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Hippocampal hyperperfusion in Alzheimer's disease

David C. Alsop, Melynda Casement, Cedric de Bazelaire, Tamara Fong, Daniel Z. Press
2008 NeuroImage  
Many of the regions with the earliest atrophy in Alzheimer's Disease (AD) do not show prominent deficits on functional imaging studies of flow or metabolism.  ...  CBF was significantly lower in the bilateral precuneus, parietal association cortex and the left inferior temporal lobe but was non-significantly increased in the hippocampus and other medial temporal  ...  ACKNOWLEDGEMENTS This work was supported in part by a research grant from the Alzheimer's Association, and by the National Institutes of Health through grants AG19599, MH65434, and NS047431.  ... 
doi:10.1016/j.neuroimage.2008.06.006 pmid:18602481 pmcid:PMC2675915 fatcat:ecamhf7k35ee7gepzcx6yrn2ga

Alzheimer's Disease and Habitual Exercise: Relationship Mediated and Fostered by Vascular Risk Profiles?

Takashi Tarumi
2012 Journal of Gerontology & Geriatric Research  
of Alzheimer's disease for the future generations.  ...  Vascular function and risk factors for vascular disease are largely modifiable and may pave a way in identifying an effective intervention against Alzheimer's disease.  ... 
doi:10.4172/2167-7182.1000e111 fatcat:tluddkagufepbph54znepiidwu

Distinct cerebral perfusion patterns in FTLD and AD

W. T. Hu, Z. Wang, V. M.- Y. Lee, J. Q. Trojanowski, J. A. Detre, M. Grossman
2010 Neurology  
Compared with controls, patients with AD showed significant hypoperfusion in the medial parietal/precuneus and lateral parietal cortex, and hyperperfusion in regions of the frontal lobe.  ...  Compared with controls, patients with FTLD showed significant hypoperfusion in regions of the frontal lobe bilaterally, and hyperperfusion in posterior cingulate and medial parietal/precuneus regions.  ...  disease burden in hyperperfused areas is difficult to obtain.  ... 
doi:10.1212/wnl.0b013e3181f11e35 pmid:20819999 pmcid:PMC2938974 fatcat:og3jmkrytzb5pce43ib3a6cuhq

Cerebral Blood Flow Measured by Arterial Spin Labeling MRI as a Preclinical Marker of Alzheimer's Disease

Christina E. Wierenga, Chelsea C. Hays, Zvinka Z. Zlatar, Jack C. de la Torre
2014 Journal of Alzheimer's Disease  
There is growing recognition that cerebral hypoperfusion is related to the pathogenesis of Alzheimer's disease (AD), implicating the measurement of cerebral blood flow (CBF) as a possible biomarker of  ...  Studies using ASL MRI in humans indicate that CBF changes are present several years before the development of the clinical symptoms of AD.  ...  Introduction Alzheimer's disease (AD) is the third leading cause of death in the United States, with approximately 500,000 AD-related deaths each year [1] .  ... 
doi:10.3233/jad-141467 pmid:25159672 pmcid:PMC5279221 fatcat:atsjnxtyxrbi3oiemmhh4xv4ye

Systematic review of structural and functional brain alterations in psychosis of epilepsy

James Allebone, Richard Kanaan, Sarah J Wilson
2017 Journal of Neurology, Neurosurgery and Psychiatry  
Understanding POE as a disease of brain networks has important implications for neuroimaging research and clinical practice.  ...  Our results show: (1) conflicting evidence of volumetric change in the hippocampus and amygdala; (2) distributed structural pathology beyond the mesial temporal lobe; and (3) changes in frontotemporal  ...  Acknowledgements we thank our colleagues in Melbourne School of Psychological Sciences at the University of Melbourne, the Florey institute of Neuroscience and Mental Health, and the Comprehensive epilepsy  ... 
doi:10.1136/jnnp-2017-317102 pmid:29275328 fatcat:3zbctn2l6fdsdm42hp6baf3tz4


A.N. Sergeeva, Research Center of Neurology, L.A. Dobryinina, Z.Sh. Gadgieva, M.R. Zabitova, E.V. Seliverstova, M.V. Krotenkova, Research Center of Neurology, Research Center of Neurology, Research Center of Neurology, Research Center of Neurology, Research Center of Neurology
2019 Russian Electronic Journal of Radiology  
Hippocampal Hyperperfusion in Alzheimer's Disease. Neu-roimage. 2008 Oct 1;42(4):1267-74. doi: 10.1016/j.neuroimage.2008.06.006 6.  ...  Korsakova. 2002; 102 (7): 3-8 (in Russian). 5. Alsop DC, Casement M, de Bazelaire C, Fong T, Press DZ. Hippocampal Hyperperfusion in Alzheimer's Disease.  ... 
doi:10.21569/2222-7415-2019-9-4-8-17 fatcat:dcmxf4yhtngi3crbegpeszgl4e

Genetic Association Between KIBRA Polymorphism and Alzheimer's Disease with in a Japanese Population

Eri Kawai, Nobuto Shibata, Tomoyuki Nagata, Shunichiro Shinagawa, Kenji Tgai, Tohru Ohnuma, Hiromi Shimazaki, Aiko Toda, Koji Kasanuki, Toshiki Takayama, Ayako Suzuki, Kazuhiko Nakayama (+2 others)
2015 Neuromolecular medicine  
Functional studies suggest that KIBRA is a potential candidate gene for memory and Alzheimer's disease (AD) risk.  ...  The SPECT study revealed hyperperfusion in the C allele carrier group was detected in the right inferior frontal gyrus compared with the T/T group.  ...  Introduction Alzheimer's disease (AD) is the most common neurodegenerative disease.  ... 
doi:10.1007/s12017-015-8348-8 pmid:25800888 fatcat:dlxbwwlyzzatbnkz4dkljsmmnu

Regional Cerebral Blood Flow in Mild Cognitive Impairment and Alzheimer's Disease Measured with Arterial Spin Labeling Magnetic Resonance Imaging

Alba Sierra-Marcos
2017 International Journal of Alzheimer's Disease  
Alzheimer's disease (AD) depicts dynamic changes in regional brain function from early stages of the disease.  ...  Nevertheless, the results obtained from ASL studies in AD and MCI are still controversial, since rCBF maps may show both hypoperfusion or hyperperfusion areas in brain structures involved in different  ...  rather than a loss in hippocampal neural activity.  ... 
doi:10.1155/2017/5479597 pmid:28573062 pmcid:PMC5442339 fatcat:kl4y5ve3yzc7xja4mizhd5fwva

Page 4224 of Psychological Abstracts Vol. 84, Issue 9 [page]

1997 Psychological Abstracts  
—Unawareness of deficits is a challenging problem frequently encountered in individuais with Alzheimer’s disease (AD).  ...  (Portland State U, Graduate School of Social Work, Portland, OR) Awareness deficits in Alzheimer’s disease: Issues in assessment and intervention.  ... 

Circulating Progenitor Cells Correlate with Memory, Posterior Cortical Thickness, and Hippocampal Perfusion

Daniel A. Nation, Alick Tan, Shubir Dutt, Elissa C. McIntosh, Belinda Yew, Jean K. Ho, Anna E. Blanken, Jung Yun Jang, Kathleen E. Rodgers, Aimée Gaubert, David Knopman
2017 Journal of Alzheimer's Disease  
Further study of progenitor cell depletion in older adults may benefit efforts to prevent or delay dementia.  ...  Method-Thirty-two older adults, free of stroke and cardiovascular disease, were recruited from the community and evaluated for diagnosis of MCI versus cognitively normal (CN).  ...  This finding is consistent with several prior studies demonstrating hippocampal hyperperfusion in CN older adults at genetic risk for AD [42] , those with subtle memory decline [43] and in MCI [44]  ... 
doi:10.3233/jad-170587 pmid:29103037 pmcid:PMC5924766 fatcat:3fxiefyoh5fjhhucfvkddg6ymq

Effects of Hypoperfusion in Alzheimer's Disease

Benjamin P. Austin, Veena A. Nair, Timothy B. Meier, Guofan Xu, Howard A. Rowley, Cynthia M. Carlsson, Sterling C. Johnson, Vivek Prabhakaran, J. Wesson Ashford, Allyson Rosen, Maheen Adamson, Peter Bayley (+4 others)
2011 Journal of Alzheimer's Disease  
The role of hypoperfusion in Alzheimer's disease (AD) is a vital component to understanding the pathogenesis of this disease.  ...  state (consistently reported in precuneus/ posterior cingulate and lateral parietal cortex) and those implicated in disease risk.  ...  As for hyperperfusion in the hippocampal regions, it should be noted that increased blood flow to this region is in contrast to the previously discussed hypoperfusion [see 21 above] .  ... 
doi:10.3233/jad-2011-0010 pmid:21971457 pmcid:PMC3303148 fatcat:x7vwrfqbebadbezmuasio55zwq

Statistical voxel-wise analysis of ictal SPECT reveals pattern of abnormal perfusion in patients with temporal lobe epilepsy

Bárbara Juarez Amorim, Elba Cristina Sá de Camargo Etchebehere, Edwaldo Eduardo Camargo, Pablo Augusto Rio, Leonardo Bonilha, Chris Rorden, Li Min Li, Fernando Cendes
2005 Arquivos de Neuro-Psiquiatria  
Ictal BSI in SPM analysis revealed hyperperfusion within ipsilateral temporal lobe (epileptogenic focus) and also contralateral parieto-occipital region, ipsilateral posterior cingulate gyrus, occipital  ...  CONCLUSION: In a group analysis of ictal BSI of patients with TLE, voxel-wise analysis detects a network of distant regions of perfusional alteration which may play active role in seizure genesis and propagation  ...  Statistical analysis of BSI has been used to analyze the regions of the brain that show diff e rences in perfusion in pathologies such as Alzheimer's disease 4 , systemic lupus erythematosus 5 and in the  ... 
doi:10.1590/s0004-282x2005000600014 pmid:16400416 fatcat:a6zrsv73jngelfwd3tua6m7heu

Neural correlates of psychotic symptoms in dementia with Lewy bodies

Yasuhiro Nagahama, Tomoko Okina, Norio Suzuki, Minoru Matsuda
2009 Brain  
Delusions of theft and persecution were associated with relative hyperperfusion in the right rostral medial frontal cortex, left medial superior frontal gyrus and bilateral dorsolateral frontal cortices  ...  This study revealed that different psychotic symptoms in dementia with Lewy bodies were associated with distinguishable cerebral networks.  ...  importance since neuropsychiatric symptoms are more frequent in dementia with Lewy bodies than Alzheimer's disease, even in the early stages of the disease and they cause a higher degree of caregiver  ... 
doi:10.1093/brain/awp295 pmid:19920063 fatcat:lgkr3x7uwvgttfmhmkldvirdvi

Recent developments in imaging of epilepsy

Roland Wiest, Roland Beisteiner
2019 Current Opinion in Neurology  
Imaging constitutes one of the key pillars in the diagnostic workup after a first seizure as well as for the presurgical workup in epilepsy.  ...  The role of imaging in emergency situations, mainly to support the adequate diagnosis, as well as its role in planning of noninvasive image-guided therapies is less well established.  ...  These mechanisms are being investigated in clinical trials on brain tumors, Alzheimer's disease, Parkinson's disease (PD), dementia and amyotrophic lateral sclerosis.  ... 
doi:10.1097/wco.0000000000000704 pmid:31107703 pmcid:PMC6635047 fatcat:irxeszfturf7rfhh2ogjkoeczm

Prefrontal Lobe Brain Reserve Capacity with Resistance to Higher Global Amyloid Load and White Matter Hyperintensity Burden in Mild Stage Alzheimer's Disease

Ya-Ting Chang, Chi-Wei Huang, Nai-Ching Chen, Kun-Ju Lin, Shu-Hua Huang, Yen-Hsiang Chang, Shih-Wei Hsu, Wen-Neng Chang, Chun-Chung Lui, Che-Wei Hsu, Chiung-Chih Chang, Pradeep Garg
2016 PLoS ONE  
Amyloid deposition and white matter lesions (WMLs) in Alzheimer's disease (AD) are both considered clinically significant while a larger brain volume is thought to provide greater brain reserve (BR) against  ...  For global WML loads, the prefrontal (r = -0.458, p = 0.019) and hippocampal volume (r = -0.469, p = 0.016) showed significant correlations while the prefrontal (r = -0.417, p = 0.043) PLOS ONE |  ...  Another study reported that hippocampal atrophy may be associated with prefrontal hyperperfusion, suggesting a compensatory mechanism of the prefrontal region in AD [36] .  ... 
doi:10.1371/journal.pone.0149056 pmid:26872386 pmcid:PMC4752238 fatcat:c6aaykvdjrb3tgz5dzoh5kre3q
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