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Sleep-Wake Neurochemistry
2018
Sleep Medicine Clinics
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Acknowledgements The authors' research has been supported by Swiss National Science Foundation, Zürich
Holst & Landolt Sleep-Wake Neurochemistry ...
-expressing cholinergic neurons of the BF during wakefulness also promotes arousal, whereas activation during NREM sleep leads to transition, at roughly equal amount, into wakefulness and REM sleep (Han ...
Holst & Landolt Sleep-Wake Neurochemistry 6 Interestingly, activation of BF GABA-ergic neurons substantially enhanced wakefulness. ...
doi:10.1016/j.jsmc.2018.03.002
pmid:29759265
fatcat:mtcgm7wf5jcexdt5r7ltfdyggq
Ionic control of sleep and wakefulness
2016
Science
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Brain electrical activity differs markedly between wakefulness and sleep. Concomitant shifts in the ion composition of brain extracellular fluids were thought to be a consequence rather than a cause of the sleep-wake-dependent changes in neuronal activity. On page 550 of this issue, Ding et al. ( 1 ) report the surprising observation that ionic changes in the extracellular fluid are a potent control of sleep-wake-dependent neuronal activity.
doi:10.1126/science.aaf8178
pmid:27126024
fatcat:jmwl3nc55vfgdhsqotdqc2gf7e
Sleep homeostasis: A role for adenosine in humans?
2008
Biochemical Pharmacology
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Data from Landolt et al. [82]. (B) 200 mg caffeine, administered 16 h prior to bedtime (n = 9). Data from Landolt et al. [83]. ...
Data from Landolt et al.
b i o c h e m i c a l p h a r m a c o l o g y 7 5 ( 2 0 0 8 ) 2 0 7 0 -2 0 7 9 ...
doi:10.1016/j.bcp.2008.02.024
pmid:18384754
fatcat:34ou2cnhnfd4reaxbq6ksalfna
Clinical and Experimental Human Sleep-Wake Pharmacogenetics
[chapter]
2018
Handbook of Experimental Pharmacology
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Dysregulation of these neurochemical systems may cause sleep-wake disorders, which are commonly classified into Landolt et al. ...
The interference with these physiological sleep-wake regulatory mechanisms can disturb the quality of sleep (Clark and Landolt, 2017) . ...
competitive blockade of adenosine A1 and A2A receptors in the central nervous system, caffeine attenuates the build-up of sleep pressure during wakefulness and delays the endogenous circadian clock (Landolt ...
doi:10.1007/164_2018_175
fatcat:aqqq7hebdncotonx2zkbzho4x4
Sleep Homeostasis, Metabolism, and Adenosine
2015
Current Sleep Medicine Reports
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Holst and Hans-Peter Landolt declare that they have no conflict of interest. ...
doi:10.1007/s40675-014-0007-3
fatcat:kfzph5akjvbqhn32qpnqy7fuwq
Insufficient Non-REM Sleep Intensity in Narcolepsy-Cataplexy
2007
Sleep
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Power spectra of consecutive 20-second epochs were computed off-line by using a fast-Fourier transform (Hanning window, linear detrending, average of five 4-second epochs), resulting in a frequency resolution ...
doi:10.1093/sleep/30.8.980
pmid:17702267
pmcid:PMC1978383
fatcat:grgq4amnwra4rmlbbcxelgsyru
Asymmetric prefrontal cortex functions predict asymmetries in number space
2010
Brain and Cognition
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Asymmetric prefrontal cortex functions predict asymmetries in number space Bachmann, V; Fischer, M H; Landolt, H P; Brugger, P Bachmann, V; Fischer, M H; Landolt, H P; Brugger, P (2010). ...
doi:10.1016/j.bandc.2010.08.011
pmid:20864241
fatcat:3revn4pxevhivnchwdffqzvsiy
Sleep Loss Produces False Memories
2008
PLoS ONE
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People sometimes claim with high confidence to remember events that in fact never happened, typically due to strong semantic associations with actually encoded events. Sleep is known to provide optimal neurobiological conditions for consolidation of memories for long-term storage, whereas sleep deprivation acutely impairs retrieval of stored memories. Here, focusing on the role of sleep-related memory processes, we tested whether false memories can be created (a) as enduring memory
doi:10.1371/journal.pone.0003512
pmid:18946511
pmcid:PMC2567433
fatcat:zrbwmpppg5gkbkecuae734z5fy
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... ns due to a consolidation-associated reorganization of new memory representations during post-learning sleep and/or (b) as an acute retrieval-related phenomenon induced by sleep deprivation at memory testing.
Sleep Abnormalities During Abstinence in Alcohol-Dependent Patients
2001
CNS Drugs
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Catechol-O-methyltransferase, dopamine, and sleep-wake regulation
2015
Sleep Medicine Reviews
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HP Landolt has no conflicts of interest, financial or otherwise. ...
doi:10.1016/j.smrv.2014.10.006
pmid:25466290
fatcat:ksrpy4tae5f5hazywulyuhwqoy
Genotype-Dependent Differences in Sleep, Vigilance, and Response to Stimulants
2008
Current pharmaceutical design
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To better understand the neurobiology of sleep disorders, detailed understanding of circadian and homeostatic sleep-wake regulation in healthy volunteers is mandatory. Sleep physiology and the repercussions of experimentallyinduced sleep deprivation on sleep and waking electroencephalogram (EEG), vigilance and subjective state are highly variable, even in healthy individuals. Accumulating evidence suggests that many aspects of normal sleep-wake regulation are at least in part genetically
doi:10.2174/138161208786549344
pmid:19075716
fatcat:uecthg4a5rd2rpdkom47w745um
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... led. Current heritability estimates of sleep phenotypes vary between approximately 20-40 % for habitual sleep duration, to over 90 % for the spectral characteristics of the EEG in nonREM sleep. The molecular mechanisms underlying the trait-like, inter-individual variation are virtually unknown, and the human genetics of normal sleep is only at the beginning of being explored. The first studies identified distinct polymorphisms in genes contributing to the endogenous circadian clock and neurochemical systems previously implicated in sleep-wake regulation, to modulate sleep architecture and sleep EEG, vulnerability to sleep loss, and subjective and objective effects of caffeine on sleep. These insights are reviewed here. They disclose molecular mechanisms contributing to normal sleep-wake regulation in humans, and have potentially important implications for the neurobiology of sleep-wake disorders and their pharmacological treatment. Large inter-individual differences are observed in many sleep and sleep-related variables including sleep timing, sleep duration, sleep structure, and preferred time of day for completion of distinct cognitive tasks. Age and sex may explain a large proportion of this inter-individual variance [4] . Nevertheless, each of these phenotypes is also under genetic control. Consistent with this notion, a moderate to high degree of heritability, i.e., the percentage of variance explained by overall genetic effects, has been demonstrated for several sleep and sleep-related variables. Twin studies are the classical approach to estimate and quantify the relative impact of genes compared with influences of the environment. Sleep Timing The timing of sleep, as well as many other circadian rhythms in physiology, behavior and neurological functions are strongly determined by a self-sustained circadian oscillator. This oscillator consists at the molecular level of a network of inter-locked transcriptional/translational feedback loops, which involve several clock-related genes including the transcription regulators CLOCK, BMAL1, PER1-3, CRY1-2, and TIM [8]. Nocturnal sleep time, but also peaks and troughs of alertness, are highly variable among healthy individuals. Selfrating scales such as the Horne-Östberg Chronotype Questionnaire [9] and the Diurnal Type Scale [10] show normal distribution of diurnal preference along an "eveningnessmorningness" axis [11] . Such a distribution in a quantitative
The BDNF Val66Met Polymorphism Modulates Sleep Intensity: EEG Frequency- and State-Specificity
2012
Sleep
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The power spectra (fast Fourier transform, Hanning window) of artifact-free, 50%-overlapping 2-s (waking EEG) or 4-s (sleep EEG) epochs were computed with MATLAB (The MathWorks Inc, Natick, MA, USA). ...
doi:10.5665/sleep.1690
pmid:22379239
pmcid:PMC3274334
fatcat:wlojhatzmrdqjfhmvpoddx5bgy
"No Thanks, Coffee Keeps Me Awake": Individual Caffeine Sensitivity Depends on ADORA2A Genotype
2012
Sleep
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Hans-Peter Landolt, PhD ...
CITATION Landolt HP. "No thanks, coffee keeps me awake": individual caffeine sensitivity depends on ADORA2A genotype. SLEEP 2012;35 (7) :899-900. ...
doi:10.5665/sleep.1942
pmid:22754033
pmcid:PMC3368971
fatcat:5fjn5onvyrhgbowtxy4i7aylhm
Caffeine Attenuates Waking and Sleep Electroencephalographic Markers of Sleep Homeostasis in Humans
2004
Neuropsychopharmacology
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Power spectra, conditioned by application of a Hanning window and linear detrending, were computed off-line by a fast Fourier transform (FFT) routine (MATLAB s , The MathWorks Inc., Natick, MA). ...
These results are consistent with our previous findings (Landolt et al, 1995b) . ...
doi:10.1038/sj.npp.1300526
pmid:15257305
fatcat:yh4355xkdfdqjh2t5xebl7srj4
Genetics and Genomic Basis of Sleep in Healthy Humans
[chapter]
2017
Principles and Practice of Sleep Medicine
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Landolt & D.-J. Dijk Genetic basis of human sleep 4 of these polymorphism for sleep physiology. ...
Landolt, H.-P. Genetic determinants of sleep EEG profiles in healthy humans. Prog Brain Res 193, 51-61 (2011). De Gennaro, L., et al. ...
doi:10.1016/b978-0-323-24288-2.00030-1
fatcat:6ferckdzkzdthgu57nebfbdsue
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