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Higher availability of α4β2 nicotinic receptors (nAChRs) in dorsal ACC is linked to more efficient interference control

Pichon Swann, Garibotto Valentina, Wissmeyer Michael, Seimbille Yann, Antico Lia, Ratib Osman, Vuilleumier Patrik, Haller Sven, Picard Fabienne
2020 NeuroImage  
Nicotinic acetylcholine receptors (nAChRs) are widely distributed in the human brain and play an important role in the neuromodulation of brain networks implicated in attentional processes.  ...  Here we investigate the link between the availability of α4β2 nAChRs in the cingulo-insular network and behavioral measures of interference control using two versions of the Stroop paradigm, a task known  ...  Geneva) for their help in the recruitment of the individuals, and Marie-Louise Montandon for her work in MRI analyses.  ... 
doi:10.1016/j.neuroimage.2020.116729 pmid:32165264 fatcat:ovukywqk2bbzpgxr5rehvjno7m

Associations of cannabis use disorder with cognition, brain structure, and brain function in African Americans

Marinka M G Koenis, Joke Durnez, Amanda L Rodrigue, Samuel R Mathias, Aaron F Alexander-Bloch, Jennifer A Barrett, Gaelle E Doucet, Sophia Frangou, Emma E M Knowles, Josephine Mollon, Dominique Denbow, Katrina Aberizk (+7 others)
2020 Human Brain Mapping  
CUD was associated with altered functional connectivity in a network comprising the motor-hand region in the superior parietal gyri and the anterior insula (p < .04).  ...  In a large sample collected irrespective of cannabis used to minimize recruitment bias, we confirm the literature on poorer cognitive functioning in CUD, and an absence of volumetric brain differences  ...  ACKNOWLEDGMENTS The authors would like to thank Dr. Alecia Dager for helpful comments and discussion on earlier versions of this manuscript.  ... 
doi:10.1002/hbm.25324 pmid:33340172 pmcid:PMC7978126 fatcat:ogenupyspfe47dych2674kxjb4

Functional Characterization of the Cingulo-Opercular Network in the Maintenance of Tonic Alertness

Sepideh Sadaghiani, Mark D'Esposito
2014 Cerebral Cortex  
A key component is the cingulo-opercular (CO) network composed of anterior insula/operculum, dorsal anterior cingulate cortex, and thalamus.  ...  Conversely, heightened selective attention to pitch increased activity in the dorsal attention (DAT) network but not in the CO network.  ...  The interpretation of CO network function within an attentional framework moreover finds support in our recent observation that core CO network regions selectively show the brain's highest density of nicotinic  ... 
doi:10.1093/cercor/bhu072 pmid:24770711 pmcid:PMC4537431 fatcat:7r6nmm5bh5chbnyojbrzhnk2ri

Neurobiological Substrates of Tourette's Disorder

James F. Leckman, Michael H. Bloch, Megan E. Smith, Daouia Larabi, Michelle Hampson
2010 Journal of child and adolescent psychopharmacology  
Preliminary evidence also points to abnormalities in the frontoparietal network that is thought to maintain adaptive online control.  ...  Evidence supporting abnormalities in dopaminergic and noradrenergic neurotransmission remains strong, although the precise mechanisms remain the subject of speculation.  ...  In addition, the figure and an edited version of the figure legend appeared in the Journal of Child Psychology and Psychiatry .  ... 
doi:10.1089/cap.2009.0118 pmid:20807062 pmcid:PMC2958453 fatcat:j6djiml4ubfqjlskibcvrynynu

Panel and Study Groups

2013 Neuropsychopharmacology  
Although the expression in GAD67 expression is probably one of the most replicated findings to date, there have been relatively few studies of this finding with respect to genetic variation or brain development  ...  Methods: We have studied over 238 normal human brains in both DLPFC and hippocampus ranging in age from week 14 in the fetus to 80 years of age, using Illumina microchip arrays, qRT-PCR and RNA Seq.  ...  controls subjects resulting in a network with increased density of connections.  ... 
doi:10.1038/npp.2013.278 fatcat:expu2u3f3reypazj7tt7jhybfa

The EEG as an index of neuromodulator balance in memory and mental illness

Costa Vakalopoulos
2014 Frontiers in Neuroscience  
According to this model alpha rhythm reflects the relative predominance of cholinergic muscarinic signals and delta rhythm that of monoaminergic receptor effects.  ...  The monoamine-acetylcholine balance hypothesis is a theory of neurophysiological markers of the EEG and a detailed description of the findings that support this proposal are presented in this paper.  ...  Contrary to the idea that alpha oscillations are simply a reflection of resting states, the power of alpha is considered by others as a hallmark of sustained alertness and positively correlated with cingulo-insular-thalamic  ... 
doi:10.3389/fnins.2014.00063 pmid:24782698 pmcid:PMC3986529 fatcat:psw6xg5aevdqvajywwkbykbas4

Panel, Mini-panel and Study Group

2014 Neuropsychopharmacology  
Methods: In a series of studies in healthy individuals and unaffected first-degree relatives of schizophrenia patients we have established and confirmed the link of these phenotypes to the genetic liability  ...  association with a genome-wide supported psychosis risk variant in ITIH3/4 as well as the enrichment of gene sets and pathways involved in dopamine neurotransmission.  ...  Gene coexpression networks were constructed using WGCNA and high-density eQTL analyses were conducted.  ... 
doi:10.1038/npp.2014.279 pmid:25466712 pmcid:PMC4261146 fatcat:v6fgkukh6zgtdmswrjpk46dvhi

ACNP 57th Annual Meeting: Poster Session II

2018 Neuropsychopharmacology  
Increasing evidence suggests a role for systemic and neurological inflammation in the pathophysiology of fear and trauma exposure based psychiatric disorders (Micholpoulos et al., 2017; Haroon et al.,  ...  These data indicate that when limited to adulthood, high CRP loads representing physiological levels in humans do not appear to be sufficient to alter susceptibility to trauma.  ...  Density and soma size of Iba1 + microglia were quantified using unbiased stereology in the corpus striatum, which expresses the highest density of dopamine D2 receptors and is a primary site of antipsychotic  ... 
doi:10.1038/s41386-018-0267-6 fatcat:febeq6uwefgdzm65ccmzrmjwjy

Cortico-Striatal-Thalamic Loop Circuits of the Salience Network: A Central Pathway in Psychiatric Disease and Treatment

Sarah K. Peters, Katharine Dunlop, Jonathan Downar
2016 Frontiers in Systems Neuroscience  
Frontiers in Systems Neuroscience | www.frontiersin.org December 2016 | Volume 10 | Article 104 FIGURE 2 | Cortical and subcortical nodes of the SN from meta-analyses of functional magnetic resonance imaging  ...  Frontiers in Systems Neuroscience | www.frontiersin.org  ...  Entering the term ''SN'' yields a set of cortical regions that overlaps very closely with the more anterior cingulo-insular network of Yeo et al. (2011) .  ... 
doi:10.3389/fnsys.2016.00104 pmid:28082874 pmcid:PMC5187454 fatcat:bjpxyytj2jharc4vv36gw54swa

What can computational models learn from human selective attention? A review from an audiovisual crossmodal perspective [article]

Di Fu, Cornelius Weber, Guochun Yang, Matthias Kerzel, Weizhi Nan, Pablo Barros, Haiyan Wu, Xun Liu, Stefan Wermter
2019 arXiv   pre-print
This article reviews studies of selective attention in unimodal visual and auditory and crossmodal audiovisual setups from the multidisciplinary perspectives of psychology and cognitive neuroscience, and  ...  In the past 50 years, research on selective attention has been a central topic in cognitive science.  ...  ACKNOWLEDGMENTS We especially appreciate feedback and support from the Knowledge Technology Group in Hamburg and the Carelab in Beijing.  ... 
arXiv:1909.05654v1 fatcat:onh2t5hjtbcqxcpp2i22xt5rcm

ACNP 55th Annual Meeting: Poster Session III

2016 Neuropsychopharmacology  
In our presentation last year at the ACNP, we reported a) the pharmacological characterization of the COX-1 and COX-2 radioligands using in vitro enzymatic assays in monkey and human blood, and b) initial  ...  In contrast, COX-2 is minimally expressed at baseline in several peripheral tissues but markedly upregulated by inflammation at the level of both gene transcription and protein synthesis.  ...  Results: This connectome-wide analysis identified foci of dysconnectivity associated with reward responsivity in the nucleus accumbens (NAc), default mode network (DMN) and cingulo-opercular network (CON  ... 
doi:10.1038/npp.2016.242 fatcat:4efd43swjbboranfrcs3pp32h4

What Can Computational Models Learn From Human Selective Attention? A Review From an Audiovisual Unimodal and Crossmodal Perspective

Di Fu, Cornelius Weber, Guochun Yang, Matthias Kerzel, Weizhi Nan, Pablo Barros, Haiyan Wu, Xun Liu, Stefan Wermter
2020 Frontiers in Integrative Neuroscience  
This article reviews studies of selective attention in unimodal visual and auditory and crossmodal audiovisual setups from the multidisciplinary perspectives of psychology and cognitive neuroscience, and  ...  In the past 50 years, research on selective attention has been a central topic in cognitive science.  ...  ACKNOWLEDGMENTS We especially appreciate feedback and support from the Knowledge Technology Group in Hamburg and the Carelab in Beijing.  ... 
doi:10.3389/fnint.2020.00010 pmid:32174816 pmcid:PMC7056875 fatcat:3g5ybs4lprb5dpeecqh37kk7fq

Poster Session III

2010 Neuropsychopharmacology  
Our current work investigates the role of the 5-HT6 receptor in compulsive responding.  ...  Discussion: Our hypothesis is that given the opposite signaling between 5-HT6 receptors and dopamine D2 receptors in striatopallidal MSNs, selective over-expression of 5-HT6 receptors in these neurons  ...  MCD also eliminated D2 DAR localization from fractions 4-9, although the receptor was still found in heavier membrane fractions 10-11.  ... 
doi:10.1038/npp.2010.218 fatcat:i5knteqsgveybffza7g6b4iqei

ACNP 57th Annual Meeting: Poster Session III

2018 Neuropsychopharmacology  
There is growing evidence that the biological mechanisms of depression significantly overlap with those observed during the aging process, leading to an acceleration of brain and systemic aging in depressed  ...  In a previous study, we developed the SASP (Senescence-Associated Secretory Phenotype) index, which is a composite measure of biomarkers related to senescence processes and can be viewed as an indicator  ...  nicotinic cholinergic receptors (nAChRs) in response to nicotine.  ... 
doi:10.1038/s41386-018-0268-5 fatcat:wiooxnisvfhovadauljiso4ie4

Introduction to JINS Special Issue on Human Brain Connectivity in the Modern Era: Relevance to Understanding Health and Disease

Deanna M. Barch, Mieke Verfaellie, Stephen M. Rao
2016 Journal of the International Neuropsychological Society  
This work also involved the use of instrumentation supported by the NIH Shared Instrumentation Grant Program and/or High-End Instrumentation Grant Program; specifically, grant number(s) S10RR022976 and  ...  Mapping human whole-brain structural networks with diffusion MRI. PLoS One, 2(7), e597.  ...  Deletion of the alpha 7 nicotinic acetylcholine receptor gene improves cognitive deficits and synaptic pathology in a mouse model of Alzheimer's disease.  ... 
doi:10.1017/s1355617716000047 fatcat:f2preenihbes5ftkrxbo7tgt64
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