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High dimensional precision medicine from patient-derived xenografts [article]

Naim U. Rashid, Daniel J. Luckett, Jingxiang Chen, Michael T. Lawson, Longshaokan Wang, Yunshu Zhang, Eric B. Laber, Yufeng Liu, Jen Jen Yeh, Donglin Zeng, Michael R. Kosorok
2019 arXiv   pre-print
Individualized treatment rules (ITRs) formalize precision medicine as maps from the patient covariate space into the space of allowable treatments.  ...  Precision medicine offers potential to improve patient outcomes by leveraging this heterogeneity.  ...  A recent study utilized patient-derived xenografts (PDXs) to perform a large-scale screening in mice to evaluate a large number of FDA-approved and preclinical cancer therapies (Gao et al., 2015) .  ... 
arXiv:1912.06667v1 fatcat:ktups4kiazf4hlshtbcrsxakjy

Patient-Derived Cancer Organoids for Precision Oncology Treatment

Mark N. Pernik, Cylaina E. Bird, Jeffrey I. Traylor, Diana D. Shi, Timothy E. Richardson, Samuel K. McBrayer, Kalil G. Abdullah
2021 Journal of Personalized Medicine  
The emergence of three-dimensional human organoids has opened the door for the development of patient-derived cancer organoid (PDO) models, which closely recapitulate parental tumor tissue.  ...  The mainstays of preclinical cancer modeling include in vitro cell lines and patient-derived xenografts, but these models lack the cellular heterogeneity seen in human tumors.  ...  However, these remain challenging cell lines to create, with overall yields of 5-10% when attempting to establish patient-derived high-grade glioma cell lines.  ... 
doi:10.3390/jpm11050423 pmid:34067714 fatcat:yurtes6zhnb5nkcb3socfsb3rm

Organoid cultures from benign and malignant prostate epithelium

S. D. Kaffenberger, D. Gao, Y. Chen
2015 AACR Education book  
To overcome some of the limitations of cancer cell lines, patient-derived xenografts (PDX) have been utilized as a more physiologic model of patient tumors.  ...  Recently, three-dimensional cancer "organoid" culture methods have been developed to establish patient-derived cancer lines at increased efficiency and without some  ...  The development of organoid culturing technology may provide a promising strategy for precision medicine in the future.  ... 
doi:10.1158/aacr.edb-15-9176 fatcat:a3c4p5e2png65ci35hml5awcei

Organoid modeling for cancer precision medicine

Michael A Cantrell, Calvin J Kuo
2015 Genome Medicine  
Cancer precision medicine  ...  Editorial summary Three-dimensional organotypic culture models show great promise as a tool for cancer precision medicine, with potential applications for oncogene modeling, gene discovery and chemosensitivity  ...  On the other hand, in vivo mouse 'avatars' (patient-derived xenografts) or genetically engineered mouse models (GEMMs) allow three-dimensional tissue context and stromal recapitulation, but have the potential  ... 
doi:10.1186/s13073-015-0158-y pmid:25825593 pmcid:PMC4377844 fatcat:pwd446lt35f7dip5cp2sikv4ue

Development of Preclinical Models to Understand and Treat Colorectal Cancer

Judith Sebolt-Leopold
2018 Clinics in Colon and Rectal Surgery  
Integral to the application of precision medicine for patients diagnosed with metastatic CRC is the need to understand the molecular determinants of response for a given therapy.  ...  Integral to the application of precision medicine for patients diagnosed with metastatic CRC is the need to understand the molecular determinants of response for a given therapy.  ...  Ideally, PDX models established at the time a patient initiates standard of care treatment could eventually serve to inform the design of individualized precision medicine approaches.  ... 
doi:10.1055/s-0037-1602240 pmid:29720906 pmcid:PMC5930111 fatcat:t4jekimh7jc6znqkjhv4nr73hm

Future role of endoscopic ultrasound in personalized management of pancreatic cancer

NamQ Nguyen, Marie Ooi, An Phan
2017 Endoscopic Ultrasound  
Using tissue from resected PDAC specimens has several weaknesses and is only possible in 20% of patients with PDAC.  ...  medicine.  ...  Steps involved in generating patient-derived cancer xenograft that allows further assessment of personalizing medicine Figure 2 . 2 Steps involved in creating patient-derived cancer organoid to allow  ... 
doi:10.4103/eus.eus_84_17 pmid:29063873 pmcid:PMC5664850 fatcat:6sv22hgxdbbx5msbjrtx7nzumm

Organoid Culture of Isolated Cells from Patient-derived Tissues with Colorectal Cancer

Ai-Wen Wu, Bing-Ying Xie
2016 Chinese Medical Journal  
Methods: We subcutaneously injected surgically resected CRC tissues from a patient into BALB/c-nu mice to build patient-derived xenografts (PDXs).  ...  Histological features of CRC patient's tumor tissues and mice tumor xenograft tissues were highly similar, with high-column-like epithelium and extracellular matrix.  ...  Feng Hao and scientist Wen-Na Zhang from Crown Bioscience, Inc., for their technical support. Financial support and sponsorship  ... 
doi:10.4103/0366-6999.191782 pmid:27748340 pmcid:PMC5072260 fatcat:srtlpireb5b33c2og6emtxl7xa

The power and the promise of organoid models for cancer precision medicine with next-generation functional diagnostics and pharmaceutical exploitation

Yu-Shui Ma, Xiao-Li Yang, Rui Xin, Ting-Miao Wu, Yi Shi, Dan Dan Zhang, Hui-Min Wang, Pei-Yao Wang, Ji-Bin Liu, Da Fu
2021 Translational Oncology  
As organ-specific three-dimensional cell clusters derived from cancer tissue or cancer-specific stem cells, cancer-derived organoids are organized in the same manner of the cell sorting and spatial lineage  ...  This review attempts to provide insights into the organoid models for cancer precision medicine.  ...  Characteristics and multi-dimensional comparison of patient-derived cancer cell lines, multicellular cancer spheroids, patient-derived xenografts, and cancer patient-derived organoids models.  ... 
doi:10.1016/j.tranon.2021.101126 pmid:34020369 fatcat:ziqi4o65izg7nlibsggg6e2c7u

Cryopreserved biopsy tissues of rectal cancer liver metastasis for assessment of anticancer drug response in�vitro and in�vivo

Yuan Zhang, Wei‑Jian Huang, Qiu‑Rui Yang, Hong‑Dan Zhang, Xue‑Jing Zhu, Min Zeng, Xu Zhou, Zhen‑Yu Wang, Wei‑Jian Li, Hong‑Shu Jing, Xue‑Bin Zhang, Yao‑Ping Shi (+4 others)
2019 Oncology Reports  
The patientderived xenograft models were successfully established using both fresh and warmed biopsy tissues.  ...  Precision‑cut slices derived from the warmed tissues provided an efficient tool to assess anticancer drug response in vitro.  ...  From these, 11 xenografts derived from 20 fresh RLM biopsies and 10 xenografts derived from 20 warmed RLM biopsies were successfully established (take rates, 55 and 50%, respectively).  ... 
doi:10.3892/or.2019.7450 pmid:31894341 pmcid:PMC6967191 fatcat:klc3z6f4gvhdvir4ccu4s2nyym

Current Status and Perspectives of Patient-Derived Models for Ewing's Sarcoma

Tadashi Kondo
2020 Cancers  
Moreover, the predictive utility of patient-derived cancer models is expected to facilitate drug development and precision medicine.  ...  Patient-derived cancer models, including cell lines, organoids, and xenografts, are indispensable tools in cancer research.  ...  The feasibility of using PDXs for precision medicine was suggested in a previous study. Stebbing et al. [93] reported how they used PDXs for precision medicine in Ewing's sarcoma.  ... 
doi:10.3390/cancers12092520 pmid:32899796 pmcid:PMC7563399 fatcat:4eea2ujmp5bsna6ggome76n6rm

Application of Prostate Cancer Models for Preclinical Study: Advantages and Limitations of Cell Lines, Patient-Derived Xenografts, and Three-Dimensional Culture of Patient-Derived Cells

Takeshi Namekawa, Kazuhiro Ikeda, Kuniko Horie-Inoue, Satoshi Inoue
2019 Cells  
Recent tissue engineering enables generation of PCa patient-derived xenografts (PDXs) from both primary and metastatic lesions.  ...  These PCa models will be applied to the development of new strategies for cancer precision medicine.  ...  Considering current clinical streams towards cancer precision medicine, patient-derived cancer models are powerful and promising "avatars" of the original tumors, and these PCa platforms are favorable  ... 
doi:10.3390/cells8010074 pmid:30669516 pmcid:PMC6357050 fatcat:fn2lwh3ftvcm3mm4mfxwk2e6ri

Current Status of Patient-Derived Ovarian Cancer Models

Yoshiaki Maru, Yoshitaka Hippo
2019 Cells  
In this regard, patient-derived cells and tumors are gaining more attention in precise and physiological modeling of in situ tumors, which could also pave the way to implementation of precision medicine  ...  In this article, we comprehensively overviewed the current status of various platforms for patient-derived OC models.  ...  This work was supported in part by research grants from Chiba Prefecture and KAKENHI (19K09816) from the Japan Society for the Promotion of Science.  ... 
doi:10.3390/cells8050505 pmid:31130643 pmcid:PMC6562658 fatcat:zhkytzkxkvaetfrlzu2df7csdm

Conditional Cell Reprogramming in Modeling Digestive System Diseases

Ruihua Zhao, Rui Li, Tianqi An, Xuefeng Liu
2021 Frontiers in Cell and Developmental Biology  
medicine.  ...  is a newly developed primary technology that uses irradiated Swiss-3T3-J2 mouse fibroblast cells and the Rho-associated kinase (ROCK) inhibitor Y-27632 to rapidly and efficiently generate many cells from  ...  Tissue samples can be obtained from surgical core biopsies, fine-needle aspiration (FNA) or patient-derived xenograft (PDX).  ... 
doi:10.3389/fcell.2021.669756 pmid:34150763 pmcid:PMC8211013 fatcat:bdcsh3glnfhfji4bs3kernaosm

Conditional Reprogramming for Patient-Derived Cancer Models and Next-Generation Living Biobanks

Palechor-Ceron, Krawczyk, Dakic, Simic, Yuan, Blancato, Wang, Hubbard, Zheng, Dan, Strome, Cullen (+10 others)
2019 Cells  
Genomics-based precision oncology only help 2–20% patients with solid cancer. Functional diagnostics and patient-derived cancer models are needed for precision cancer biology.  ...  cancer medicine.  ...  ., and Georgetown University receive potential royalties and payments from Propagenix.  ... 
doi:10.3390/cells8111327 pmid:31717887 pmcid:PMC6912808 fatcat:efwcmifv4vdkvnwe234us4q66m

Modeling human pancreatic ductal adenocarcinoma for translational research: current options, challenges, and prospective directions

Reecha Suri, Jacquelyn W. Zimmerman, Richard A. Burkhart
2020 Annals of Pancreatic Cancer  
From two-dimensional (2D) cell lines to the advanced modeling available today, we aim to characterize the critical tools in efforts to further understand PDAC biology.  ...  Early detection, an improved understanding of tumor biology, and novel therapeutic discoveries are needed in order to improve overall patient survival.  ...  PDOs have shown feasibility as a modality for precision medicine and pharmacotyping, and Comparison of two-dimensional (2D) cell lines, xenografts, spheroids, and three-dimensional (3D) organoids according  ... 
doi:10.21037/apc-20-29 pmid:33889840 pmcid:PMC8059695 fatcat:vtjw4kfrt5hdlleyu7pabmkjge
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