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Heritability of fractional anisotropy in human white matter: A comparison of Human Connectome Project and ENIGMA-DTI data

Peter Kochunov, Neda Jahanshad, Daniel Marcus, Anderson Winkler, Emma Sprooten, Thomas E. Nichols, Susan N. Wright, L. Elliot Hong, Binish Patel, Timothy Behrens, Saad Jbabdi, Jesper Andersson (+41 others)
2015 NeuroImage  
We calculated the heritability of the fractional anisotropy (FA) measure derived from diffusion tensor imaging (DTI) reconstruction in 481 HCP subjects (194/287 M/F) consisting of 57/60 pairs of mono-and  ...  The NIH-funded Human Connectome Project (HCP) is providing data valuable for analyzing the degree of genetic influence underlying brain connectivity revealed by state-of-the-art neuroimaging methods.  ...  analyzed DTI data from the Human Connectome Project (HCP) .  ... 
doi:10.1016/j.neuroimage.2015.02.050 pmid:25747917 pmcid:PMC4387079 fatcat:s4lpvm3wozd27fdqjc36aewfoe

The common genetic influence over processing speed and white matter microstructure: Evidence from the Old Order Amish and Human Connectome Projects

Peter Kochunov, Paul M. Thompson, Anderson Winkler, Mary Morrissey, Mao Fu, Thomas R. Coyle, Xiaoming Du, Florian Muellerklein, Anya Savransky, Christopher Gaudiot, Hemalatha Sampath, George Eskandar (+8 others)
2016 NeuroImage  
Discovery analyses were performed in 146 individuals from large Old Order Amish (OOA) families and findings were replicated in 485 twins and siblings of the Human Connectome Project (HCP).  ...  To understand genetic influences on processing speed and white matter FA, we assessed processing speed and diffusion imaging fractional anisotropy (FA) in related individuals from two populations.  ...  This work was supported in part by a Consortium grant (U54 EB020403) from the NIH Institutes contributing to the Big Data to Knowledge (BD2K) Initiative.  ... 
doi:10.1016/j.neuroimage.2015.10.050 pmid:26499807 pmcid:PMC4691385 fatcat:jdf424leijdmpnjfzc5heos46u

The comprehensive genetic architecture of brain white matter [article]

Bingxin Zhao, Tengfei Li, Yue Yang, Xifeng Wang, Tianyou Luo, Yue Shan, Ziliang Zhu, Di Xiong, Yun Li, Jason L Stein, Hongtu Zhu
2020 bioRxiv   pre-print
In summary, this large-scale tract-specific study provides a big step forward in understanding the genetics of white matter and its genetic links to other complex traits.  ...  White matter keeps human brain globally connected and shapes communication and connectivity patterns among brain regions.  ...  Heritability of fractional anisotropy in human white matter: a 25 comparison of Human Connectome Project and ENIGMA-DTI data. Neuroimage 26 111, 300-311 (2015). 27 25. Zhao, B. et al.  ... 
doi:10.1101/2020.05.23.112409 fatcat:fc5dp3rjivcspdppaqkcwov5p4

Node-Specific Heritability in the Mouse Connectome [article]

Nian Wang, Robert J Anderson, David G Ashbrook, Vivek Gopalakrishnan, Youngser Park, Carey E Priebe, Yi Qi, Joshua T Vogelstein, Robert W Williams, G. Allan Johnson
2019 bioRxiv   pre-print
We report whole brain diffusion connectomes of four strains of mice (C57BL/6J, DBA/2J, CAST/EiJ, and BTBR)at spatial resolution 20,000 times higher than the human connectome.  ...  We derived volumes and scalardiffusionmetricsfor 322 regions of the brain.Volume was the most heritable traitfollowed by FA,RD, and AD.  ...  ACKNOWLEDGEMENTS We are grateful to Gary Cofer, James Cook, and Lucy Upchurch for invaluable technical assistance. We thank Tatiana Johnson for special care in manuscript preparation and submission.  ... 
doi:10.1101/701755 fatcat:pmo7u4ias5h3hnntkx6dpcagoe

Homogenizing Estimates of Heritability Among SOLAR-Eclipse, OpenMx, APACE, and FPHI Software Packages in Neuroimaging Data

Peter Kochunov, Binish Patel, Habib Ganjgahi, Brian Donohue, Meghann Ryan, Elliot L. Hong, Xu Chen, Bhim Adhikari, Neda Jahanshad, Paul M. Thompson, Dennis Van't Ent, Anouk den Braber (+9 others)
2019 Frontiers in Neuroinformatics  
We performed this evaluation in a simulated twin-sibling pedigree and phenotypes and in diffusion tensor imaging (DTI) data from three twin-sibling cohorts, the human connectome project (HCP), netherlands  ...  twin register (NTR) and BrainSCALE projects provided as a part of the enhancing neuro imaging genetics analysis (ENIGMA) consortium.  ...  We performed this evaluation in a simulated twin-sibling pedigree and phenotypes and in diffusion tensor imaging (DTI) data from three twin-sibling cohorts, the human connectome project (HCP), netherlands  ... 
doi:10.3389/fninf.2019.00016 pmid:30914942 pmcid:PMC6422938 fatcat:zo5ci45nwra7jcwcvthim5xury

Large-scale neuroimaging and genetic study reveals genetic architecture of brain white matter microstructure [article]

Bingxin Zhao, Jingwen Zhang, Joseph Ibrahim, Rebecca Santelli, Yun Li, Tengfei Li, Yue Shan, Ziliang Zhu, Fan Zhou, Huiling Liao, Thomas Nichols, Hongtu Zhu
2018 bioRxiv   pre-print
Here, we analyzed the genetic architecture of WM tracts using DTI and single-nucleotide polymorphism (SNP) data of unrelated individuals in the UK Biobank (n ~ 8000).  ...  The DTI parameters were generated using the ENIGMA-DTI pipeline. We found that DTI parameters are substantially heritable on most WM tracts.  ...  Heritability of fractional anisotropy in human white matter: a comparison of Human Connectome Project and ENIGMA-DTI data. Neuroimage. 2015;111:300-11. 24.  ... 
doi:10.1101/288555 fatcat:viianp24kjhaxd6ouwvl7sjn6u

Variability and Heritability of Mouse Brain Structure: Microscopic MRI Atlases and Connectomes for Diverse Strains

Nian Wang, Robert J Anderson, David G Ashbrook, Vivek Gopalakrishnan, Youngser Park, Carey E Priebe, Yi Qi, Rick Laoprasert, Joshua T Vogelstein, Robert W Williams, G Allan Johnson
2020 NeuroImage  
We measured narrow sense heritability (h2) I.e. the fraction of variance explained by strains in a simple ANOVA model for volumes and scalar diffusion metrics, and estimates of residual technical error  ...  Microscopic whole brain MRI/DTI has allowed us to identify significant heritable phenotypes in brain volume, scalar DTI metrics, and quantitative connectomes.  ...  Acknowledgments NW acquired the MR data, generated the DTI images and connectomes and produced many of the figures. He assisted in preparation of the manuscript.  ... 
doi:10.1016/j.neuroimage.2020.117274 pmid:32818613 pmcid:PMC8442986 fatcat:cdmz45yj5neo7jhc2zxnvmdtki

Diffusion Imaging, White Matter, and Psychopathology

Moriah E. Thomason, Paul M. Thompson
2011 Annual Review of Clinical Psychology  
Rapid advances in diffusion tensor imaging (DTI) have led to substantial insights into human brain development and disease processes and have thrust white matter into the focus of researchers and clinicians  ...  Here we review brain changes that have been studied with DTI over the human lifespan and findings in a variety of neuropsychiatric disorders.  ...  human connectome.  ... 
doi:10.1146/annurev-clinpsy-032210-104507 pmid:21219189 fatcat:no57jfghrbf5jer23t6uep27we

Genetics of the connectome

Paul M. Thompson, Tian Ge, David C. Glahn, Neda Jahanshad, Thomas E. Nichols
2013 NeuroImage  
Here we review a variety of genetic analysis methods--such as genome-wide association studies (GWAS), linkage and candidate gene studies--that have been fruitfully adapted to imaging data to implicate  ...  Connectome-wide genome-wide scans have also been conducted, and we review the multivariate methods required to handle the extremely high dimension of the genomic and network data.  ...  Acknowledgments P.M.T. is supported, in part, by NIH R01 grants NS080655, MH097268, AG040060, EB008432, MH089722, HD050735 and P41 EB015922.  ... 
doi:10.1016/j.neuroimage.2013.05.013 pmid:23707675 pmcid:PMC3905600 fatcat:dv26qigaovc4vdpm6jkealvoly

White matter integrity in young medication-naïve bipolar II depressed adults

Arthur Dun Ping Mak, Owen Ngo Wang Leung, Idy Wing Yi Chou, Sheila Lok Yiu Wong, Winnie Chiu-wing Chu, David Yeung, Suzanne Ho-wai So, Suk Ling Ma, Linda Chiu Wah Lam, Chi Ming Leung, Sing Lee
2021 Scientific Reports  
BPII showed no increased WM disruptions vs UD or HC in any of the 15 a priori WM tracts.  ...  AbstractIt is unknown if young medication-naïve bipolar II (BPII) depressed patients have increased white matter (WM) disruptions. 27 each of young (average 23 years) and treatment-naïve BPII depressed  ...  The imaging and DTI processing approaches adopted in our study may have shortcomings compared to those used in the Human Connectome Project (HCP).  ... 
doi:10.1038/s41598-021-81355-9 pmid:33469064 fatcat:gagqxjtq4rgavpn4ezcrjxtbpy

Altered White Matter Microstructural Organization in Post-Traumatic Stress Disorder across 3,049 Adults: Results from the PGC-ENIGMA PTSD Consortium [article]

Emily Dennis, Seth E Disner, Negar Fani, Lauren E Salminen, Mark Logue, Emily K Clarke-Rubright, Courtney C Haswell, Christopher Averill, Lee A Baugh, Jessica Bomyea, Steven E Bruce, Jiook Cha (+95 others)
2019 bioRxiv   pre-print
between PTSD and disrupted white matter organization measured by lower fractional anisotropy (FA) in the tapetum region of the corpus callosum (Cohens d=-0.12, p=0.0021).  ...  A growing number of studies have examined alterations in white matter organization in people with posttraumatic stress disorder (PTSD) using diffusion MRI (dMRI), but the results have been mixed, which  ...  Multi-site genetic analysis of diffusion images and voxelwise heritability analysis: A pilot project of the ENIGMA-DTI working group.  ... 
doi:10.1101/677153 fatcat:3uzwtu6zwrforacronrlofa35i

The ENIGMA Consortium: large-scale collaborative analyses of neuroimaging and genetic data

Paul M. Thompson, Jason L. Stein, Sarah E. Medland, Derrek P. Hibar, Alejandro Arias Vasquez, Miguel E. Renteria, Roberto Toro, Neda Jahanshad, Gunter Schumann, Barbara Franke, Margaret J. Wright, Nicholas G. Martin (+277 others)
2014 Brain Imaging and Behavior  
Penke et al. (2010) showed strong correlations among measures of DTI-derived fractional anisotropy (FA) from a range of major white matter tracts in the Lothian Birth Cohort 1936 (LBC1936), a group of  ...  Continuing work is exploring genetic associations with subcortical volumes (ENIGMA2) and white matter microstructure (ENIGMA-DTI).  ... 
doi:10.1007/s11682-013-9269-5 pmid:24399358 pmcid:PMC4008818 fatcat:ujnpcizkpfdaxg6egpb43sskai

Female-specific association of NOS1 genotype with white matter microstructure in ADHD patients and controls

Hanneke van Ewijk, Janita Bralten, Esther D.A. van Duin, Marina Hakobjan, Jan K. Buitelaar, Dirk J. Heslenfeld, Pieter J. Hoekstra, Catharina Hartman, Martine Hoogman, Jaap Oosterlaan, Barbara Franke
2017 Journal of Child Psychology and Psychiatry and Allied Disciplines  
NOS1 plays an important role in neurite outgrowth and may thus influence brain development, specifically white matter (WM) microstructure, which is known to be altered in ADHD.  ...  Conclusions-NOS1-ex1f VNTR is associated with WM microstructure in females in a large sample of participants with ADHD and healthy controls.  ...  The authors thank all families that participated in this study and all researchers who collected the data.  ... 
doi:10.1111/jcpp.12742 pmid:28589541 pmcid:PMC5513773 fatcat:ebmsixnnx5eunpnc5govwhcoxa

Multimodal neuroimaging of male and female brain structure in health and disease across the life span

Neda Jahanshad, Paul M. Thompson
2016 Journal of Neuroscience Research  
In a large population study of healthy adults, using high-resolution diffusion MRI from the Human Connectome Project, Kochunov et al. (2015) determined the proportion of variance in FA that is explainable  ...  Analyzing data from 128 individuals scanned up to five times annually, Simmonds et al. found that in general, female-as measured with DTI-matures primarily during adolescence, while the white matter microstructure  ...  CONFLICT OF INTEREST STATEMENT The authors have no conflicts of interests to declare. ROLE OF AUTHORS NJ and PT jointly wrote this review.  ... 
doi:10.1002/jnr.23919 pmid:27870421 pmcid:PMC5119539 fatcat:jp7fc7xy4rdddnspb5bs24dp6a

ENIGMA and Global Neuroscience: A Decade of Large-Scale Studies of the Brain in Health and Disease Across More Than 40 Countries

Paul Thompson
2020 Biological Psychiatry  
the human brain in health and disease.  ...  This review summarizes the last decade of work by the ENIGMA (Enhancing NeuroImaging Genetics through Meta Analysis) Consortium, a global alliance of over 1400 scientists across 43 countries, studying  ...  A full list of ENIGMA Consortium current and past members can be found here http://enigma.ini.usc.edu/ongoing/members/. Conflict of interest  ... 
doi:10.1016/j.biopsych.2020.02.167 fatcat:rcamgpjlcvfgzikfleqbunef3u
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