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Sleep-Wake Neurochemistry

Sebastian C. Holst, Hans-Peter Landolt
2018 Sleep Medicine Clinics  
Acknowledgements The authors' research has been supported by Swiss National Science Foundation, Zürich Holst & Landolt Sleep-Wake Neurochemistry  ...  -expressing cholinergic neurons of the BF during wakefulness also promotes arousal, whereas activation during NREM sleep leads to transition, at roughly equal amount, into wakefulness and REM sleep (Han  ...  Holst & Landolt Sleep-Wake Neurochemistry 6 Interestingly, activation of BF GABA-ergic neurons substantially enhanced wakefulness.  ... 
doi:10.1016/j.jsmc.2018.03.002 pmid:29759265 fatcat:mtcgm7wf5jcexdt5r7ltfdyggq

Ionic control of sleep and wakefulness

Hans-Peter Landolt, Sebastian C. Holst
2016 Science  
Brain electrical activity differs markedly between wakefulness and sleep. Concomitant shifts in the ion composition of brain extracellular fluids were thought to be a consequence rather than a cause of the sleep-wake-dependent changes in neuronal activity. On page 550 of this issue, Ding et al. ( 1 ) report the surprising observation that ionic changes in the extracellular fluid are a potent control of sleep-wake-dependent neuronal activity.
doi:10.1126/science.aaf8178 pmid:27126024 fatcat:jmwl3nc55vfgdhsqotdqc2gf7e

Sleep homeostasis: A role for adenosine in humans?

Hans-Peter Landolt
2008 Biochemical Pharmacology  
Data from Landolt et al. [82]. (B) 200 mg caffeine, administered 16 h prior to bedtime (n = 9). Data from Landolt et al. [83].  ...  Data from Landolt et al. b i o c h e m i c a l p h a r m a c o l o g y 7 5 ( 2 0 0 8 ) 2 0 7 0 -2 0 7 9  ... 
doi:10.1016/j.bcp.2008.02.024 pmid:18384754 fatcat:34ou2cnhnfd4reaxbq6ksalfna

Clinical and Experimental Human Sleep-Wake Pharmacogenetics [chapter]

Hans-Peter Landolt, Sebastian C. Holst, Amandine Valomon
2018 Handbook of Experimental Pharmacology  
Dysregulation of these neurochemical systems may cause sleep-wake disorders, which are commonly classified into Landolt et al.  ...  The interference with these physiological sleep-wake regulatory mechanisms can disturb the quality of sleep (Clark and Landolt, 2017) .  ...  competitive blockade of adenosine A1 and A2A receptors in the central nervous system, caffeine attenuates the build-up of sleep pressure during wakefulness and delays the endogenous circadian clock (Landolt  ... 
doi:10.1007/164_2018_175 fatcat:aqqq7hebdncotonx2zkbzho4x4

Sleep Homeostasis, Metabolism, and Adenosine

Sebastian C. Holst, Hans-Peter Landolt
2015 Current Sleep Medicine Reports  
Holst and Hans-Peter Landolt declare that they have no conflict of interest.  ... 
doi:10.1007/s40675-014-0007-3 fatcat:kfzph5akjvbqhn32qpnqy7fuwq

Insufficient Non-REM Sleep Intensity in Narcolepsy-Cataplexy

Ramin Khatami, Hans-Peter Landolt, Peter Achermann, Julia V. Rétey, Esther Werth, Johannes Mathis, Claudio L. Bassetti
2007 Sleep  
Power spectra of consecutive 20-second epochs were computed off-line by using a fast-Fourier transform (Hanning window, linear detrending, average of five 4-second epochs), resulting in a frequency resolution  ... 
doi:10.1093/sleep/30.8.980 pmid:17702267 pmcid:PMC1978383 fatcat:grgq4amnwra4rmlbbcxelgsyru

Asymmetric prefrontal cortex functions predict asymmetries in number space

Valérie Bachmann, Martin H. Fischer, Hans-Peter Landolt, Peter Brugger
2010 Brain and Cognition  
Asymmetric prefrontal cortex functions predict asymmetries in number space Bachmann, V; Fischer, M H; Landolt, H P; Brugger, P Bachmann, V; Fischer, M H; Landolt, H P; Brugger, P (2010).  ... 
doi:10.1016/j.bandc.2010.08.011 pmid:20864241 fatcat:3revn4pxevhivnchwdffqzvsiy

Sleep Loss Produces False Memories

Susanne Diekelmann, Hans-Peter Landolt, Olaf Lahl, Jan Born, Ullrich Wagner, Jan Lauwereyns
2008 PLoS ONE  
People sometimes claim with high confidence to remember events that in fact never happened, typically due to strong semantic associations with actually encoded events. Sleep is known to provide optimal neurobiological conditions for consolidation of memories for long-term storage, whereas sleep deprivation acutely impairs retrieval of stored memories. Here, focusing on the role of sleep-related memory processes, we tested whether false memories can be created (a) as enduring memory
more » ... ns due to a consolidation-associated reorganization of new memory representations during post-learning sleep and/or (b) as an acute retrieval-related phenomenon induced by sleep deprivation at memory testing.
doi:10.1371/journal.pone.0003512 pmid:18946511 pmcid:PMC2567433 fatcat:zrbwmpppg5gkbkecuae734z5fy

Sleep Abnormalities During Abstinence in Alcohol-Dependent Patients

Hans-Peter Landolt, J. Christian Gillin
2001 CNS Drugs  
doi:10.2165/00023210-200115050-00006 pmid:11475945 fatcat:l3la3abx6bg5habkd2rntd3mla

Catechol-O-methyltransferase, dopamine, and sleep-wake regulation

Yves Dauvilliers, Mehdi Tafti, Hans Peter Landolt
2015 Sleep Medicine Reviews  
HP Landolt has no conflicts of interest, financial or otherwise.  ... 
doi:10.1016/j.smrv.2014.10.006 pmid:25466290 fatcat:ksrpy4tae5f5hazywulyuhwqoy

Genotype-Dependent Differences in Sleep, Vigilance, and Response to Stimulants

Hans-Peter Landolt
2008 Current pharmaceutical design  
To better understand the neurobiology of sleep disorders, detailed understanding of circadian and homeostatic sleep-wake regulation in healthy volunteers is mandatory. Sleep physiology and the repercussions of experimentallyinduced sleep deprivation on sleep and waking electroencephalogram (EEG), vigilance and subjective state are highly variable, even in healthy individuals. Accumulating evidence suggests that many aspects of normal sleep-wake regulation are at least in part genetically
more » ... led. Current heritability estimates of sleep phenotypes vary between approximately 20-40 % for habitual sleep duration, to over 90 % for the spectral characteristics of the EEG in nonREM sleep. The molecular mechanisms underlying the trait-like, inter-individual variation are virtually unknown, and the human genetics of normal sleep is only at the beginning of being explored. The first studies identified distinct polymorphisms in genes contributing to the endogenous circadian clock and neurochemical systems previously implicated in sleep-wake regulation, to modulate sleep architecture and sleep EEG, vulnerability to sleep loss, and subjective and objective effects of caffeine on sleep. These insights are reviewed here. They disclose molecular mechanisms contributing to normal sleep-wake regulation in humans, and have potentially important implications for the neurobiology of sleep-wake disorders and their pharmacological treatment. Large inter-individual differences are observed in many sleep and sleep-related variables including sleep timing, sleep duration, sleep structure, and preferred time of day for completion of distinct cognitive tasks. Age and sex may explain a large proportion of this inter-individual variance [4] . Nevertheless, each of these phenotypes is also under genetic control. Consistent with this notion, a moderate to high degree of heritability, i.e., the percentage of variance explained by overall genetic effects, has been demonstrated for several sleep and sleep-related variables. Twin studies are the classical approach to estimate and quantify the relative impact of genes compared with influences of the environment. Sleep Timing The timing of sleep, as well as many other circadian rhythms in physiology, behavior and neurological functions are strongly determined by a self-sustained circadian oscillator. This oscillator consists at the molecular level of a network of inter-locked transcriptional/translational feedback loops, which involve several clock-related genes including the transcription regulators CLOCK, BMAL1, PER1-3, CRY1-2, and TIM [8]. Nocturnal sleep time, but also peaks and troughs of alertness, are highly variable among healthy individuals. Selfrating scales such as the Horne-Östberg Chronotype Questionnaire [9] and the Diurnal Type Scale [10] show normal distribution of diurnal preference along an "eveningnessmorningness" axis [11] . Such a distribution in a quantitative
doi:10.2174/138161208786549344 pmid:19075716 fatcat:uecthg4a5rd2rpdkom47w745um

The BDNF Val66Met Polymorphism Modulates Sleep Intensity: EEG Frequency- and State-Specificity

Valérie Bachmann, Carina Klein, Sereina Bodenmann, Nikolaus Schäfer, Wolfgang Berger, Peter Brugger, Hans-Peter Landolt
2012 Sleep  
The power spectra (fast Fourier transform, Hanning window) of artifact-free, 50%-overlapping 2-s (waking EEG) or 4-s (sleep EEG) epochs were computed with MATLAB (The MathWorks Inc, Natick, MA, USA).  ... 
doi:10.5665/sleep.1690 pmid:22379239 pmcid:PMC3274334 fatcat:wlojhatzmrdqjfhmvpoddx5bgy

"No Thanks, Coffee Keeps Me Awake": Individual Caffeine Sensitivity Depends on ADORA2A Genotype

Hans-Peter Landolt
2012 Sleep  
Hans-Peter Landolt, PhD  ...  CITATION Landolt HP. "No thanks, coffee keeps me awake": individual caffeine sensitivity depends on ADORA2A genotype. SLEEP 2012;35 (7) :899-900.  ... 
doi:10.5665/sleep.1942 pmid:22754033 pmcid:PMC3368971 fatcat:5fjn5onvyrhgbowtxy4i7aylhm

Caffeine Attenuates Waking and Sleep Electroencephalographic Markers of Sleep Homeostasis in Humans

Hans-Peter Landolt, Julia V Rétey, Karin Tönz, Julie M Gottselig, Ramin Khatami, Isabelle Buckelmüller, Peter Achermann
2004 Neuropsychopharmacology  
Power spectra, conditioned by application of a Hanning window and linear detrending, were computed off-line by a fast Fourier transform (FFT) routine (MATLAB s , The MathWorks Inc., Natick, MA).  ...  These results are consistent with our previous findings (Landolt et al, 1995b) .  ... 
doi:10.1038/sj.npp.1300526 pmid:15257305 fatcat:yh4355xkdfdqjh2t5xebl7srj4

Genetics and Genomic Basis of Sleep in Healthy Humans [chapter]

Hans-Peter Landolt, Derk-Jan Dijk
2017 Principles and Practice of Sleep Medicine  
Landolt & D.-J. Dijk Genetic basis of human sleep 4 of these polymorphism for sleep physiology.  ...  Landolt, H.-P. Genetic determinants of sleep EEG profiles in healthy humans. Prog Brain Res 193, 51-61 (2011). De Gennaro, L., et al.  ... 
doi:10.1016/b978-0-323-24288-2.00030-1 fatcat:6ferckdzkzdthgu57nebfbdsue
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