAKAYANAGI ...doi:10.2116/analsci.5.491 fatcat:c63s3yyx3neyfkosbd6t4xfnwe
Engei Gakkai zasshi
TOMITA Cinnamomeae is type II showing a plus second principal component score due to prominent perforations (Tables 2, 3, Fig. 14) . ... TOMITA grains for the six traits in each cultivar or species were subjected to principal component analysis by using a program of a computer package, BMDP file, in the Computer Center of Chiba University ...doi:10.2503/jjshs.58.211 fatcat:zxgn2v4rejdu3h5ai3sg2whok4
doi:10.1620/tjem.147.219 pmid:4082179 fatcat:574q7l3yojhfhhvt25sv4icujy
In recent years, the development of self-injectable formulations has attracted much attention, and the development of formulations to control pharmacokinetics, as well as drug release and migration in the skin, has become an active research area. In the present study, the development of a lipid-based depot formulation containing leuprorelin acetate (LA) as an easily metabolizable drug in the skin was prepared with a novel non-lamellar liquid-crystal-forming lipid ofdoi:10.3390/pharmaceutics14040785 pmid:35456619 pmcid:PMC9031317 fatcat:mq52awdjnbenhcwl5mdnxlwl7i
more »... tradecenyl) glycerol ester (MGE). Small-angle X-ray scattering, cryo-transmission electron microscopy, and nuclear magnetic resonance observations showed that the MGE-containing formulations had a face-centered cubic packed micellar structure. In addition, the bioavailability (BA) of LA after subcutaneous injection was significantly improved with the MGE-containing formulation compared with the administration of LA solution. Notably, higher Cmax and faster Tmax were obtained with the MGE-containing formulation, and the BA increased with increasing MGE content in the formulation, suggesting that LA migration into the systemic circulation and its stability might be enhanced by MGE. These results may support the development of self-administered formulations of peptide drugs as well as nucleic acids, which are easily metabolized in the skin.
The position of host factors required for viral replication within a human protein-protein interaction (PPI) network can be exploited to identify drug targets that are robust to drug-mediated selective pressure. Host factors can physically interact with viral proteins, be a component of pathways regulated by viruses (where proteins themselves do not interact with viral proteins) or be required for viral replication but unregulated by viruses. Here, we demonstrate a method of combining a humandoi:10.1101/344861 fatcat:wkr7bjpjejbfpdm3b7dtgss2r4
more »... I network with virus-host protein interaction data to improve antiviral drug discovery for influenza viruses by identifying target host proteins. Network analysis shows that influenza virus proteins physically interact with host proteins in network positions significant for information flow. We have isolated a subnetwork of the human PPI network which connects virus-interacting host proteins to host factors that are important for influenza virus replication without physically interacting with viral proteins. The subnetwork is enriched for signaling and immune processes. Selecting proteins based on network topology within the subnetwork, we performed an siRNA screen to determine if the subnetwork was enriched for virus replication host factors and if network position within the subnetwork offers an advantage in prioritization of drug targets to control influenza virus replication. We found that the subnetwork is highly enriched for target host proteins - more so than the set of host factors that physically interact with viral proteins. Our findings demonstrate that network positions are a powerful predictor to guide antiviral drug candidate prioritization.
Black carbon aerosol (BCA) in the Arctic has profound impacts on the global climate system through radiation processes. Despite its enormous impacts, current global scale models, powerful tools for estimating overall impact, tend to underestimate the levels of BCA in the Arctic over several seasons. Using a global aerosol transport simulation with a horizontal grid resolution of 3.5 km, we determined that a higher resolution significantly reduced the underestimation of BCA levels in the Arctic,doi:10.1038/srep26561 pmid:27222352 pmcid:PMC4879630 fatcat:v7p43i2nojbdtptilfu45q6nmq
more »... mainly due to an enhancement of the representation of low-pressure and frontal systems. The BCA mass loading in the Arctic simulated with 3.5-km grid resolution was 4.2-times larger than that simulated with coarse (56-km) grid resolution. Our results also indicated that grid convergence had not occurred on both the contrast between the cloud/cloud free areas and the poleward BCA mass flux, despite the use of the 3.5-km grid resolution. These results suggest that a global aerosol transport simulation using kilometre-order or finer grid resolution is required for more accurate estimation of the distribution of pollutants in the Arctic. Over the last three decades, black carbon aerosol (BCA), primarily derived from the burning of biomass, agricultural waste, and fossil fuels, has been an important research topic due to extensive impacts on the global climate through atmospheric radiation processes 1,2 . BCA absorbs sunlight and heats the atmosphere 3 , and when it accumulates on snow-covered surfaces it reduces reflectance 2 . Through these processes, BCA has played a significant role in the warming of the Arctic 2 and has become a key topic in climate research. The Fifth Assessment Report of the Intergovernmental Panel for Climate Change (IPCC AR5) 1 reported that there is still considerable uncertainty in radiative forcing (0.3-1.2 W m −2 ), with the most accurate estimation of 0.64 W m −2 being about one-third that of carbon dioxide. To reduce this uncertainty, many studies have coupled global climate models (GCMs) with aerosol transport models. However, the geographical distribution of BCA simulated by the different models displays considerable variation 4 , and almost all of the models underestimate compared with in situ measurements in the Arctic (e.g., sites at Alert, Barrow, and Zeppelin 5 ) in spring and winter. A recent modelling study indicated that BCA simulated by the models overestimated BCA levels compared with in situ measurements in summer, but the variation between the results of each model was large 6 . Although, recent studies have reported that the underestimation can be reduced by implementing missing of BCA emission in the Arctic 6-8 , it has been commonly accepted that the BCA found in the Arctic has been carried long distances from the mid-latitudes 9 , due to the limited number of BCA emission sources in the region 10 . Accordingly, it is reasonable to assume that current-generation GCMs should accurately resolve the processes responsible for this long-range transport 11 , as a prerequisite for conducting accurate estimations of Arctic BCA levels. Many studies have attempted to understand the uncertainties of the BCA levels in the Arctic by focusing on emission inventories and the microphysical processes of BCA. One study estimated the BCA emission from Asia and Europe using a data assimilation system (Kalman filter) 12 and concluded that an emission inventory with a fine resolution could be a solution to reduce the underestimation 8 .
Copyright © 2016 Takahashi, Yu, Sakai and Tomita. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). ...doi:10.3389/fncel.2016.00144 pmid:27375431 pmcid:PMC4891983 fatcat:c3c6fhstkrby5by7n7yh3omdxy
In some pathological conditions, microglia activation * Correspondence to: Hiroaki Tomita, MD, PhD, Department of Disaster Psychiatry, International Research Institute of Disaster Science, Tohoku University ...doi:10.3233/nib-160110 fatcat:ufdfxer5vbgg7lfvgbhkco6tre
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