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High-resolution x-ray luminescence computed tomography
2020
Medical Imaging 2020: Biomedical Applications in Molecular, Structural, and Functional Imaging
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Recently, x-ray luminescence computed tomography (XLCT) imaging was introduced as a hybrid molecular imaging modality that combines the high-spatial resolution of x-ray imaging and molecular sensitivity ...
The narrow x-ray beam based XLCT imaging has been demonstrated to achieve high spatial resolution, even at depth, with great molecular sensitivity. ...
INTRODUCTION Combining the merits of both x-ray imaging (high-spatial resolution) and optical imaging (high-molecular sensitivity), x-ray luminescence computed tomography (XLCT) imaging has become an attractive ...
doi:10.1117/12.2544493
pmid:32214600
pmcid:PMC7096071
fatcat:ogrquj7i6re6ldykmhoakg7mdq
X-ray micro-modulated luminescence tomography (XMLT)
2014
Optics Express
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2013 pre-print arXiv:1311.4107v1 fatcat:gtafdj26hrcmhcytultj6ixeyu
In this paper, we suggest a micro-modulated luminescence tomography (MLT) approach to quantify a nanophosphor distribution in a thick biological sample with high resolution. ...
LiGa5O8:Cr3+ nanoparticles were recently synthesized to facilitate luminescence energy storage with x-ray pre-excitation and the subsequently stimulated luminescence emission by visible/near-infrared ( ...
Xing, "X-ray luminescence computed tomography via selective excitation: a feasibility study," IEEE Trans Med Imaging 29(12), 1992-1999 (2010). [31] W. Cong, C. Wang, and G. ...
doi:10.1364/oe.22.005572
pmid:24663898
pmcid:PMC4086334
fatcat:43hisw3upjbtxlqftpvijruiyi
Stored luminescence computed tomography
2014
Applied Optics
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2013 pre-print arXiv:1309.3585v1 fatcat:z6j36x7s5necvcszddriihqqwm
Here we propose stored luminescence computed tomography (SLCT), perform realistic numerical simulation, and demonstrate a much-improved spatial resolution in a preclinical research context. ...
The characteristics of X-ray energy storage and NIR stimulated emission is highly desirable to design targeting probes and improve molecular and cellular imaging. ...
To shorten the scanning time, a cone beam x-ray luminescence computed tomography strategy was proposed [19] . ...
doi:10.1364/ao.53.005672
pmid:25321362
fatcat:sm2gpulzgnhclgfjtldiszw37u
X-ray luminescence optical tomography imaging: experimental studies
2013
Optics Letters
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We present a hybrid imaging modality, x-ray luminescence optical tomography (XLOT), in which collimated x-ray beams are used to excite phosphor-based contrast agents. ...
Images are reconstructed from the optical signals, using the known x-ray beam location and spatial extent as priors. ...
Another example is the emerging technique of x-ray luminescence computed tomography (XLCT) that combines the high sensitivity of optical detection with the high spatial resolution of x-ray imaging [4, ...
doi:10.1364/ol.38.002339
pmid:23811921
pmcid:PMC5204368
fatcat:uo5xcpx6uvd65pqgbn77sbu2h4
Focused x-ray luminescence imaging system for small animals based on a rotary gantry
2021
Journal of Biomedical Optics
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In particular, x-ray luminescence computed tomography (XLCT) has been demonstrated as a powerful technique for the high-resolution imaging of deeply embedded contrast agents in three dimensions (3D) for ...
X-ray luminescence imaging emerged about 10 years ago to address this issue by combining the molecular sensitivity of optical probes with the high spatial resolution of x-ray imaging through tissue. ...
Specifically, x-ray luminescence computed tomography (XLCT) is a powerful imaging modality capable of the high-resolution imaging of deeply embedded x-ray excitable contrast agents in 3D. ...
doi:10.1117/1.jbo.26.3.036004
pmid:33738992
pmcid:PMC7970409
fatcat:ponmwlb2ynhofdfxdofrfmfjby
Advances in functional X-ray imaging techniques and contrast agents
2012
Physical Chemistry, Chemical Physics - PCCP
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X-rays have been used for non-invasive high-resolution imaging of thick biological specimens since their discovery in 1895. ...
In this review, we discuss how X-ray absorption, X-ray fluorescence, and Xray excited optical luminescence can be used for physiological, elemental, and molecular imaging of vasculature, tumours, pharmaceutical ...
X-ray imaging based on X-ray attenuation
Projection X-ray imaging and Computed tomography (CT) X-ray projection imaging and computed tomography (CT) are techniques which detect Xray attenuation in a ...
doi:10.1039/c2cp41858d
pmid:22962667
pmcid:PMC3569739
fatcat:4sk2n7gvubgddhkuaoaz2k2qlm
Modulated Luminescent Tomography
[article]
2014
arXiv
pre-print
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We propose and analyze a mathematical model of Modulated Luminescent Tomography. ...
We show that when single X-rays or focused X-rays are used as an excitation, the problem is similar to the inversion of weighted X-ray transforms. ...
Two such techniques, X-ray luminescence computed tomography (XLCT), [7] and X-ray micromodulated luminescence tomography (XMLT) [1, 2] , described below, have been proposed recently. ...
arXiv:1406.6752v1
fatcat:yczjx54jkvgnhgqm4ta4mz76ve
Translational Molecular Imaging Computing: Advances in Theories and Applications
2016
BioMed Research International
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The papers selected for this special issue represent recent progress in molecular imaging computing, including applications, high-performance computing technologies, method and algorithm improvement, and ...
Computed tomography (CT) is one of the commonly used imaging techniques. Now, the use of CT has increased rapidly. ...
To improve image resolution, a new hybrid imaging modality, X-ray luminescence computed tomography (XLCT), has been developed. XLCT utilizes X-ray luminescent nanophosphors (NPs) as imaging probes. ...
doi:10.1155/2016/1569605
pmid:28097127
pmcid:PMC5206409
fatcat:apwqvywt3bandekcs2ev6igrjy
X-ray micromodulated luminescence tomography in dual-cone geometry
2014
Journal of Biomedical Optics
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The x-ray-induced luminescence data allow for reliable image reconstruction with high spatial resolution and large imaging depth. ...
We propose a scanning method utilizing dual-cone beams of x-rays to induce luminescence from nanophosphors and reconstruct the three-dimensional distribution of these particles in a biological sample or ...
Nanophosphors of high-density luminescent materials provide high contrast and absorption for x-rays. ...
doi:10.1117/1.jbo.19.7.076002
pmid:24990086
pmcid:PMC4079083
fatcat:qqwivjb5wze77ib6cq76ew2jhy
Cone-beam x-ray luminescence computed tomography based on x-ray absorption dosage
2018
Journal of Biomedical Optics
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Conebeam x-ray luminescence computed tomography based on x-ray absorption dosage," Abstract. ...
With the advances of x-ray excitable nanophosphors, x-ray luminescence computed tomography (XLCT) has become a promising hybrid imaging modality. ...
Introduction With the advances of x-ray excitable nanophosphors, x-ray luminescence computed tomography (XLCT) has attracted more attention for its promising performance. ...
doi:10.1117/1.jbo.23.2.026006
pmid:29473348
fatcat:4bhjmpbrvje5to6qdbf54iwxeu
Spectrally resolving and scattering-compensated x-ray luminescence∕fluorescence computed tomography
2011
Journal of Biomedical Optics
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light upon x-ray excitation. 3, 4 As optical probes, these nanophosphors potentially allow sensitive and specific high-resolution imaging in vivo. 5 Using the nanophosphors, x-ray luminescence computed ...
This methodology can be adapted for x-ray fluorescence computed tomography (XFCT) as well. ...
doi:10.1117/1.3592499
pmid:21721815
pmcid:PMC3133802
fatcat:eeazyca7evbuxj6eud3fk76e5u
Development of a focused-X-ray luminescence tomography (FXLT) system
[article]
2017
arXiv
pre-print
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In this paper, with a superfine focused X-ray beam we design a focused-X-ray luminescence tomography (FXLT) system for spatial resolution better than 150 micrometers and molecular sensitivity of 2 micromolar ...
Recently, X-ray luminescence computed tomography (XLCT) has emerged as a hybrid molecular imaging modality and shown great promises in overcoming the optical scattering in deep tissues. ...
luminescence computed tomography (XLCT). ...
arXiv:1709.10186v1
fatcat:7uwf7ah5orfj7ft5x4n2qqklby
Tomographic molecular imaging of x-ray-excitable nanoparticles
2010
Optics Letters
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X-ray luminescence computed tomography (XLCT) is proposed as a new dual molecular/anatomical imaging modality. ...
XLCT is based on the selective excitation and optical detection of x-ray-excitable nanoparticles. ...
X-ray computed tomography (CT) is widely used for imaging the anatomy with high spatial resolution, but its use in molecular imaging remains limited. ...
doi:10.1364/ol.35.003345
pmid:20967061
fatcat:acwbx6jl2feolcxxisgzwvdhwa
High resolution fluorescence bio-imaging upconversion nanoparticles in insects
2017
Optics Express
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The locations were further confirmed by X-ray tomography, where most particles aggregated inside the ant's mouth. ...
High resolution, fast, and economical optical imaging system opens the door for studying more complex biological systems. ...
The inset presents photo luminescence (PL) spectra of the UCNPs in the green spots. upconversion nanoparticles inside fire ants using synchrotron radiation micro X-ray computed tomography (SR-µXCT)
Conformation ...
doi:10.1364/oe.25.001030
pmid:28157984
fatcat:ablc3wwfh5a4vglsg7bsi3fzpm
Resolving adjacent nanophosphors of different concentrations by excitation-based cone-beam X-ray luminescence tomography
2017
Biomedical Optics Express
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Cone-beam X-ray luminescence computed tomography (CB-XLCT) has been proposed as a new molecular imaging modality recently. ...
It can obtain both anatomical and functional tomographic images of an object efficiently, with the excitation of nanophosphors in vivo or in vitro by cone-beam X-rays. ...
Tian, "Cone beam x-ray luminescence computed tomography: A feasibility study," Med. Phys. 40(3), 031111 (2013). 15. X. Liu, Q. Liao, and H. ...
doi:10.1364/boe.8.003952
pmid:29026681
pmcid:PMC5611915
fatcat:t5rwoielrrhmbdmqoxzhb3oywa
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