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The GABAergic system in prefrontal cortex and hippocampus modulates context-related extinction learning and renewal in humans

Silke Lissek, Anne Golisch, Benjamin Glaubitz, Martin Tegenthoff
2016 Brain Imaging and Behavior  
Participants treated with the GABA A agonist lorazepam prior to extinction learning were impaired in encoding changed associations during extinction learning, regardless of context, and in retrieving extinction  ...  Context-related extinction learning and renewal in humans is mediated by hippocampal and prefrontal regions.  ...  Acknowledgements This work was supported by a grant from the DFG, Deutsche Forschungsgemeinschaft (FOR 1581 Extinction Learning) to SL and MT.  ... 
doi:10.1007/s11682-016-9662-y pmid:27928709 pmcid:PMC5707232 fatcat:vyyvxd4wnnclhoje4fwvkr33he

Effects of Noradrenergic Stimulation Upon Context-Related Extinction Learning Performance and BOLD Activation in Hippocampus and Prefrontal Cortex Differ Between Participants Showing and Not Showing Renewal

Silke Lissek, Anne Klass, Martin Tegenthoff
2019 Frontiers in Behavioral Neuroscience  
acquisition of a context-related predictive-learning task affects subsequent learning and renewal in humans.  ...  During recall, ATO REN showed reduced overall context-dependent renewal associated with higher activation in medial PFC and right hippocampus.  ...  We appreciate the continued scientific support of Philips, Germany, including MR acquisition tools used in this study.  ... 
doi:10.3389/fnbeh.2019.00078 pmid:31105536 pmcid:PMC6491890 fatcat:3xmdhomuird4pgnfuchm2kqjxa

Left Inferior Frontal Gyrus Participates in Mediating the Renewal Effect Irrespective of Context Salience

Silke Lissek, Anne Klass, Martin Tegenthoff
2020 Frontiers in Behavioral Neuroscience  
In a within-subjects design, participants completed two sessions of an associative learning task in randomized order.  ...  In the SWITCH group, activation in left opercular inferior frontal gyrus (iFG) during the recall phase was associated with a renewal effect, together with activity in the bilateral posterior hippocampus  ...  We appreciate the continued scientific support of Philips, Germany, including MR acquisition tools used in this study.  ... 
doi:10.3389/fnbeh.2020.00043 pmid:32292332 pmcid:PMC7118360 fatcat:h6ktrcfz6zcslcyaltwyfyesva

Enhancing Effects of NMDA-Receptor Blockade on Extinction Learning and Related Brain Activation Are Modulated by BMI

Anne Golisch, Stefanie Heba, Benjamin Glaubitz, Martin Tegenthoff, Silke Lissek
2017 Frontiers in Behavioral Neuroscience  
A distributed network including prefrontal and hippocampal regions is involved in context-related extinction learning as well as in renewal.  ...  Animal studies have demonstrated that prefrontal, but not hippocampal N-methyl-D-aspartate receptor (NMDAR) antagonism disrupted extinction learning and processing of task context.  ...  We appreciate the continued scientific support of Philips, Germany.  ... 
doi:10.3389/fnbeh.2017.00034 pmid:28326025 pmcid:PMC5339306 fatcat:7xmubjruknbpvh2bn646557n5e

Cortisol disrupts the neural correlates of extinction recall

Valerie L. Kinner, Christian J. Merz, Silke Lissek, Oliver T. Wolf
2016 NeuroImage  
In this functional magnetic resonance imaging study, we investigated the effects of cortisol administration on the neural correlates of extinction memory retrieval in a predictive learning task.  ...  The renewal effect describes the recovery of extinguished responses that may occur after a change in context and indicates that extinction memory retrieval is sometimes prone to failure.  ...  Acknowledgments We gratefully acknowledge the help of Nuria Mackes and Lina Reimers during data collection and recruitment of participants.  ... 
doi:10.1016/j.neuroimage.2016.03.005 pmid:26973167 fatcat:wo2tjqltxfhcla4g5tnypcvyda

The DA antagonist tiapride impairs context-related extinction learning in a novel context without affecting renewal

Silke Lissek, Benjamin Glaubitz, Oliver T. Wolf, Martin Tegenthoff
2015 Frontiers in Behavioral Neuroscience  
Renewal describes the recovery of an extinguished response if recall is tested in a context different from the extinction context.  ...  This fMRI study investigated effects of DA-antagonism upon context-related extinction in a predictive learning task in which extinction occurred either in a novel (ABA) or an unchanged (AAA) context.  ...  We appreciate the continued support of Philips, Germany.  ... 
doi:10.3389/fnbeh.2015.00238 pmid:26388752 pmcid:PMC4558976 fatcat:rusf2pk56vbell43kt4ixt3qla

Noradrenergic stimulation modulates activation of extinction-related brain regions and enhances contextual extinction learning without affecting renewal

Silke Lissek, Benjamin Glaubitz, Onur Güntürkün, Martin Tegenthoff
2015 Frontiers in Behavioral Neuroscience  
Renewal in extinction learning describes the recovery of an extinguished response if the extinction context differs from the context present during acquisition and recall.  ...  During extinction of previously acquired cue-outcome associations, cues were presented in a novel context (ABA) or in the acquisition context (AAA).  ...  In the final test phase termed extinction recall, the cue is again presented in context A, renewing the response learned during acquisition.  ... 
doi:10.3389/fnbeh.2015.00034 pmid:25745389 pmcid:PMC4333811 fatcat:cuoyenxodfdglgljufeypaqrla

Higher functional connectivity between prefrontal regions and the dorsal attention network predicts absence of renewal

Silke Lissek, Martin Tegenthoff
2021 Behavioural Brain Research  
Renewal describes the recovery of an extinguished response when extinction and recall contexts differ, demonstrating the context-dependency of extinction.  ...  Since showing renewal is a trait-like processing tendency, individuals with and without renewal may differ in resting-state functional connectivity of prefrontal regions with networks mediating attentional  ...  Acknowledgements We appreciate the continued scientific support of Philips, Germany, including MR acquisition tools used in this study.  ... 
doi:10.1016/j.bbr.2021.113413 pmid:34119509 fatcat:abwji2a7hbftlh4ts72pmbmwpi

Neuroimaging of Fear-Associated Learning

John A Greco, Israel Liberzon
2015 Neuropsychopharmacology  
Extinction retention testing points to the ventromedial prefrontal cortex as an essential region in the recall of the safety trace, and explicit learning of fear and safety associations recruits additional  ...  Fear conditioning has been commonly used as a model of emotional learning in animals and, with the introduction of functional neuroimaging techniques, has proven useful in establishing the neurocircuitry  ...  ACKNOWLEDGMENTS We thank the Joshua Judson Stern Foundation for its generous support of their work. In addition, we acknowledge Arash Javanbakht for his assistance in the preparation of this review.  ... 
doi:10.1038/npp.2015.255 pmid:26294108 pmcid:PMC4677141 fatcat:l5ju66dekrftplgwsru2wqbhwa

A translational perspective on neural circuits of fear extinction: Current promises and challenges

Dieuwke Sevenster, Renée M. Visser, Rudi D'Hooge
2018 Neurobiology of Learning and Memory  
Fear extinction is the well-known process of fear reduction through repeated re-exposure to a feared stimulus without the aversive outcome.  ...  The last two decades have witnessed a surge of interest in extinction learning.  ...  Conflict of interest De authors declare no conflict of interest.  ... 
doi:10.1016/j.nlm.2018.07.002 pmid:29981423 pmcid:PMC6805216 fatcat:v3mowm77jjaltk6eodpbvc7wpy

Renewal of conditioned fear in a novel context is associated with hippocampal activation and connectivity

A. Hermann, R. Stark, M. R. Milad, C. J. Merz
2016 Social Cognitive and Affective Neuroscience  
Forty-six healthy men took part in a 2-day, context-dependent, cued fear conditioning paradigm with fear acquisition, extinction learning (day 1) and extinction recall in the acquisition, extinction and  ...  Individuals with a stronger renewal of conditioned SCRs in the novel context showed increased effective connectivity of hippocampal activation foci with structures in the fear and extinction network.  ...  In addition, we acknowledge the helpful comments raised by the reviewers.  ... 
doi:10.1093/scan/nsw047 pmid:27053767 pmcid:PMC5015796 fatcat:ikkn2td76fgddizz227ulbllfq

Impaired Contextual Modulation of Memories in PTSD: An fMRI and Psychophysiological Study of Extinction Retention and Fear Renewal

S. N. Garfinkel, J. L. Abelson, A. P. King, R. K. Sripada, X. Wang, L. M. Gaines, I. Liberzon
2014 Journal of Neuroscience  
Control subjects displayed appropriate contextual modulation of memory recall, with extinction (safety) memory prevailing in the safety context, and fear memory prevailing in the danger context.  ...  Proposed mechanisms include enhanced fear learning and impaired extinction or extinction recall.  ...  These results add to accumulating evidence of preserved fear and extinction learning in PTSD, consistent with the presence of either a specific extinction recall deficit, or a more general context-processing  ... 
doi:10.1523/jneurosci.4287-13.2014 pmid:25274821 pmcid:PMC4262698 fatcat:2bj4sr7qyfakhnkchjqmzrqpz4

Medial prefrontal pathways for the contextual regulation of extinguished fear in humans

Fredrik Åhs, Philip A. Kragel, David J. Zielinski, Rachael Brady, Kevin S. LaBar
2015 NeuroImage  
The maintenance of anxiety disorders is thought to depend, in part, on deficits in extinction memory, possibly due to reduced contextual control of extinction that leads to fear renewal.  ...  hippocampus on right amygdala activity during extinction recall.  ...  Acknowledgment This study was supported by grants NIH R01 DA027802 and NSF BCS 1460909 to KSL, as well as a Swedish Research Council Postdoctoral Fellowship award and a Sweden-America Foundation Postdoctoral  ... 
doi:10.1016/j.neuroimage.2015.07.051 pmid:26220745 pmcid:PMC4618170 fatcat:sahro6dfujgy3p2l5br77kwyry

Extinction learning is slower, weaker and less context specific after alcohol

James A. Bisby, John A. King, Valentina Sulpizio, Fanny Degeilh, H. Valerie Curran, Neil Burgess
2015 Neurobiology of Learning and Memory  
Thus, alcohol impaired extinction rather than acquisition of fear, suggesting that extinction is more dependent than acquisition on alcohol-sensitive representations of spatial context.  ...  However, a test of fear recall the next day showed persistent fear in the alcohol group across both viewpoints.  ...  We predicted that formation of the CS-US association during acquisition would be spared under alcohol, whereas the binding of the CS-US with its context would be impaired.  ... 
doi:10.1016/j.nlm.2015.07.014 pmid:26234587 pmcid:PMC4655873 fatcat:bqhr6ronpvfp3fcutppv6y6ps4

Sex specific recruitment of a medial prefrontal cortex-hippocampal-thalamic system during context-dependent renewal of responding to food cues in rats

Lauren C. Anderson, Gorica D. Petrovich
2017 Neurobiology of Learning and Memory  
This research was supported in part by National Institute of Health grant R01DK085721 to G.D.P.  ...  Males and females learned the acquisition and extinction of Pavlovian cue-food associations similarly, but only males showed robust renewal of responding to the food cue.  ...  Nevertheless, similar recruitment of the PL and ILA during context-mediated renewal of responding to food cues in the current study may be due to different functions, extinction recall or expression of  ... 
doi:10.1016/j.nlm.2016.12.004 pmid:27940080 pmcid:PMC5334368 fatcat:6dzg3x3zzrhi7lioemi67qbi6y
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