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Bipolar offspring

Kiki Chang, Hans Steiner, Kimberly Dienes, Nancy Adleman, Terence Ketter
2003 Biological Psychiatry  
Children of parents with bipolar disorder (bipolar offspring) represent a rich cohort for study with potential for illumination of prodromal forms of bipolar disorder.  ...  which may be indicators of even higher risk for bipolar disorder, initial attempts at early intervention in prodromal pediatric bipolar disorder, and implications for future research.  ...  Thus, the model of bipolar disorder in evolution is consistent with other medical models of disease.  ... 
doi:10.1016/s0006-3223(03)00061-1 pmid:12788239 fatcat:xgiavhklmbcfrajmwuhtxn4afe

Preventive psychiatry: a blueprint for improving the mental health of young people

Paolo Fusar-Poli, Christoph U Correll, Celso Arango, Michael Berk, Vikram Patel, John P A Ioannidis
2021 World Psychiatry  
frameworks, and neurodevelopmentally-sensitive clinical staging models.  ...  for reducing the risk profile of the population as a whole.  ...  Collaborative harmonization efforts should mitigate these obstacles and integrate polygenetic and poly-environmental information to better map the complex pathophysiology of psychotic, bipolar and common  ... 
doi:10.1002/wps.20869 pmid:34002494 fatcat:dz6qyr5nf5bljc2eclvisg3nkq

Mental health dished up-the use of iPSC models in neuropsychiatric research

Rhiannon V McNeill, Georg C Ziegler, Franziska Radtke, Matthias Nieberler, Klaus-Peter Lesch, Sarah Kittel-Schneider
2020 Journal of neural transmission  
Genetic and molecular mechanisms that play a causal role in mental illnesses are challenging to elucidate, particularly as there is a lack of relevant in vitro and in vivo models.  ...  Using the above search criteria, a total of 3515 studies were found. After screening, a final total of 56 studies were deemed eligible for inclusion in our study.  ...  In non-syndromic cases of autism, there has been little research performed using iPSC-based models.  ... 
doi:10.1007/s00702-020-02197-9 pmid:32377792 pmcid:PMC7578166 fatcat:kyds4jr6vjelfbtalqjovkbhpm

Epigenetic epidemiology: Promises for public health research

Kelly M. Bakulski, M. Daniele Fallin
2014 Environmental and Molecular Mutagenesis  
Epigenetics may represent a mechanistic link between environmental exposures, or genetics, and many common diseases, or may simply provide a quantitative biomarker for exposure or disease for areas of  ...  Overview Epidemiology is the study of the distribution of disease in populations and the causes, consequences, prevention, and treatment strategies for those diseases.  ...  Animal toxicological models are crucial, proof-of-principal studies showing epigenetic susceptibility to environmental conditions.  ... 
doi:10.1002/em.21850 pmid:24449392 pmcid:PMC4011487 fatcat:cxa3xep5e5h35pdfkujymxatme

Circadian rhythms and metabolism: from the brain to the gut and back again

Matthew R. Cribbet, Ryan W. Logan, Mathew D. Edwards, Erin Hanlon, Clara Bien Peek, Jeremy J. Stubblefield, Sridhar Vasudevan, Fiona Ritchey, Ellen Frank
2016 Annals of the New York Academy of Sciences  
The study of human behavior, especially in the context of psychiatric disorders, such as bipolar disorder and major depression, forces us to see how inextricably linked mental health and metabolic health  ...  Research across the translational spectrum confirms the importance of the circadian system for glucose metabolism and offers promising clues as to when and why these systems go awry.  ...  Conflicts of interest Dr. Frank serves as a consultant to Servier and Mitsubishi-Tanabe and holds equity in Health-Rhythms, Inc. and Psychiatic Assessments, Inc.  ... 
doi:10.1111/nyas.13188 pmid:27589593 pmcid:PMC5428740 fatcat:dhqfly74qneopehwiasr6r6euy

Human Genetics and Clinical Aspects of Neurodevelopmental Disorders [chapter]

Gholson J. Lyon, Jason O'Rawe
2015 The Genetics of Neurodevelopmental Disorders  
Prevention of illness through environmental modification has been, and likely always will be, the major driver for global health (Mukherjee, 2010; Sporn, 2011) .  ...  Some of these syndromes are referred to as 'complex' diseases simply because the presentation is so incredibly heterogeneous that is it very likely that there will be multiple different genetic and environmental  ... 
doi:10.1002/9781118524947.ch13 fatcat:lmw63tcii5ct7k7czxzkekuzci

Altered MicroRNA Expression Profiles in Postmortem Brain Samples from Individuals with Schizophrenia and Bipolar Disorder

Michael P. Moreau, Shannon E. Bruse, Richard David-Rus, Steven Buyske, Linda M. Brzustowicz
2011 Biological Psychiatry  
Both conditions were associated with reduced miRNA expression levels, with a much more pronounced effect observed for bipolar disorder.  ...  Of miRNAs analyzed, 19% exhibited positive evidence of altered expression due to a diagnosis of schizophrenia or bipolar disorder.  ...  Magnitude of expression changes Fold changes with 95% confidence intervals for miRNAs with posterior probability of nonzero effect of diagnosis exceeding 95% (black bars represent the bipolar group, gray  ... 
doi:10.1016/j.biopsych.2010.09.039 pmid:21183010 pmcid:PMC3038345 fatcat:e2usdpgj2bhpdobixcfcm65uvi

A rapid and systematic review and economic evaluation of the clinical and cost-effectiveness of newer drugs for treatment of mania associated with bipolar affective disorder

C Bridle, S Palmer, A-M Bagnall, J Darba, S Duffy, M Sculpher, R Riemsma
2004 Health Technology Assessment  
Non-UK purchasers will have to pay a small fee for post and packing. For European countries the cost is £2 per monograph and for the rest of the world £3 per monograph.  ...  Bipolar disorder has complex genetic, biochemical and environmental pathways. Treatment is dependent on the phase of the disorder being experienced.  ...  Decision models Critical appraisal was based on a range of questions, including 1. structure of model 2. time horizon 3. details of key input parameters and their sources 4. methods of analysis (e.g. handling  ... 
doi:10.3310/hta8190 pmid:15147609 fatcat:nbwpnfoht5epnjwgc75o46kkka

Reporting guidelines on remotely collected electronic mood data in mood disorder (eMOOD)—recommendations

Maria Faurholt-Jepsen, John R. Geddes, Guy M. Goodwin, Michael Bauer, Anne Duffy, Lars Vedel Kessing, Kate Saunders
2019 Translational Psychiatry  
To get better understanding of the nature, correlates and implications of mood and mood instability, and to standardize this process, we propose guidelines for reporting of electronic mood data (eMOOD)  ...  This paper provides an overview of remotely collected electronic mood data in mood disorders and discusses why standardized reporting is necessary to evaluate and inform mood research in Psychiatry.  ...  In unipolar and bipolar disorder, mood deviations present both in the form of a mood episode and in the form of sub-syndromal mood instability, and mood instability has been suggested as a part of the  ... 
doi:10.1038/s41398-019-0484-8 pmid:31175283 pmcid:PMC6555812 fatcat:bzg3ema6mvdtzl5bk7itdvmjri

Artificial intelligence applications in psychoradiology

Fei Li, Huaiqiang Sun, Bharat B Biswal, John A Sweeney, Qiyong Gong
2021 Psychoradiology  
path forward for the combination of psychoradiology and AI for complementing clinical examinations in patients with psychiatric disorders, as well as limitations in the application of AI that should be  ...  illness, prediction of prognosis before treatment, and guidance for selection of effective treatments that target patient-relevant pathophysiological features.  ...  Wenjing Zhang, Lekai Luo, Wanfang You, and Yuxia Wang, who are from Huaxi MR Research Center (HMRRC), Department of Radiology, West China Hospital of Sichuan University, for performing aspects of the work  ... 
doi:10.1093/psyrad/kkab009 fatcat:7z3shbc4vzfg7pwmfyumqsgtia

Immune signatures and disorder-specific patterns in a cross-disorder gene expression analysis

Simone de Jong, Stephen J. Newhouse, Hamel Patel, Sanghyuck Lee, David Dempster, Charles Curtis, Jose Paya-Cano, Declan Murphy, C. Ellie Wilson, Jamie Horder, M. Andreina Mendez, Philip Asherson (+12 others)
2016 British Journal of Psychiatry  
Method Analysis of whole-genome blood gene expression and genetic risk scores of 318 individuals.  ...  Results Weighted gene co-expression analysis results reveal disorder-specific signatures for childhood ADHD and MDD, and also highlight two immune-related gene co-expression modules correlating inversely  ...  The views expressed are those of the author(s) and not necessarily those of the NHS, the NIHR or the Department of Health.  ... 
doi:10.1192/bjp.bp.115.175471 pmid:27151072 pmcid:PMC5007452 fatcat:fwpyjm5vnveo3lqxazr62wasda

What we learn about bipolar disorder from large‐scale neuroimaging: Findings and future directions from the ENIGMA Bipolar Disorder Working Group

Christopher R. K. Ching, Derrek P. Hibar, Tiril P. Gurholt, Abraham Nunes, Sophia I. Thomopoulos, Christoph Abé, Ingrid Agartz, Rachel M. Brouwer, Dara M. Cannon, Sonja M. C. Zwarte, Lisa T. Eyler, Pauline Favre (+105 others)
2020 Human Brain Mapping  
The Enhancing Neuro Imaging Genetics through Meta-Analysis (ENIGMA) Bipolar Disorder Working Group was formed in 2012 to empower discoveries, generate consensus findings and inform future hypothesis-driven  ...  Here we discuss key findings from the BD working group, its ongoing projects and future directions for large-scale, collaborative studies of mental illness.  ...  Clinical information will also allow for analyses such as network modeling of individual symptoms (Borsboom & Cramer, 2013) and thus a more detailed characterization than traditional diagnostic categories  ... 
doi:10.1002/hbm.25098 pmid:32725849 pmcid:PMC8675426 fatcat:josya5kxsrcgvfhhbbjxkflpg4

Can an Integrated Science Approach to Precision Medicine Research Improve Lithium Treatment in Bipolar Disorders?

Jan Scott, Bruno Etain, Frank Bellivier
2018 Frontiers in Psychiatry  
For example, although clinical syndrome subtyping of BD has not led to customized individual treatments, we emphasize the importance of assessing clinical response phenotypes in biomarker research.  ...  Clinical practice guidelines identify lithium as a first line treatment for mood stabilization and reduction of suicidality in bipolar disorders (BD); however, most individuals show sub-optimal response  ...  DISCUSSION Clinical syndrome subtyping has failed to inform personalization of treatments in psychiatry (10, 19, 79) .  ... 
doi:10.3389/fpsyt.2018.00360 pmid:30186186 pmcid:PMC6110814 fatcat:r7lmtp6k2vb33lacpwqbugf3lq

Personality traits in bipolar disorder and influence on outcome

Timea Sparding, Erik Pålsson, Erik Joas, Stefan Hansen, Mikael Landén
2017 BMC Psychiatry  
By creating a PCA-model, it is possible do detect variables that contribute similar information to the model, as well as variables that contribute with unique information to an observation.  ...  Data är insamlade inom ramen för St. Görans bipolärprojekt, en longitudinell, prospektiv studie av patienter med bipolära syndrom.  ... 
doi:10.1186/s12888-017-1332-0 pmid:28468681 pmcid:PMC5415752 fatcat:kywzt5anyvg4rbqkhvtyeduudi

Jumping on the Train of Personalized Medicine: A Primer for Non-Geneticist Clinicians: Part 2. Fundamental Concepts in Genetic Epidemiology

Aihua Li, David Meyre
2014 Current Psychiatry Reviews  
We therefore write this series of three reviews to help non-geneticist clinicians to jump into the fast-moving field of personalized medicine.  ...  In the first article of this series, we reviewed the fundamental concepts in molecular genetics.  ...  ACKNOWLEDGEMENTS We thank Jackie Hudson, Alexandra Mayhew and Hudson Reddon for editing of the manuscript, and the reviewers for their helpful comments.  ... 
doi:10.2174/1573400510666140319235334 pmid:25598767 pmcid:PMC4287874 fatcat:4zhwoouarfdrjlnotx7desex24
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