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Reinstatement of Conditioned Suppression in Mice

Trinette Dirikx, Ellen Gillard, Clara Muyls, Tom Beckers, Dirk Hermans, Debora Vansteenwegen, Rudi D'Hooge
2006 Psychologica Belgica  
With this paradigm we demonstrated reinstatement of fear in humans in direct verbal measures (Hermans, Dirikx, Vansteenwegen, Baeyens, Van den Bergh, & Eelen, 2005; Dirikx, Hermans, Baeyens, & Eelen,  ...  More specifically, in spite of the successful demonstrations of reinstatement in human fear conditioning (Dirikx, Hermans, Vansteenwegen, Baeyens, & Eelen, 2004, in press; Hermans et al., 2005; Van Damme  ... 
doi:10.5334/pb-46-1-2-185 fatcat:37hiu7w46rczrequz36zrd45ku


Kevin C. Kahn, William M. Corwin, T. Don Dennis, Herman D'Hooge, David E. Hubka, Linda A. Hutchins, John T. Montague, Fred J. Pollack
1981 Proceedings of the eighth symposium on Operating systems principles - SOSP '81  
The Intel iAPX 432 is an objectbased microcomputer which, together with its operating system iMAX, provides a multiprocessor computer system designed around the ideas of data abstraction, iMAX is implemented in Ada and provides, through its interface and facilities, an Ada view of the 432 system. Of paramount concern in this system is the uniformity of approach among the architecture, the operating system, and the language. Some interesting aspects of both the external and internal views of
more » ... are discussed to illustrate this uniform approach. Permission to copy without fee all or part of this material is granted provided that the copies are not made or distributed for direct commercial advantage, the ACM copyright notice and the title of the publication and its date appear, and notice is given that copying is by permission of the Association for Computing Machinery. To copy otherwise, or to republish, requires a fee and/or specific permission.
doi:10.1145/800216.806601 dblp:conf/sosp/KahnCDDHHMP81 fatcat:lzeygaloqbaslcume7dur7mtnq

Stimulus generalization and return of fear in C57BL/6J mice

Yannick Boddez, Zsuzsanna Callaerts-Vegh, Bram Vervliet, Frank Baeyens, Rudi D'Hooge, Dirk Hermans, Tom Beckers
2012 Frontiers in Behavioral Neuroscience  
.; D'Hooge, R.; Hermans, D.; Beckers, T.R.J. Return of fear following successful exposure therapy is a common problem.  ...  ., 2004; Hermans et al., 2006) . These laboratory protocols have been connected to return of fear in clinical practice.  ... 
doi:10.3389/fnbeh.2012.00041 pmid:22811661 pmcid:PMC3397411 fatcat:sfxuhphf7fea5bwztqzw2hwl54

Iterative reconstruction of the ultrasound attenuation coefficient from the backscattered radio-frequency signal

Natalia Ilyina, Jeroen Hermans, Erik Verboven, Koen Van Den Abeele, Emiliano D'Agostino, Jan D'hooge
2014 2014 IEEE International Ultrasonics Symposium  
Accurate estimation of the local acoustic attenuation based on the backscatter signal has several applications, e.g. ultrasound tissue characterization. Most of the existing techniques determine the attenuation coefficient of the tissue directly from the spectrum of the backscattered signal. In these approaches other effects, such as diffraction, that may influence the attenuation estimation should be corrected for. This correction may be impractical in vivo. In the present study the simulation
more » ... of ultrasound wave propagation was used for the estimation of the attenuation characteristics. Indeed, the local attenuation coefficient was estimated by iteratively solving the forward wave propagation problem and matching the synthetic backscattered signal to the measured one. The proposed methodology was experimentally validated using tissuemimicking phantoms with different attenuation characteristics showing promising results.
doi:10.1109/ultsym.2014.0600 fatcat:pqkk6xtv2jfttmcpg45o53sptm

A mouse model for fucosidosis recapitulates storage pathology and neurological features of the milder form of the human disease

Heike Wolf, Markus Damme, Stijn Stroobants, Rudi D'Hooge, Hans Christian Beck, Irm Hermans-Borgmeyer, Renate Lüllmann-Rauch, Thomas Dierks, Torben Lübke
2016 Disease Models & Mechanisms  
In several animal models of LSDs, a progressive loss of Purkinje cells is accompanied by reactive and progressive astrogliosis in affected areas (D'Hooge et al., 1999; Damme et al., 2011; Kollmann et  ... 
doi:10.1242/dmm.025122 pmid:27491075 pmcid:PMC5047687 fatcat:bxay5mihrzcebgbynmn33kqpoi

Increased Cardiac Myocyte PDE5 Levels in Human and Murine Pressure Overload Hypertrophy Contribute to Adverse LV Remodeling

Sara Vandenwijngaert, Peter Pokreisz, Hadewich Hermans, Hilde Gillijns, Marijke Pellens, Noortje A. M. Bax, Giulia Coppiello, Wouter Oosterlinck, Agnes Balogh, Zoltan Papp, Carlijn V. C. Bouten, Jozef Bartunek (+8 others)
2013 PLoS ONE  
The intracellular second messenger cGMP protects the heart under pathological conditions. We examined expression of phosphodiesterase 5 (PDE5), an enzyme that hydrolyzes cGMP, in human and mouse hearts subjected to sustained left ventricular (LV) pressure overload. We also determined the role of cardiac myocyte-specific PDE5 expression in adverse LV remodeling in mice after transverse aortic constriction (TAC). Methodology/Principal Findings: In patients with severe aortic stenosis (AS)
more » ... ng valve replacement, we detected greater myocardial PDE5 expression than in control hearts. We observed robust expression in scattered cardiac myocytes of those AS patients with higher LV filling pressures and BNP serum levels. Following TAC, we detected similar, focal PDE5 expression in cardiac myocytes of C57BL/6NTac mice exhibiting the most pronounced LV remodeling. To examine the effect of cell-specific PDE5 expression, we subjected transgenic mice with cardiac myocyte-specific PDE5 overexpression (PDE5-TG) to TAC. LV hypertrophy and fibrosis were similar as in WT, but PDE5-TG had increased cardiac dimensions, and decreased dP/dt max and dP/dt min with prolonged tau (P,0.05 for all). Greater cardiac dysfunction in PDE5-TG was associated with reduced myocardial cGMP and SERCA2 levels, and higher passive force in cardiac myocytes in vitro. Conclusions/Significance: Myocardial PDE5 expression is increased in the hearts of humans and mice with chronic pressure overload. Increased cardiac myocyte-specific PDE5 expression is a molecular hallmark in hypertrophic hearts with contractile failure, and represents an important therapeutic target.
doi:10.1371/journal.pone.0058841 pmid:23527037 pmcid:PMC3601083 fatcat:g2anojmdh5evzbcbz2m6dqpph4

Matrix-Binding Vascular Endothelial Growth Factor (VEGF) Isoforms Guide Granule Cell Migration in the Cerebellum via VEGF Receptor Flk1

C. Ruiz de Almodovar, C. Coulon, P. A. Salin, E. Knevels, N. Chounlamountri, K. Poesen, K. Hermans, D. Lambrechts, K. Van Geyte, J. Dhondt, T. Dresselaers, J. Renaud (+23 others)
2010 Journal of Neuroscience  
Vascular endothelial growth factor (VEGF) regulates angiogenesis, but also has important, yet poorly characterized roles in neuronal wiring. Using several genetic and in vitro approaches, we discovered a novel role for VEGF in the control of cerebellar granule cell (GC) migration from the external granule cell layer (EGL) toward the Purkinje cell layer (PCL). GCs express the VEGF receptor Flk1, and are chemoattracted by VEGF, whose levels are higher in the PCL than EGL. Lowering VEGF levels in
more » ... ice in vivo or ectopic VEGF expression in the EGL ex vivo perturbs GC migration. Using GC-specific Flk1 knock-out mice, we provide for the first time in vivo evidence for a direct chemoattractive effect of VEGF on neurons via Flk1 signaling. Finally, using knock-in mice expressing single VEGF isoforms, we show that pericellular deposition of matrix-bound VEGF isoforms around PC dendrites is necessary for proper GC migration in vivo. These findings identify a previously unknown role for VEGF in neuronal migration.
doi:10.1523/jneurosci.0477-10.2010 pmid:21068311 pmcid:PMC6633861 fatcat:3vjmsxcxlzbbjgkdv7i7x5lkkm

The impact of acute pressure overload on regional changes in the timing of myocardial contraction. Insight from a closed chest, closed pericardium animal model

M. Cikes, N. Jakus, G. R. Sutherland, P. Haemers, J. D'Hooge, P. Claus
2013 European Heart Journal  
D'Hooge, P. Claus.  ...  Hermans, E.P. Daskalopoulos, J.J. Debets, B.J.A. Janssen, W.M. Blankesteijn. Cardiovascular Research Institute Maastricht (CARIM), Maastricht, Netherlands S. Brunner 1 , S. Lehner 1 , H.  ... 
doi:10.1093/eurheartj/eht310.p5364 fatcat:llijm6foyvehrc64q2fnwio3au

Standardized orthotopic xenografts in zebrafish reveal glioma cell-line-specific characteristics and tumor cell heterogeneity

Alessandra M. Welker, Brian D. Jaros, Vinay K. Puduvalli, Jaime Imitola, Balveen Kaur, Christine E. Beattie
2015 Disease Models & Mechanisms  
., D'Hooge, R., Beck, H. C., Hermans-Borgmeyer, I., Lü llmann-Rauch, R., Dierks, T. and Lübke, T.  ... 
doi:10.1242/dmm.022921 pmid:26659251 pmcid:PMC4770147 fatcat:ro4vnprlqfhhbbfzu25eiu75jy

Deprenyl and the relationship between its effects on spatial memory, oxidant stress and hippocampal neurons in aged male rats

M Kiray, H A Bagriyanik, C Pekcetin, B U Ergur, N Uysal, D Ozyurt, Z Buldan
2005 Physiological Research  
Although apoptosis may play a role in the Vol. 55 normal aging process, both apoptosis and aging were affected by oxidant stress (Zhang and Herman 2002) .  ...  Apoptosis is suggested to be considered in normal aging and neurodegenerative disorders (Zhang and Herman 2002). The anti-apoptotic activity of deprenyl may also be responsible for this effect.  ... 
pmid:15910165 fatcat:nrarrvkmrjfkhmh2p5shdsyb3i

List of referees, 2006

2006 European Heart Journal  
Windt L de Winter RJ Decramer M Degroot N Deharo J-C Delacretaz E Delcroix M Deligiannis A Della Bella P Demers C Deng M Denvir MA Derumeaux GA Desideri A Desideri G Despres J-P Deten A D'hooge  ...  Hauer R Haverich A Haverkamp W Hawley JA Hayoz D He J Headrick JP Heagerty A Healey JS Heeneman S Heeschen C Heidbuchel H Heidenreich PA Herbots L Herijgers P Heringlake M Herlitz J Herman  ... 
doi:10.1093/eurheartj/ehl547 fatcat:53mi6zj3kjgava2r6h2qof6evq

Page 3140 of Mathematical Reviews Vol. 58, Issue 4 [page]

1979 Mathematical Reviews  
G 17636 D’Hooge, L... .. 18660 Diamond, Jack... 16610 Diamond, Phil... 20602 Dianov, V. 1..... 19044 Diaz-Miranda, Antonio 18505 ke a 179939 Di Comite, Claudio . 18242 Diday, Edwin... . 20442 tom Dieck  ...  A.M... 19902 Director, Stephen W. 20834 Dishkant, Herman. See DiSkant, G. P. Diskam, G. P.... 16146 Ditkin, V. A... .. 17702 a ee 19690 Divinsky, N..... 16743 Divnié, M. T. ... 17456 vee, Me. Ts. w..  ... 

Page 1955 of Mathematical Reviews Vol. 55, Issue 6 [page]

1978 Mathematical Reviews  
C 12986 Chen, Kuo Tsai 13414 Chen, Ming Po 13041 Chenais, Denise 14401 Cheng, Sui Sun. 12985 Chernoff, Herman 13639 Chester, W....... 12881 Chevalier, Georges. . 13138 Chew, Kim Ho... . 13011 Cay G.  ...  14307, 14341, 14347 Desoineux-Moulis, N 13462 DeTemple, Duane W. . 13331 Detweiler, S...... 14047 Devel, Johanna . 13070 DeVore, Ronald A 13733 Pete. 13527 De Wilde, M...... 13446 Deza, Mikhail 12534 D'Hooge  ... 

Cardijn in Congo. De ontwikkeling en betekenis van de Katholieke Arbeidersjeugd in Belgisch-Congo

Karl Catteeuw
1999 Brood en Rozen  
HERMANS, "De verovering van het arbeidsmidden" in de pedagogische werking van de KAJ (vóór 1940). In: M. PLUYMERS & L. VINTS (red.), Cardijn. Een mens, een beweging.  ...  D'Hooge had tijdens de Christus-Koningprocessie enkele inlandse jongens in zijn oude kajottersuniformen en met een fietswimpel laten marcheren.  ... 
doi:10.21825/br.v4i2.2795 fatcat:64legwrorjdcdmkhuc7e4fbtyq

Acute exposure to stress improves performance in trace eyeblink conditioning and spatial learning tasks in healthy men

R. Duncko, B. Cornwell, L. Cui, K. R. Merikangas, C. Grillon
2007 Learning & memory (Cold Spring Harbor, N.Y.)  
This task has been extensively applied as a highly sensitive and specific tool for investigating hippocampal involvement in spatial learning (D'Hooge and De Deyn 2001) .  ...  activation during stress, playing a major role in mediating effects of stress on cognitive functions, particularly through its action on receptors located in the hippocampus, amygdale, and prefrontal cortex (Herman  ... 
doi:10.1101/lm.483807 pmid:17522023 pmcid:PMC1876756 fatcat:672sc7lxd5d7tgwf4kwktipxse
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