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High-Resolution Dynamic $^{31}$P-MR Spectroscopic Imaging for Mapping Mitochondrial Function

Bryan Clifford, Yuning Gu, Yuchi Liu, Kihwan Kim, Sherry Huang, Yudu Li, Fan Lam, Zhi-Pei Liang, Xin Yu
2020 IEEE Transactions on Biomedical Engineering  
To enable non-invasive dynamic metabolic mapping in rodent model studies of mitochondrial function using 31P-MR spectroscopic imaging (MRSI).  ...  We developed a novel method for high-resolution dynamic 31P-MRSI.  ...  Because the combination of high spatial, and temporal resolutions needed for imaging mitochondrial oxidative capacity necessitates relatively high gradient duty cycles compared to conventional MRSI methods  ... 
doi:10.1109/tbme.2020.2969892 pmid:32011244 pmcid:PMC7384926 fatcat:mu2ttphj2rakjo62wxb7hn2lp4

Dynamic31P-MRSI using spiral spectroscopic imaging can map mitochondrial capacity in muscles of the human calf during plantar flexion exercise at 7 T

Ladislav Valkovič, Marek Chmelík, Martin Meyerspeer, Borjan Gagoski, Christopher T. Rodgers, Martin Krššák, Ovidiu C. Andronesi, Siegfried Trattnig, Wolfgang Bogner
2016 NMR in Biomedicine  
"Dynamic 31P-MRSI using spiral spectroscopic imaging can map mitochondrial capacity in muscles of the human calf during plantar flexion exercise at 7 T.  ...  KEYWORDS dynamic 31 P-MRS, high energy phosphate, MRSI, skeletal muscle, spiral spectroscopic imaging, ultra-high field Abbreviations used: 31 P-MRI, phosphorus MRI; 31 P-MRS, phosphorus MRS; 31 P-MRSI  ...  reported 2D PCr imaging with a 20 × 20 matrix (5.6 mL nominal spatial resolution) and 6 s temporal resolution at 3 T. 28 Our spectral-spatial encoding approach via spiral spectroscopic imaging, therefore  ... 
doi:10.1002/nbm.3662 pmid:27862510 pmcid:PMC5132121 fatcat:kgsb7dussvaxjey6oqxqx7gz5e

Assessing tissue metabolism by phosphorous-31 magnetic resonance spectroscopy and imaging: a methodology review

Yuchi Liu, Yuning Gu, Xin Yu
2017 Quantitative Imaging in Medicine and Surgery  
However, a major impediment for the clinical applications of 31 P-MRS/MRI is the prohibitively long acquisition time and/or the low spatial resolution that are necessary to achieve adequate signal-to-noise  ...  Magnetic resonance spectroscopy (MRS) and magnetic resonance imaging (MRI) provide the unique opportunity for in vivo assessment of several fundamental events in tissue metabolism without the use of ionizing  ...  Recently, a subspace based approach, called SPectroscopic Imaging by exploiting spatiospectral CorrElation (SPICE), has emerged as a promising technique for high-resolution MRSI (178) .  ... 
doi:10.21037/qims.2017.11.03 pmid:29312876 pmcid:PMC5756783 fatcat:ucdlvhvvmraubkfsz4mqej3emq

The current status of magnetic resonance spectroscopy--basic and clinical aspects

L Chan
1985 Western Journal of Medicine  
Most metabolic MR spectroscopic studies have focused on the phosphorus 31 nucleus.  ...  to a high-intensity magnetic field.  ...  However, siting considerations for high-field NMR instruments for spectroscopy are more complicated than for low-field imaging systems.  ... 
pmid:3911590 pmcid:PMC1306487 fatcat:j7c45nsubrdcbp4qsrtair25n4

Advanced Skeletal Muscle MR Imaging Approaches in the Assessment of Muscular Dystrophies

Dinesh A Kumbhare
2014 International Journal of Physical Medicine & Rehabilitation  
(1H), muscle bioenergetics (31P) or cellular function (23Na).  ...  In this article, we review MR imaging techniques that have been used to quantify skeletal muscle involvement in the various muscle dystrophies, such as in vivo spectroscopic procedures to quantify lipids  ...  Investigating the recovery of PCr following exercise allows for inferences to be made about mitochondrial function.  ... 
doi:10.4172/2329-9096.1000248 fatcat:jr4trelkobh33njscxzq33ll5y

A role for bioenergetic abnormalities in the pathophysiology of schizophrenia

Dost Öngür
2013 Klinik Psikofarmakoloji Bülteni-Bulletin of Clinical Psychopharmacology  
There is extensive evidence for abnormalities in brain bioenergetics in SZ, including PET studies of cerebral glucose utilization (20), 31P MRS studies of high energy phosphate (HEP) molecules (21-22),  ...  Thus, supporting glutamatergic neurotransmission appears to be one of the main functions for the brain's energy production machinery (14).  ...  This would mask any abnormalities, requiring dynamic measures such as 31P MT MRS to address the issue. 31P MT MRS involves suppression of signal from one resonance (e.g.  ... 
doi:10.5455/bcp.20131218011431 fatcat:i5e4fourbjhphhhvestvyhiofi

In Vivo Magnetic Resonance Spectroscopy Methods for Investigating Cardiac Metabolism

Morteza Esmaeili, Riyas Vettukattil
2022 Metabolites  
For cardiac MRS, proton (1H), phosphorus (31P), and hyperpolarized 13-carbon (13C) provide valuable metabolic information for diagnosis and treatment assessment purposes.  ...  This review addresses the recent advances in metabolic imaging by MRS from primarily the literature published since 2015.  ...  Summary MR spectroscopy is one of the few currently available techniques for in vivo metabolic imaging, enabling in vivo assessments of cardiac energy metabolism and mitochondrial functions.  ... 
doi:10.3390/metabo12020189 pmid:35208262 pmcid:PMC8877606 fatcat:hifjisrcyfga7nwz54jbssjuv4

In-vivo 31 P-MRS of skeletal muscle and liver: A way for non-invasive assessment of their metabolism

Ladislav Valkovič, Marek Chmelík, Martin Krššák
2017 Analytical Biochemistry  
As signal localization is essential for liver 31P-MRS and is important for dynamic muscle examinations as well, typical localization strategies for 31P-MR are also described.  ...  In addition to direct assessment of high energy phosphorus containing metabolite content within tissues, phosphorus magnetic resonance spectroscopy (31P-MRS) provides options to measure phospholipid metabolites  ...  Acknowledgement The financial support for the research of the authors at their home institutions by the Christian Doppler Society e Clinical Molecular MR Imaging (MOLIMA), by the OeNB Jubilaeumsfond (grant  ... 
doi:10.1016/j.ab.2017.01.018 pmid:28119063 pmcid:PMC5478074 fatcat:5fzgmb2kf5d6znf7xkjhakfhcq

Exercising calf muscle T2∗ changes correlate with pH, PCr recovery and maximum oxidative phosphorylation

Albrecht Ingo Schmid, Kiril Schewzow, Georg Bernd Fiedler, Sigrun Goluch, Elmar Laistler, Michael Wolzt, Ewald Moser, Martin Meyerspeer
2014 NMR in Biomedicine  
Based on combined accurately localised 31P MRS and T Ã 2 weighted MRI, both with high temporal resolution, strong correlations of the skeletal muscle S EPI during exercise and tissue pH time courses and  ...  Localised 31P MRS and S EPI data from gastrocnemius medialis of 19 healthy subjects were combined in one scanning session to study direct relationships between phosphocreatine (PCr), pH kinetics and parameters  ...  Acknowledgements This work was financially supported by the Austrian BMWFJ FFG Project Nr. 832107, 'Research Studio for High Field MR Components' and The Austrian Science Fund (FWF) Project Nr.  ... 
doi:10.1002/nbm.3092 pmid:24610788 pmcid:PMC4260669 fatcat:46zkeccfural7c3437tj5bdcgi

Multinuclear Magnetic Resonance Spectroscopy of Human Skeletal Muscle Metabolism in Training and Disease [chapter]

Ladislav Valkovič, Radka Klepochová, Martin Krššák
2018 Muscle Cell and Tissue - Current Status of Research Field  
In this chapter, techniques and application of multinuclear ( 1 H, 13 C, and 31 P) in vivo magnetic resonance spectroscopy (MRS) for the assessment of skeletal muscle metabolism in health and disease are  ...  Taken together, multinuclear in vivo MRS on humans helped to uncover defects in skeletal muscle metabolic pathways in insulin-resistant conditions; and to discover links between defects in mitochondrial  ...  Acknowledgements The financial support for the research of the authors at their home institutions by the Christian Doppler Society-Clinical Molecular MR Imaging (MOLIMA), by the OeNB Jubilaeumsfond (grant  ... 
doi:10.5772/intechopen.77107 fatcat:gjyphvyntrgsbbjqsgdxthcf5e

Bevacizumab impairs oxidative energy metabolism and shows antitumoral effects in recurrent glioblastomas: a 31P/1H MRSI and quantitative magnetic resonance imaging study

E. Hattingen, A. Jurcoane, O. Bahr, J. Rieger, J. Magerkurth, S. Anti, J. P. Steinbach, U. Pilatus
2011 Neuro-Oncology  
has antitumoral activity in recurrent GBM. 31 P and 1 H MRSI, apparent diffusion coefficient (ADC), and high-resolution T2 and T2 ′ mapping (indirect marker of oxygen extraction) were investigated in  ...  We employed in vivo magnetic resonance spectroscopic imaging (MRSI) and quantitative magnetic resonance imaging to investigate whether bevacizumab alters oxygen and energy metabolism and whether this effect  ...  Ralf Deichmann from the Brain Imaging Center Frankfurt.  ... 
doi:10.1093/neuonc/nor132 pmid:21890539 pmcid:PMC3223092 fatcat:bnujnh7dy5hxhh4cfrsdgbs2um

In vivo X-Nuclear MRS Imaging Methods for Quantitative Assessment of Neuroenergetic Biomarkers in Studying Brain Function and Aging

Xiao-Hong Zhu, Wei Chen
2018 Frontiers in Aging Neuroscience  
Recent advancements in developing multimodal high-field in vivo X-nuclear (e.g., 2H, 17O and 31P) MRS imaging techniques have shown promise for quantitative and noninvasive measurement of fundamental cerebral  ...  However, there is an unmet need in the development of novel neuroimaging tools and sensitive biomarkers for detecting abnormal energy metabolism and impaired mitochondrial function, especially in an early  ...  Hannes Wiesner, for their support, technical assistance and contribution to the development of the in vivo MRS imaging technologies as described in this review article.  ... 
doi:10.3389/fnagi.2018.00394 pmid:30538629 pmcid:PMC6277487 fatcat:ylmgxifozfed3c2x4nbvujszw4

Musculoskeletal MRI at 7 T: do we need more or is it more than enough?

Giacomo Aringhieri, Virna Zampa, Michela Tosetti
2020 European Radiology Experimental  
Ultra-high field magnetic resonance imaging (UHF-MRI) provides important diagnostic improvements in musculoskeletal imaging.  ...  European Union and Food and Drug Administration approvals for clinical imaging at UHF have been the first step towards a more routinely use of this technology, but some drawbacks are still present limiting  ...  Acknowledgements We would like to acknowledge the team of the Imago7 Foundation (Pisa, Italy) for the collaboration.  ... 
doi:10.1186/s41747-020-00174-1 pmid:32761480 fatcat:vop5ceckdrbp3g22xmd3mpjeia

Evaluating pH in the Extracellular Tumor Microenvironment Using CEST MRI and Other Imaging Methods

Liu Qi Chen, Mark D. Pagel
2015 Advances in Radiology  
of MR spectroscopy and imaging.  ...  A variety of noninvasive imaging methods have been developed for measuring tumor pHe.  ...  Figure 8 . 8 1 H MR spectroscopic imaging of tumor pHe.  ... 
doi:10.1155/2015/206405 pmid:27761517 pmcid:PMC5066878 fatcat:s5zwbdvjlfhn7djsaqvyeypqrq

Non Invasive Investigation of Muscle Function Marseille (France), October 4–6, 2001

D Bendahan
2002 Magnetic Resonance Materials in Physics, Biology and Medicine  
These studies were supported by a grant from the Foundation for the Earth and Life Sciences (ALW) with financial aid from the Netherlands Foundation for Scientific Research (NWO).  ...  Acknowledgements: We are grateful to Bé Wieringa and Frank Oerlemans (Nijmegen University) for generously providing the CK deficient mouse strains.  ...  Such data can be mapped for strain and displacement as is done with cardiac images.  ... 
doi:10.1016/s1352-8661(02)00065-0 fatcat:m5oehmju7ngf3c3tltkz52rsla
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