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Shapelet is a discriminative subsequence of time series. An advanced shapelet-based method is to embed shapelet into accurate and fast random forest. However, it shows several limitations. First, random shapelet forest requires a large training cost for split threshold searching. Second, a single shapelet provides limited information for only one branch of the decision tree, resulting in insufficient accuracy and interpretability. Third, randomized ensemble causes interpretability declining.arXiv:1903.07799v2 fatcat:hjzpu753c5gmvbygr7tss5gutq
more »... that, this paper presents Random Pairwise Shapelets Forest (RPSF). RPSF combines a pair of shapelets from different classes to construct random forest. It omits threshold searching to be more efficient, includes more information for each node of the forest to be more effective. Moreover, a discriminability metric, Decomposed Mean Decrease Impurity (DMDI), is proposed to identify influential region for every class. Extensive experiments show RPSF improves the accuracy and training speed of shapelet-based forest. Case studies demonstrate the interpretability of our method.
Nanoporous Materials [Working Title]
Nanoporous TiO 2 In 2018, Shi et al. prepared nanoporous TiO 2 by dealloying an Al-Si-Ti precursor alloy and calcining  . ...doi:10.5772/intechopen.82028 fatcat:2segz7rc3fdrvikbvrzwumadge
Mutually exclusive splicing is an important mechanism for expanding protein diversity. An extreme example is the Down syndrome cell adhesion molecular (Dscam1) gene of insects, containing four clusters of variable exons (exons 4, 6, 9, and 17), which potentially generates tens of thousands of protein isoforms through mutually exclusive splicing, of which regulatory mechanisms are still elusive. Here, we systematically analyzed the variable exon 4, 6, and 9 clusters of Dscam1 in Coleopteradoi:10.3389/fgene.2021.644238 pmid:33859670 pmcid:PMC8042237 fatcat:x5wo2xchgzgbhczkzlgodyabmy
more »... s. Through comparative genomics and RNA secondary structure prediction, we found apparent evidence that the evolutionarily conserved RNA base pairing mediates mutually exclusive splicing in the Dscam1 exon 4 cluster. In contrast to the fly exon 6, most exon 6 selector sequences in Coleoptera species are partially located in the variable exon region. Besides, bidirectional RNA–RNA interactions are predicted to regulate the mutually exclusive splicing of variable exon 9 of Dscam1. Although the docking sites in exon 4 and 9 clusters are clade specific, the docking sites-selector base pairing is conserved in secondary structure level. In short, our result provided a mechanistic framework for the application of long-range RNA base pairings in regulating the mutually exclusive splicing of Coleoptera Dscam1.
A 55-year-old Chinese man presented with a 17-month history of pustules, papules, nodules, plaques, and ulcers involving most of his body, including the scalp, face, neck, trunk, and extremities. Several superficial ulcers with vegetative exophytic margins and plaques were also present. Cribriform sinuses were on the plaque surfaces and ulcer bases. Pus discharged under pressure. C-reactive protein level was 120.07 mg/dL, with the erythrocyte sedimentation rate at 95 mm/h. Repeated smears anddoi:10.1016/j.dsi.2014.12.009 fatcat:ufg4tlwwuvdtnerdkzgmxf5s7u
more »... ltures were negative. Forearm incisional biopsy showed pseudoepitheliomatous hyperplasia and diffuse neutrophilic infiltration with microabscesses. Vegetative pyoderma gangrenosum was diagnosed. Lesions markedly abated after systemic corticosteroid therapy.
The immunoglobulin (Ig) superfamily receptor Down syndrome cell adhesion molecule (Dscam) gene can generate tens of thousands of isoforms via alternative splicing, which is essential for both nervous and immune systems in insects. However, further information is required to develop a comprehensive view of Dscam diversification across the broad spectrum of Chelicerata clades, a basal branch of arthropods and the second largest group of terrestrial animals. Results: In this study, a genome-widedoi:10.1186/s12864-017-4420-0 pmid:29351731 pmcid:PMC5775551 fatcat:pljqpv2w5bdipnymt5jzyh3au4
more »... mprehensive analysis of Dscam genes across Chelicerata species revealed a burst of nonclassical Dscams, categorised into four types-mDscam, sDscamα, sDscamβ, and sDscamγ-based on their size and structure. Although the mDscam gene class includes the highest number of Dscam genes, the sDscam genes utilise alternative promoters to expand protein diversity. Furthermore, we indicated that the 5′ cassette duplicate is inversely correlated with the sDscam gene duplicate. We showed differential and sDscambiased expression of nonclassical Dscam isoforms. Thus, the Dscam isoform repertoire across Chelicerata is entirely dominated by the number and expression levels of nonclassical Dscams. Taken together, these data show that Chelicerata evolved a large conserved and lineage-specific repertoire of nonclassical Dscams. Conclusions: This study showed that arthropods have a large diversified Chelicerata-specific repertoire of nonclassical Dscam isoforms, which are structurally and mechanistically distinct from those of insects. These findings provide a global framework for the evolution of Dscam diversity in arthropods and offer mechanistic insights into the diversification of the clade-specific Ig superfamily repertoire.
Drosophila melanogaster Down syndrome cell adhesion molecule (Dscam1) can potentially generate 38,016 different isoforms through stochastic, yet highly biased, alternative splicing. Genetic studies demonstrated that stochastic expression of multiple Dscam1 isoforms provides each neuron with a unique identity for self/non-self-discrimination. However, due to technical obstacles, the functional significance of the highly specific bias in isoform expression remains entirely unknown. Here, wedoi:10.1101/622217 fatcat:b2c2ec52ureozmxuqgwru7d4ky
more »... e conclusive evidence that Dscam1 splicing bias is required for precise mushroom body (MB) axonal wiring in flies in a variable exon-specific manner. We showed that targeted deletion of the intronic docking site perturbed base pairing-mediated regulation of inclusion of variable exons. Unexpectedly, we generated mutant flies with normal overall Dscam1 protein levels and an identical number but global changes in exon 4 and exon 9 isoform bias (DscamΔ4D and DscamΔ9D), respectively. DscamΔ9D mutant exhibited remarkable mushroom body defects, which were correlated with the extent of the disrupted isoform bias. By contrast, the DscamΔ4D animals exhibited a much less severe defective phenotype than DscamΔ9D animals, suggestive of a variable domain-specific requirement for isoform bias. Importantly, mosaic analysis revealed that changes in isoform bias caused axonal defects but did not influence the self-avoidance of axonal branches. We concluded that, in contrast to the Dscam1 isoform number that provides the molecular basis for neurite self-avoidance, isoform bias may play a non-repulsive role in mushroom body axonal wiring.
In this paper, in order to study the dissipativity of nonlinear neutral functional differential equations, a generalization of the Halanay inequality is given. We apply this generalized Halanay inequality to an analysis of the dissipativity of two classes of nonlinear neutral delay integro-differential equations and the sufficient conditions are presented to ensure these systems are dissipative.doi:10.1186/s13660-018-1894-5 fatcat:w2p6ufeleze4fgcnj4fhnufoly
Lecture Notes in Computer Science
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