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Conformational changes in Sindbis virions resulting from exposure to low pH and interactions with cells suggest that cell penetration may occur at the cell surface in the absence of membrane fusion

Angel M Paredes, Davis Ferreira, Michelle Horton, Ali Saad, Hiro Tsuruta, Robert Johnston, William Klimstra, Kate Ryman, Raquel Hernandez, Wah Chiu, Dennis T Brown
2004 Virology  
We have investigated the requirements for the induction of virus-mediated, low pH-induced cell -cell fusion and cell -virus fusion.  ...  None of these treatments resulted in the disassembly of the virus protein icosahedral shell that is a requisite for the process of virus membrane -cell membrane fusion.  ...  Acknowledgments This research has been supported by the NIAID and NCRR of NIH, the Department of Energy, the Robert A.  ... 
doi:10.1016/j.virol.2004.03.046 pmid:15207623 fatcat:7rfgaqi6bfbh3lkjrdnxctx5hq