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Common variants contribute to intrinsic functional architecture of human brain [article]

Bingxin Zhao, Tengfei Li, Stephen M. Smith, Di Xiong, Xifeng Wang, Yue Yang, Tianyou Luo, Ziliang Zhu, Yue Shan, Mads E. Hauberg, Jaroslav Bendl, John F. Fullard (+5 others)
2020 bioRxiv   pre-print
Heritability of intrinsic brain activity was enriched in brain tissues.  ...  Genetic correlation analysis suggested the shared genetic influences among intrinsic brain function, brain structure, and brain structural connectivity.  ...  These 1,777 traits were then used to explore the genetic architecture of intrinsic 26 brain activity.  ... 
doi:10.1101/2020.07.30.229914 fatcat:b2gxihmeinhrfdowsscievvuw4

Genetic control over the resting brain

D. C. Glahn, A. M. Winkler, P. Kochunov, L. Almasy, R. Duggirala, M. A. Carless, J. C. Curran, R. L. Olvera, A. R. Laird, S. M. Smith, C. F. Beckmann, P. T. Fox (+1 others)
2010 Proceedings of the National Academy of Sciences of the United States of America  
or neurological illnesses or to identify genes influencing intrinsic brain function. default mode | functional MRI | heritability | resting state networks  ...  unique genes influence the structure and function of the network.  ...  Financial support for this study was provided by National Institute of Mental Health (NIMH) Grants MH0708143 (to D.C.G.), MH078111 (to J.B.), MH083824 (to D.C.G.), and EB006395 (to P.K.).  ... 
doi:10.1073/pnas.0909969107 pmid:20133824 pmcid:PMC2824276 fatcat:tsa4lfzgbfbuzn4asf7hayvntm

Heritability of individualized cortical network topography

Kevin M Anderson, Tian Ge, Ru Kong, Lauren M Patrick, R Nathan Spreng, Mert R Sabuncu, B T Thomas Yeo, Avram J Holmes
2021 Proceedings of the National Academy of Sciences of the United States of America  
in brain functioning, guiding both individualized prediction and the interpretation of analyses that integrate genetics and neuroimaging.  ...  Genetic factors had a regionally variable influence on brain organization, such that the heritability of network topography was greatest in prefrontal, precuneus, and posterior parietal cortex.  ...  Mounting evidence documents the heritable basis of large-scale brain network function (28) (29) (30) (31) as well as the ability of functional brain connectivity to serve as a trait-like fingerprint  ... 
doi:10.1073/pnas.2016271118 pmid:33622790 fatcat:ux5p6cosf5hpflci4w75hez4ca

Editorial Focus on "Invariant and heritable local cortical organization as revealed by fMRI"

Hugo Merchant, Ravi S. Menon
2018 Journal of Neurophysiology  
in a variety of networks such as the World Wide Web, and the brain is no exception (Barabási and Bonabeau 2003) .  ...  This connectivity distribution is characteristic of scale-free networks that are known to show a robust architecture in which information can be transferred and integrated with a high level of efficiency  ...  in a variety of networks such as the World Wide Web, and the brain is no exception (Barabási and Bonabeau 2003) .  ... 
doi:10.1152/jn.00429.2018 pmid:29975168 fatcat:6poq6jo5kvb2bmehka7gxtyfla

Heritability of individualized cortical network topography [article]

Kevin Michael Anderson, Tian Ge, Ru Kong, Lauren M Patrick, R. Nathan Spreng, Mert R Sabuncu, B.T. Thomas Yeo, Avram Holmes
2020 bioRxiv   pre-print
in brain functioning, guiding both individualized prediction and the interpretation of analyses that integrate genetics and neuroimaging.  ...  Genetic factors had a regionally variable influence on brain organization, such that the heritability of network topography was greatest in prefrontal, precuneus, and posterior parietal cortex.  ...  Suggesting genetic factors may influence the functioning of large-scale brain networks, patterns of intrinsic connectivity within population-average defined network templates are heritable [28] [29] [  ... 
doi:10.1101/2020.07.30.229427 fatcat:ewywffxrezbzhanp2yvk5opmgy

Genetic and Environmental Contributions to Functional Connectivity Architecture of the Human Brain

Zhi Yang, Xi-Nian Zuo, Katie L. McMahon, R. Cameron Craddock, Clare Kelly, Greig I. de Zubicaray, Ian Hickie, Peter A. Bandettini, F. Xavier Castellanos, Michael P. Milham, Margaret J. Wright
2016 Cerebral Cortex  
These results suggest that the source of interindividual variation in functional connectome has a modular architecture: individual modules represented by intrinsic connectivity networks are genetic controlled  ...  Here, we use a classical twin study design to examine the heritability of intrinsic functional network properties in 101 twin pairs, including network activity (i.e., variance of a network's specific temporal  ...  Discussion Systematic investigation of the intrinsic functional networks in the largest twin sample to date quantified genetic and environmental influence on the functional connectivity architecture of  ... 
doi:10.1093/cercor/bhw027 pmid:26891986 pmcid:PMC4830303 fatcat:3gzxbrdnrvgczadotegbfmnj2e

Heritability analysis with repeat measurements and its application to resting-state functional connectivity

Tian Ge, Avram J. Holmes, Randy L. Buckner, Jordan W. Smoller, Mert R. Sabuncu
2017 Proceedings of the National Academy of Sciences of the United States of America  
The authors would like to thank B. T. Thomas Yeo for providing the 51 spatial components of the seven-network parcellation of the cortex.  ...  This research used resources provided by the Center for Functional Neuroimaging Technologies and a P41 Biotechnology Resource Grant (P41EB015896) supported by the NIH.  ...  The heritability analysis of the functional connectivity profile seeded in the PCC, a core region of the DMN (31), further confirmed that the intrinsic connectivity of large-scale brain networks is under  ... 
doi:10.1073/pnas.1700765114 pmid:28484032 pmcid:PMC5448225 fatcat:p4cs6qwrrjclxb3lm7yqty2v2m

Multivariate analysis reveals shared genetic architecture of brain morphology and human behavior [article]

Ronald de Vlaming, Eric A.W. Slob, Philip R Jansen, Alain Dagher, Philipp D. Koellinger, Patrick J.F. Groenen, Cornelius A Rietveld
2021 bioRxiv   pre-print
Here, we introduce multivariate genomic-relatedness restricted maximum likelihood (MGREML) and provide estimates of the heritability of grey-matter volume in 74 regions of interest (ROIs) in the brain.  ...  Human variation in brain morphology and behavior are related and highly heritable.  ...  Average SNP-based heritability of relative grey matter volume in networks of intrinsic functional connectivity. b.  ... 
doi:10.1101/2021.04.19.440478 fatcat:pabtsvrfnvcgphndc6x5e3gqk4

Genetic overlap between in-scanner head motion and the default network connectivity [article]

Yuan Zhou, Jie Chen, Yu Luo, Dang Zheng, Li-Lin Rao, Xinying Li, Jianxin Zhang, Shu Li, Karl Friston, Xi-Nian Zuo
2016 bioRxiv   pre-print
The association between in-scanner head motion and intrinsic functional connectivity (iFC) may confound explanations for individual differences in functional connectomics.  ...  After establishing that both head motion and default network iFC are moderately heritable, we found large genetic correlations (-0.52 to -0.73) between head motion and the default network iFCs.  ...  Acknowledgments The authors thank the twins for their participating this study and thank Jie Zhang  ... 
doi:10.1101/087023 fatcat:r42rsgr75bbyvlwasjwuhrifwi

General Functional Connectivity: shared features of resting-state and task fMRI drive reliable individual differences in functional brain networks [article]

Maxwell L Elliott, Annchen R Knodt, M. Justin Kim, Tracy R Melzer, Ross Keenan, David Ireland, Sandhya Ramrakha, Richie Poulton, Avshalom Caspi, Terrie E Moffitt, Ahmad R Hariri
2018 bioRxiv   pre-print
Intrinsic connectivity, commonly measured using resting-state fMRI, has emerged as a fundamental feature of the brain.  ...  Here we present general functional connectivity (GFC) as a method for leveraging shared features across resting-state and task fMRI and demonstrate that GFC is substantially more reliable than intrinsic  ...  reliability of estimating individual 823 differences in the intrinsic architecture of functional networks.  ... 
doi:10.1101/330530 fatcat:drygm7p5xzhllopi6g6nq3dgla

Human functional connectivity: New tools, unresolved questions

R. L. Buckner
2010 Proceedings of the National Academy of Sciences of the United States of America  
The general strategy of functional connectivity is to determine the network of brain regions that show correlated activity fluctuations over time with the seed region (1).  ...  Estimating Properties of Brain Architecture from Connectivity Patterns The complex matrices of correlations between regions also provide insight into global properties of connectivity, such as whether  ... 
doi:10.1073/pnas.1005987107 pmid:20547869 pmcid:PMC2890705 fatcat:mkbozjira5fsvgnbgwvt5227lq

Do more intelligent brains retain heightened plasticity for longer in development? A computational investigation

Michael S.C. Thomas
2016 Developmental Cognitive Neuroscience  
Twin studies indicate that the heritability of general cognitive ability - the genetic contribution to individual differences - increases with age.  ...  These methods utilized population-based artificial neural network models of cognitive development.  ...  grant from the Wellcome Trust and the Education Endowment Foundation to the University of London Centre for Educational Neuroscience.  ... 
doi:10.1016/j.dcn.2016.04.002 pmid:27261925 pmcid:PMC6988599 fatcat:mg5222ywyncdvaffmlzw6z6wre

Connectomic Intermediate Phenotypes for Psychiatric Disorders

Alex Fornito, Edward T. Bullmore
2012 Frontiers in Psychiatry  
they are disorders of brain connectivity.The recent proliferation of new MRI techniques for comprehensively mapping the entire connectivity architecture of the brain, termed the human connectome, has  ...  In this article, we review research using these connectomic techniques to understand how genetic variation influences the connectivity and topology of human brain networks.  ...  We examined the heritability of cost-efficient properties of functional brain network topology using resting-state fMRI in healthy twins (Fornito et al., 2011b) .  ... 
doi:10.3389/fpsyt.2012.00032 pmid:22529823 pmcid:PMC3329878 fatcat:vnbbf6p2qjgfxizmgfj2bsvtdm

Graph-based network analysis of resting-state functional MRI

Jinhui Wang
2010 Frontiers in Systems Neuroscience  
The properties of both the intraand inter-regional connectivity of resting-state brain activity have been well documented, promoting our understanding of the brain as a complex network.  ...  insights into the understanding of the underlying physiological mechanisms of brain function.  ...  developmental principle for intrinsic functional brain architecture.  ... 
doi:10.3389/fnsys.2010.00016 pmid:20589099 pmcid:PMC2893007 fatcat:iqwisy6vindatgzaetzcjvn3fu

Dynamic changes in brain lateralization correlate with human cognitive performance

Xinran Wu, Xiangzhen Kong, Deniz Vatansever, Zhaowen Liu, Kai Zhang, Barbara J. Sahakian, Trevor W. Robbins, Jianfeng Feng, Paul Thompson, Jie Zhang, Matthew F. S. Rushworth
2022 PLoS Biology  
Finally, the laterality dynamics are associated with functional connectivity changes of higher-order brain networks and correlate with regional metabolism and structural connectivity.  ...  Integrating dynamic network approaches with the concept of hemispheric laterality, we map the spatiotemporal architecture of whole-brain lateralization in a large sample of high-quality resting-state fMRI  ...  Dynamic architecture of whole-brain functional lateralization. (a) MLI, i.e., time average of DLI. (b) LFs, i.e., standard deviation of laterality time series.  ... 
doi:10.1371/journal.pbio.3001560 pmid:35298460 pmcid:PMC8929635 fatcat:paohmepvfnehvciuaxobd63yye
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