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Translating the MAM model of psychosis to humans

Gemma Modinos, Paul Allen, Anthony A. Grace, Philip McGuire
2015 Trends in Neurosciences  
We review a number of recent neuroimaging studies that examine components of the putative model in people with an ultra high risk (UHR) of psychosis.  ...  Whilst data from these studies are broadly consistent with the MAM model, that the potential for comparing various kinds of neurobiological data across animal and human studies imposes some limitations  ...  Acknowledgments This work was supported by a NARSAD Young Investigator Grant (#21200, G.M.).  ... 
doi:10.1016/j.tins.2014.12.005 pmid:25554679 pmcid:PMC4455929 fatcat:4uonordwmffkhgyfr7zqhbiu2a

Associations of hippocampal metabolism and regional brain grey matter in neuroleptic-naïve ultra-high-risk subjects and first-episode schizophrenia

Igor Nenadic, Raka Maitra, Soumyajit Basu, Maren Dietzek, Nils Schönfeld, Carsten Lorenz, Alexander Gussew, G. Paul Amminger, Patrick McGorry, Jürgen R. Reichenbach, Heinrich Sauer, Christian Gaser (+1 others)
2015 European Neuropsychopharmacology  
Hippocampal pathology has been shown to be central to the pathophysiology of schizophrenia and a putative risk marker for developing psychosis.  ...  We applied both 1 H MRS (proton magnetic resonance spectroscopy) at 3 Tesla and voxel-based morphometry (VBM) of high-resolution brain structural images in order to study the association of the metabolites  ...  Conflict of interest This study was partially supported through grants of German Research Foundation ( Acknowledgements The authors would like to thank all study participants for their support.  ... 
doi:10.1016/j.euroneuro.2015.05.005 pmid:26088723 fatcat:tl36zbpoffgxhpueavkfllc4mm

Neuroimaging as a Window Into the Pathophysiological Mechanisms of Schizophrenia

Nina Vanessa Kraguljac, Adrienne Carol Lahti
2021 Frontiers in Psychiatry  
In this review, we consider a number of key scientific questions relevant in the context of neuroimaging studies aimed at unraveling the pathophysiology of schizophrenia and take the opportunity to reflect  ...  signatures, as a clear characterization of primary pathophysiological processes is an imperative prerequisite for rational drug development and for alleviating disease burden in our patients.  ...  Egerton A, Stone JM, Chaddock CA, Barker GJ, Bonoldi I, Howard RM, et al. Relationship between brain glutamate levels and clinical outcome in individuals at ultra high risk of psychosis.  ... 
doi:10.3389/fpsyt.2021.613764 pmid:33776813 pmcid:PMC7991588 fatcat:ctp6oeh6vfhrfaytcd3qhxidom

10–14 April, Orlando, Florida: A summary of topics and trends

Luis Alameda, Abhishekh Ashok, Suzanne Avery, Ali Bani-Fatemi, Susan Berkhout, Mike Best, Kelsey Bonfils, Marco Colizzi, Maria Dauvermann, Stefan Du Plessis, Dominic Dwyer, Emily Eisner (+27 others)
2019 Psychiatry Research  
In summary, the congress covered a broad range of topics relevant to the field of psychiatry today.  ...  The overall theme of this year's congress was United in Progress - with the aim of cultivating a collaborative effort towards advancing the field of schizophrenia research.  ...  The findings suggest brain age differences between controls and two patient groups, namely firstepisode schizophrenia patients, and those at ultra-high risk for psychosis.  ... 
doi:10.1016/j.psychres.2019.112672 pmid:31780184 fatcat:t5abnoixhfdkdb45olhmlxk3nq

Brain structure, function, and neurochemistry in schizophrenia and bipolar disorder—a systematic review of the magnetic resonance neuroimaging literature

Badari Birur, Nina Vanessa Kraguljac, Richard C. Shelton, Adrienne Carol Lahti
2017 npj Schizophrenia  
We conducted a systematic review of case-control studies contrasting magnetic resonance imaging studies in schizophrenia and bipolar disorder.  ...  A literature search in PubMed of studies published between January 2005 and December 2016 was conducted, and 50 structural, 29 functional, 7 magnetic resonance spectroscopy, and 8 combined imaging and  ...  across the psychosis spectrum, [35] [36] [37] , with a majority of studies reporting that volume loss is greater in schizophrenia compared to BD, 38 even when examining individual hippocampal subfields  ... 
doi:10.1038/s41537-017-0013-9 pmid:28560261 pmcid:PMC5441538 fatcat:xbdmi3qm7ffy5je2vpu5c4jhpy

The 4th Schizophrenia International Research Society Conference, 5–9 April 2014, Florence, Italy: A summary of topics and trends

Olukayode Abayomi, Davide Amato, Candace Bailey, Byron Bitanihirwe, Lynneice Bowen, Shimon Burshtein, Alexis Cullen, Montserrat Fusté, Ana P. Herrmann, Babak Khodaie, Sanja Kilian, Qortni A. Lang (+19 others)
2014 Schizophrenia Research  
In addition, the following report provides an overview of the conference for those who were present, but could not participate in all sessions, and those who did not have the opportunity to attend, but  ...  Anne O'Shea collected the reports and put them in to one manuscript in order and organized the references. Dr. DeLisi then edited the manuscript for accuracy, language and scholarship.  ...  Acknowledgments The information in this report and the accuracy of each statement were the sole responsibility of each rapporteur and based on personal interpretation of what was heard.  ... 
doi:10.1016/j.schres.2014.08.032 pmid:25306204 pmcid:PMC4394607 fatcat:lhwpf5jvd5g2hlsutb44qojrvi

Advances in Multimodal Data Fusion in Neuroimaging: Overview, Challenges, and Novel Orientation

Yu-Dong Zhang, Zhengchao Dong, Shui-Hua Wang, Xiang Yu, Xujing Yao, Qinghua Zhou, Hua Hu, Min Li, Carmen Jiménez-Mesa, Javier Ramirez, Francisco J. Martinez, Juan Manuel Gorriz
2020 Information Fusion  
Multimodal fusion in neuroimaging combines data from multiple imaging modalities to overcome the fundamental limitations of individual modalities.  ...  We provide a review that encompasses (1) an overview of current challenges in multimodal fusion (2) the current medical applications of fusion for specific neurological diseases, (3) strengths and limitations  ...  Acknowledgments This study was partly supported by Royal Society International Ex-  ... 
doi:10.1016/j.inffus.2020.07.006 pmid:32834795 pmcid:PMC7366126 fatcat:3cmhcplb5bf2fgpx3kukifbj74

4th European conference on schizophrenia research: together for better treatment and care

2013 European Archives of Psychiatry and Clinical Neuroscience  
Objective: During the past two decades, the construct of a clinical high risk (HR) state for psychosis, has evolved to capture the prepsychotic phase, describing people presenting with potentially prodromal  ...  Data is stored at the study centre in Hannover. Results: From 2003 to 2011 we collected reference-day-data from 6986 inpatients being treated for a F20 ICD-10 diagnosis.  ...  S-28 The high risk state for psychosis S-28-001 The ultra-high risk approach: current state and future directions A.  ... 
doi:10.1007/s00406-013-0433-0 pmid:23959132 fatcat:zgntoorsxvbbppkld4nuedpfnm

Revolution of Alzheimer Precision Neurology. Passageway of Systems Biology and Neurophysiology

Harald Hampel, Nicola Toschi, Claudio Babiloni, Filippo Baldacci, Keith L. Black, Arun L.W. Bokde, René S. Bun, Francesco Cacciola, Enrica Cavedo, Patrizia A. Chiesa, Olivier Colliot, Cristina-Maria Coman (+32 others)
2018 Journal of Alzheimer's Disease  
dysfunction within distinct molecular, cellular and large-scale neural network systems in both animal models as well as through tests for the usefulness of these candidate dynamic systems biomarkers in  ...  The Precision Neurology development process implements systems theory with system biology and neurophysiology in a parallel, bidirectional research path: a combined hypothesis-driven investigation of systems  ...  towards sub-millimeter imaging at ultra-high field.  ... 
doi:10.3233/jad-179932 pmid:29562524 pmcid:PMC6008221 fatcat:j3u6gkzfqbg47kv4o2hpkjadn4

Multivariate Analysis of Structural and Functional Neuroimaging Can Inform Psychiatric Differential Diagnosis

Drozdstoy Stoyanov, Sevdalina Kandilarova, Katrin Aryutova, Rositsa Paunova, Anna Todeva-Radneva, Adeliya Latypova, Ferath Kherif
2020 Diagnostics  
The emerging field of translational neuroimaging attempted to bridge the explanatory gap by means of simultaneous application of clinical assessment tools and functional magnetic resonance imaging, which  ...  In this paper we report results from convergent cross-validation of biological signatures of disease in a sample of patients with schizophrenia as compared to depression.  ...  In several studies it is demonstrated that hyper-responsiveness of the amygdala and related emotional regions of the brain is observed in people with schizophrenia [54] and individuals at ultra-high  ... 
doi:10.3390/diagnostics11010019 pmid:33374207 fatcat:fewqwmjqdzgszf5xuuss4sdqaa

7th European Conference on Schizophrenia Research: Time for precision medicine?

2019 European Archives of Psychiatry and Clinical Neuroscience  
The costs for publication were fully covered by delegates' payments of registration fees.  ...  Results: O-04-005 Empathy measures in individuals at ultra-high risk for psychosis D. J. Kuis (GGZ Drenthe, Research), Groningen, The Netherlands; T. van de Giessen, B. E.  ...  Flückiger Objective: Schizotypy and clinical high-risk criteria can identify individuals at risk for developing psychosis.  ... 
doi:10.1007/s00406-019-01045-6 fatcat:4tbfk4p4yngqto7uxhrdczle54

Function–structure associations of the brain: Evidence from multimodal connectivity and covariance studies

Jing Sui, Rene Huster, Qingbao Yu, Judith M. Segall, Vince D. Calhoun
2014 NeuroImage  
magnetic resonance imaging (sMRI), functional MRI (fMRI), diffusion tensor imaging (DTI) and electroencephalography (EEG).  ...  To examine the function-structure associations of the brain in a more comprehensive and integrated manner, we reviewed a number of multimodal studies that combined two or more functional (fMRI and/or EEG  ...  This study reveals new evidence for converging three-modal pathology of the medial prefrontal region in schizophrenia.  ... 
doi:10.1016/j.neuroimage.2013.09.044 pmid:24084066 pmcid:PMC3969780 fatcat:tngvfiyrdreyvmcg55qyqs6o6u

The 3rd Schizophrenia International Research Society Conference, 14–18 April 2012, Florence, Italy: Summaries of oral sessions

Brandon Abbs, Rashmin M. Achalia, Adegoke O. Adelufosi, Ahmet Yiğit Aktener, Natalie J. Beveridge, Savita G. Bhakta, Rachael K. Blackman, Emre Bora, M.S. Byun, Maurice Cabanis, Ricardo Carrion, Christina A. Castellani (+25 others)
2012 Schizophrenia Research  
It is hoped that it will provide an overview for those who were present, but could not participate in all sessions, and those who did not have the opportunity to attend, but who would be interested in  ...  The following report is a composite of these reviews.  ...  The information in these reports and the accuracy of each statement were the sole responsibility of each rapporteur and are based on personal interpretations of what was heard.  ... 
doi:10.1016/j.schres.2012.07.024 pmid:22910407 pmcid:PMC3877922 fatcat:kjoz7q232zejnfnvpuogpobsfa

Visualizing the Potential Impairment of Polymyxin B to Central Nervous System Through MR Susceptibility-Weighted Imaging

Ni Zhang, Lichong Zhu, Qiuhong Ouyang, Saisai Yue, Yichun Huang, Shuang Qu, Runwei Li, Yuanyuan Qiao, Man Xu, Fangfei He, Bin Zhao, Lai Wei (+2 others)
2021 Frontiers in Pharmacology  
This result may pave a noninvasive approach for in-depth studies of PMB medication strategy, monitoring the BBB changes during PMB treatment, and even assessing the risk after PMB successive medication  ...  Systematic studies clearly reveal that the prepared Fe3O4 nanoparticles can serve as an appropriate magnetic resonance contrast agent with high transverse relaxivity and outstanding biosafety, which thus  ...  Systematic studies clearly reveal that the prepared Fe 3 O 4 nanoparticles can serve as an appropriate magnetic resonance contrast agent with high transverse relaxivity and outstanding biosafety, which  ... 
doi:10.3389/fphar.2021.784864 pmid:34925041 pmcid:PMC8675099 fatcat:oifanfogvzaxndde7j2dyikwuy

Panel, Mini-panel and Study Group

2014 Neuropsychopharmacology  
Methods: In a series of studies in healthy individuals and unaffected first-degree relatives of schizophrenia patients we have established and confirmed the link of these phenotypes to the genetic liability  ...  association with a genome-wide supported psychosis risk variant in ITIH3/4 as well as the enrichment of gene sets and pathways involved in dopamine neurotransmission.  ...  Recently, we and others reported the results of proton magnetic resonance spectroscopy (1H MRS) studies that found elevated glutamate levels in the associative striatum of subjects at ultra-high risk for  ... 
doi:10.1038/npp.2014.279 pmid:25466712 pmcid:PMC4261146 fatcat:v6fgkukh6zgtdmswrjpk46dvhi
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