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In-vivo magnetic resonance imaging (MRI) of laminae in the human cortex

Robert Trampel, Pierre-Louis Bazin, Kerrin Pine, Nikolaus Weiskopf
2017 NeuroImage  
This paper reviews the methods and in-vivo MRI studies on the anatomical layers in the human cortex based on conventional and quantitative MRI (excluding diffusion imaging).  ...  The rapid development of MRI scanners, motion correction techniques, analysis methods and biophysical modeling promise to overcome the challenges of spatial resolution, precision and specificity of systematic  ...  Acknowledgements We would like to thank Daniel H€ anelt and Jochen Schmidt for proofreading the manuscript. NW has received funding from the European Research  ... 
doi:10.1016/j.neuroimage.2017.09.037 pmid:28942063 fatcat:k2agtp5dtzctnbx7ttqdu6baxm

Quantitative sodium MRI of the human brain at 9.4 T provides assessment of tissue sodium concentration and cell volume fraction during normal aging

Keith Thulborn, Elaine Lui, Jonathan Guntin, Saad Jamil, Ziqi Sun, Theodore C. Claiborne, Ian C. Atkinson
2015 NMR in Biomedicine  
Acknowledgements The authors acknowledge financial support from the NIH grant RO1 CA129553 Abbreviations TSC tissue sodium concentration  ...  The relevance of sodium imaging is in the quantitative characterization of tissue ion homeostasis at spatial resolutions relevant to these anatomical dimensions.  ...  The ROI were based on readily identifiable standard anatomical landmarks on the sodium images and included: frontal, parietal, temporal and occipital lobes, hippocampus, basal ganglia, thalamus, brainstem  ... 
doi:10.1002/nbm.3312 pmid:26058461 pmcid:PMC4674376 fatcat:kaby3lpdcvckbbmkrfehvayqpa

Microstructural imaging of human neocortex in vivo

Luke J. Edwards, Evgeniya Kirilina, Siawoosh Mohammadi, Nikolaus Weiskopf
2018 NeuroImage  
We review recent literature that has applied and developed MRI-based in vivo histology to probe the microstructure of the human neocortex, focusing specifically on myelin, iron, and neuronal fibre mapping  ...  The neocortex of the human brain is the seat of higher brain function.  ...  Shown is the result of applying tractography algorithms to diffusion data from an ex vivo sample of human occipital cortex recorded at a resolution of (0.242 mm) 3 on a 9.4 T scanner.  ... 
doi:10.1016/j.neuroimage.2018.02.055 pmid:29588229 fatcat:bqpmgy66xbchpfjllfdoapg374

Quantitative MRI and MR Spectroscopy of Multiple Sclerosis, Alzheimer's Disease, Epilepsy and Cancer Microimaging Techniques

Rakesh Sharma
2009 Nature Precedings  
•CNT can penetrate anywhere across the membrane channels (200 nm) in body tissues • Microimaging provide high sensitivity and resolution upto micron level • Sodium [Na] ex and [Na] i are MRI visible  ...  Outcome: Frontal(F), Parietal(P),Temporal(T), Occipital(O) lobes and Hippocampus(H) visible First time 21 Tesla MRI processed images of Mice Brain Reveal Details Morphology Hippocampus DG and other regions  ...  Fit of short TE in vivo data (SVS, SE, TE 30 ms) -patient info -localization info -metabolic info -diagnostic info  ... 
doi:10.1038/npre.2009.3485.1 fatcat:qp6l4km5yvdjvcwtsrqlwlauai

The Intrinsic Shape of Human and Macaque Primary Visual Cortex

Oliver Hinds, Jonathan R. Polimeni, Niranjini Rajendran, Mukund Balasubramanian, Lawrence L. Wald, Jean C. Augustinack, Graham Wiggins, H. Diana Rosas, Bruce Fischl, Eric L. Schwartz
2008 Cerebral Cortex  
Human V1 was imaged ex vivo using high-resolution (200 mm) magnetic resonance imaging at 7 T. Macaque V1 was identified in published histological serial section data.  ...  The intrinsic shape of V1 was found to be similar across human subjects using both nonparametric boundary matching and a simple elliptical shape model fit to the data and is very close to that of the macaque  ...  Discussion In this work, we present computer-flattened surface representations of V1 derived from high-resolution structural MRI of ex vivo human occipital lobes and publicly available histological images  ... 
doi:10.1093/cercor/bhn016 pmid:18308709 pmcid:PMC2733317 fatcat:fovg7u3zt5alhpjdlltoh2ziri

Sub-millimetre resolution laminar fMRI using Arterial Spin Labelling in humans at 7 T

Sriranga Kashyap, Dimo Ivanov, Martin Havlicek, Laurentius Huber, Benedikt A Poser, Kâmil Uludağ
2021 PLoS ONE  
This study demonstrates that laminar perfusion fMRI in humans is feasible at 7 T and that caution must be exercised when interpreting BOLD signal laminar profiles as direct representation of the cortical  ...  a 3D-EPI readout at 7 T.  ...  Acknowledgments All data were acquired at the Scannexus B.V. facilities, Maastricht, The Netherlands.  ... 
doi:10.1371/journal.pone.0250504 pmid:33901230 pmcid:PMC8075193 fatcat:4u24nbmpf5cjroxycsr2i7xuwi

In vivo NAD assay reveals the intracellular NAD contents and redox state in healthy human brain and their age dependences

Xiao-Hong Zhu, Ming Lu, Byeong-Yeul Lee, Kamil Ugurbil, Wei Chen
2015 Proceedings of the National Academy of Sciences of the United States of America  
This work was supported by NIH Grants RO1 NS041262, NS057560, and NS070839, R24 MH106049, S10 RR026783, P41 EB015894, and P30 NS076408 and the Keck Foundation.  ...  Results In Vivo 31 P MRS of Human Brain at 7 T. Fig. 1 displays the in vivo 31 P MR spectra acquired from the occipital lobes in two representative healthy subjects with different ages.  ...  T 1 values of NAD + and NADH have been determined in the cat brain at 9.4 and 16.4 T (17) .  ... 
doi:10.1073/pnas.1417921112 pmid:25730862 pmcid:PMC4352772 fatcat:semm3ae7qranbpx62wo5vomina

Histological and MRI markers of white matter damage in focal epilepsy

Francesco Deleo, Maria Thom, Luis Concha, Andrea Bernasconi, Boris C. Bernhardt, Neda Bernasconi
2018 Epilepsy Research  
Diffusion-weighted MRI and its analytical extensions, particularly diffusion tensor imaging (DTI), have been the most widely used technique to image the white matter in vivo for the last two decades, and  ...  Ex vivo and post-mortem studies show pathological changes in epileptic patients in white matter myelination, axonal integrity, and cellular composition.  ...  In this review article, we aim to provide an overview of most recent findings in the study of white matter, derived from histology, ex vivo and in vivo MRI, and connectomics.  ... 
doi:10.1016/j.eplepsyres.2017.11.010 pmid:29227798 fatcat:revbskgtczhyreai5al2pd6miu

Meyer's loop tractography for image-guided surgery depends on imaging protocol and hardware

Maxime Chamberland, Chantal M.W. Tax, Derek K. Jones
2018 NeuroImage: Clinical  
Methods: Diffusion MRI data were acquired for the same thirteen healthy subjects using standard and state-of-the-art protocols on three scanners with different maximum gradient amplitudes (MGA): Siemens  ...  This has direct implications for neurosurgical planning, where part of the OR is at risk due to an under-estimation of its location using conventional acquisition protocols.  ...  The authors are also grateful to the Natural Sciences and Engineering Research Council of Canada (NSERC) (PDF-502385-2017), the Netherlands Organisation for Scientific Research (NWO) (680-50-1527), the  ... 
doi:10.1016/j.nicl.2018.08.021 pmid:30128284 pmcid:PMC6096050 fatcat:5ge5sxozb5bmtie7og7mxmuxv4

Transcallosal Connectivity Changes from Infancy to Late Adulthood: An Ex Vivo Diffusion Spectrum Imaging Study of Macaque Brains

Yuguang Meng, Xiaodong Zhang
2015 Brain Connectivity  
Since non-human primate (NHP) brains resemble most aspects of the human brain, a thorough knowledge of interhemispheric cortical connectivity changes in NHP brains throughout the developmental and aging  ...  the functional defects or alterations in the associated cortical areas during brain development and aging in humans.  ...  The authors are grateful to the pathology department of Yerkes National Primate Research Center for the sample collection and to anonymous reviewers for their valuable suggestions.  ... 
doi:10.1089/brain.2014.0285 pmid:25389564 pmcid:PMC4394181 fatcat:3sw24mzegnhvlla5vwyihzxfu4

Accurate prediction of V1 location from cortical folds in a surface coordinate system

Oliver P. Hinds, Niranjini Rajendran, Jonathan R. Polimeni, Jean C. Augustinack, Graham Wiggins, Lawrence L. Wald, H. Diana Rosas, Andreas Potthast, Eric L. Schwartz, Bruce Fischl
2008 NeuroImage  
quality of this atlas provides direct evidence that surface-based intersubject registration methods are superior to volume-based methods at superimposing functional areas of cortex and therefore are better  ...  suited to support multisubject averaging for functional imaging experiments targeting the cerebral cortex.  ...  and Stroke (R01 NS052585), as well as the Mental Illness and Neuroscience Discovery (MIND) Institute and is part of the National Alliance for Medical Image Computing (NAMIC), funded by the National Institutes  ... 
doi:10.1016/j.neuroimage.2007.10.033 pmid:18055222 pmcid:PMC2258215 fatcat:aljlwjfsxngjnek4ybateybczi

Single photon-emission computed tomography

Thomas A. Holly, Brian G. Abbott, Mouaz Al-Mallah, Dennis A. Calnon, Mylan C. Cohen, Frank P. DiFilippo, Edward P. Ficaro, Michael R. Freeman, Robert C. Hendel, Diwakar Jain, Scott M. Leonard, Kenneth J. Nichols (+2 others)
2010 Journal of Nuclear Cardiology  
Adequate staging and treatment of the neck in squamous cell carcinoma of the oral cavity and oropharynx (OSCC) is of paramount importance.  ...  With regard to the prevalence of 20-40% of occult neck metastases found in the ND specimens, the majority of patients undergo surgery of the lymphatic drainage basin without therapeutic benefit.  ...  Fusion of CT with SPECT has the added benefit of providing not only useful anatomic information but functional assessment as well.  ... 
doi:10.1007/s12350-010-9246-y pmid:20552312 fatcat:jrn7kubn45b3zjmtdwoln2pupa

Small Animal Imaging with Magnetic Resonance Microscopy

B. Driehuys, J. Nouls, A. Badea, E. Bucholz, K. Ghaghada, A. Petiet, L. W. Hedlund
2008 ILAR journal  
High-resolution anatomical imaging reveals increasingly exquisite detail in healthy animals and subtle architectural aberrations that occur in genetically altered models.  ...  The ability of MRM to provide a detailed functional and anatomical picture in rats and mice, and to track this picture over time, makes it a promising platform with broad applications in biomedical research  ...  Acknowledgments The authors thank Sally Zimney for assistance in the preparation of the manuscript and Al Johnson for fostering many of the developments reviewed in this article.  ... 
doi:10.1093/ilar.49.1.35 pmid:18172332 pmcid:PMC2770253 fatcat:wk7ojmdznnbhhf6svqb547cmri

Key clinical benefits of neuroimaging at 7 T

Siegfried Trattnig, Elisabeth Springer, Wolfgang Bogner, Gilbert Hangel, Bernhard Strasser, Barbara Dymerska, Pedro Lima Cardoso, Simon Daniel Robinson
2018 NeuroImage  
A B S T R A C T The growing interest in ultra-high field MRI, with more than 35.000 MR examinations already performed at 7 T, is related to improved clinical results with regard to morphological as well  ...  Since the signal-to-noise ratio increases with the field strength of the MR scanner, the most evident application at 7 T is to gain higher spatial resolution in the brain compared to 3 T.  ...  Acknowledgements This work was supported by the FFG Bridge Early Stage Grant #846505, the Anniversary Fund of the Oesterreichische Nationalbank, project number 15680 and the Austrian Science Fund (FWF)  ... 
doi:10.1016/j.neuroimage.2016.11.031 pmid:27851995 pmcid:PMC5832016 fatcat:snjc6lnyxrgsbkrve3fui7cgzm

PET imaging of brain inflammation during early epileptogenesis in a rat model of temporal lobe epilepsy

Stefanie Dedeurwaerdere, Paul D Callaghan, Tien Pham, Gita L Rahardjo, Halima Amhaoul, Paula Berghofer, Mitchell Quinlivan, Filomena Mattner, Christian Loc'h, Andrew Katsifis, Marie-Claude Grégoire
2012 EJNMMI Research  
Similar in vivo [ 18 F]-PBR111 increases in V t and the simplified ratio were found in key regions such as the hippocampus (P < 0.05) and amygdala (P < 0.01).  ...  This work enables future longitudinal investigation of the role of brain inflammation during epileptogenesis and evaluation of anti-inflammatory treatments.  ...  Acknowledgements The authors would like to acknowledge the help of Patrice Ballantyne and Dr. Hongqin Wang during the execution of the experiments.  ... 
doi:10.1186/2191-219x-2-60 pmid:23136853 pmcid:PMC3570346 fatcat:safqguzd4bepbk2q6eipy4c37e
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