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Enhancing Effects of NMDA-Receptor Blockade on Extinction Learning and Related Brain Activation Are Modulated by BMI

Anne Golisch, Stefanie Heba, Benjamin Glaubitz, Martin Tegenthoff, Silke Lissek
2017 Frontiers in Behavioral Neuroscience  
Renewal describes the recovery of an extinguished response if the context of extinction differs from the context of recall.  ...  In both extinction and recall, the memantine group showed a deactivation in extinction-related brain regions, particularly in the prefrontal cortex, while hippocampal activity was increased.  ...  ACKNOWLEDGMENTS We thank Tobias Otto for programming the stimulus presentation software. We appreciate the continued scientific support of Philips, Germany.  ... 
doi:10.3389/fnbeh.2017.00034 pmid:28326025 pmcid:PMC5339306 fatcat:7xmubjruknbpvh2bn646557n5e

Cortisol disrupts the neural correlates of extinction recall

Valerie L. Kinner, Christian J. Merz, Silke Lissek, Oliver T. Wolf
2016 NeuroImage  
In this functional magnetic resonance imaging study, we investigated the effects of cortisol administration on the neural correlates of extinction memory retrieval in a predictive learning task.  ...  The renewal effect describes the recovery of extinguished responses that may occur after a change in context and indicates that extinction memory retrieval is sometimes prone to failure.  ...  Acknowledgments We gratefully acknowledge the help of Nuria Mackes and Lina Reimers during data collection and recruitment of participants.  ... 
doi:10.1016/j.neuroimage.2016.03.005 pmid:26973167 fatcat:wo2tjqltxfhcla4g5tnypcvyda

Renewal of conditioned fear in a novel context is associated with hippocampal activation and connectivity

A. Hermann, R. Stark, M. R. Milad, C. J. Merz
2016 Social Cognitive and Affective Neuroscience  
Individuals with a stronger renewal of conditioned SCRs in the novel context showed increased effective connectivity of hippocampal activation foci with structures in the fear and extinction network.  ...  Hippocampal activation distinguished conditioned responding in the novel compared with the extinction context.  ...  In addition, we acknowledge the helpful comments raised by the reviewers.  ... 
doi:10.1093/scan/nsw047 pmid:27053767 pmcid:PMC5015796 fatcat:ikkn2td76fgddizz227ulbllfq

Hippocampal involvement in contextual modulation of fear extinction

Jinzhao Ji, Stephen Maren
2007 Hippocampus  
Several recovery effects (renewal, spontaneous recovery, and reinstatement) after extinction suggest that the contextual modulation of extinction is a critical behavioral mechanism underlying fear extinction  ...  In this article, the authors will first discuss the fundamental behavioral features of the context effects of extinction and its underlying behavioral mechanisms.  ...  Acknowledgments The authors would like to thank Ewelina Knapska and April Qian for editing on an earlier draft of the manuscript.  ... 
doi:10.1002/hipo.20331 pmid:17604353 fatcat:ukvmgyv3l5aj7hm23kz75vqoti

Neural Underpinnings of Cortisol Effects on Fear Extinction

Christian Josef Merz, Tanja Christina Hamacher-Dang, Rudolf Stark, Oliver Tobias Wolf, Andrea Hermann
2017 Neuropsychopharmacology  
Context-and stimulus-dependent cortisol effects on extinction learning will be characterized in this study and tested in the extinction and in a new context.  ...  Taken together, cortisol reduced fear recall at the beginning of extinction and facilitated the consolidation of the extinction memory as evidenced by an inhibitory activation pattern one week later.  ...  In addition, we thank the members of the biochemical laboratory of the Department of Biological and Clinical Psychology (University of Trier) for saliva analyses and Sabine Kagerer for language editing  ... 
doi:10.1038/npp.2017.227 pmid:28948980 fatcat:me24xlp6uvd6hepporq2xezlw4

How Administration of the Beta-Blocker Propranolol Before Extinction can Prevent the Return of Fear

Marijn C W Kroes, Klodiana-Daphne Tona, Hanneke E M den Ouden, Susanne Vogel, Guido A van Wingen, Guillén Fernández
2015 Neuropsychopharmacology  
Prediction error-related responses in the ventral striatum persisted during beta-blockade.  ...  A single dose of propranolol before extinction learning caused a loss of conditioned fear responses, and prevented the subsequent return of fear and decreased explicit memory for the fearful events in  ...  The funding agencies or corporation had no role in the design of the study, collection, and analysis of data and publication decision.  ... 
doi:10.1038/npp.2015.315 pmid:26462618 pmcid:PMC4820039 fatcat:3hrngd3cbfdhfplguc3k22n4lq

Context, learning, and extinction

Samuel J. Gershman, David M. Blei, Yael Niv
2010 Psychological review  
Redish et al. (2007) proposed a reinforcement learning model of context-dependent learning and extinction in conditioning experiments, using the idea of "state classification" to categorize new observations  ...  In the current article, the authors propose an interpretation of this idea in terms of normative statistical inference.  ...  Effect of hippocampal lesions on ABA renewal. a.  ... 
doi:10.1037/a0017808 pmid:20063968 fatcat:zo5ev52rlbcbxmtoab7x636ywm

Effects of sleep on memory for conditioned fear and fear extinction

Edward F. Pace-Schott, Anne Germain, Mohammed R. Milad
2015 Psychological bulletin  
REM sleep is accompanied by selective activation of the same limbic structures implicated in the learning and memory of fear and extinction.  ...  Time-of-day effects on extinction learning and generalization are also seen.  ...  The authors would like to thank Marie-France Marin, Ph.D., Lisa Maeng, Ph.D., and Kara Cover for helpful comments.  ... 
doi:10.1037/bul0000014 pmid:25894546 pmcid:PMC4486610 fatcat:ltko75362fce3n4jvxeqrf5554

Stress and Fear Extinction

Stephen Maren, Andrew Holmes
2015 Neuropsychopharmacology  
Here we examine emerging evidence that stress impairs recovery from trauma by impairing fear extinction, a form of learning thought to underlie the suppression of trauma-related fear memories.  ...  A better understanding of the neurobiological basis of stress effects on extinction promises to yield novel approaches to improving therapeutic outcomes for PTSD and other anxiety and trauma-related disorders  ...  Indeed, in addition to the reduced vmPFC activity and heightened amygdala activity reported in prior studies of extinction, PTSD patients exhibited weaker hippocampal activation to the CS − during renewal  ... 
doi:10.1038/npp.2015.180 pmid:26105142 pmcid:PMC4677122 fatcat:hjjdjhy6hnfc5ovxy3ryrltd3u

Rodent models of impaired fear extinction

Nicolas Singewald, Andrew Holmes
2018 Psychopharmacology  
forms of fear relapse; modeled in the laboratory by measuring spontaneous recovery, reinstatement and renewal of fear.  ...  Various rodent models of impaired extinction have thus been generated with the objective of approximating this clinical, relapse prone aberrant extinction learning.  ...  NS is supported by the FWF (Austrian Science Fund, I2433-B26, DK W-1206 and SFB F4410). AH is supported by the NIAAA Intramural Research Program.  ... 
doi:10.1007/s00213-018-5054-x pmid:30377749 pmcid:PMC6373188 fatcat:4m3lk3xauzdcde3wd4yoyimjku

Rethinking Extinction

Joseph E. Dunsmoor, Yael Niv, Nathaniel Daw, Elizabeth A. Phelps
2015 Neuron  
In the past decade, extinction has moved beyond the realm of associative learning theory and behavioral experimentation in animals and has become a topic of considerable interest in the neuroscience of  ...  We discuss the neurobiology, cognitive factors, and major computational theories, and revisit the predominant view that extinction results in new learning that interferes with expression of the original  ...  Whether procedures that target hippocampal activity, like pre-extinction administration of scopolamine, are effective in humans awaits study.  ... 
doi:10.1016/j.neuron.2015.09.028 pmid:26447572 pmcid:PMC4598943 fatcat:kytkncwi2je7zhyh4oli5ugppi

A mechanism-oriented approach to psychopathology: The role of Pavlovian conditioning

Frauke Nees, Angela Heinrich, Herta Flor
2015 International Journal of Psychophysiology  
In addition to the hedonic value, the learning phase (i.e. habituation, acquisition, extinction, extinction recall), the role of stimulus properties (i.e., cue and context), and event timing (e.g. delay  ...  We suggest a mechanistic approach that focuses on the role of learning as a core mechanism that can be studied in animals and humans.  ...  Acknowledgment This work was supported by the Deutsche Forschungsgemeinschaft: grant SFB636/C1 to H.F.  ... 
doi:10.1016/j.ijpsycho.2015.05.005 pmid:25979157 fatcat:43vovh7j5ndejnmcnbp3bcpehq

Seeking a Spotless Mind: Extinction, Deconsolidation, and Erasure of Fear Memory

Stephen Maren
2011 Neuron  
mechanisms underlying the safety memories acquired during extinction.  ...  The purpose of this review is to consider how these models have contributed to recent advances in understanding the molecular and cellular mechanisms and neural circuits in the brain involved in learning  ...  Extinction and the Contextual Regulation of Fear During Pavlovian conditioning, animals learn that a CS predicts the occurrence of a US.  ... 
doi:10.1016/j.neuron.2011.04.023 pmid:21658578 pmcid:PMC3112357 fatcat:woaew3cjhfe5fh6tpzuwfkuapy

From Extinction Learning to Anxiety Treatment: Mind the Gap

Joseph K. Carpenter, Megan Pinaire, Stefan G. Hofmann
2019 Brain Sciences  
Laboratory models of extinction learning in animals and humans have the potential to illuminate methods for improving clinical treatment of fear-based clinical disorders.  ...  This paper will identify how translational research that investigates methods of enhancing extinction learning can more effectively model such elements of human fear learning, and how doing so will enhance  ...  Conflicts of Interest: The authors declare no conflict of interest.  ... 
doi:10.3390/brainsci9070164 pmid:31336700 pmcid:PMC6680899 fatcat:ds6xuyeeevc77hxwhcolgtie4q

The metabotropic glutamate receptor, mGlu5, is required for extinction learning that occurs in the absence of a context change

Marion Agnes Emma André, Onur Güntürkün, Denise Manahan-Vaughan
2014 Hippocampus  
Treatment with the mGlu5 antagonist, 2-methyl-6-(phenylethynyl) pyridine, before maze exposure on Day 4 completely inhibited extinction learning in the AAA paradigm but had no effect in the ABA paradigm  ...  These data support that although extinction learning in a new context is unaffected by mGlu5 antagonism, extinction of the consolidated context is impaired.  ...  ACKNOWLEDGMENTS The authors gratefully acknowledge the technical assistance of Jens Klausnitzer, Anne Borkowski, and Juliane Boege.  ... 
doi:10.1002/hipo.22359 pmid:25160592 pmcid:PMC4322473 fatcat:cuch577n6fcinemfndtgyxvap4
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