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4D physiologically adaptable cardiac patch: A 4-month in vivo study for the treatment of myocardial infarction

Haitao Cui, Chengyu Liu, Timothy Esworthy, Yimin Huang, Zu-xi Yu, Xuan Zhou, Hong San, Se-jun Lee, Sung Yun Hann, Manfred Boehm, Muhammad Mohiuddin, John P. Fisher (+1 others)
2020 Science Advances  
In this study, a four-dimensional (4D) cardiac patch with physiological adaptability has been printed by beam-scanning stereolithography.  ...  By combining a unique 4D self-morphing capacity with expandable microstructure, the specific design has been shown to improve both the biomechanical properties of the patches themselves and the dynamic  ...  Anderson (Animal MRI core, NHLBI) for carrying out the MRI analysis.  ... 
doi:10.1126/sciadv.abb5067 pmid:32637623 pmcid:PMC7314523 fatcat:ywgyfmsx6re4npo4bdhxoq6evm

Current Developments in 3D Bioprinting for Tissue and Organ Regeneration–A Review

Swarnima Agarwal, Shreya Saha, Vamsi Krishna Balla, Aniruddha Pal, Ananya Barui, Subhadip Bodhak
2020 Frontiers in Mechanical Engineering  
Here, we aim to provide a comprehensive review of the 3D bioprinting technology along with associated 3D bioprinting strategies including ink-jet printing, extrusion printing, stereolithography and laser  ...  However, traditional tissue engineering approaches comprising of scaffolds, growth factors and cells showed limited success in fabrication of complex 3D shapes and in vivo organ regeneration leading to  ...  Multiple efforts have been made for restoration of functional myocardium via 3D printing in biomaterials such as scaffolds or tissues-on a-chip.  ... 
doi:10.3389/fmech.2020.589171 fatcat:kgaa2ten4jhy3lq3rc3sxh7c5e

Recent progress in extrusion 3D bioprinting of hydrogel biomaterials for tissue regeneration: a comprehensive review with a focus on advanced fabrication techniques

Mohsen Askari, Moqaddaseh Afzali Naniz, Monireh Kouhi, Azadeh Saberi, Ali Zolfagharian, Mahdi Bodaghi
2020 Biomaterials Science  
Over the last decade, 3D bioprinting has received immense attention from research communities for developing functional tissues.  ...  ex vivo.  ...  of 3D bioprinting technologies in creating high-resolution constructs.  ... 
doi:10.1039/d0bm00973c pmid:33185203 fatcat:4uk6foagxbduhinqplhimwcexq

Proceedings of the World Molecular Imaging Congress 2021, October 5-8, 2021: General Abstracts

2022 Molecular Imaging and Biology  
Improvements in image resolution after the application of the method have also been demonstrated.  ...  The second parameter is an initial resolution parameter (width). The original image is never revisited after the first iteration.  ...  The mean %ID/g for the control mice following ex vivo biodistribution at 48h was below 0.3%ID/g for all organs.  ... 
doi:10.1007/s11307-021-01693-y pmid:34982365 pmcid:PMC8725635 fatcat:4sfb3isoyfdhfbiwxfr55gvqym

Cardiac mechanostructure: Using mechanics and anisotropy as inspiration for developing epicardial therapies in treating myocardial infarction

Kiera D. Dwyer, Kareen L.K. Coulombe
2021 Bioactive Materials  
In order to engineer cardiac biomaterials with the appropriate properties to enhance function after MI, the changes in the myocardium induced by MI must be clearly identified.  ...  printing of actuating epicardial implants from patient MRI or CT scans [164] .  ...  Strain Mapping Combines ultrasound imaging with post-imaging analysis 3D strain mapping Diffusion Tension Magnetic Resonance Imaging (DT-MRI) Based on principle orientation of microstructure  ... 
doi:10.1016/j.bioactmat.2020.12.015 pmid:33553810 pmcid:PMC7822956 fatcat:lqtt2gzo5zdahj7766n4zadfom

5th International Symposium on Focused Ultrasound

Menashe Zaaroor, Alon Sinai, Dorit Goldsher, Ayelet Eran, Maria Nassar, Ilana Schlesinger, Jonathon Parker, Vinod Ravikumar, Pejman Ghanouni, Sherman Stein, Casey Halpern, Vibhor Krishna (+1008 others)
2016 Journal of Therapeutic Ultrasound  
T2* MRI confirmed safety of the BBB opening approach.  ...  A5 Focused ultrasound facilitated gene delivery for neuro-restoration in Parkinson's disease mice  ...  MRI of ex vivo sample following treatment.  ... 
doi:10.1186/s40349-016-0076-5 fatcat:4vm7i5mt6vheni3hflxd3pwl2i

Exploiting Advanced Hydrogel Technologies to Address Key Challenges in Regenerative Medicine

Daniel A. Foyt, Michael D. A. Norman, Tracy T. L. Yu, Eileen Gentleman
2018 Advanced Healthcare Materials  
[55] While lacking the high resolution of LAB methodologies (≈25 µm), this layer-by-layer process can often increase printing speeds.  ...  Hydrogels as Ex Vivo Tissue Models It was not long after George Otto Gey managed to culture Henrietta Lacks's cervical cancer cells in a dish [11] that researchers realized that cells behave differently  ... 
doi:10.1002/adhm.201700939 pmid:29316363 pmcid:PMC5922416 fatcat:gnssyw4nrfflhizzyzqjr2ekiu

Fiber Scaffold Patterning for Mending Hearts: 3D Organization Bringing the Next Step

Marleen Kristen, Madison J. Ainsworth, Nino Chirico, Casper F. T. Ven, Pieter A. Doevendans, Joost P. G. Sluijter, Jos Malda, Alain Mil, Miguel Castilho
2019 Advanced Healthcare Materials  
Recent advances in manufacturing technologies have resulted in the precise fabrication of 3D fiber scaffolds with high architectural control that can support and guide new tissue growth, opening exciting  ...  The most common conditions that lead to HF are coronary artery disease, myocardial infarction, valve disorders, high blood pressure, and cardiomyopathy.  ...  The equilibrium between tissue regeneration and graft degradation was achieved in newly formed scaffold-tissue after 3 months in vivo with ex vivo mechanical properties comparable with the native aorta  ... 
doi:10.1002/adhm.201900775 pmid:31603288 fatcat:nbsemhxenzd6xed5arzoyeb4ly

Whole Organ Engineering: Approaches, Challenges, and Future Directions

Sogu Sohn, Maxwell Van Buskirk, Michael J. Buckenmeyer, Ricardo Londono, Denver Faulk
2020 Applied Sciences  
developmental biology, anatomy, physiology, and cellular interactions with enabling technologies such as advanced biomaterials and biofabrication to create bioartificial organs that recapitulate native organs in vivo  ...  Lee and colleagues used FRESH and collagen bioink to print a human neonatal-scaled heart of a MRI-derived heart model, a 1:1 scale human tri-leaflet heart valve that was mechanically functional in an ex  ...  Furthermore, Uygun assessed early graft function of the recellularized livers via auxiliary transplantation in rats and ex vivo whole blood perfusion, finding hepatic function and cellular function preserved  ... 
doi:10.3390/app10124277 fatcat:gseoobeu2nc33eb67ocazvjtei

International Society for Therapeutic Ultrasound Conference 2016

Brian Fowlkes, Pejman Ghanouni, Narendra Sanghvi, Constantin Coussios, Paul C. Lyon, Michael Gray, Christophoros Mannaris, Marie de Saint Victor, Eleanor Stride, Robin Cleveland, Robert Carlisle, Feng Wu (+723 others)
2017 Journal of Therapeutic Ultrasound  
Another challenge stems from the need for a high rate of image acquisition. This may be currently associated with a high radiation dose.  ...  O21 Tests of thermal ablation with a 230 kHz transcranial MRI-guided focused ultrasound system in a large animal model Nathan McDannold 1 , Jonathan Sutton 1 , Natalia Vykhodtseva 1 , Margaret Livingstone  ...  Temperature elevation by HIFU in ex-vivo porcine muscle was also studied experimentally by MRI and numerically.  ... 
doi:10.1186/s40349-016-0079-2 fatcat:wjrvxyhd5bappjipymenn5swwq

2017 TERMIS - Americas Conference & Exhibition Charlotte, NC December 3–6, 2017

2017 Tissue Engineering. Part A  
Our results exhibited that the scaffolds possessed high conductivity in vitro and ex vivo as well as remarkable mechanical stability and strength.  ...  The subcutaneous implantation of the engineered scaffolds in rats exhibited high biocompatibility and biodegradation in vivo.  ...  Ex vivo MRI of spinal cord revealed hypointense regions in the thoracic part, that correlated with in vivo MRI scans during hydrogel injection.  ... 
doi:10.1089/ten.tea.2017.29003.abstracts pmid:29173019 fatcat:y5mu2h7aqjcy3cffg42ukwxwpm

Abstracts from the International Society for Therapeutic Ultrasound Conference 2017

2018 Journal of Therapeutic Ultrasound  
Histograms derived from T2* maps MRI clearly shows that sonication with BBB algorithm results in left shift in T2* values that would be consistent with hypointense voxels on T2*w MRI and abnormatilies  ...  Acoustic energy was delivered to the brain using "BBB configuration function" based on algorithm reported (O'Reilly et al. 2012) to determine optimal acoustic pressure for BBB opening via 1.5f 0 and 2.5f  ...  High-resolution MRI (7T) and microbubble-enhanced US imaging was performed pre-and post-injection of AML.  ... 
doi:10.1186/s40349-018-0110-x fatcat:4nn4nwntgbfl5cdwvqc3wfxszu

A combined local and global motion estimation and compensation method for cardiac CT

Qiulin Tang, Beshan Chiang, Akinola Akinyemi, Alexander Zamyatin, Bibo Shi, Satoru Nakanishi, Bruce R. Whiting, Christoph Hoeschen
2014 Medical Imaging 2014: Physics of Medical Imaging  
This is demonstrated by a preclinical study with a small-animal emphysema model, performed both ex vivo and in vivo.  ...  The first generation of phantoms was segmented from patient dedicated breast computed tomography data and fabricated into physical models using high-resolution 3D printing. Two variations were made.  ...  FTIR chemical imaging allows the spatial distribution of chemistry to be rapidly imaged at a high (diffraction limited) spatial resolution where a pixel represents an area of 5.5 ? 5.5 µm2 of tissue.  ... 
doi:10.1117/12.2043492 fatcat:fyzpc5m6jbh7fjohqpdmtzkhte

46th ESAO Congress 3–7 September 2019 Hannover, Germany

2019 International Journal of Artificial Organs  
Key to all state of the art developments in computer assisted surgery is the engineering on anatomy, enabled by multifunctional softwares and 3D printing technologies.  ...  Biomechanical modeling allows for patientspecific outcome prediction after surgical interventions and should become a routine practice in patient treatment.  ...  The aim of this study was the hemo -and fluid dynamic investigation of a valveless pulsatile pump for HFpEF using in-vitro, ex-vivo, computational fluid dynamic (CFD), and 4D flow MRI imaging studies.  ... 
doi:10.1177/0391398819860985 fatcat:s5xpxxvq2fhtdacxuf5iw6n3z4

The 13th International Conference on Advances in Quantitative Laryngology, Voice and Speech Research (June 2–4, 2019, Montreal, Quebec, Canada)

2019 Applied Sciences  
Conclusions The results clearly indicated that, despite the high devoicing rate which is similar to that of Tokyo Japanese, the subject partially maintains the dialectal rule of laryngeal articulation  ...  The oscillation of the vocal folds, identified from in-vivo and ex-vivo high-speed imaging (see, e.g., [3] ), is externally forced.  ...  Introduction The 3D ex vivo observation of vocal folds at micron scale is a challenging task using micro Magnetic Resonance Imaging (limited spatial resolution), multiphoton nonlinear scanning microscopy  ... 
doi:10.3390/app9132665 fatcat:xg47la5zkngzxaqe4cdeyv63rq
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