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High-resolution x-ray luminescence computed tomography

Michael C. Lun, Changqing Li, Barjor S. Gimi, Andrzej Krol
2020 Medical Imaging 2020: Biomedical Applications in Molecular, Structural, and Functional Imaging  
Recently, x-ray luminescence computed tomography (XLCT) imaging was introduced as a hybrid molecular imaging modality that combines the high-spatial resolution of x-ray imaging and molecular sensitivity  ...  The narrow x-ray beam based XLCT imaging has been demonstrated to achieve high spatial resolution, even at depth, with great molecular sensitivity.  ...  INTRODUCTION Combining the merits of both x-ray imaging (high-spatial resolution) and optical imaging (high-molecular sensitivity), x-ray luminescence computed tomography (XLCT) imaging has become an attractive  ... 
doi:10.1117/12.2544493 pmid:32214600 pmcid:PMC7096071 fatcat:ogrquj7i6re6ldykmhoakg7mdq

X-ray micro-modulated luminescence tomography (XMLT)

Wenxiang Cong, Fenglin Liu, Chao Wang, Ge Wang
2014 Optics Express  
In this paper, we suggest a micro-modulated luminescence tomography (MLT) approach to quantify a nanophosphor distribution in a thick biological sample with high resolution.  ...  LiGa5O8:Cr3+ nanoparticles were recently synthesized to facilitate luminescence energy storage with x-ray pre-excitation and the subsequently stimulated luminescence emission by visible/near-infrared (  ...  Xing, "X-ray luminescence computed tomography via selective excitation: a feasibility study," IEEE Trans Med Imaging 29(12), 1992-1999 (2010). [31] W. Cong, C. Wang, and G.  ... 
doi:10.1364/oe.22.005572 pmid:24663898 pmcid:PMC4086334 fatcat:43hisw3upjbtxlqftpvijruiyi

Stored luminescence computed tomography

Wenxiang Cong, Chao Wang, Ge Wang
2014 Applied Optics  
Here we propose stored luminescence computed tomography (SLCT), perform realistic numerical simulation, and demonstrate a much-improved spatial resolution in a preclinical research context.  ...  The characteristics of X-ray energy storage and NIR stimulated emission is highly desirable to design targeting probes and improve molecular and cellular imaging.  ...  To shorten the scanning time, a cone beam x-ray luminescence computed tomography strategy was proposed [19] .  ... 
doi:10.1364/ao.53.005672 pmid:25321362 fatcat:sm2gpulzgnhclgfjtldiszw37u

X-ray luminescence optical tomography imaging: experimental studies

Changqing Li, Kun Di, Julien Bec, Simon R. Cherry
2013 Optics Letters  
We present a hybrid imaging modality, x-ray luminescence optical tomography (XLOT), in which collimated x-ray beams are used to excite phosphor-based contrast agents.  ...  Images are reconstructed from the optical signals, using the known x-ray beam location and spatial extent as priors.  ...  Another example is the emerging technique of x-ray luminescence computed tomography (XLCT) that combines the high sensitivity of optical detection with the high spatial resolution of x-ray imaging [4,  ... 
doi:10.1364/ol.38.002339 pmid:23811921 pmcid:PMC5204368 fatcat:uo5xcpx6uvd65pqgbn77sbu2h4

Focused x-ray luminescence imaging system for small animals based on a rotary gantry

Michael C. Lun, Wenxiang Cong, Mohammad Arifuzzaman, Meenakshi Ranasinghe, Sriparna Bhattacharya, Jeffrey N. Anker, Ge Wang, Changqing Li
2021 Journal of Biomedical Optics  
In particular, x-ray luminescence computed tomography (XLCT) has been demonstrated as a powerful technique for the high-resolution imaging of deeply embedded contrast agents in three dimensions (3D) for  ...  X-ray luminescence imaging emerged about 10 years ago to address this issue by combining the molecular sensitivity of optical probes with the high spatial resolution of x-ray imaging through tissue.  ...  Specifically, x-ray luminescence computed tomography (XLCT) is a powerful imaging modality capable of the high-resolution imaging of deeply embedded x-ray excitable contrast agents in 3D.  ... 
doi:10.1117/1.jbo.26.3.036004 pmid:33738992 pmcid:PMC7970409 fatcat:ponmwlb2ynhofdfxdofrfmfjby

Advances in functional X-ray imaging techniques and contrast agents

Hongyu Chen, Melissa M. Rogalski, Jeffrey N. Anker
2012 Physical Chemistry, Chemical Physics - PCCP  
X-rays have been used for non-invasive high-resolution imaging of thick biological specimens since their discovery in 1895.  ...  In this review, we discuss how X-ray absorption, X-ray fluorescence, and Xray excited optical luminescence can be used for physiological, elemental, and molecular imaging of vasculature, tumours, pharmaceutical  ...  X-ray imaging based on X-ray attenuation Projection X-ray imaging and Computed tomography (CT) X-ray projection imaging and computed tomography (CT) are techniques which detect Xray attenuation in a  ... 
doi:10.1039/c2cp41858d pmid:22962667 pmcid:PMC3569739 fatcat:4sk2n7gvubgddhkuaoaz2k2qlm

Modulated Luminescent Tomography [article]

Plamen Stefanov, Wenxiang Cong, Ge Wang
2014 arXiv   pre-print
We propose and analyze a mathematical model of Modulated Luminescent Tomography.  ...  We show that when single X-rays or focused X-rays are used as an excitation, the problem is similar to the inversion of weighted X-ray transforms.  ...  Two such techniques, X-ray luminescence computed tomography (XLCT), [7] and X-ray micromodulated luminescence tomography (XMLT) [1, 2] , described below, have been proposed recently.  ... 
arXiv:1406.6752v1 fatcat:yczjx54jkvgnhgqm4ta4mz76ve

Translational Molecular Imaging Computing: Advances in Theories and Applications

Jinchao Feng, Wenxiang Cong, Kuangyu Shi, Shouping Zhu, Jun Zhang
2016 BioMed Research International  
The papers selected for this special issue represent recent progress in molecular imaging computing, including applications, high-performance computing technologies, method and algorithm improvement, and  ...  Computed tomography (CT) is one of the commonly used imaging techniques. Now, the use of CT has increased rapidly.  ...  To improve image resolution, a new hybrid imaging modality, X-ray luminescence computed tomography (XLCT), has been developed. XLCT utilizes X-ray luminescent nanophosphors (NPs) as imaging probes.  ... 
doi:10.1155/2016/1569605 pmid:28097127 pmcid:PMC5206409 fatcat:apwqvywt3bandekcs2ev6igrjy

X-ray micromodulated luminescence tomography in dual-cone geometry

Wenxiang Cong, Zhengwei Pan, Robert Filkins, Alok Srivastava, Nadeem Ishaque, Plamen Stefanov, Ge Wang
2014 Journal of Biomedical Optics  
The x-ray-induced luminescence data allow for reliable image reconstruction with high spatial resolution and large imaging depth.  ...  We propose a scanning method utilizing dual-cone beams of x-rays to induce luminescence from nanophosphors and reconstruct the three-dimensional distribution of these particles in a biological sample or  ...  Nanophosphors of high-density luminescent materials provide high contrast and absorption for x-rays.  ... 
doi:10.1117/1.jbo.19.7.076002 pmid:24990086 pmcid:PMC4079083 fatcat:qqwivjb5wze77ib6cq76ew2jhy

Cone-beam x-ray luminescence computed tomography based on x-ray absorption dosage

Tianshuai Liu, Junyan Rong, Peng Gao, Wenli Zhang, Wenlei Liu
2018 Journal of Biomedical Optics  
Conebeam x-ray luminescence computed tomography based on x-ray absorption dosage," Abstract.  ...  With the advances of x-ray excitable nanophosphors, x-ray luminescence computed tomography (XLCT) has become a promising hybrid imaging modality.  ...  Introduction With the advances of x-ray excitable nanophosphors, x-ray luminescence computed tomography (XLCT) has attracted more attention for its promising performance.  ... 
doi:10.1117/1.jbo.23.2.026006 pmid:29473348 fatcat:4bhjmpbrvje5to6qdbf54iwxeu

Spectrally resolving and scattering-compensated x-ray luminescence∕fluorescence computed tomography

Wenxiang Cong, Haiou Shen, Ge Wang
2011 Journal of Biomedical Optics  
light upon x-ray excitation. 3, 4 As optical probes, these nanophosphors potentially allow sensitive and specific high-resolution imaging in vivo. 5 Using the nanophosphors, x-ray luminescence computed  ...  This methodology can be adapted for x-ray fluorescence computed tomography (XFCT) as well.  ... 
doi:10.1117/1.3592499 pmid:21721815 pmcid:PMC3133802 fatcat:eeazyca7evbuxj6eud3fk76e5u

Development of a focused-X-ray luminescence tomography (FXLT) system [article]

Michael C Lun, Wei Zhang, Yue Zhao, Jeffrey Anker, Wenxiang Cong, Ge Wang, Changqing Li
2017 arXiv   pre-print
In this paper, with a superfine focused X-ray beam we design a focused-X-ray luminescence tomography (FXLT) system for spatial resolution better than 150 micrometers and molecular sensitivity of 2 micromolar  ...  Recently, X-ray luminescence computed tomography (XLCT) has emerged as a hybrid molecular imaging modality and shown great promises in overcoming the optical scattering in deep tissues.  ...  luminescence computed tomography (XLCT).  ... 
arXiv:1709.10186v1 fatcat:7uwf7ah5orfj7ft5x4n2qqklby

Tomographic molecular imaging of x-ray-excitable nanoparticles

Guillem Pratx, Colin M. Carpenter, Conroy Sun, Ravi P. Rao, Lei Xing
2010 Optics Letters  
X-ray luminescence computed tomography (XLCT) is proposed as a new dual molecular/anatomical imaging modality.  ...  XLCT is based on the selective excitation and optical detection of x-ray-excitable nanoparticles.  ...  X-ray computed tomography (CT) is widely used for imaging the anatomy with high spatial resolution, but its use in molecular imaging remains limited.  ... 
doi:10.1364/ol.35.003345 pmid:20967061 fatcat:acwbx6jl2feolcxxisgzwvdhwa

High resolution fluorescence bio-imaging upconversion nanoparticles in insects

Masfer Alkahtani, Yunyun Chen, Julie J. Pedraza, Jorge M. González, Dilworth Y. Parkinson, Philip R. Hemmer, Hong Liang
2017 Optics Express  
The locations were further confirmed by X-ray tomography, where most particles aggregated inside the ant's mouth.  ...  High resolution, fast, and economical optical imaging system opens the door for studying more complex biological systems.  ...  The inset presents photo luminescence (PL) spectra of the UCNPs in the green spots. upconversion nanoparticles inside fire ants using synchrotron radiation micro X-ray computed tomography (SR-µXCT) Conformation  ... 
doi:10.1364/oe.25.001030 pmid:28157984 fatcat:ablc3wwfh5a4vglsg7bsi3fzpm

Resolving adjacent nanophosphors of different concentrations by excitation-based cone-beam X-ray luminescence tomography

Peng Gao, Huangsheng Pu, Junyan Rong, Wenli Zhang, Tianshuai Liu, Wenlei Liu, Yuanke Zhang, Hongbing Lu
2017 Biomedical Optics Express  
Cone-beam X-ray luminescence computed tomography (CB-XLCT) has been proposed as a new molecular imaging modality recently.  ...  It can obtain both anatomical and functional tomographic images of an object efficiently, with the excitation of nanophosphors in vivo or in vitro by cone-beam X-rays.  ...  Tian, "Cone beam x-ray luminescence computed tomography: A feasibility study," Med. Phys. 40(3), 031111 (2013). 15. X. Liu, Q. Liao, and H.  ... 
doi:10.1364/boe.8.003952 pmid:29026681 pmcid:PMC5611915 fatcat:t5rwoielrrhmbdmqoxzhb3oywa
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