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Height Resolution of Antibody Spots Measured by Spinning-Disk Interferometry on the BioCD
2016
Micromachines
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Spinning-disc interferometry (SDI) is a high-speed laser scanning approach to surface metrology that uses common-path interferometry to measure protein spots on a BioCD disk. ...
Based on high-resolution laser scanning images of printed antibody spots, we quantify the protein sensitivity as a function of the scan parameters. ...
Abbreviations The following abbreviations are used in this manuscript:
BioCD Biological compact disc APDMES Aminopropaldimethyl ethoxy silane PBS Phosphate buffered saline SDI Spinning disk interferometry ...
doi:10.3390/mi7020031
pmid:30407404
pmcid:PMC6190026
fatcat:iledxvmjerf5vkaf2mfjslu37q
Invited Review Article: Review of centrifugal microfluidic and bio-optical disks
2009
Review of Scientific Instruments
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The two main classes of spinning biodisks are microfluidic disks and bio-optical compact disks ͑BioCD͒. ...
BioCDs use spinning-disk interferometry, under the condition of common-path phase quadrature, to perform interferometric label-free detection of molecular recognition and binding. ...
ACKNOWLEDGMENTS This work was supported in part by Quadraspec, Inc., the Indiana Economic Development Corporation, and NIH NCI Grant No. R21CA125336. ...
doi:10.1063/1.3236681
pmid:19895047
pmcid:PMC2782362
fatcat:qj5ijrybjrd4rb52bqhzk3xwly
High-Speed Interferometric Detection of Label-Free Immunoassays on the Biological Compact Disc
2006
Clinical Chemistry
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Protein on the disc is scanned by a focused laser spot as the disc spins. ...
The binding of antigen or antibodies is detected directly, without labels, by a change in the interferometric intensity. ...
This work was performed through a sponsored research grant through the Purdue Research Foundation from QuadraSpec, Inc. ...
doi:10.1373/clinchem.2006.072793
pmid:16990417
fatcat:mz2gpqf5fvetfixw2vbf3dtyoy
Differential phase-contrast BioCD biosensor
2007
Applied Optics
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Common-path differential phase-contrast interferometry measures the spatial gradient of surface dipole density on a bio-optical compact disk (BioCD) and is sensitive to small changes in dipole density ...
The recognition molecules are antibody IgG proteins that are deposited in periodic patterns on the BioCD using soft lithography or photolithography on the silanized silica surfaces of dielectric mirrors ...
This work was supported by sponsored research from QuadraSpec, Inc., through the Purdue Research Foundation. ...
doi:10.1364/ao.46.006196
pmid:17712386
fatcat:z6qsf6ntw5fwdlsguvx6sf4nu4
Adaptive interferometry of protein on a BioCD
2007
Applied Optics
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Adaptive spinning-disk interferometry is capable of measuring surface profiles of a thin biolayer with subnanometer longitudinal resolution. ...
We performed biosensing of immobilized monolayers of antibodies on the disk in both transmission and reflection detection modes. ...
This work was supported by NSF grant ECS-0200424, and by research sponsored by QuadraSpec, Inc. through the Purdue Research Foundation. ...
doi:10.1364/ao.46.005384
pmid:17676154
fatcat:u24dliiumrd7tpkuvwgindzdju
Common-path interferometric detection of protein monolayer on the BioCD
2007
Applied Optics
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The bio-optical compact disk (BioCD) is an optical biosensor that performs common-path molecular interferometry of patterned proteins on a disk spinning at high speed. ...
The scaling mass sensitivity of the IL channel on oxide on silicon was measured to be 0.17 pg͞mm. ...
The radius of the focal spot is ϳ18 m on the disk. Higher resolution can be achieved by switching the 10 cm lens with a short focal-length lens. ...
doi:10.1364/ao.46.007836
pmid:17994133
fatcat:s6spbgzdorb7nbxrsllkchrt7i
Critical assessment of relevant methods in the field of biosensors with direct optical detection based on fibers and waveguides using plasmonic, resonance, and interference effects
2020
Analytical and Bioanalytical Chemistry
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Improvement of optics is only one way to increase the quality of biosensors. ...
by different companies. ...
Spinning disc The idea of backscattering by nanostructured surfaces was used for a new class of analytical sensors to detect immobilized biomolecules with high speed and high sensitivity by using a spinning-disc ...
doi:10.1007/s00216-020-02581-0
pmid:32313998
fatcat:qukey6tyhbbj3b4oykkbyzwzu4