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Heritable influences on amygdala and orbitofrontal cortex contribute to genetic variation in core dimensions of personality

G.J. Lewis, M.S. Panizzon, L. Eyler, C. Fennema-Notestine, C.-H. Chen, M.C. Neale, T.L. Jernigan, M.J. Lyons, A.M. Dale, W.S. Kremen, C.E. Franz
2014 NeuroImage  
To advance understanding concerning the pathway from genetic variation to personality, here we examined whether measures of heritable variation in neuroanatomical size in candidate regions (amygdala and  ...  medial orbitofrontal cortex) were associated with heritable effects on personality.  ...  Numerous organizations have provided invaluable assistance in the conduct of the VET Registry, including: Department of Defense; National Personnel Records Center, National Archives and Records Administration  ... 
doi:10.1016/j.neuroimage.2014.09.043 pmid:25263286 pmcid:PMC4745648 fatcat:jwmr3dltyvap7lornlyzcscqna

Genetic variation in MAOA modulates ventromedial prefrontal circuitry mediating individual differences in human personality

J W Buckholtz, J H Callicott, B Kolachana, A R Hariri, T E Goldberg, M Genderson, M F Egan, V S Mattay, D R Weinberger, A Meyer-Lindenberg
2007 Molecular Psychiatry  
Our data implicate a neural circuit for variation in human personality under genetic control, provide an anatomically consistent mechanism for vmPFC-amygdala interactions underlying this variation, and  ...  We utilized path analysis to parse the effective connectivity within this system, and provide evidence that vmPFC regulates amygdala indirectly by influencing rostral cingulate cortex function.  ...  studying the impact of genetic variation linked to personality on human brain structure and function. 14 In the present paper we pursue this approach, focusing on genetic variation in the X-linked Monoamine  ... 
doi:10.1038/sj.mp.4002020 pmid:17519928 fatcat:lip3nqtom5gdfekrydtde3rabu

Redefining the endophenotype concept to accommodate transdiagnostic vulnerabilities and etiological complexity

Theodore P Beauchaine, John N Constantino
2017 Biomarkers in Medicine  
Our objectives in writing this essay are to revisit the definition of endophenotype, and to contextualize its current scientific utility in behavioral neuroscience given claims that core assumptions made  ...  Such optimism was spawned in large part by Gottesman and Gould's [3] now famous paper on the promise of endophenotypes.  ...  In addition, poor functional connectivity between the amygdala and the orbitofrontal cortex, and poor top-down control of the amygdala by the medial PFC, are implicated in emotional lability [66] .  ... 
doi:10.2217/bmm-2017-0002 pmid:28891303 fatcat:z2aangtoybbcbjp6zwcyzmg6yi

A Translational Neuroscience Approach to Understanding the Development of Social Anxiety Disorder and Its Pathophysiology

Andrew S. Fox, Ned H. Kalin
2014 American Journal of Psychiatry  
orbitofrontal cortex.  ...  Notably, the components of this circuit are differentially influenced by heritable and environmental factors, and specific lesion studies have demonstrated a causal role for multiple components of the  ...  Targeted lesion studies in primates have also assessed the causal influences of the hippocampus and orbitofrontal cortex on components of AT.  ... 
doi:10.1176/appi.ajp.2014.14040449 pmid:25157566 pmcid:PMC4342310 fatcat:6ienvzefyvarrebpxo7w7rnlwi

Neurobiological Findings in Youth with Borderline Personality Disorder

Romuald Brunner, Romy Henze, Julia Richter, Michael Kaess
2015 Scandinavian Journal of Child and Adolescent Psychiatry and Psychology  
This article focuses on recent findings in the field of neuroimaging, neuropsychology, neuroendocrinology, genetics, and pain perception, and it aims to integrate these findings in a developmental psychopathology  ...  Genetic studies could reveal that the stability of BPD traits in youth is largely influenced by a combination of genetic and non-shared environmental factors.  ...  Genetics Only moderate influence has been attributed to genetics in the etiology of BPD (8) .  ... 
doi:10.21307/sjcapp-2015-003 fatcat:ogdip3f6wzbmbesyy4nfaaq5de

Genetic and neurocognitive contributions to the development of psychopathy

Essi Viding, Eamon J. McCrory
2012 Development and Psychopathology  
An overview is provided of recent twin, molecular genetic, and magnetic resonance imaging studies that are helping to inform a model of developmental vulnerability to adult psychopathy.  ...  One potential implication is that interventions for children with antisocial behavior and callous-unemotional traits may need to be tailored to take into account their distinct pattern of neurocognitive  ...  The authors focused on a hierarchical model of psychopathic personality in which a higher-order general factor substantially explained the variation in the three psychopathic personality dimensions in  ... 
doi:10.1017/s095457941200048x pmid:22781866 fatcat:ylzv5jn2ibeflazye4hs5fx3q4

How Serious is ADHD?

Robert Eme
2017 Journal of General Practice  
Hence, given the continuing challenges to the validity of ADHD, this article provided a concise overview of the evidence that establishes ADHD as brain disorder associated with a set of well-defined symptoms  ...  that causes serious impairment in many life activities.  ...  of the variation in symptoms is explained by genetic factors (2, 3, 7, 9] .  ... 
doi:10.4172/2329-9126.1000321 fatcat:fp2cj7wmkbhw7iv5yubmuies4m

Dissecting impulsivity and its relationships to drug addictions

J. David Jentsch, James R. Ashenhurst, M. Catalina Cervantes, Stephanie M. Groman, Alexander S. James, Zachary T. Pennington
2014 Annals of the New York Academy of Sciences  
Further dissection of these relationships is needed before the next phase of genetic and genomic discovery will be able to reveal the biological sources of the vulnerability for addiction indexed by impulsivity  ...  ) disorder, 25 borderline personality disorder 26, 27 and (of most relevance to this review) substance-use disorders. 22, 23, [28] [29] [30] [31] [32] [33] Impulsivity also appears to be a significant  ...  Because impulsivity predates substance use in many circumstances and because impulsivity is itself a heritable trait, 272 the discovery of genetic influences on impulsive behavior is crucial.  ... 
doi:10.1111/nyas.12388 pmid:24654857 pmcid:PMC4360991 fatcat:a7qeidlg3nh23mef3kp3ayncyu

Right ventromedial prefrontal cortex: a neuroanatomical correlate of impulse control in boys

Aaron D. Boes, Antoine Bechara, Daniel Tranel, Steve W. Anderson, Lynn Richman, Peg Nopoulos
2008 Social Cognitive and Affective Neuroscience  
Variation in the development of these regions may influence one's propensity for impulsivity and, by extension, one's vulnerability to disorders involving low impulse control (e.g. substance abuse).  ...  Emerging data on the neural mechanisms of impulse control highlight brain regions involved in emotion and decision making, including the ventromedial prefrontal cortex (vmPFC), anterior cingulate cortex  ...  These differences form a core dimension of human personality and behavior that is fairly heritable, emerges early in the course of development and persists across developmental stages (McKay and Halperin  ... 
doi:10.1093/scan/nsn035 pmid:19015086 pmcid:PMC2656876 fatcat:rhwticvtyjbilftno2nhgtnjda

You say 'prefrontal cortex' and I say 'anterior cingulate': meta-analysis of spatial overlap in amygdala-to-prefrontal connectivity and internalizing symptomology

H A Marusak, M E Thomason, C Peters, C Zundel, F Elrahal, C A Rabinak
2016 Translational Psychiatry  
Based on functional characterizations and the studies contributing to each peak, observed amygdala-ACC subcircuits may reflect separate transdiagnostic neural signatures.  ...  These results suggest disruptions in unique amygdala-ACC subcircuits across internalizing, genetic and environmental risk studies.  ...  The funders had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and design to submit  ... 
doi:10.1038/tp.2016.218 pmid:27824358 pmcid:PMC5314129 fatcat:2cqakmyoc5dn5gao2pjfjagldu

Validity and utility of Hierarchical Taxonomy of Psychopathology (HiTOP): II. Externalizing superspectrum

Robert F Krueger, Kelsey A Hobbs, Christopher C Conway, Danielle M Dick, Michael N Dretsch, Nicholas R Eaton, Miriam K Forbes, Kelsie T Forbush, Katherine M Keyes, Robert D Latzman, Giorgia Michelini, Christopher J Patrick (+12 others)
2021 World Psychiatry  
The externalizing superspectrum is one aspect of the general approach to psychopathology offered by HiTOP and can make diagnostic classification more useful in both research and the clinic.  ...  The externalizing superspectrum ranges from normative levels of impulse control and self-assertion, to maladaptive disinhibition and antagonism, to extensive polysubstance involvement and personality psychopathology  ...  This is also borne out by studies that have directly estimated the mag nitude of genetic influences on an externalizing factor, and have found it to be highly heritable 41, 102 .  ... 
doi:10.1002/wps.20844 pmid:34002506 fatcat:bauhxfwrr5dxtki6654sbhyebm

Prediction Along a Developmental Perspective in Psychiatry: How Far Might We Go?

Frauke Nees, Lorenz Deserno, Nathalie E. Holz, Marcel Romanos, Tobias Banaschewski
2021 Frontiers in Systems Neuroscience  
We discuss prediction strategies and how the integration of different factors and methods may provide useful contributions to research and at the same time may inform prevention and intervention.  ...  They may manifest in altered neurodevelopmental trajectories and need to be validated capitalizing on large-scale multi-modal epidemiological longitudinal cohorts.  ...  Since the SES is a significant moderator of genetic heritability, the heritability was higher in high SES, above 70%, and in contrast with only 10% in low SES individuals (Turkheimer et al., 2003; Henrich  ... 
doi:10.3389/fnsys.2021.670404 fatcat:bizyn6yo25bxjj2t7f73y5ltya

Neural and behavioral signatures of social evaluation and adaptation in childhood and adolescence: The Leiden Consortium on Individual Development (L-CID)

Eveline A. Crone, Michelle Achterberg, Simone Dobbelaar, Saskia Euser, Bianca van den Bulk, Mara van der Meulen, Lina van Drunen, Lara Wierenga, Marian J. Bakermans-Kranenburg, Marinus H. van IJzendoorn
2020 Developmental Cognitive Neuroscience  
Based on their role in social evaluation processing, we suggest to examine medial prefrontal cortex connections with lateral prefrontal cortex and the ventral striatum as potential neural differential  ...  We present a neurobehavioral model showing commonalities in neural responses to experiences of social acceptance and rejection, and multiple pathways for responding to social context.  ...  ) and an innovative ideas grant of the European Research Council (ERC CoG PROSOCIAL 681632 to E.A.C.).  ... 
doi:10.1016/j.dcn.2020.100805 pmid:33040969 pmcid:PMC7390777 fatcat:j56rd3cn2nfvdocqobrh4enpla

Genetics of impulsive behaviour

L. Bevilacqua, D. Goldman
2013 Philosophical Transactions of the Royal Society of London. Biological Sciences  
Lesions of the NAcc core contribute to premature responses in the 5CSRTT [46] .  ...  Heritability increased from 30 to 51 per cent from age 12 to 14 suggesting an increasing role of genetic influence with age.  ... 
doi:10.1098/rstb.2012.0380 pmid:23440466 pmcid:PMC3638385 fatcat:5b32pevtsnbx5edgcizimhcady

Temperament theory and the study of cognition–emotion interactions across development

Heather A. Henderson, Theodore D. Wachs
2007 Developmental Review  
Studies are reviewed in which some well-documented contextual effects on the expression of temperament can be interpreted in terms of the influence of biological and non-biological factors on CNS functioning  ...  In this paper we review current definitions and measurement approaches used to assess individual differences in children's temperament.  ...  At a neural level, reward-relevant information is processed through cells in the orbitofrontal cortex, basolateral amygdala, lateral hypothalamus, and the nucleus accumbens of the ventral striatum (Berridge  ... 
doi:10.1016/j.dr.2007.06.004 fatcat:bqfpfwtmyzhiji6j3jrevdhcta
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