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Harvard Aging Brain Study: Dataset and accessibility

Alexander Dagley, Molly LaPoint, Willem Huijbers, Trey Hedden, Donald G. McLaren, Jasmeer P. Chatwal, Kathryn V. Papp, Rebecca E. Amariglio, Deborah Blacker, Dorene M. Rentz, Keith A. Johnson, Reisa A. Sperling (+1 others)
2017 NeuroImage  
Harvard Aging Brain Study Methods Data Structure As a longitudinal project, the HABS dataset consists of multiple study visit dates each year, necessitating a temporal grouping scheme for storage and subsequent  ...  The Harvard Aging Brain Study Database The HABS data sharing system is designed specifically to make HABS data available to researchers from around the world.  ...  We thank all the collaborators and contributors to the Harvard Aging Brain Study (https://www.nmr.mgh.harvard.edu/lab/harvardagingbrain/aboutus).  ... 
doi:10.1016/j.neuroimage.2015.03.069 pmid:25843019 pmcid:PMC4592689 fatcat:oml76lriqrbbpebca7oyhjejtm

The Midlife in the United States (MIDUS) Series: A National Longitudinal Study of Health and Well-being

Barry T Radler
2014 Open Health Data  
More information on this project's restrictions and a data use agreement can be found in the Access Notes section of this webpage: http:// www.icpsr.umich.edu/icpsrweb/ICPSR/studies/22840 Accessibility  ...  clinic visit that collects biomarker data, and (4) affective neuroscience measures of brain images and functioning.  ... 
doi:10.5334/ohd.ai pmid:25558376 pmcid:PMC4280664 fatcat:mfigjz564rgy3jihv2rbklpdru

Czech Brain Aging Study (CBAS): prospective multicentre cohort study on risk and protective factors for dementia in the Czech Republic

Katerina Sheardova, Martin Vyhnalek, Zuzana Nedelska, Jan Laczo, Ross Andel, Rafal Marciniak, Jiri Cerman, Ondrej Lerch, Jakub Hort
2019 BMJ Open  
The Czech Brain Aging Study (CBAS) is the first large, prospective study to address these issues in Central/Eastern Europe by enrolling non-demented adults aged 55+ years, collecting a variety of personal  ...  Annual follow-ups include collection of socioeconomic, lifestyle and personal history information, neurology, neuropsychology, laboratory, vital sign and brain MRI data.  ...  Acknowledgements All of the Czech Brain Aging Study (CBAS) participants and their relatives are appreciated for their involvement in the project and their dedication.  ... 
doi:10.1136/bmjopen-2019-030379 pmid:31857299 pmcid:PMC6937049 fatcat:gtezlkwguvdqzhzgtx4yzmljxe

Maternal vitamin B12, folate during pregnancy and neurocognitive outcomes in young adults of the Pune Maternal Nutrition Study (PMNS) prospective birth cohort: study protocol

Rishikesh V Behere, Gopikrishna Deshpande, Souvik Kumar Bandyopadhyay, Chittaranjan Yajnik
2021 BMJ Open  
We now plan to assess neurocognitive function and MRI measurements of brain structural–functional connectivity at young adult age to study its association with maternal nutritional exposures during the  ...  We found an association between maternal B12 status in pregnancy and child's neurocognitive status at 9 years of age.  ...  of early life exposures with brain outcomes in adult age.  ... 
doi:10.1136/bmjopen-2020-046242 pmid:34551940 pmcid:PMC8461273 fatcat:xdwkf36xwjespcyi73hhl5nj7q

Preprocessing and Quality Control Strategies for Illumina DASL Assay-Based Brain Gene Expression Studies with Semi-Degraded Samples

Maggie L. Chow, Mary E. Winn, Hai-Ri Li, Craig April, Anthony Wynshaw-Boris, Jian-Bing Fan, Xiang-Dong Fu, Eric Courchesne, Nicholas J. Schork
2012 Frontiers in Genetics  
data, and corrects for batch effects can be applied to all studies, even those pursued with degraded samples.  ...  pipeline to accommodate and detect problems with microarray-based gene expression values obtained with degraded brain samples.  ...  -HD-4-3383, the Brain and Tissue Bank for Developmental Disorders (Miami, FL), Autism Tissue Program (Princeton, NJ) and Harvard Brain Tissue Resource Center (Belmont, MA).  ... 
doi:10.3389/fgene.2012.00011 pmid:22375143 pmcid:PMC3286152 fatcat:3dkgvx4k7jakfdl55dgdkirp5a

A Case for Critical Data Studies in Library and Information Studies

Tami Oliphant
2017 Journal of Critical Library and Information Studies  
, and present data along with the ability to code, derive insights from large datasets, navigate and structure large datasets, and to assist in data-driven decision-making. 11 However, the notion that  ...  The proliferation, ubiquity, and growth of data, big data, and digital infrastructure raise a number of questions for library and information studies (LIS) practitioners, researchers, and educators.  ...  54 An LIS perspective encompasses a broad exploration of issues related to providing access to data or information and contents of datasets (exclusion and inclusion), the embeddedness of data in information  ... 
doi:10.24242/jclis.v1i1.22 fatcat:tv4cfoejibbffci2dbqsztaibm

Maternal-fetal in vivo imaging: a combined PET and MRI study

Helene Benveniste, Joanna S Fowler, William D Rooney, Daryn H Moller, W Walter Backus, Donald A Warner, Pauline Carter, Payton King, Bruce Scharf, David A Alexoff, Yeming Ma, Paul Vaska (+4 others)
2003 Journal of Nuclear Medicine  
Though there are several in vitro and in vivo methods to examine this issue, all have limitations. Furthermore, ethical and safety considerations generally preclude such studies in pregnant humans.  ...  We present here a nonhuman primate animal model and the methodology for combining PET and MRI to identify fetal organs and to measure maternal and fetal isotope distribution using (18)F-FDG and a whole-body  ...  ACKNOWLEDGMENTS We thank David Schlyer and Michael Schueller for cyclotron operations; Richard Ferrieri, Colleen Shea, Victor Garza, and Youwen Xu for 18 F-FDG preparation; and Maryann Kershaw and Kerry  ... 
pmid:12960202 fatcat:sv3rf52n4rh6bgw5cx2bruyjkq

Survey Based Study: Classification of Patients with Alzheimer's Disease

Shaimaa A. Al-Majeed, Mohammed S. H. Al- Tamimi
2020 Iraqi Journal of Science  
Neuroimaging is a description, whether in two-dimensions (2D) or three-dimensions (3D), of the structure and functions of the brain.  ...  We explore the challenges of this field and evaluate the performance of these studies along with their negative aspects.  ...  The study downloaded an open-access database of 126 examples (28 DBs and 98 HCs) including a variety of imaging studies.  ... 
doi:10.24996/ijs.2020.61.11.31 fatcat:6aveka5crnb5vnijqia4d24dl4

Panel and Study Groups

2013 Neuropsychopharmacology  
Methods: We have studied over 238 normal human brains in both DLPFC and hippocampus ranging in age from week 14 in the fetus to 80 years of age, using Illumina microchip arrays, qRT-PCR and RNA Seq.  ...  We have had the opportunity to study both genetic variation and expression in genes in this pathway (GAD1, GAD2, SLC12A2 (NKCC1) and SLC12A5 (KCC2) across human brain development in hippocampus and dorsolateral  ...  Methods: We have studied over 238 normal human brains in both DLPFC and hippocampus ranging in age from week 14 in the fetus to 80 years of age, using Illumina microchip arrays, qRT-PCR and RNA Seq.  ... 
doi:10.1038/npp.2013.278 fatcat:expu2u3f3reypazj7tt7jhybfa

A comparative study on different segmentation and classification methods for the diagnosis of Alzheimer Disease

Pushpa B.R, Nayana.P.Kamal, Amal P.S
2019 International Journal of Research in Pharmaceutical Sciences  
Alzheimer Disease (AD) is one of the brain disorders which progressively expand over the years. It gradually harms the reasoning ability and memory of the affected person.  ...  A comparative analysis for the segmentation which comprises FCM and K-means clustering methods and classification of AD using SVM and CNN performed.  ...  Additionally, open Access Series of Imaging Studies (OASIS) data set are considered; it is a scienti ic community aimed to provide neuroimaging datasets to avail freely.  ... 
doi:10.26452/ijrps.v10i3.1422 fatcat:nzbixxrgqje33fayam5sw3xzmm

Link-Level Functional Connectivity Neuroalterations in Autism Spectrum Disorder: A Developmental Resting-State fMRI Study

Lluis Borràs-Ferrís, Úrsula Pérez-Ramírez, David Moratal
2019 Diagnostics  
We compared FC of individuals with ASD and healthy controls, matched by age and intelligence quotient (IQ), and split into three age groups (50 children, 98 adolescents, and 32 adults), from a developmental  ...  These results help to gain a better understanding of the involved regions on autism and its connection with the affected superior cognitive brain functions.  ...  Acknowledgments: We are thankful to the initiative ABIDE to provide the huge public release and open sharing autism database what has made possible to carry out this study in better conditions and improve  ... 
doi:10.3390/diagnostics9010032 pmid:30901848 pmcid:PMC6468479 fatcat:rxrjpwuc6fbbjledju62pgjp2m

Genome-Wide Association Studies Suggest Limited Immune Gene Enrichment in Schizophrenia Compared to 5 Autoimmune Diseases

Jennie G. Pouget, Vanessa F. Gonçalves, Sarah L. Spain, Hilary K. Finucane, Soumya Raychaudhuri, James L. Kennedy, Jo Knight
2016 Schizophrenia Bulletin  
Instead, there may be a role for pleiotropic effects of a small number of immune genes that also regulate brain development and plasticity.  ...  The major histocompatibility complex is consistently the most powerful region of association in genome-wide association studies (GWASs) of schizophrenia and has been interpreted as strong genetic evidence  ...  Slowikowski, BSc (Harvard University) and Harm-Jan Westra, PhD (Harvard University) for assistance with writing and troubleshooting scripts for the permutation analysis.  ... 
doi:10.1093/schbul/sbw059 pmid:27242348 pmcid:PMC4988748 fatcat:vetvvvebnjepba4mq6qhr4mstm

Association of body mass index in early adulthood and middle age with future site-specific cancer mortality: the Harvard Alumni Health Study

L. Gray, I-M. Lee, H. D. Sesso, G. D. Batty
2011 Annals of Oncology  
Design: In the Harvard Alumni Health Study cohort, 19 593 males had a physical examination at the university between 1914 and 1952 (mean age: 18.4 years) and returned a questionnaire in 1962 or 1966 (mean  ...  age = 45.1 years).  ...  methods study population The Harvard Alumni Health Study is an ongoing cohort study of chronic disease risk factors in male undergraduates at the Harvard University, Boston, USA who matriculated between  ... 
doi:10.1093/annonc/mdr270 pmid:21677311 pmcid:PMC3331729 fatcat:tcjztj5fcrferoea4xdgmtz6t4

Multimodal brain imaging study of 19,825 participants reveals adverse effects of moderate drinking [article]

Remi Daviet, Gökhan Aydogan, Kanchana Jagannathan, Nathaniel Spilka, Philipp Koellinger, Henry R Kranzler, Gideon Nave, Reagan Wetherill
2020 bioRxiv   pre-print
middle-aged and older adults from the UK Biobank.  ...  Here we examine the associations between alcohol intake and brain structure using structural, diffusion tensor, and neurite orientation dispersion and density imaging data from 19,825 generally healthy  ...  , age, age-squared, age-cubed, height, brain volume, the Townsend index of social deprivation measured at the zip code level 30 and handedness (right/left/ambidextrous; dummy-coded).  ... 
doi:10.1101/2020.03.27.011791 fatcat:5lev7ay2bbeutf6jw47g677mcu

Image Acquisition and Quality Assurance in the Boston Adolescent Neuroimaging of Depression and Anxiety Study

Viviana Siless, Nicholas A. Hubbard, Robert Jones, Jonathan Wang, Nicole Lo, Clemens C.C. Bauer, Mathias Goncalves, Isabelle Frosch, Daniel Norton, Genesis Vergara, Kristina Conroy, Flavia Vaz De Souza (+13 others)
2020 NeuroImage: Clinical  
We focused on an age range that is critical for brain development and for the onset of mental illness.  ...  We present a thorough overview of our imaging sequences, hardware, and scanning protocol. We detail similarities and differences between this study and other HCP studies.  ...  the collection and dissemination of standardized and open-access brain imaging data.  ... 
doi:10.1016/j.nicl.2020.102242 pmid:32339824 pmcid:PMC7184183 fatcat:gusvwk2xhrhinlvi2apzqpvbsa
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