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Resting State Cortical Electroencephalographic Rhythms in Alzheimer`s Disease

Claudio Babiloni, Fabrizio Vecchio, Roberta Lizio, Giovanni B. Frisoni, Raffaele Ferri, Guido Rodriguez, Paolo M. Rossini
2010 The Open Nuclear Medicine Journal  
However, age is the main risk factor for neurodegenerative disorders such as Alzheimer's disease (AD) that impact on cognition.  ...  Physiological brain aging is characterized by a loss of synaptic contacts and neuronal apoptosis that provoke age-dependent decline of cognitive functions.  ...  Roberta Lizio carried out this research in the framework of Doctoral School on "Neurophysiology" at the Department of Physiology and Pharmacology, University of Rome Sapienza -Italy.  ... 
doi:10.2174/1876388x01002010063 fatcat:z2cgswco3ffllkhc5seierzv2a

Electroencephalographic Rhythms in Alzheimer's Disease

Roberta Lizio, Fabrizio Vecchio, Giovanni B. Frisoni, Raffaele Ferri, Guido Rodriguez, Claudio Babiloni
2011 International Journal of Alzheimer's Disease  
Modern neurophysiological techniques, such as electroencephalography (EEG) and event-related potentials (ERPs), are useful tools in the investigation of brain cognitive function in normal and pathological  ...  However, age is the major risk factor for most common neurodegenerative disorders that impact on cognition, like Alzheimer's disease (AD).  ...  for delta, theta, alpha 1, alpha 2, beta 1 (13) (14) (15) (16) (17) (18) (19) (20) , and beta 2 (20-30 Hz) bands in normal elderly (Nold), mild cognitive impairment (MCI) and mild Alzheimer's disease  ... 
doi:10.4061/2011/927573 pmid:21629714 pmcid:PMC3100729 fatcat:72hx7mkpizchvjtyomoaa6tafa

Healthy and Pathological Brain Aging: From the Perspective of Oscillations, Functional Connectivity, and Signal Complexity

Ryouhei Ishii, Leonides Canuet, Yasunori Aoki, Masahiro Hata, Masao Iwase, Shunichiro Ikeda, Keiichiro Nishida, Manabu Ikeda
2017 Neuropsychobiology  
Healthy aging is associated with impairment in cognitive information processing.  ...  oscillatory responses during cognitive or motor tasks, functional connectivity between brain regions, and changes in signal complexity.  ...  Findings in other EEG studies on mild cognitive impairment (MCI) indicate that alpha rhythm can also discriminate patients with a stable cognitive state from those with unstable global cognition [19]  ... 
doi:10.1159/000486870 pmid:29466802 fatcat:p4kewmq2kfdvbi3prwhzkcg4dy

"Small World" architecture in brain connectivity and hippocampal volume in Alzheimer's disease: a study via graph theory from EEG data

Fabrizio Vecchio, Francesca Miraglia, Francesca Piludu, Giuseppe Granata, Roberto Romanello, Massimo Caulo, Valeria Onofrj, Placido Bramanti, Cesare Colosimo, Paolo Maria Rossini
2016 Brain Imaging and Behavior  
Weighted and undirected networks were built by the eLORETA solutions of the cortical sources' activities moving from EEG recordings.  ...  Brain imaging plays an important role in the study of Alzheimer's disease (AD), where atrophy has been found to occur in the hippocampal formation during the very early disease stages and to progress in  ...  The first is the functional relationships between hippocampal volume and cortical sources regarding the network of delta and alpha rhythms.  ... 
doi:10.1007/s11682-016-9528-3 pmid:26960946 fatcat:4lo4yuzayjhdhh4gkl7ql4ylki

Resting state cortical EEG rhythms in Alzheimer's disease [chapter]

Fabrizio Vecchio, Claudio Babiloni, Roberta Lizio, Fabrizio De Vico Fallani, Katarzyna Blinowska, Giulio Verrienti, Giovanni Frisoni, Paolo M. Rossini
2013 Supplements to Clinical Neurophysiology  
This review provides an overview of the studies on resting state eyes closed EEG rhythms recorded in amnesic mild cognitive impairment (MCI) and AD subjects.  ...  In this line, digital electroencephalography (EEG) allows non-invasive analysis cortical neuronal synchronization as revealed by resting state brain rhythms.  ...  In AD patients with global cognitive impairment, hippocampal atrophy was associated to increased power of delta and theta rhythms in temporal and parietal regions (Helkala et al., 1996) , in line with  ... 
doi:10.1016/b978-0-7020-5307-8.00015-6 pmid:24053043 fatcat:efdzlz2hkfb5dkelrj2ztqf7g4

Electro-Physiological Approaches to Monitoring Neuro- Degenerative Diseases [chapter]

Manuel J., Camilo Orozco, Francisco Ole
2013 Neurodegenerative Diseases  
Hippocampal volume and cortical sources of EEG alpha rhythms in mild cognitive impairment and "lzheimer disease. Neuroimage. Jan -. [ ] Duffy FH, Mc"nulty G", "lbert MS.  ...  The cognitive and EEG changes are probably related to atrophy of the cholinergic neurons in the hippocampal structures [ ].  ... 
doi:10.5772/55228 fatcat:qfesgxx4vrfujemu2ejcko7rmq

Individual analysis of EEG frequency and band power in mild Alzheimer's disease

D Moretti
2004 Clinical Neurophysiology  
Methods: EEGs were recorded at rest in 30 normal elderly subjects (Nold), 60 mild Alzheimer disease (AD) and 20 vascular dementia (VaD) patients, comparable for Mini Mental State Evaluation scores (MMSE  ...  Objective: This EEG study investigates the role of the cholinergic system, cortico-cortical connections, and sub-cortical white matter on the relationship between individual EEG frequencies and their relative  ...  Conclusions The present EEG study investigated the respective role of the cholinergic system and cortico-cortical connections (impaired in mild AD), and the sub-cortical white matter (lesioned in VaD)  ... 
doi:10.1016/s1388-2457(03)00345-6 pmid:14744569 fatcat:72yeygobbra2hcpmj554uziv3i

Disease Tracking Markers for Alzheimer's Disease at the Prodromal (MCI) Stage

Valeria Drago, Claudio Babiloni, David Bartrés-Faz, Anna Caroli, Beatriz Bosch, Tilman Hensch, Mira Didic, Hans-Wolfgang Klafki, Michela Pievani, Jorge Jovicich, Luca Venturi, Philipp Spitzer (+18 others)
2011 Journal of Alzheimer's Disease  
Older persons with Mild Cognitive Impairment (MCI) feature neurobiological Alzheimer's Disease (AD) in 50% to 70% of the cases and develop dementia within the next 5 to 7 years.  ...  Several spectral markers of resting state EEG rhythms that might reflect neurodegenerative processes in the prodromal stage of AD (EEG power density, functional coupling, spectral coherence, and synchronization  ...  Specifically, it has been shown that posterior low frequency alpha sources were maximum in MCI with larger hippocampal volume, intermediate in MCI with smaller hippocampal volume, and low in AD patients  ... 
doi:10.3233/jad-2011-0043 pmid:21971460 fatcat:m7dg5wpj3rfqpdlvxfkamgqfe4

Ibuprofen treatment modifies cortical sources of EEG rhythms in mild Alzheimer's disease

Claudio Babiloni, Giovanni B. Frisoni, Claudio Del Percio, Orazio Zanetti, Cristina Bonomini, Emanuele Cassetta, Patrizio Pasqualetti, Carlo Miniussi, Mario De Rosas, Anna Valenzano, Giuseppe Cibelli, Fabrizio Eusebi (+1 others)
2009 Clinical Neurophysiology  
Here we evaluated the hypothesis that long-term ibuprofen treatment affects cortical sources of resting electroencephalographic (EEG) rhythms in mild AD patients.  ...  EEG rhythms were delta (2-4 Hz), theta (4-8 Hz), alpha 1 (8-10.5 Hz), alpha 2 (10.5-13 Hz), beta 1 (13-20 Hz), and beta 2 (20-30 Hz). LORETA was used for EEG source analysis.  ...  We also thank Angelini SpA and Astra-Zeneca Pharmaceuticals for the supply of active drug tablets and relative placebo.  ... 
doi:10.1016/j.clinph.2009.02.005 pmid:19324592 fatcat:y2tnla4skvfunkgl6shi6wvlim

Sensory evoked and event related oscillations in Alzheimer's disease: a short review

Görsev G. Yener, Erol Başar
2010 Cognitive Neurodynamics  
Our findings support the notion of disconnectivity of cortico-cortical connections in AD.  ...  Diagnosis and treatment of Alzheimer's disease (AD) depend on clinical evaluation and there is a strong need for an objective tool as a biomarker.  ...  Cortical EEG sources were correlated with MR-based measurements of the lobar brain volume (white and gray matter).  ... 
doi:10.1007/s11571-010-9138-5 pmid:22132038 pmcid:PMC2974091 fatcat:fmwhxo2rifeivcqd7hwkn32oz4

Neurophysiological Markers of Alzheimer's Disease: Quantitative EEG Approach

Una Smailovic, Vesna Jelic
2019 Neurology and Therapy  
, while they often inadequately mirror the degree of cognitive and functional deficits in affected subjects.  ...  global synchronization and anteriorization of neuronal generators of fast-frequency resting-state EEG activity in patients along the AD continuum.  ...  This notion was substantiated in a study by Babiloni et al., who demonstrated a correlation of the level of hippocampal and occipital gray matter volume and density with cortical alpha activity, estimated  ... 
doi:10.1007/s40120-019-00169-0 pmid:31833023 pmcid:PMC6908537 fatcat:kbe3r2r5ivatfldkdembt5trqi

Neurophysiological Hallmarks of Neurodegenerative Cognitive Decline: The Study of Brain Connectivity as A Biomarker of Early Dementia

Paolo Maria Rossini, Francesca Miraglia, Francesca Alù, Maria Cotelli, Florinda Ferreri, Riccardo Di Iorio, Francesco Iodice, Fabrizio Vecchio
2020 Journal of Personalized Medicine  
Mild cognitive impairment (MCI) is an intermediate stage between dementia and normal brain aging.  ...  If the risk factors favoring degenerative mechanisms are modified during early stages (i.e., in the prodromal), the degenerative process and the loss of abilities in daily living activities will be delayed  ...  , Alpha band connectivity was negatively correlated, while slow (delta) and fast-frequency (beta, gamma) bands positively correlated with the hippocampal volume of Alzheimer subjects.  ... 
doi:10.3390/jpm10020034 pmid:32365890 pmcid:PMC7354555 fatcat:srfn4n6ohnhovcxql26exo7vly

Biomarkers in Alzheimer's disease with a special emphasis on event-related oscillatory responses [chapter]

Görsev G. Yener, Erol Başar
2013 Supplements to Clinical Neurophysiology  
Studies of SE coherence in mild AD subjects imply almost intact connectivity in all frequency ranges, whereas ER coherence is decreased in wide connections in alpha, theta, and delta frequency ranges.  ...  In addition, the most common finding in spontaneous EEG of AD is decrease of fast and increase of slow frequencies.  ...  In previous studies of spontaneous electroencephalography (EEG), AD patients had increased delta and theta, and decreased alpha rhythms compared to healthy controls and/or amnesic mild cognitive impairment  ... 
doi:10.1016/b978-0-7020-5307-8.00020-x pmid:24053044 fatcat:4ebjx3kzozfiff5xrwsmxeqq3u

Abnormalities of Cortical Sources of Resting State Delta Electroencephalographic Rhythms Are Related to Epileptiform Activity in Patients With Amnesic Mild Cognitive Impairment Not Due to Alzheimer's Disease

Claudio Babiloni, Giuseppe Noce, Carlo Di Bonaventura, Roberta Lizio, Maria Teresa Pascarelli, Federico Tucci, Andrea Soricelli, Raffaele Ferri, Flavio Nobili, Francesco Famà, Eleonora Palma, Pierangelo Cifelli (+4 others)
2020 Frontiers in Neurology  
EEG activity (spike-sharp wave discharges, giant spikes) and amnesic mild cognitive impairment not due to Alzheimer's disease (noADMCI-EEA) than matched noADMCI patients without EEA (noADMCI-noEEA).  ...  In the present exploratory and retrospective study, we hypothesized that cortical sources of resting state eyes-closed electroencephalographic (rsEEG) rhythms might be more abnormal in patients with epileptiform  ...  The members and institutional affiliations of the Consortia are reported in the cover page of this manuscript.  ... 
doi:10.3389/fneur.2020.514136 pmid:33192962 pmcid:PMC7644902 fatcat:jyoneyonxrevpghciaprcxyk4q

Neuroimaging markers of global cognition in early Alzheimer's disease: A magnetic resonance imaging-electroencephalography study

Markus Waser, Thomas Benke, Peter Dal-Bianco, Heinrich Garn, Jochen A. Mosbacher, Gerhard Ransmayr, Reinhold Schmidt, Stephan Seiler, Helge B. D. Sorensen, Poul J. Jennum
2018 Brain and Behavior  
Magnetic resonance imaging (MRI) and electroencephalography (EEG) are a promising means to an objectified assessment of cognitive impairment in Alzheimer's disease (AD).  ...  Individually, however, these modalities tend to lack precision in both AD diagnosis and AD staging.  ...  AD typically impairs cognitive complex domains, the sequence and severity of impairment varies from patient to patient, even more so in the earliest disease stages.  ... 
doi:10.1002/brb3.1197 pmid:30592179 pmcid:PMC6346656 fatcat:l7m5xeeahndwjpvxurtgjnqtpi
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