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Imaging the Neuroimmune Dynamics Across Space and Time
2020
Frontiers in Neuroscience
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to increase the spatial and temporal resolution of neuroimmune imaging. ...
High-resolution electron microscopy with immunostaining and 3D-reconstruction, as well as super-resolution fluorescence microscopy, provided complementary insights by revealing microglial interventions ...
and multiphoton microscopy. ...
doi:10.3389/fnins.2020.00903
pmid:33071723
pmcid:PMC7539119
fatcat:yc2c2wuxprhiti4vlfs7whmgc4
A Model of Discovery: The Role of Imaging Established and Emerging Non-mammalian Models in Neuroscience
2022
Frontiers in Molecular Neuroscience
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This review seeks to synthesize current knowledge of established and emerging non-mammalian model organisms with advances in cellular-resolution in vivo imaging techniques to suggest new approaches to ...
We will summarize current tools and in vivo imaging approaches at the single cell scale that could help lead to increased consideration of non-mammalian models in neuroscience research. ...
Cellular and sub-cellular phenomena that require very high temporal and spatial resolution to observe are largely outside the reach of intravital imaging. ...
doi:10.3389/fnmol.2022.867010
pmid:35493325
pmcid:PMC9046975
fatcat:f4uufbuojjerdf3m3qygzfqebu
Imaging Myelination In Vivo Using Transparent Animal Models
2016
Brain Plasticity
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We outline common transgenic technologies used to generate zebrafish and Xenopus that express fluorescent reporters, which can be used to image myelination. ...
As a consequence, in recent years much effort has been invested in the use of smaller, simpler, transparent model organisms to investigate mechanisms of myelination in vivo. ...
We would also like to thank members of the Lyons lab who contributed to figures: Rafael Almeida provided cartoons and an mbp:eGFP-CAAX image, Jill Williamson provided the single oligodendrocyte image, ...
doi:10.3233/bpl-160029
pmid:29765846
pmcid:PMC5928531
fatcat:lp5uz3kzrbhu5oty2cejpaoxqe
Alterations in mGluR5 Expression and Signaling in Lewy Body Disease and in Transgenic Models of Alpha-Synucleinopathy – Implications for Excitotoxicity
2010
PLoS ONE
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In this context, levels of mGluR5 were analyzed in the brains of PD and DLB human cases and alpha-syn transgenic (tg) mice and compared to age-matched, unimpaired controls, we report a 40% increase in ...
Dementia with Lewy bodies (DLB) and Parkinson's Disease (PD) are neurodegenerative disorders of the aging population characterized by the abnormal accumulation of alpha-synuclein (alpha-syn). ...
Sunny Chow for development of data processing plugins for Image J during the course of these studies.
Author Contributions ...
doi:10.1371/journal.pone.0014020
pmid:21103359
pmcid:PMC2982819
fatcat:xpxgu7nksfd3ln3hc3buwnwmp4
Advances in Light Microscopy for Neuroscience
2009
Annual Review of Neuroscience
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Mouse genetic approaches permit mosaic and inducible fluorescence-labeling strategies, whereas intrinsic contrast mechanisms allow in vivo imaging of animals and humans without use of exogenous markers ...
Since the work of Golgi and Cajal, light microscopy has remained a key tool for neuroscientists to observe cellular properties. ...
ACKNOWLEDGMENTS This review greatly benefited from critical feedback on portions of the text and contributions of images generously provided by many neuroscientists and microscopists. ...
doi:10.1146/annurev.neuro.051508.135540
pmid:19555292
pmcid:PMC2820375
fatcat:iihdajrrmramtibudjt66tvroe
ABSTRACTS OF PAPERS AT THE SEVENTY-FIRST ANNUAL MEETING OF THE SOCIETY OF GENERAL PHYSIOLOGISTS: The Optical Revolution in Physiology: From Membrane to Brain
2017
The Journal of General Physiology
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Methods: We used the Cre-loxP technique to express GCaMP3 in combination with confocal imaging. Electrical fi eld stimulation (EFS) was used to activate enteric motor neurons. ...
However, using multi-color super-resolution stochastic optical reconstruction microscopy (STORM), we observed intimate association of individual molecules within signaling complexes containing ion channels ...
Of the various approaches, multiphoton microscopy (MPM) is particularly well suited for deep, in vivo imaging due to its non-invasiveness and ability to maintain high spatial resolution at depth through ...
doi:10.1085/jgp.149.9.889
fatcat:nplsscsocfcpdntcc7wfv6pn4i
Erratum: Visualization of image data from cells to organisms
2010
Nature Methods
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systematic image data characterizing genes and proteins on a large scale. ...
Second, the availability of highthroughput techniques enables experiments on a large scale, generating large sets of image ...
Two-photon microscopy is similar to confocal scanning microscopy but uses nonlinear excitation involving two-photon (or multiphoton) absorption 86 . ...
doi:10.1038/nmeth0610-479a
fatcat:mimxo5gqnrf6zpu2uhfh7iinxm
Biomechanical coupling facilitates spinal neural tube closure in mouse embryos
2017
Proceedings of the National Academy of Sciences of the United States of America
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The authors alone are responsible for the content of this paper, which does not necessarily represent the decisions, policy, or views of the World Health Organization or its member states. ...
Failure of this closure process leads to open spina bifida, a common cause of severe neurologic disability in humans. ...
Stained embryos were imaged on a Zeiss Examiner LSM880 confocal microscope. The high-resolution images shown in SI Appendix, section 1, Fig. ...
doi:10.1073/pnas.1700934114
pmid:28607062
pmcid:PMC5495245
fatcat:joiexm5iybc4bhfxn3ch4elo5e
The AppNL-G-F mouse retina is a site for preclinical Alzheimer's disease diagnosis and research
2021
Acta Neuropathologica Communications
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Furthermore, we show that hyperspectral imaging can be used to quantify retinal Aβ, underscoring its potential as a biomarker for AD diagnosis and monitoring. ...
AbstractIn this study, we report the results of a comprehensive phenotyping of the retina of the AppNL-G-F mouse. ...
advice on hyperspectral imaging; ...
doi:10.1186/s40478-020-01102-5
pmid:33407903
pmcid:PMC7788955
fatcat:lbycxlwmcrabzngdbqvjgr33ky
Biomedical Applications of Translational Optical Imaging: From Molecules to Humans
2021
Molecules
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detail the makeup and functioning of the living state can and should be combined for maximum effect, especially if one seeks simultaneously high spatiotemporal resolution and discrimination ability within ...
Its multitude of features (intensity, wavelength, polarization, interference, coherence, timing, non-linear absorption, and even interactions with itself) able to create contrast, and thus images that ...
The specimens were then imaged at high resolution using laser-scanning confocal microscopy. ...
doi:10.3390/molecules26216651
pmid:34771060
pmcid:PMC8587670
fatcat:epwtmw4l5felvltnlaas4gwwqq
Pericyte degeneration leads to neurovascular uncoupling and limits oxygen supply to brain
2017
Nature Neuroscience
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Thus, pericyte degeneration as seen in neurological disorders such as Alzheimer's disease may contribute to neurovascular dysfunction and neurodegeneration associated with human disease. ...
Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use: ...
This research was supported by National Institutes of Health grants R01 AG023084, R01 AG039452, R01 NS034467 and R01 NS100459 to B.V.Z.; R01 NS091230 to ...
doi:10.1038/nn.4489
pmid:28135240
pmcid:PMC5323291
fatcat:gw6wa42gwnchta3jer5nsgu4pe
Neuronal metabolic rewiring promotes resilience to neurodegeneration caused by mitochondrial dysfunction
2020
Science Advances
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Neurodegeneration in mitochondrial disorders is considered irreversible because of limited metabolic plasticity in neurons, yet the cell-autonomous implications of mitochondrial dysfunction for neuronal ...
Our findings identify a previously unappreciated pathway conferring resilience to mitochondrial dysfunction and show that neurodegeneration can be reversed even at advanced disease stages. ...
Transgenic mouse models bearing mutated genes, which are associated with human spinocerebellar ataxia, have also been reported to have mitochondrial dysfunction (49, 50) , emphasizing the importance of ...
doi:10.1126/sciadv.aba8271
pmid:32923630
pmcid:PMC7455195
fatcat:cpt2acjntvcqlfnogo3xlnzejm
Proceedings of the Joint Meeting of the 126th Annual Meeting of The Japanese Association of Anatomists and the 98th Annual Meeting of The Physiological Society of Japan
2021
Journal of Physiological Sciences
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neuronal synapses and mitochondria modulated by postnatal environment Yoshiaki Shinohara 1 , Nobuhiko Ohno 1 ( ) (COI:No) SY18-1
Large-scale electron microscopy and imaging big data Yosky Kataoka ...
technologies Tetsu Tanaka 1 ( ) (COI:No) Symposium6
SY7-4 Large-scale electron microscopic volume imaging of interfascicular oligodendrocytes in the mouse corpus callosum Tatsuhide Tanaka 1 , Nobuhiko ...
doi:10.1186/s12576-021-00809-x
fatcat:nh2jab2kgne67bsk2vrksdflya
1st Annual Meeting: The Canadian Association for Neuroscience / Association canadienne de neuroscience
2007
Canadian Journal of Neurological Sciences
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using multiphoton fluorescence microscopy. ...
Unilateral transient focal cerebral ischemia was induced by intraluminal filament occlusion of the left MCA during 1 hour followed by imaging session with a high resolution/high sensitivity CCD camera ...
doi:10.1017/s0317167100017066
fatcat:aupmr4ntyjd6xes4gp5epa2epm
Abstract Book, XIII International Congress of Histochemistry and Cytochemistry ICHC2008, Imaging of Cell Dynamics, 23rd-27th August 2008, Medical University of Gdansk, Poland
2008
Folia Histochemica et Cytobiologica
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disorders using animal models and/or human post-mortem tissue. ...
Here, we report that KS is expressed by microglia in spinal cord of SOD-G93A transgenic mouse (ALS model mouse). ...
To reach this goal, changes in the chemical coding of sympathetic neurons supplying porcine urinary bladder, an animal which can be used as a very good model for human lower urinary tract, have been elucidated ...
doi:10.5603/4388
doaj:cdebe86bf2604301b2401e99ae9a504c
fatcat:7j6nazvgnjf2bhooy5awdzq7uy
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