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Digital image analysis of plus disease in retinopathy of prematurity

Tariq Aslam, Brian Fleck, Niall Patton, Manuel Trucco, Hind Azegrouz
<span title="">2009</span> <i title="Wiley"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/z6imf325araxzl6nhnfmiayvfa" style="color: black;">Acta Ophthalmologica</a> </i> &nbsp;
School of Mathematical and Computer Sciences, Heriot-Watt University, Edinburgh, UK Tariq Aslam, 1,2 Brian Fleck, 1 Niall Patton, 2 Manuel Trucco 3 and Hind Azegrouz 4 1 Princess Alexandra Eye Pavilion  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1111/j.1755-3768.2008.01448.x">doi:10.1111/j.1755-3768.2008.01448.x</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/19210329">pmid:19210329</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/khyypi5h35chjmduzwwsddebxi">fatcat:khyypi5h35chjmduzwwsddebxi</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20170809094503/http://cvip.computing.dundee.ac.uk/papers/Aslam2009.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/c8/c7/c8c7415f6548b08097a3be8f87daab4ad0188492.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1111/j.1755-3768.2008.01448.x"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> Publisher / doi.org </button> </a>

Max-Min Central Vein Detection in Retinal Fundus Images

Hind Azegrouz, Emanuele Trucco
<span title="">2006</span> <i title="IEEE"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/anlh4tvwprcrtoxv5d4h6a7rye" style="color: black;">2006 International Conference on Image Processing</a> </i> &nbsp;
This paper describes a new framework for the automated tracking of the central retinal vein in retinal images. The procedure first computes a binary image of the retinal vasculature, then obtains the skeleton (medial axis) of the vascular network. Terminal and branching points of the network are then located, and the network converted into a graph representation including length and thickness information for all vessels. Finally, a MaxMin approach is used to locate the central vein:The
more &raquo; ... s central vein are the minimal paths from the optic disk to all terminal nodes found using Dijkstra algorithm. The actual central vein is selected among the all candidates by maximizing a merit function estimating the total vessel area in the image. Results are presented and compared with those provided by a manual classification on 20 images of the DRIVE set. An overall performance ratio of 92% is achieved.
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1109/icip.2006.313145">doi:10.1109/icip.2006.313145</a> <a target="_blank" rel="external noopener" href="https://dblp.org/rec/conf/icip/AzegrouzT06.html">dblp:conf/icip/AzegrouzT06</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/55h5wgtm3bfpvmts2fu2qwwzne">fatcat:55h5wgtm3bfpvmts2fu2qwwzne</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20170921233202/http://cvip.computing.dundee.ac.uk/papers/Azegrouz06MaxMin.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/8b/bc/8bbceb694fd37b18112aee6091a7c9c06296bd34.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1109/icip.2006.313145"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> ieee.com </button> </a>

Thickness dependent tortuosity estimation for retinal blood vessels

Hind Azegrouz, Emanuele Trucco, Baljean Dhillon, Thomas MacGillivray, I.J. MacCormick
<span title="">2006</span> <i title="IEEE"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/4jz775kb7vdlro6pjxr5235ezm" style="color: black;">IEEE Engineering in Medicine and Biology Society. Conference Proceedings</a> </i> &nbsp;
Hind Azegrouz and Emanuele Trucco are with Joint Research Institute Signal and Image Processing, School of Engineering and Physical Sciences, Heriot Watt University, EH14 4AS Riccarton, Scotland, UK {ha19  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1109/iembs.2006.4398495">doi:10.1109/iembs.2006.4398495</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/msnd7cul5fhtbnxtaeh7dstsq4">fatcat:msnd7cul5fhtbnxtaeh7dstsq4</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20170808065309/http://cvip.computing.dundee.ac.uk/papers/Azegrouz06.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/bd/f2/bdf2d17779dd8aa540bcf215cb267274b2b2f668.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1109/iembs.2006.4398495"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> ieee.com </button> </a>

Thickness dependent tortuosity estimation for retinal blood vessels

Hind Azegrouz, Emanuele Trucco, Baljean Dhillon, Thomas MacGillivray, I.J. MacCormick
<span title="">2006</span> <i title="IEEE"> 2006 International Conference of the IEEE Engineering in Medicine and Biology Society </i> &nbsp;
Hind Azegrouz and Emanuele Trucco are with Joint Research Institute Signal and Image Processing, School of Engineering and Physical Sciences, Heriot Watt University, EH14 4AS Riccarton, Scotland, UK {ha19  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1109/iembs.2006.260558">doi:10.1109/iembs.2006.260558</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/17945850">pmid:17945850</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/6qaksnlh7jee5l7riuyofeyxau">fatcat:6qaksnlh7jee5l7riuyofeyxau</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20170808065309/http://cvip.computing.dundee.ac.uk/papers/Azegrouz06.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/bd/f2/bdf2d17779dd8aa540bcf215cb267274b2b2f668.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1109/iembs.2006.260558"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> ieee.com </button> </a>

Caveolar domain organization and trafficking is regulated by Abl kinases and mDia1

Asier Echarri, Olivia Muriel, Dácil M. Pavón, Hind Azegrouz, Fernando Escolar, María C. Terrón, Fátima Sanchez-Cabo, Fernando Martínez, María C. Montoya, Oscar Llorca, Miguel A. del Pozo
<span title="2012-03-27">2012</span> <i title="The Company of Biologists"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/dehl5i4kbfgr7d423yjhyik2py" style="color: black;">Journal of Cell Science</a> </i> &nbsp;
The biology of caveolin-1 (Cav1)/caveolae is intimately linked to actin dynamics and adhesion receptors. Caveolar domains are organized in hierarchical levels of complexity from curved or flattened caveolae to large, higher-order caveolar rosettes. We report that stress fibers controlled by Abl kinases and mDia1 determine the level of caveolar domain organization, which conditions the subsequent inward trafficking of caveolar domains induced upon loss of cell adhesion from the extracellular
more &raquo; ... ix. Abl-deficient cells have fewer stress fibers, a smaller pool of stress-fiber co-aligned Cav1 and increased clustering of Cav1/caveolae at the cell surface. Defective caveolar linkage to stress fibers prevents the formation of big caveolar rosettes upon loss of cell adhesion, correlating with a lack of inward trafficking. Live imaging of stress fibers and Cav1 showed that the actin-linked Cav1 pool loses its spatial organization in the absence of actin polymerization and is dragged and clustered by depolymerizing filaments. We identified mDia1 as the actin polymerization regulator downstream of Abl kinases that controls the stress-fiber-linked Cav1 pool. mDia1 knockdown results in Cav1/ caveolae clustering and defective inward trafficking upon loss of cell adhesion. By contrast, cell elongation imposed by the excess of stress fibers induced by active mDia1 flattens caveolae. Furthermore, active mDia1 rescues the actin co-aligned Cav1 pool and Cav1 inward trafficking upon loss of adhesion in Abl-deficient cells. Thus, caveolar domain organization and trafficking are tightly coupled to adhesive and stress fiber regulatory pathways.
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1242/jcs.090134">doi:10.1242/jcs.090134</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/22454521">pmid:22454521</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/pdljn5hwtfaprkpmaxodkvcapq">fatcat:pdljn5hwtfaprkpmaxodkvcapq</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20170816215022/http://jcs.biologists.org/content/joces/125/13/3097.full.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/d7/7b/d77b303cbfbcf0a1fd7fd9c691c7b16183f5e5df.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1242/jcs.090134"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> Publisher / doi.org </button> </a>

ITGB1-dependent upregulation of Caveolin-1 switches TGFβ signalling from tumour-suppressive to oncogenic in prostate cancer

Teijo Pellinen, Sami Blom, Sara Sánchez, Katja Välimäki, John-Patrick Mpindi, Hind Azegrouz, Raffaele Strippoli, Raquel Nieto, Mariano Vitón, Irene Palacios, Riku Turkki, Yinhai Wang (+8 others)
<span title="2018-02-05">2018</span> <i title="Springer Nature"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/tnqhc2x2aneavcd3gx5h7mswhm" style="color: black;">Scientific Reports</a> </i> &nbsp;
Caveolin-1 (CAV1) is over-expressed in prostate cancer (PCa) and is associated with adverse prognosis, but the molecular mechanisms linking CAV1 expression to disease progression are poorly understood. Extensive gene expression correlation analysis, quantitative multiplex imaging of clinical samples, and analysis of the CAV1-dependent transcriptome, supported that CAV1 re-programmes TGFβ signalling from tumour suppressive to oncogenic (i.e. induction of SLUG, PAI-1 and suppression of CDH1, DSP,
more &raquo; ... CDKN1A). Supporting such a role, CAV1 knockdown led to growth arrest and inhibition of cell invasion in prostate cancer cell lines. Rationalized RNAi screening and high-content microscopy in search for CAV1 upstream regulators revealed integrin beta1 (ITGB1) and integrin associated proteins as CAV1 regulators. Our work suggests TGFβ signalling and beta1 integrins as potential therapeutic targets in PCa over-expressing CAV1, and contributes to better understand the paradoxical dual role of TGFβ in tumour biology. Epithelial-to-mesenchymal transition (EMT) is associated with the disruption of the normal structure of the epithelium and the invasion of carcinoma cells into the surrounding stroma 1 . EMT-associated epithelial plasticity is a relevant phenomenon in prostate cancer (PCa) progression 2 . A hallmark of EMT is the decreased or aberrant expression of the adherens junction protein E-cadherin 3 . In PCa, decreased E-cadherin expression has been shown to correlate with clinical disease progression in multiple independent studies 4-8 . A pivotal regulator of EMT is transforming growth factor beta (TGFβ) 9 . Shutdown of canonical TGFβ signalling through down-regulation or deletion of the transcriptional effector protein, SMAD4, promotes cell growth and proliferation in epithelium, and can therefore lead to carcinogenesis 10 . However, in advanced stages of cancer, the growth-suppressive function of TGFβ is often subverted to promote invasion and EMT, independent of SMAD proteins 11 . Indeed, there is evidence that TGFβ expression correlates with PCa progression and poor clinical outcome 12,13 . Also, TGFβ signalling promotes invasive growth and metastasis of PCa 14-17 . However, and despite its outstanding relevance, the principles determining this "Janus" behaviour of the TGFβ pathway have not been fully elucidated.
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1038/s41598-018-20161-2">doi:10.1038/s41598-018-20161-2</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/29402961">pmid:29402961</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC5799174/">pmcid:PMC5799174</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/ttgringf3rdgreaa3xavkz6ati">fatcat:ttgringf3rdgreaa3xavkz6ati</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20190502062918/https://iris.uniroma1.it/retrieve/handle/11573/1069594/609791/Pellinen_ITGB1-dependen_2018.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/d2/ba/d2ba052027db63a82972c1e9ab6bec736224065d.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1038/s41598-018-20161-2"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> Publisher / doi.org </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5799174" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Neuropeptide FF increases M2 activation and self-renewal of adipose tissue macrophages

Syed F. Hassnain Waqas, Anh Cuong Hoang, Ya-Tin Lin, Grace Ampem, Hind Azegrouz, Lajos Balogh, Julianna Thuróczy, Jin-Chung Chen, Ivan C. Gerling, Sorim Nam, Jong-Seok Lim, Juncal Martinez-Ibañez (+10 others)
<span title="2017-06-05">2017</span> <i title="American Society for Clinical Investigation"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/3toa7g22uzexljesj5ehm7x7da" style="color: black;">Journal of Clinical Investigation</a> </i> &nbsp;
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1172/jci90152">doi:10.1172/jci90152</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/28581443">pmid:28581443</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC5490745/">pmcid:PMC5490745</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/7hqnggpvqrce7fmu7fuorhvmgu">fatcat:7hqnggpvqrce7fmu7fuorhvmgu</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20191129211151/http://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC5490745&amp;blobtype=pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/4e/bd/4ebd5a20621406989e72c5a96698e760bc1938eb.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1172/jci90152"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> Publisher / doi.org </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5490745" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>