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High-resolution structural and functional MRI of hippocampal CA3 and dentate gyrus in patients with amnestic Mild Cognitive Impairment

Michael A. Yassa, Shauna M. Stark, Arnold Bakker, Marilyn S. Albert, Michela Gallagher, Craig E.L. Stark
2010 NeuroImage  
Functional magnetic resonance imaging (fMRI) studies have observed hyperactivity in the hippocampal region in individuals with Mild Cognitive Impairment (MCI).  ...  In a high-resolution morphometric analysis of hippocampal subfields, aMCI patients also had smaller CA3/dentate and CA1 volumes (no difference in the subiculum).  ...  Michela Gallagher is the founder of AgeneBio Incorporated, a biotechnology company that is dedicated to commercializing therapies to treat cognitive impairment in aging and she has a financial interest  ... 
doi:10.1016/j.neuroimage.2010.03.040 pmid:20338246 pmcid:PMC2909476 fatcat:ugjy2274jnavlgssmi7ee5ad3m

Association between subfield volumes of the medial temporal lobe and cognitive assessments

Masayo Ogawa, Daichi Sone, Iman Beheshti, Norihide Maikusa, Kyoji Okita, Harumasa Takano, Hiroshi Matsuda
2019 Heliyon  
segmentation of hippocampal subfields using high-resolution T1-and T2-weighted images.  ...  The aim of this study was to uncover which specific hippocampal subfields and adjacent extrahippocampal structures contribute to deficits in cognitive assessment scores in patients with MCI and AD.  ...  Yuko Furuya, and Mr. Tenshou Yamao of the National Center of Neurology and Psychiatry for their support.  ... 
doi:10.1016/j.heliyon.2019.e01828 pmid:31194147 pmcid:PMC6551380 fatcat:2dzb4qvyzvguvdzpcbmr7f3t5e

Episodic memory on the path to Alzheimer's disease

Michela Gallagher, Ming Teng Koh
2011 Current Opinion in Neurobiology  
Frank neuron loss in the entorhinal cortex is specific for AD, and related structural and functional changes across the network comprised of the entorhinal cortex and the dentate/CA3 regions hold promise  ...  The layer II neurons in the entorhinal cortex and their targets in the dentate gyrus and CA3 region of hippocampus comprise a system that rapidly encodes representations that are distinct from prior memories  ...  Acknowledgements This work was supported by a grant (P01-AG-09973) from the National Institute of Aging and the Senior Scholar Award from the Ellison Medical Foundation to Michela Gallagher.  ... 
doi:10.1016/j.conb.2011.10.021 pmid:22079495 pmcid:PMC3254732 fatcat:lkxopcjq45fgxmmd6lna7g3hsu

Horizontal Versus Longitudinal Axis of the Hippocampus: Metabolic Differentiation as Measured with High-Resolution PET/MRI

I. Yakushev, A. Fellgiebel
2011 Journal of Nuclear Medicine  
In that work the authors performed high-resolution 18 F-FDG PET and structural MRI of the hippocampus in a group of 5 healthy subjects.  ...  In contrast, patients with pure amnesia or with mild Alzheimer dementia showed significantly decreased metabolism in the hippocampal head only.  ...  molecular imaging using our newly introduced ultra-high-resolution PET-MRI fusion system (2) .  ... 
doi:10.2967/jnumed.110.085084 pmid:21233184 fatcat:hnq5conyazf33da7mv3wigrsoe

Reply: Horizontal Versus Longitudinal Axis of the Hippocampus: Metabolic Differentiation as Measured with High-Resolution PET/MRI

Z.-H. Cho, Y.-D. Son, H.-K. Kim, S.-T. Kim, S.-Y. Lee, J.-G. Chi, C.-W. Park, Y.-B. Kim
2011 Journal of Nuclear Medicine  
introduced ultra-high-resolution PET-MRI fusion system (2).  ...  REPLY: We very much appreciate the comments and suggestions of Yakushev and Fellgiebel on our paper (1), which was the first in a series we are publishing on in vivo human molecular imaging using our newly  ...  In that work the authors performed high-resolution 18 F-FDG PET and structural MRI of the hippocampus in a group of 5 healthy subjects.  ... 
doi:10.2967/jnumed.110.085407 fatcat:rpuxxzucnrd2vdfifqsgapa3wm

Reduction of Hippocampal Hyperactivity Improves Cognition in Amnestic Mild Cognitive Impairment

Arnold Bakker, Gregory L. Krauss, Marilyn S. Albert, Caroline L. Speck, Lauren R. Jones, Craig E. Stark, Michael A. Yassa, Susan S. Bassett, Amy L. Shelton, Michela Gallagher
2012 Neuron  
Under placebo treatment, hippocampal activation in the dentate gyrus/CA3 was elevated in aMCI patients compared to a healthy control group.  ...  Elevated hippocampal activation is observed in conditions that confer risk for Alzheimer's disease, including amnestic mild cognitive impairment (aMCI).  ...  Consistent with those findings, recent evidence from high-resolution fMRI in humans indicates that greater hippocampal activation in aMCI localizes to the dentate gyrus/CA3 (DG/CA3) region , suggesting  ... 
doi:10.1016/j.neuron.2012.03.023 pmid:22578498 pmcid:PMC3351697 fatcat:qm4n6sg5ungk5d5yaqjxz4deta

Individual differences in associative memory among older adults explained by hippocampal subfield structure and function

Valerie A. Carr, Jeffrey D. Bernstein, Serra E. Favila, Brian K. Rutt, Geoffrey A. Kerchner, Anthony D. Wagner
2017 Proceedings of the National Academy of Sciences of the United States of America  
Using ultra-high-field 7T structural MRI and high-resolution 3T functional MRI (hr-fMRI), we evaluated MTL subfield thickness and function in older adults representing a spectrum of cognitive health.  ...  Similarly, in vivo imaging studies of patients with mild cognitive impairment (MCI) (a clinical precursor to AD) and mild AD demonstrate focal atrophy in ERC (23-25) and CA1 (e.g., ref. 26), although some  ...  Data deposition: The human MRI data reported in this paper have been deposited in the Stanford Digital Repository (SDR), https://purl.stanford.edu/dm781xs5457. ACKNOWLEDGMENTS.  ... 
doi:10.1073/pnas.1713308114 pmid:29078387 pmcid:PMC5692588 fatcat:22ltzqkjezgm7pvj4sgsdtxz7u

Increased hippocampal activation in ApoE-4 carriers and non-carriers with amnestic mild cognitive impairment

Tammy T. Tran, Caroline L. Speck, Aparna Pisupati, Michela Gallagher, Arnold Bakker
2017 NeuroImage: Clinical  
Previous work has localized this increased activation to the dentate gyrus/CA3 subregion of the hippocampus and showed a correlation with memory impairments in those patients.  ...  Increased fMRI activation in the hippocampus is recognized as a signature characteristic of the amnestic mild cognitive impairment (aMCI) stage of Alzheimer's disease (AD).  ...  Kirby Center for Functional Brain Imaging and Alaina Gold for their assistance with data collection. This work was supported by NIH grants RC2AG036419 and P50AG05146.  ... 
doi:10.1016/j.nicl.2016.12.002 pmid:28070483 pmcid:PMC5217770 fatcat:6pq6vzg7hnbn3efjxi5vy67tvm

Hippocampal atrophy patterns in mild cognitive impairment and Alzheimer's disease

Susanne G. Mueller, Norbert Schuff, Kristine Yaffe, Catherine Madison, Bruce Miller, Michael W. Weiner
2010 Human Brain Mapping  
The aims of this study were as follows: (1) to determine patterns of volume loss in hippocampal subfields in normal aging, AD, and amnestic mild cognitive impairment (MCI). (2) To determine if measurements  ...  Entorhinal cortex (ERC), subiculum, CA1, CA1-CA2 transition zone (CA1-2), CA3 & dentate gyrus (CA3&DG) were manually marked in the anterior third of the hippocampal body.  ...  Acknowledgments Contract grant sponsor: National Institutes of Health; Contract grant numbers: RO1 AG010897, P01 AG12435.  ... 
doi:10.1002/hbm.20934 pmid:20839293 pmcid:PMC2943433 fatcat:5ez4e6uojjd6tgi7jdiotklpsi

APOE 4 worsens hippocampal CA1 apical neuropil atrophy and episodic memory

G. A. Kerchner, D. Berdnik, J. C. Shen, J. D. Bernstein, M. C. Fenesy, G. K. Deutsch, T. Wyss-Coray, B. K. Rutt
2014 Neurology  
Using a cross-sectional design, we studied 11 patients with Alzheimer disease dementia, 14 patients with amnestic mild cognitive impairment, and 14 age-matched healthy controls with no group differences  ...  Using high-resolution structural MRI, we endeavored to study the relationships among APOE ε4, hippocampal subfield and stratal anatomy, and episodic memory.  ...  ACKNOWLEDGMENT The authors thank Christina Wyss-Coray, RN, for assistance with subject recruitment and study coordination, and Maria Coburn for assistance with biospecimen cataloging and storage.  ... 
doi:10.1212/wnl.0000000000000154 pmid:24453080 pmcid:PMC3945665 fatcat:7bgdiblbqndlzgnwtrcnvcj3ry

The association between hippocampal subfield volumes and education in cognitively normal older adults and amnestic mild cognitive impairment patients

Dong Woo Kang, Hyun Kook Lim, Soo Hyun Joo, Na Rae Lee, Chang Uk Lee
2018 Neuropsychiatric Disease and Treatment  
This study examined the relationship between education, which is a standard proxy for cognitive reserve, and hippocampal subfield volumes in healthy and amnestic mild cognitive impairment (aMCI) groups  ...  Conclusion: These findings contribute to a better understanding of the association between education, hippocampal subfield volumes, and amnestic cognitive functions in the early phase of AD.  ...  Disclosure The authors report no conflicts of interest in this work.  ... 
doi:10.2147/ndt.s151659 pmid:29379287 pmcid:PMC5757976 fatcat:2phx2goqdfb4nekwhl5mnbqg7a

Selective effect of age, Apo e4, and Alzheimer's disease on hippocampal subfields

Susanne G. Mueller, Michael W. Weiner
2009 Hippocampus  
One hundred fifty seven subjects (119 cognitively healthy elderly controls, 20 MCI and 18 AD) were studied with a high resolution T2 weighted imaging sequence obtained at 4T aimed at the hippocampus.  ...  Highresolution images at 4T depict details of the internal structure of the hippocampus allowing for in vivo volumetry of hippocampal subfields.  ...  Acknowledgments Grant sponsor: National Institutes of Health; Grant numbers: RO1 AG010897, P01 AG12435.  ... 
doi:10.1002/hipo.20614 pmid:19405132 pmcid:PMC2802542 fatcat:x3ytjr7wk5fntmaxmadopfruqu

Subcortical Shape Changes, Hippocampal Atrophy and Cortical Thinning in Future Alzheimer's Disease Patients

Andrea M. Kälin, Min T. M. Park, M. Mallar Chakravarty, Jason P. Lerch, Lars Michels, Clemens Schroeder, Sarah D. Broicher, Spyros Kollias, Roger M. Nitsch, Anton F. Gietl, Paul G. Unschuld, Christoph Hock (+1 others)
2017 Frontiers in Aging Neuroscience  
Efficacy of future treatments depends on biomarkers identifying patients with mild cognitive impairment at highest risk for transitioning to Alzheimer's disease.  ...  Here, we applied recently developed analysis techniques to investigate cross-sectional differences in subcortical shape and volume alterations in patients with stable mild cognitive impairment (MCI) (n  ...  The content of this study first appeared in the doctoral thesis of the manuscripts' first author (Kälin, 2015) .  ... 
doi:10.3389/fnagi.2017.00038 pmid:28326033 pmcid:PMC5339600 fatcat:rmc4gv3donad3oahnkdbmjfvvm

Structural imaging of hippocampal subfields in healthy aging and Alzheimer's disease

Robin de Flores, Renaud La Joie, Gaël Chételat
2015 Neuroscience  
Highlights: -Hippocampal subfield structure can be assessed in vivo with (high-resolution) MRI -AD-related atrophy is initially focal (in CA1) before spreading to other subfields -This pattern of atrophy  ...  However, controversies remain regarding changes in hippocampal subfield structure in normal aging and regarding correlations between specific subfield volume and memory abilities, very likely because of  ...  Acknowledgements The authors are grateful for the financial support they have received from Association We thank Jacob W Vogel for his comments and English editing as well as Paul Yushkevich for sharing  ... 
doi:10.1016/j.neuroscience.2015.08.033 pmid:26306871 fatcat:mo2oypyj4vhyhgow7nznti3wx4

Evidence for functional specialization of hippocampal subfields detected by MR subfield volumetry on high resolution images at 4T

S.G. Mueller, L.L. Chao, B. Berman, M.W. Weiner
2011 NeuroImage  
25 cognitively impaired subjects) had CVLTII and high resolution hippocampal MRI at 4T.  ...  Animal studies suggest an involvement of CA3 and dentate gyrus (CA3&DG) in memory encoding and early retrieval and an involvement of CA1 in late retrieval, consolidation and recognition.  ...  Funding: National Institutes of Health grants: RO1 AG010897 and P01 AG12435 to M.W.W.  ... 
doi:10.1016/j.neuroimage.2011.03.028 pmid:21419225 pmcid:PMC3085574 fatcat:t3vprxl7qfb7teh6ha3n2ccmyu
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