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Heritability of brain volume change and its relation to intelligence

Rachel M. Brouwer, Anna M. Hedman, Neeltje E.M. van Haren, Hugo G. Schnack, Rachel G.H. Brans, Dirk J.A. Smit, Rene S. Kahn, Dorret I. Boomsma, Hilleke E. Hulshoff Pol
2014 NeuroImage  
An association between IQ (available for 91 participants) and brain volume change was observed, which was attributed to genes involved in both the variation in change in brain volume and in intelligence  ...  We address the question whether longitudinal changes in brain volume or in surface area in young adults are under genetic control and whether these changes are also related to general cognitive functioning  ...  Moreover, brain volume changes in the young adult brain are positively related to intelligence and this association is mediated through genes common to both intelligence and brain volume change.  ... 
doi:10.1016/j.neuroimage.2014.04.072 pmid:24816534 fatcat:my2a55mr5ffthddtdprrb4k4qa

Genetic influences on human brain structure: A review of brain imaging studies in twins

Jiska S. Peper, Rachel M. Brouwer, Dorret I. Boomsma, René S. Kahn, Hilleke E. Hulshoff Pol
2007 Human Brain Mapping  
Estimates of genetic and environmental influences on age-related changes in brain structure in children and adults await further longitudinal twin-studies.  ...  The high heritability for (global) brain volumes, including the intracranium, total brain, cerebral gray, and white matter, seems to be present throughout life.  ...  In adulthood, brain volume continues to change.  ... 
doi:10.1002/hbm.20398 pmid:17415783 fatcat:5ij6onn35ndjfbcqy7t45vcpmu

Brain Plasticity and Intellectual Ability Are Influenced by Shared Genes

R. G. H. Brans, R. S. Kahn, H. G. Schnack, G. C. M. van Baal, D. Posthuma, N. E. M. van Haren, C. Lepage, J. P. Lerch, D. L. Collins, A. C. Evans, D. I. Boomsma, H. E. Hulshoff Pol
2010 Journal of Neuroscience  
to be heritable and partly related to cognitive ability.  ...  Thus, not only does the brain continue to change well into adulthood, these changes are functionally relevant because they are related to intelligence.  ...  influences on brain volume and brain volume change.  ... 
doi:10.1523/jneurosci.5841-09.2010 pmid:20410105 pmcid:PMC6632359 fatcat:dvzn4xk6xfa3zdncmfq3keqv3q


Arthur W. Toga, Paul M. Thompson
2005 Annual Review of Neuroscience  
A variety of sophisticated brain-mapping approaches relating genetic influences on brain structure and intelligence establishes a regional distribution for this relationship that is consistent with behavioral  ...  Genetic influences on brain morphology and IQ are well studied.  ...  grant and the International Consortium for Brain Mapping, funded by the National Institute of Mental Health and the National Institute on Drug Abuse (P20 MH/DA52176).  ... 
doi:10.1146/annurev.neuro.28.061604.135655 pmid:15651931 fatcat:6dct5ykmijb57jso5zq2xop774

The evolution of human intelligence and the coefficient of additive genetic variance in human brain size

Geoffrey F. Miller, Lars Penke
2007 Intelligence  
However, adult human intelligence remains highly heritable, and is genetically correlated with brain size.  ...  This result is hard to reconcile with most current theories of human mental evolution, which emphasize directional (more-is-better) selection for higher intelligence and larger brains.  ...  Acknowledgements For helpful guidance and feedback, thanks to Rosalind Arden, Steve Gangestad, Linda Gottfredson, Keith Hunley, Earl Hunt, Osbjorn Pearson, Phil Rushton, Randy Thornhill, Ron Yeo, and an  ... 
doi:10.1016/j.intell.2006.08.008 fatcat:kyj3nbwqvvgfznkzhkxptws2uy

Neurobiology of intelligence: Health implications?

Jeremy R Gray, Paul M Thompson
2004 Discovery Medicine  
These exciting scientific advances encourage renewed responsiveness to the social and ethical dimensions of such research, including its health-relevance.  ...  Variations in intelligence and brain structure are heritable, but are also influenced by factors such as education, family environment, and environmental hazards.  ...  Acknowledgments The preparation of this article was supported in part by research grants from the National Institute of Mental Health (MH66088 to J. R.  ... 
pmid:20704978 fatcat:i4kki7qjgrbpxnqxj5h3xw4fra

Genetic variation, brain, and intelligence differences

Ian J. Deary, Simon R. Cox, W. David Hill
2021 Molecular Psychiatry  
We summarise regional brain imaging associations with intelligence and interpret these with respect to theoretical accounts.  ...  Here, we summarise and critique the last 10 years or so of molecular genetic (DNA-based) research on intelligence, including the discovery of genetic loci associated with intelligence, DNA-based heritability  ...  Having larger volumes of brain (and tissues therein) appears to be relatively strongly related to having greater numbers of neurons [107] .  ... 
doi:10.1038/s41380-021-01027-y pmid:33531661 pmcid:PMC8960418 fatcat:h2hzx6lal5ai3gsndvokusngny

Brain SCALE: Brain Structure and Cognition: an Adolescent Longitudinal Twin Study into the Genetic Etiology of Individual Differences

Inge L. C. van Soelen, Rachel M. Brouwer, Jiska S. Peper, Marieke van Leeuwen, Marinka M. G. Koenis, Toos C. E. M. van Beijsterveldt, Suzanne C. Swagerman, René S. Kahn, Hilleke E. Hulshoff Pol, Dorret I. Boomsma
2012 Twin Research and Human Genetics  
Twin studies are of great value to explore to what extent genetic and environmental factors explain individual differences in brain development and cognition.  ...  From childhood into adolescence, the child's brain undergoes considerable changes in both structure and function.  ...  Acknowledgments and Funding We would like to thank all the participants for making this study possible.  ... 
doi:10.1017/thg.2012.4 pmid:22856378 fatcat:lyjkirabuzbavaq3pm355ehesm

Genetic Architecture of Grey Matter - A Review

Naz Fathima Raj Mohamed, Yuvaraj Babu K
2020 International Journal of Research in Pharmaceutical Sciences  
The present review is to document the deeper understanding of the genetic architecture of grey matter obtained from reliable sources of information which are associated with grey matter density and volume  ...  The literature search on genetic architecture was carried out for papers published by google scholar and PubMed with the intention of retrieving all original reports that were relevant to it.  ...  Grey matter density and volume link with higher standards of intelligent scores developed with age in healthy children for intelligent scores.  ... 
doi:10.26452/ijrps.v11ispl3.2929 fatcat:sfqhapytsnfodev2hjyg74mtaa

The obese brain as a heritable phenotype: a combined morphometry and twin study

C M Weise, P Piaggi, M Reinhardt, K Chen, C R Savage, J Krakoff, B Pleger
2016 International Journal of Obesity  
Background-Body weight and adiposity are heritable traits. To date it remains unknown whether obesity-associated brain structural alterations are under a similar level of genetic control.  ...  Twin data were analyzed by applying the additive genetic, common environmental and residual effects (ACE) model to determine heritability of brain regions that were associated with BMI.  ...  It is possible that at least some regional brain volume differences reflect central endophenotypes leading to unhealthy eating and excess adiposity.  ... 
doi:10.1038/ijo.2016.222 pmid:27916985 pmcid:PMC5402354 fatcat:oo2urm4jxvfrbegcpjlu6e6k7q

Genes contributing to subcortical volumes and intellectual ability implicate the thalamus

Marc M. Bohlken, Rachel M. Brouwer, René C.W. Mandl, Neeltje E.M. van Haren, Rachel G.H. Brans, G. Caroline M. van Baal, Eco J.C. de Geus, Dorret I. Boomsma, René S. Kahn, Hilleke E. Hulshoff Pol
2013 Human Brain Mapping  
It has been shown that brain volume and general intellectual ability are to a significant extent influenced by the same genetic factors.  ...  This genetic factor is also implicated in cerebral brain volume. The thalamus, with its widespread cortical connections, may thus play a key role in human intelligence.  ...  INTRODUCTION Understanding the relative influences of genes and environment on differences in human brain structure is of key importance for understanding the dynamics of brain devel-opment and its relation  ... 
doi:10.1002/hbm.22356 pmid:24038793 fatcat:pd2n3mkyivhv7ooqvmzinzrue4

Genes, Evolution and Intelligence

Thomas J. Bouchard
2014 Behavior Genetics  
A review of a large body of evidence demonstrates that there is a g factor in a wide range of species and that, in the species studied, it relates to brain size and is heritable.  ...  I briefly discuss the evidence regarding the relationship of brain size to intelligence.  ...  Energetics: the expensive tissue hypothesis Apart from its possible relation to intelligence the evolution of the brain is of interest because of its energetics.  ... 
doi:10.1007/s10519-014-9646-x pmid:24604063 fatcat:7ywlstxkqbg7hoc7zxtpk5cgxm

A genetic analysis of brain volumes and IQ in children

Marieke van Leeuwen, Jiska S. Peper, Stéphanie M. van den Berg, Rachel M. Brouwer, Hilleke E. Hulshoff Pol, René S. Kahn, Dorret I. Boomsma
2009 Intelligence  
The relation between brain volume and intelligence was entirely explained by a common set of genes influencing both sets of phenotypes. Crown  ...  Phenotypic correlations between the brain volumes and intelligence traits ranged between .20 and .33. Processing speed and brain volume did not correlate.  ...  Acknowledgements We would like to acknowledge the following grants: Quantitative genetic modeling of variation in cognitive brain maturation (NWO 051.02.060, 668.772); Spinozapremie (NWO/SPI 56-464-14192  ... 
doi:10.1016/j.intell.2008.10.005 fatcat:ki7bpxo5nfb4vbzkh5jpwgx64q

Intelligence and brain size in 100 postmortem brains: sex, lateralization and age factors

S. F. Witelson, H. Beresh, D. L. Kigar
2005 Brain  
The study of intelligence in relation to postmortem cerebral volume is not available to date.  ...  Numerous studies relating measures of brain size such as brain weight, head circumference, CT or MRI brain volume to different intelligence test measures, with variously defined samples of subjects have  ...  We are indebted to the patients and their families for their contribution and to the oncologists, pathologists, medical and nursing staff and administrators of McMaster University and Hamilton Health Sciences  ... 
doi:10.1093/brain/awh696 pmid:16339797 fatcat:hmnscshmfrdbtkgimehhdjulpy

Genetics of intelligence

Ian J Deary, Frank M Spinath, Timothy C Bates
2006 European Journal of Human Genetics  
Special mention is also made of multivariate studies that examine the genetic correlation between intelligence test scores and their correlates such as processing speed, birth weight and brain size.  ...  This article provides an overview of the biometric and molecular genetic studies of human psychometric intelligence.  ...  Acknowledgements Ian J Deary is the recipient of a Royal Society-Wolfson Research Merit Award.  ... 
doi:10.1038/sj.ejhg.5201588 pmid:16721405 fatcat:yzuj3d4mibbovl4ojrsrgydyku
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