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Heritability and reliability of automatically segmented human hippocampal formation subregions

Christopher D. Whelan, Derrek P. Hibar, Laura S. van Velzen, Anthony S. Zannas, Tania Carrillo-Roa, Katie McMahon, Gautam Prasad, Sinéad Kelly, Joshua Faskowitz, Greig deZubiracay, Juan E. Iglesias, Theo G.M. van Erp (+7 others)
2016 NeuroImage  
The human hippocampal formation can be divided into a set of cytoarchitecturally and functionally distinct subregions, involved in different aspects of memory formation.  ...  Our findings indicate that eleven of the twelve human hippocampal subregions segmented using FreeSurfer version 6.0 may serve as reliable and informative quantitative phenotypes for future multi-site imaging  ...  Data collection and sharing for this project was funded in part by the Alzheimer's Disease Neuroimaging Initiative (ADNI) (National Institutes of Health Grant U01 AG024904) and DOD ADNI (Department of  ... 
doi:10.1016/j.neuroimage.2015.12.039 pmid:26747746 pmcid:PMC4883013 fatcat:wnldqatrujcxxnmyswtxowfgpi

Hair cortisol concentrations are associated with hippocampal subregional volumes in children

Attila Keresztes, Laurel Raffington, Andrew R. Bender, Katharina Bögl, Christine Heim, Yee Lee Shing
2020 Scientific Reports  
In 84 children (age range: 6-7 years), we assessed whether volumes of hippocampal subregions were related to cumulative glucocorticoid levels (hair cortisol), parenting stress, and performance on memory  ...  Parenting stress did not significantly correlate with hair cortisol, and there was no evidence to suggest that individual differences in hippocampal subregional volumes manifest in memory performance.  ...  Acknowledgements We thank all members of the Jacobs study team for their vital contribution, and all participants and family members for taking part in the study.  ... 
doi:10.1038/s41598-020-61131-x pmid:32184428 fatcat:ehruqqmymnazpbpznn3cszxhra

Multimodal Parcellations and Extensive Behavioral Profiling Tackling the Hippocampus Gradient

Anna Plachti, Simon B Eickhoff, Felix Hoffstaedter, Kaustubh R Patil, Angela R Laird, Peter T Fox, Katrin Amunts, Sarah Genon
2019 Cerebral Cortex  
supporting the role of the hippocampus in the construction of abstract representations for spatial navigation and episodic memory.  ...  of the hippocampus.  ...  Notes The authors also thank Dr Nicola Palomero-Gallagher and Shahrzad Kharabian for fruitful discussions. Conflict of Interest: None declared.  ... 
doi:10.1093/cercor/bhy336 pmid:30721944 fatcat:6d4egnatybbufayhinlwjhnzru

Why looking at the whole hippocampus is not enough—a critical role for anteroposterior axis, subfield and activation analyses to enhance predictive value of hippocampal changes for Alzheimer's disease diagnosis

Aleksandra Maruszak, Sandrine Thuret
2014 Frontiers in Cellular Neuroscience  
Finally, we indicate that apart from hippocampal subfield volumetry, the characteristic pattern of hippocampal hyperactivation associated with seizures and neurogenesis changes is another promising candidate  ...  Our review presents how changes in hippocampal volume, shape, symmetry and activation are reflected by cognitive impairment and how they are linked with neurogenesis alterations.  ...  The intermediate subregion in humans is often not distinguished (Poppenk et al., 2013) .  ... 
doi:10.3389/fncel.2014.00095 pmid:24744700 pmcid:PMC3978283 fatcat:noschig2fbbfxjtkplnycbdzca

MRI Asymmetry Index of Hippocampal Subfields Increases Through the Continuum From the Mild Cognitive Impairment to the Alzheimer's Disease

Alessia Sarica, Roberta Vasta, Fabiana Novellino, Maria Grazia Vaccaro, Antonio Cerasa, Aldo Quattrone
2018 Frontiers in Neuroscience  
Hippocampal Subfields Asymmetry in MCI and AD Conclusions: Our findings showed that hippocampal subfields AI varies differently among the four groups HC, sMCI, pMCI, and AD.  ...  Thus, aim of the present work was to evaluate the Asymmetry Index (AI) of hippocampal substructures as possible MRI biomarkers of Dementia.  ...  However, despite the novelty of this approach, the high heritability and reliability of the automatic segmentation of the hippocampal formation subregions by Freesurfer 6.0 was demonstrated by Whelan  ... 
doi:10.3389/fnins.2018.00576 pmid:30186103 pmcid:PMC6111896 fatcat:bbn35sshwbgytfr4vnfige726i

Recent Advances in Imaging Alzheimer's Disease

Meredith N. Braskie, Arthur W. Toga, Paul M. Thompson, George Perry, Xiongwei Zhu, Mark A. Smith, Aaron Sorensen, Jesús Avila
2012 Journal of Alzheimer's Disease  
, manual segmentation of these structures is 202 time-consuming and is a limiting factor when a large 203 study sample size is needed to obtain reliable results. 204 Methods for fully automatic segmentation  ...  In one study, 143 the relationship between amyloid load and episodic 144 memory was mediated by hippocampal volume [32]. 145 Higher levels of [ 11 C]PIB signal in the brain are 146 heritable [33], associated  ...  This 228 method has been extended to segment hippocampi of 229 large numbers of AD and MCI patients automatically.  ... 
doi:10.3233/jad-2012-129016 pmid:22672880 pmcid:PMC4110110 fatcat:3wwvmj6wbrgrjebxkketx54x6a

GLIDE: GPU-Based Linear Regression for Detection of Epistasis

Tony Kam-Thong, Chloé-Agathe Azencott, Lawrence Cayton, Benno Pütz, André Altmann, Nazanin Karbalai, Philipp G. Sämann, Bernhard Schölkopf, Bertram Müller-Myhsok, Karsten M. Borgwardt
2012 Human Heredity  
Here, we present GLIDE, which maps phenotypes to pairs of genetic loci and systematically searches for the epistatic interactions expected to reveal part of this missing heritability.  ...  This enabled us to conduct a systematic two-locus mapping study on seven disease data sets from the Wellcome Trust Case Control Consortium and on in-house hippocampal volume data in 6 h per data set, while  ...  Support through the German Ministry for Education and Research Web Resources The URLs for data and software presented herein are as follows: GLIDE  ... 
doi:10.1159/000341885 pmid:22965145 fatcat:fxf6ergpqjgyha677xfda7t47m

Effects of memory training on cortical thickness in the elderly

Andreas Engvig, Anders M. Fjell, Lars T. Westlye, Torgeir Moberget, Øyvind Sundseth, Vivi Agnete Larsen, Kristine B. Walhovd
2010 NeuroImage  
Structural changes in cerebral grey and white matter were assessed using MRprotocols optimized for reliable longitudinal analysis.  ...  Regional left hippocampal volumes before training were found to predict memory-training benefit.  ...  Acknowledgements The authors acknowledge the Research Council of Norway for an operating grant to AMF and KBW (Grant number: 186092), and the Kavli Research Center for Aging and Dementia for salary support  ... 
doi:10.1016/j.neuroimage.2010.05.041 pmid:20580844 fatcat:pgo6wk3o5fglfpvfnegqoznica

2014 Update of the Alzheimer's Disease Neuroimaging Initiative: A review of papers published since its inception

Michael W. Weiner, Dallas P. Veitch, Paul S. Aisen, Laurel A. Beckett, Nigel J. Cairns, Jesse Cedarbaum, Robert C. Green, Danielle Harvey, Clifford R. Jack, William Jagust, Johan Luthman, John C. Morris (+7 others)
2015 Alzheimer's & Dementia  
and tracking of Alzheimer's disease (AD).  ...  fluid (CSF) biomarkers in a multicenter setting; (2) elucidation of the patterns and rates of change of imaging and CSF biomarker measurements in control subjects, MCI patients, and AD patients.  ...  Weiner has served on the scientific advisory boards for Lilly, Araclon and Institut Catala de Neurociencies Aplicades, Gulf War Veterans Illnesses Advisory Committee, VACO, Biogen Idec, and Pfizer; has  ... 
doi:10.1016/j.jalz.2014.11.001 pmid:26073027 pmcid:PMC5469297 fatcat:2k7ag6astffy5gphqxf5lodkdq

The Alzheimer's Disease Neuroimaging Initiative: A review of papers published since its inception

Michael W. Weiner, Dallas P. Veitch, Paul S. Aisen, Laurel A. Beckett, Nigel J. Cairns, Robert C. Green, Danielle Harvey, Clifford R. Jack, William Jagust, Enchi Liu, John C. Morris, Ronald C. Petersen (+7 others)
2012 Alzheimer's & Dementia  
Automatic image segmentation is prone to systematic errors, which are introduced when these mostly knowledge-based protocols mistranslate manual segmentation protocols into the automatic format.  ...  the human brain.  ... 
doi:10.1016/j.jalz.2011.09.172 pmid:22047634 pmcid:PMC3329969 fatcat:kkpjb6lv6zbe3lkv7nllgxdnga

The Alzheimer's Disease Neuroimaging Initiative: A review of papers published since its inception

Michael W. Weiner, Dallas P. Veitch, Paul S. Aisen, Laurel A. Beckett, Nigel J. Cairns, Robert C. Green, Danielle Harvey, Clifford R. Jack, William Jagust, Enchi Liu, John C. Morris, Ronald C. Petersen (+8 others)
2013 Alzheimer's & Dementia  
Automatic image segmentation is prone to systematic errors, which are introduced when these mostly knowledge-based protocols mistranslate manual segmentation protocols into the automatic format.  ...  the human brain.  ... 
doi:10.1016/j.jalz.2013.05.1769 pmid:23932184 pmcid:PMC4108198 fatcat:epydl5poq5evrobxws3qerdolu

The TWIN-E Project in Emotional Wellbeing: Study Protocol and Preliminary Heritability Results Across Four MRI and DTI Measures

Justine M. Gatt, Mayuresh S. Korgaonkar, Peter R. Schofield, Anthony Harris, C. Richard Clark, Karen L. Oakley, Kaushik Ram, Hope Michaelson, Sarsha Yap, Melinda Stanners, Vikki Wise, Leanne M. Williams
2012 Twin Research and Human Genetics  
the heritability, clinical plausibility, and reliability of each of these measures in a large adult twin cohort.  ...  Preliminary heritability results are provided for the first 50% of the MRI subgroup (n = 142) for the grey matter volume, thickness, and surface area measures, and white matter diffuse tensor imaging fractional  ...  The awarded study proposal was entitled 'Gene-brain pathways in emotional brain stability and instability' (full title), or 'The Emotional Wellbeing Project' (short form).  ... 
doi:10.1017/thg.2012.12 pmid:22856376 fatcat:acmn5wwctrd3rcqhau5l2nq5ym

Functional topography of the human entorhinal cortex

Tobias Navarro Schröder, Koen V Haak, Nestor I Zaragoza Jimenez, Christian F Beckmann, Christian F Doeller
2015 eLife  
Localising the human homologue of the rodent MEC and LEC has important implications for translating studies on the hippocampo-entorhinal memory system from rodents to humans.  ...  Despite extensive research on the role of the rodent medial and lateral entorhinal cortex (MEC/LEC) in spatial navigation, memory and related disease, their human homologues remain elusive.  ...  Backus for help with data analysis and creation of figures and J. Bellmund, S. Collin and B. Milivojevic for useful discussions and comments on earlier versions of the manuscript.  ... 
doi:10.7554/elife.06738 pmid:26052748 pmcid:PMC4458840 fatcat:6rjq4q7p7naadmgapx3c3ryvni

Multivariate genome-wide association study of rapid automatised naming and rapid alternating stimulus in Hispanic American and African–American youth

Dongnhu Thuy Truong, Andrew Kenneth Adams, Steven Paniagua, Jan C Frijters, Richard Boada, Dina E Hill, Maureen W Lovett, E Mark Mahone, Erik G Willcutt, Maryanne Wolf, John C Defries, Alessandro Gialluisi (+7 others)
2019 Journal of Medical Genetics  
BackgroundRapid automatised naming (RAN) and rapid alternating stimulus (RAS) are reliable predictors of reading disability. The underlying biology of reading disability is poorly understood.  ...  Chromatin contact maps of adult hippocampal tissue indicate a potential enhancer–promoter interaction regulating RNLS expression.  ...  We also thank Dr Mellissa DeMille, Dr andrew DeWan, Dr Jeffrey Malins, Dr chintan Mehta and Dr Hongyu Zhao for invaluable discussion and critical evaluation of this manuscript.  ... 
doi:10.1136/jmedgenet-2018-105874 pmid:30995994 pmcid:PMC6678051 fatcat:ro45b7x2yfesvjpdu5ni2ri7qm

The association of PTSD symptom severity with amygdala nuclei volumes in traumatized youths

Olga Therese Ousdal, Anne Marita Milde, Gertrud Sofie Hafstad, Erlend Hodneland, Grete Dyb, Alexander R. Craven, Annika Melinder, Tor Endestad, Kenneth Hugdahl
2020 Translational Psychiatry  
As such, investigations of amygdala total volume may not provide an adequate index of the association between amygdala and stress-related mental illness.  ...  The amygdala is a core component in neurobiological models of stress and stress-related pathologies, including post-traumatic stress disorder (PTSD).  ...  Acknowledgements This work was supported by the Western Norway Regional Health Authority (OTO #911780, #911813 and #912045) and the Norwegian Directorate of Health.  ... 
doi:10.1038/s41398-020-00974-4 pmid:32807799 fatcat:p5kvm6eyejdd5cfnsvecuniwna
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