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Temporal Lobe Epilepsy: Quantitative MR Volumetry in Detection of Hippocampal Atrophy

Nikdokht Farid, Holly M. Girard, Nobuko Kemmotsu, Michael E. Smith, Sebastian W. Magda, Wei Y. Lim, Roland R. Lee, Carrie R. McDonald
2012 Radiology  
Purpose: To determine the ability of fully automated volumetric magnetic resonance (MR) imaging to depict hippocampal atrophy (HA) and to help correctly lateralize the seizure focus in patients with temporal  ...  Results : Quantitative MR imaging-derived hippocampal asymmetries discriminated patients with TLE from control subjects with high sensitivity (86.7%-89.5%) and specificity (92.2%-94.1%).  ...  Thus, hippocampal volumetry is a strong surrogate marker for the presence and severity of HA.  ... 
doi:10.1148/radiol.12112638 pmid:22723496 pmcid:PMC3401351 fatcat:zrpazxxi4bghnnqnpoqymlb45a

Hippocampal MRS and subfield volumetry at 7T detects dysfunction not specific to seizure focus

Natalie L. Voets, Carl J. Hodgetts, Arjune Sen, Jane E. Adcock, Uzay Emir
2017 Scientific Reports  
Hippocampal subfields were manually segmented from 600μm isotropic resolution susceptibilityweighted images.  ...  Hippocampal subfield and metabolic abnormalities detected at 7T appear to reflect pathophysiological processes beyond epileptogenesis.  ...  Figure 6 . 6 Associations between 7T volumetry, MRS and memory performance.  ... 
doi:10.1038/s41598-017-16046-5 pmid:29170537 pmcid:PMC5700920 fatcat:eoftctjmkbhxnjik42uhazpybm

Evidence for functional specialization of hippocampal subfields detected by MR subfield volumetry on high resolution images at 4T

S.G. Mueller, L.L. Chao, B. Berman, M.W. Weiner
2011 NeuroImage  
These preliminary findings demonstrate that subfield volumetry has the potential to study non invasively subfield specific memory functions.  ...  Entorhinal cortex, subiculum, CA1, CA1-CA2 transition zone, and CA3&DG were manually marked on five slices in the anterior hippocampal body on the MRI.  ...  Acknowledgments The authors would like to express their gratitude to Ms Jennifer Hlavin and Mr.  ... 
doi:10.1016/j.neuroimage.2011.03.028 pmid:21419225 pmcid:PMC3085574 fatcat:t3vprxl7qfb7teh6ha3n2ccmyu

Memory impairments associated with hippocampal versus parahippocampal-gyrus atrophy: an MR volumetry study in Alzheimer's disease

S. Köhler, S.E. Black, M. Sinden, C. Szekely, D. Kidron, J.L. Parker, J.K. Foster, M. Moscovitch, G. Wincour, J.P. Szalai, M.J. Bronskill
1998 Neuropsychologia  
[ We determined MR!  ...  lobe atrophy are considered to be cardinal features of Alzheimer|s disease "AD#[ The goal of the present magnetic resonance "MR# volumetry study was to investigate the relationship between both features  ...  ther MR volumetry study in AD found a positive cor! relation between hippocampal volume and CVLT recall after a longer delay as well ð02Ł[ Instead\ it is more prob!  ... 
doi:10.1016/s0028-3932(98)00017-7 pmid:9740363 fatcat:n5kdkye3bjd6fmd4ev4rqhybzy

Hippocampal alterations in children with temporal lobe epilepsy with or without a history of febrile convulsions: evaluations with MR volumetry and proton MR spectroscopy

Wen-Chau Wu, Chao-Ching Huang, Hsiao-Wen Chung, Michelle Liou, Chun-Jen Hsueh, Chang-Shin Lee, Ming-Long Wu, Cheng-Yu Chen
2005 American Journal of Neuroradiology  
In this study, we sought to examine the hippocampal alterations in epileptic children with or without FC history by using MR spectroscopy and volumetry.  ...  MR volumetry and spectroscopy are equally capable of showing the trends of hippocampal alternations in children with TLE with or without FC history.  ...  Nevertheless, MR spectroscopy and volumetry still likely provide the trends of hippocampal alterations in the evaluation of childhood TLE and FC.  ... 
pmid:15891196 pmcid:PMC8158609 fatcat:7llm2dtfofbfpkbdhfddceyivu

Comparative Lateralizing Ability of Multimodality MRI in Temporal Lobe Epilepsy

Karabekir Ercan, Hediye Pinar Gunbey, Erhan Bilir, Elcin Zan, Halil Arslan
2016 Disease Markers  
Volumetry, MRS, and DTI studies provide complementary information of hippocampal pathology.  ...  T1-weighted 3D dataset for volumetry, single-voxel1H MR spectroscopy (MRS), and diffusion tensor imaging (DTI) were performed for bilateral hippocampi of all subjects.Results.  ...  Hippocampal qMR studies compared volumetry, T2 relaxometry, DWI, and MRS [15] [16] [17] [18] [19] [20] before.  ... 
doi:10.1155/2016/5923243 pmid:27974864 pmcid:PMC5126436 fatcat:3ohwyvztvzafrgeqkalfonshqq

Validation of hippocampal volumes measured using a manual method and two automated methods (FreeSurfer and IBASPM) in chronic major depressive disorder

Woo Suk Tae, Sam Soo Kim, Kang Uk Lee, Eui-Cheol Nam, Keun Woo Kim
2008 Neuroradiology  
Introduction To validate the usefulness of the packages available for automated hippocampal volumetry, we measured hippocampal volumes using one manual and two recently developed automated volumetric methods  ...  Conclusion The automated hippocampal volumetric methods showed good agreement with manual hippocampal volumetry, but the volume measured using FreeSurfer was 35% larger and the agreement was questionable  ...  Manual hippocampal volumetry To reduce manual tracing errors, the coronal T1-W MR images were magnified four times and trilinear interpolation was performed.  ... 
doi:10.1007/s00234-008-0383-9 pmid:18414838 fatcat:lqgbvhki2ffvrkrbr2hit4kj4a

QUALITATIVE AND QUANTITATIVE (VOLUMETRIC) HIPPOCAMPAL MRI ASSESSMENT IN TEMPORAL LOBE EPILEPSY

Dr. Hassan Bukhari, Dr. Saeeda, Dr. Mohammad Tahir
2018 Zenodo  
Keywords: Temporal lobe epilepsy, hippocampal volumetric assessment, hippocampal sclerosis  ...  Objective: To determine the accuracy of hippocampal quantitative (volumetric) assessment in diagnosing hippocampal atrophy in patients with temporal lobe epilepsy by comparing it with qualitative (visual  ...  ., hippocampal volumetry identified hippocampal sclerosis in 95% of patients with visually detected hippocampal sclerosis and in 13% visually normal MR imaging findings. [11] Thus quantitative techniques  ... 
doi:10.5281/zenodo.1745479 fatcat:kgz7cxagz5c4db7ss23bfb7xqy

Qualitative and Quantitative Hippocampal MRI Assessments in Intractable Epilepsy

Paramdeep Singh, Rupinderjeet Kaur, Kavita Saggar, Gagandeep Singh, Amarpreet Kaur
2013 BioMed Research International  
Visual assessment and hippocampal volumetry were done on oblique coronal IR/T2W and T1W MP-RAGE images, respectively.  ...  In controls, right hippocampal volume was slightly more than the left with no effect of age or gender. In TLE patients, hippocampal volumetry provided maximum concordance with EEG.  ...  MR signs of bilateral hippocampal atrophy/sclerosis were found in none of the patients.  ... 
doi:10.1155/2013/480524 pmid:23984369 pmcid:PMC3745906 fatcat:4pvlhb7sz5hvncqc72vjiehble

MR Volumetry of Hippocampus in Normal Adult Malay of Age 50 Years Old and Above

Muhammad Fadli Embong, Ruwaida Yaacob, Mohd Shafie Abdullah, Ahmad Helmy Abdul Karim, Anis Kausar Ghazali, Win Mar Salmah Jalaluddin
2013 Malaysian Journal of Medical Sciences  
Oblique coronal images of temporal lobes were obtained and hippocampal volumetry was done manually and normalised with intracranial volume.  ...  Mean right and left hippocampal volumes (HCVs) were 3.43 cm³ (SD 0.32) and 3.26 cm³ (SD 0.34), with a significant difference between them (P < 0.001).  ...  Although the automated methods can reliably detect hippocampal sclerosis, manual hippocampal volumetry is still the gold standard.  ... 
pmid:24043993 pmcid:PMC3773349 fatcat:6holtdpfbfc55aw6ww3fnl2a5u

Comparative Diagnostic Utility of Different MR Modalities in Mild Cognitive Impairment and Alzheimer's Disease

Kejal Kantarci, YueCheng Xu, Maria M. Shiung, Peter C. O'Brien, Ruth H. Cha, Glenn E. Smith, Robert J. Ivnik, Bradley F. Boeve, Steven D. Edland, Emre Kokmen, Eric G. Tangalos, Ronald C. Petersen (+1 others)
2002 Dementia and Geriatric Cognitive Disorders  
This study compares diagnostic accuracy of magnetic resonance (MR)-based hippocampal volumetry, single voxel (SV) 1 H MR Spectroscopy (MRS) and MR diffusion weighted imaging (DWI) measurements in discriminating  ...  Sixty-one normally aging elderly, 24 MCI, and 22 AD patients underwent MR-based hippocampal volumetry, 1 H MRS, and DWI. 1 H MRS voxels were placed over both of the posterior cingulate gyri and N-acetyl  ...  The test-retest reproducibility of entorhinal cortex volumetry however, is lower than hippocampal volumetry, therefore we used hippocampal volumetry as the structural MR measurement in this study.  ... 
doi:10.1159/000066021 pmid:12411762 pmcid:PMC2796574 fatcat:ag43dh5vnnb3bbxzmd7pwgu3ky

Fully Automated Atlas-Based Hippocampal Volumetry for Detection of Alzheimer's Disease in a Memory Clinic Setting

Per Suppa, Ulrich Anker, Lothar Spies, Irene Bopp, Brigitte Rüegger-Frey, Richard Klaghofer, Carola Gocke, Harald Hampel, Sacha Beck, Ralph Buchert
2015 Journal of Alzheimer's Disease  
This indicates that fully automated MR-based hippocampal volumetry fulfills the requirements for a relevant core feasible biomarker for detection of AD in everyday patient care in a secondary care memory  ...  The aim of the present study, therefore, was to evaluate fully automated atlas-based hippocampal volumetry for detection of AD in the setting of a secondary care expert memory clinic for outpatients.  ...  INTRODUCTION In the beginning of the 1990s, magnetic resonance (MR)-based hippocampal volumetry was recognized to be useful to support the diagnosis of Alzheimer's disease (AD) [1] .  ... 
doi:10.3233/jad-141446 pmid:25201782 fatcat:cskmsyynsfgtza7wutkxms3toy

Amygdalar and hippocampal volumetry in control participants: differences regarding handedness

C A Szabo, J Xiong, J L Lancaster, L Rainey, P Fox
2001 American Journal of Neuroradiology  
MR images were spatially normalized, and volumes were painted with a 1.0-mm(3) resolution cursor on an SGI workstation.  ...  The MR imaging sequence was a 3D T1-weighted gradient-echo acquisition of the whole brain (24/6 [TR/TE]; flip angle, 25 degrees).  ...  Hippocampal volumetry has become a clinical tool in identifying unilateral or bilateral hippocampal volume changes in cases of temporal lobe epilepsy (1, 2) .  ... 
pmid:11498423 pmcid:PMC7975203 fatcat:rkkawbcbundktf5oodrentlw7u

Development of a computer-aided diagnostic system for Alzheimer's disease using magnetic resonance imaging [article]

Kenya Murase, Naohiko Gondo, Tsutomu Soma
2016 arXiv   pre-print
We investigated the effect of the inhomogeneity of magnetic field strength and statistical noise on the accuracy of our automatic volumetry and the PDE approach using the simulated MR images generated  ...  Our automatic volumetry and PDE approach were robust against inhomogeneous magnetic field strength.  ...  The authors are also grateful to Mr. Youichi Yamazaki for his help in developing the present system.  ... 
arXiv:1605.02463v1 fatcat:aavxb2z5qzgixmwd5bkwwhv55q

Role of hippocampal volumetry in drug resistant epilepsy

Namrita Sachdev, Shivani Gupta, Yashvant Singh
2019 International Journal of Research in Medical Sciences  
Manual hippocampal volumetry should be routinely done in patients with Drug resistant epilepsy.  ...  volumetry detected more patients with hippocampal atrophy in our study compared to visual assessment.  ...  Thus, manual hippocampal volumetry is a better tool to pick up hippocampal atrophy.  ... 
doi:10.18203/2320-6012.ijrms20193398 fatcat:6usavftpvfc4bbukobdmx2nq3i
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