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High-Resolution Dynamic $^{31}$P-MR Spectroscopic Imaging for Mapping Mitochondrial Function
2020
IEEE Transactions on Biomedical Engineering
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To enable non-invasive dynamic metabolic mapping in rodent model studies of mitochondrial function using 31P-MR spectroscopic imaging (MRSI). ...
We developed a novel method for high-resolution dynamic 31P-MRSI. ...
Because the combination of high spatial, and temporal resolutions needed for imaging mitochondrial oxidative capacity necessitates relatively high gradient duty cycles compared to conventional MRSI methods ...
doi:10.1109/tbme.2020.2969892
pmid:32011244
pmcid:PMC7384926
fatcat:mu2ttphj2rakjo62wxb7hn2lp4
Dynamic31P-MRSI using spiral spectroscopic imaging can map mitochondrial capacity in muscles of the human calf during plantar flexion exercise at 7 T
2016
NMR in Biomedicine
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"Dynamic 31P-MRSI using spiral spectroscopic imaging can map mitochondrial capacity in muscles of the human calf during plantar flexion exercise at 7 T. ...
KEYWORDS dynamic 31 P-MRS, high energy phosphate, MRSI, skeletal muscle, spiral spectroscopic imaging, ultra-high field Abbreviations used: 31 P-MRI, phosphorus MRI; 31 P-MRS, phosphorus MRS; 31 P-MRSI ...
reported 2D PCr imaging with a 20 × 20 matrix (5.6 mL nominal spatial resolution) and 6 s temporal resolution at 3 T. 28 Our spectral-spatial encoding approach via spiral spectroscopic imaging, therefore ...
doi:10.1002/nbm.3662
pmid:27862510
pmcid:PMC5132121
fatcat:kgsb7dussvaxjey6oqxqx7gz5e
Assessing tissue metabolism by phosphorous-31 magnetic resonance spectroscopy and imaging: a methodology review
2017
Quantitative Imaging in Medicine and Surgery
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However, a major impediment for the clinical applications of 31 P-MRS/MRI is the prohibitively long acquisition time and/or the low spatial resolution that are necessary to achieve adequate signal-to-noise ...
Magnetic resonance spectroscopy (MRS) and magnetic resonance imaging (MRI) provide the unique opportunity for in vivo assessment of several fundamental events in tissue metabolism without the use of ionizing ...
Recently, a subspace based approach, called SPectroscopic Imaging by exploiting spatiospectral CorrElation (SPICE), has emerged as a promising technique for high-resolution MRSI (178) . ...
doi:10.21037/qims.2017.11.03
pmid:29312876
pmcid:PMC5756783
fatcat:ucdlvhvvmraubkfsz4mqej3emq
The current status of magnetic resonance spectroscopy--basic and clinical aspects
1985
Western Journal of Medicine
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Most metabolic MR spectroscopic studies have focused on the phosphorus 31 nucleus. ...
to a high-intensity magnetic field. ...
However, siting considerations for high-field NMR instruments for spectroscopy are more complicated than for low-field imaging systems. ...
pmid:3911590
pmcid:PMC1306487
fatcat:j7c45nsubrdcbp4qsrtair25n4
Advanced Skeletal Muscle MR Imaging Approaches in the Assessment of Muscular Dystrophies
2014
International Journal of Physical Medicine & Rehabilitation
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(1H), muscle bioenergetics (31P) or cellular function (23Na). ...
In this article, we review MR imaging techniques that have been used to quantify skeletal muscle involvement in the various muscle dystrophies, such as in vivo spectroscopic procedures to quantify lipids ...
Investigating the recovery of PCr following exercise allows for inferences to be made about mitochondrial function. ...
doi:10.4172/2329-9096.1000248
fatcat:jr4trelkobh33njscxzq33ll5y
A role for bioenergetic abnormalities in the pathophysiology of schizophrenia
2013
Klinik Psikofarmakoloji Bülteni-Bulletin of Clinical Psychopharmacology
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There is extensive evidence for abnormalities in brain bioenergetics in SZ, including PET studies of cerebral glucose utilization (20), 31P MRS studies of high energy phosphate (HEP) molecules (21-22), ...
Thus, supporting glutamatergic neurotransmission appears to be one of the main functions for the brain's energy production machinery (14). ...
This would mask any abnormalities, requiring dynamic measures such as 31P MT MRS to address the issue. 31P MT MRS involves suppression of signal from one resonance (e.g. ...
doi:10.5455/bcp.20131218011431
fatcat:i5e4fourbjhphhhvestvyhiofi
In Vivo Magnetic Resonance Spectroscopy Methods for Investigating Cardiac Metabolism
2022
Metabolites
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For cardiac MRS, proton (1H), phosphorus (31P), and hyperpolarized 13-carbon (13C) provide valuable metabolic information for diagnosis and treatment assessment purposes. ...
This review addresses the recent advances in metabolic imaging by MRS from primarily the literature published since 2015. ...
Summary MR spectroscopy is one of the few currently available techniques for in vivo metabolic imaging, enabling in vivo assessments of cardiac energy metabolism and mitochondrial functions. ...
doi:10.3390/metabo12020189
pmid:35208262
pmcid:PMC8877606
fatcat:hifjisrcyfga7nwz54jbssjuv4
In-vivo 31 P-MRS of skeletal muscle and liver: A way for non-invasive assessment of their metabolism
2017
Analytical Biochemistry
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As signal localization is essential for liver 31P-MRS and is important for dynamic muscle examinations as well, typical localization strategies for 31P-MR are also described. ...
In addition to direct assessment of high energy phosphorus containing metabolite content within tissues, phosphorus magnetic resonance spectroscopy (31P-MRS) provides options to measure phospholipid metabolites ...
Acknowledgement The financial support for the research of the authors at their home institutions by the Christian Doppler Society e Clinical Molecular MR Imaging (MOLIMA), by the OeNB Jubilaeumsfond (grant ...
doi:10.1016/j.ab.2017.01.018
pmid:28119063
pmcid:PMC5478074
fatcat:5fzgmb2kf5d6znf7xkjhakfhcq
Exercising calf muscle T2∗ changes correlate with pH, PCr recovery and maximum oxidative phosphorylation
2014
NMR in Biomedicine
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Based on combined accurately localised 31P MRS and T Ã 2 weighted MRI, both with high temporal resolution, strong correlations of the skeletal muscle S EPI during exercise and tissue pH time courses and ...
Localised 31P MRS and S EPI data from gastrocnemius medialis of 19 healthy subjects were combined in one scanning session to study direct relationships between phosphocreatine (PCr), pH kinetics and parameters ...
Acknowledgements This work was financially supported by the Austrian BMWFJ FFG Project Nr. 832107, 'Research Studio for High Field MR Components' and The Austrian Science Fund (FWF) Project Nr. ...
doi:10.1002/nbm.3092
pmid:24610788
pmcid:PMC4260669
fatcat:46zkeccfural7c3437tj5bdcgi
Multinuclear Magnetic Resonance Spectroscopy of Human Skeletal Muscle Metabolism in Training and Disease
[chapter]
2018
Muscle Cell and Tissue - Current Status of Research Field
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In this chapter, techniques and application of multinuclear ( 1 H, 13 C, and 31 P) in vivo magnetic resonance spectroscopy (MRS) for the assessment of skeletal muscle metabolism in health and disease are ...
Taken together, multinuclear in vivo MRS on humans helped to uncover defects in skeletal muscle metabolic pathways in insulin-resistant conditions; and to discover links between defects in mitochondrial ...
Acknowledgements The financial support for the research of the authors at their home institutions by the Christian Doppler Society-Clinical Molecular MR Imaging (MOLIMA), by the OeNB Jubilaeumsfond (grant ...
doi:10.5772/intechopen.77107
fatcat:gjyphvyntrgsbbjqsgdxthcf5e
Bevacizumab impairs oxidative energy metabolism and shows antitumoral effects in recurrent glioblastomas: a 31P/1H MRSI and quantitative magnetic resonance imaging study
2011
Neuro-Oncology
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has antitumoral activity in recurrent GBM. 31 P and 1 H MRSI, apparent diffusion coefficient (ADC), and high-resolution T2 and T2 ′ mapping (indirect marker of oxygen extraction) were investigated in ...
We employed in vivo magnetic resonance spectroscopic imaging (MRSI) and quantitative magnetic resonance imaging to investigate whether bevacizumab alters oxygen and energy metabolism and whether this effect ...
Ralf Deichmann from the Brain Imaging Center Frankfurt. ...
doi:10.1093/neuonc/nor132
pmid:21890539
pmcid:PMC3223092
fatcat:bnujnh7dy5hxhh4cfrsdgbs2um
In vivo X-Nuclear MRS Imaging Methods for Quantitative Assessment of Neuroenergetic Biomarkers in Studying Brain Function and Aging
2018
Frontiers in Aging Neuroscience
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Recent advancements in developing multimodal high-field in vivo X-nuclear (e.g., 2H, 17O and 31P) MRS imaging techniques have shown promise for quantitative and noninvasive measurement of fundamental cerebral ...
However, there is an unmet need in the development of novel neuroimaging tools and sensitive biomarkers for detecting abnormal energy metabolism and impaired mitochondrial function, especially in an early ...
Hannes Wiesner, for their support, technical assistance and contribution to the development of the in vivo MRS imaging technologies as described in this review article. ...
doi:10.3389/fnagi.2018.00394
pmid:30538629
pmcid:PMC6277487
fatcat:ylmgxifozfed3c2x4nbvujszw4
Musculoskeletal MRI at 7 T: do we need more or is it more than enough?
2020
European Radiology Experimental
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Ultra-high field magnetic resonance imaging (UHF-MRI) provides important diagnostic improvements in musculoskeletal imaging. ...
European Union and Food and Drug Administration approvals for clinical imaging at UHF have been the first step towards a more routinely use of this technology, but some drawbacks are still present limiting ...
Acknowledgements We would like to acknowledge the team of the Imago7 Foundation (Pisa, Italy) for the collaboration. ...
doi:10.1186/s41747-020-00174-1
pmid:32761480
fatcat:vop5ceckdrbp3g22xmd3mpjeia
Evaluating pH in the Extracellular Tumor Microenvironment Using CEST MRI and Other Imaging Methods
2015
Advances in Radiology
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of MR spectroscopy and imaging. ...
A variety of noninvasive imaging methods have been developed for measuring tumor pHe. ...
Figure 8 . 8 1 H MR spectroscopic imaging of tumor pHe. ...
doi:10.1155/2015/206405
pmid:27761517
pmcid:PMC5066878
fatcat:s5zwbdvjlfhn7djsaqvyeypqrq
Non Invasive Investigation of Muscle Function Marseille (France), October 4–6, 2001
2002
Magnetic Resonance Materials in Physics, Biology and Medicine
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These studies were supported by a grant from the Foundation for the Earth and Life Sciences (ALW) with financial aid from the Netherlands Foundation for Scientific Research (NWO). ...
Acknowledgements: We are grateful to Bé Wieringa and Frank Oerlemans (Nijmegen University) for generously providing the CK deficient mouse strains. ...
Such data can be mapped for strain and displacement as is done with cardiac images. ...
doi:10.1016/s1352-8661(02)00065-0
fatcat:m5oehmju7ngf3c3tltkz52rsla
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