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Formation of ring-banded spherulites of α and β modifications in Poly(butylene adipate)

Jin Liu, Hai-Mu Ye, Jun Xu, Bao-Hua Guo
2011 Polymer  
The morphology and crystalline structure of banded spherulites of poly(butylene adipate) (PBA) were investigated by polarized optical microscopy (POM), wide-angle X-ray diffraction (WAXD), atomic force microscopy (AFM) and scanning electronic microscopy (SEM). It was found that after purification and fractionation, the obtained PBA fractions with different molecular weight formed ring-banded spherulites at different temperature ranges. Pure a and b form of PBA can form regular ring-banded
more » ... lites. AFM and SEM observations of the thin film revealed that the alternative ridges and valleys along the radial direction consisted of edge-on and flat-on lamellae, respectively, indicating the ring-bands in PBA spherulites are the consequence of lamellar twisting. In addition, sequential growth of a and b form in one PBA spherulite at the same temperature is reported and interpreted by competition of primary nucleation and radial growth of the two crystalline modifications. At a certain temperature range, the a form PBA has larger primary nucleation rate but lower radial growth rate than the b form PBA, leading to formation of spherulites consisted of a form at center and b form at the outer region. But finally, a layer of a form ringless region appears at the outside of the b form ring-banded region before impingement of the neighboring spherulites. These results suggest that besides crystallization temperature, molecular weight has considerable effect on the formation of crystal modification of PBA and the corresponding banded spherulites.
doi:10.1016/j.polymer.2011.08.001 fatcat:vogmxgidcfclxlyy2cbnxlo36e

Design, Synthesis, DFT Study and Antifungal Activity of Pyrazolecarboxamide Derivatives

Jin-Xia Mu, Yan-Xia Shi, Ming-Yan Yang, Zhao-Hui Sun, Xing-Hai Liu, Bao-Ju Li, Na-Bo Sun
2016 Molecules  
A series of novel pyrazole amide derivatives were designed and synthesized by multi-step reactions from phenylhydrazine and ethyl 3-oxobutanoate as starting materials, and their structures were characterized by NMR, MS and elemental analysis. The antifungal activity of the title compounds was determined. The results indicated that some of title compounds exhibited moderate antifungal activity. Furthermore, DFT calculations were used to study the structure-activity relationships (SAR).
doi:10.3390/molecules21010068 pmid:26760990 fatcat:wfluob2flvdvndygty4tryjjda

Simulational study on streamer discharge in transformer oil under positive nanosecond pulse voltage

Li Yuan, Mu Hai-Bao, Deng Jun-Bo, Zhang Guan-Jun, Wang Shu-Hong
2013 Wuli xuebao  
In this paper, we investigate the streamer discharge process in transformer oil under positive nanosecond pulse voltage through developing a two-dimensional axially symmetric fluid model and simulating the physics of discharge inception and propagation. The streamer discharge profile and distributions of electric field and space charge density are obtained under different conditions such as the amplitude of applied voltage, rise time and gap distance. Simulation results show that space charges
more » ... nhance the front field of streamer head, which is conducive to the longer propagation of discharge channel, therefore "ionization wave" is formed. The magnitude and rise time of applied voltage have evident influences on the average speed of streamer propagation. It can be observed that the higher the applied impulse voltage, the faster the streamer propagates, and the steeper the rise time of applied impulse, when streamer arrives at the same position, the larger the discharging radius will be and the smaller maximal electric field will be. The cases of different gap distances indicate that longer gap distance corresponds to a faster average speed of streamer. It is considered that fielddependent molecular ionization predominates the charge generation mechanism of streamer discharge process in transformer oil, and space charge effect contributes to further developing ionization until the whole gap eventually breakdowns. The study is dedicated to the better understanding of the process from inception to breakdown of discharging in transformer oil, as well as ionization mechanism in liquid dielectric.
doi:10.7498/aps.62.124703 fatcat:pdsamyclzbfghcf663nph5zftm

Practical Security of High-Dimensional Quantum Key Distribution with Intensity Modulator Extinction

Yang Wang, Ge-Hai Du, Yang-Bin Xu, Chun Zhou, Mu-Sheng Jiang, Hong-Wei Li, Wan-Su Bao
2022 Entropy  
Quantum key distribution (QKD) has attracted much attention due to its unconditional security. High-dimensional quantum key distribution (HD-QKD) is a brand-new type of QKD protocol that has many excellent advantages. Nonetheless, practical imperfections in realistic devices that are not considered in the theoretical security proof may have an impact on the practical security of realistic HD-QKD systems. In this paper, we research the influence of a realistic intensity modulator on the
more » ... security of HD-QKD systems with the decoy-state method and finite-key effects. We demonstrate that there is a certain impact in the secret key rate and the transmission distance when taking practical factors into security analysis.
doi:10.3390/e24040460 pmid:35455123 pmcid:PMC9026895 fatcat:fc7iaghfv5ecpiygssssvcy42u

A new quinolinone and its natural/artificial derivatives from a shark gill-derived fungus Penicillium crustosum AP2T1

Yi Zhang, Jun Mu, Yan Feng, Stephanie Grond, Frank Essmann, Markus Kramer, Hai-Yan Bao
2015 Figshare  
Zhang Y, Mu J, Han J, Gu X. 2012. An improved brine shrimp larvae lethality microwell test method. Toxicol Mech Methods 22(1):23−30.  ... 
doi:10.6084/m9.figshare.1486380.v1 fatcat:z44szvebuvhnlfe46t5cwtgdlu

A new quinolinone and its natural/artificial derivatives from a shark gill-derived fungus Penicillium polonicum AP2T1

Yi Zhang, Jun Mu, Frank Essmann, Yan Feng, Markus Kramer, Hai-Yan Bao, Stephanie Grond
2016 Figshare  
Zhang Y, Mu J, Han J, Gu X. 2012. An improved brine shrimp larvae lethality microwell test method. Toxicol Mech Methods 22(1):23−30.  ... 
doi:10.6084/m9.figshare.1486380.v2 fatcat:dqyilsue3fgzlkmacpusfdsh6i

Reversible Structural Modulation of Fe-Pt Bimetallic Surfaces and Its Effect on Reactivity

Teng Ma, Qiang Fu, Hai-Yan Su, Hong-Yang Liu, Yi Cui, Zhen Wang, Ren-Tao Mu, Wei-Xue Li, Xin-He Bao
2009 ChemPhysChem  
doi:10.1002/cphc.200900053 pmid:19399822 fatcat:psyyk7s7cngkxorrylbw7wyxui

Magnolol, a Natural Polyphenol, Attenuates Dextran Sulfate Sodium-Induced Colitis in Mice

Ling Zhao, Hai-tao Xiao, Huai-xue Mu, Tao Huang, Ze-si Lin, Linda Zhong, Guang-zhi Zeng, Bao-min Fan, Cheng-yuan Lin, Zhao-xiang Bian
2017 Molecules  
Magnolol is a lignan with anti-inflammatory activity identified in Magnolia officinalis. Ulcerative colitis (UC), one of the types of inflammatory bowel disease (IBD), is a disease that causes inflammation and ulcers in the colon. To investigate the effect of magnolol in dextran sulfate sodium (DSS)-induced experimental UC model, male C57 mice were treated with 2% DSS drinking water for 5 consecutive days followed by intragastric administration with magnolol (5, 10 and 15 mg/kg) daily for 7
more » ... . The results showed that magnolol significantly attenuated disease activity index, inhibited colonic shortening, reduced colonic lesions and suppressed myeloperoxidase (MPO) activity. Moreover, colonic pro-inflammatory cytokines (TNF-α, IL-6, and IL-1β) induced by colitis were dramatically decreased by magnolol. To further unveil the metabolic signatures upon magnolol treatment, mass spectrometry-based metabolomic analysis of the small molecular metabolites in mice serum were performed. Compared with controls, abnormality of serum metabolic phenotypes in DSS-treated mice were effectively reversed by different doses of magnolol. In particular, magnolol treatment effectively elevated the serum levels of tryptophan metabolites including kynurenic acid (KA), 5-hydroxyindoleacetic acid, indoleacetic acid (IAA), indolelactic acid and indoxylsulfuric acid, which are potential aryl hydrocarbon receptor (AHR) ligands to impact colitis. These findings suggest that magnolol exerts anti-inflammatory effect on DSS-induced colitis and its underlying mechanisms are associated with the restoring of tryptophan metabolites that inhibit the colonic inflammation. Molecules 2017, 22, 1218 2 of 15 while long-term treatment with these drugs are not quite effective [3, 4] . Other steroid drugs such as azathioprine and 6-mercaptopurine exist non-negligible side effects [5, 6] . Infliximab is the most often used biological agent for IBD, while the clinical response is only around 65% [7]. To date, the underlying cause of IBD is not well-understood and alarmingly, in light of the soaring numbers of IBD cases, promising therapeutics have yet to be developed. Magnolol (5,5 -di-2-propen-1-yl-2,2 -Bichavicol) is a lignan exacted from the bark of Magnolia officinalis, the compounds of which demonstrating anti-cancer, anti-stress, anti-anxiety, anti-depressant, anti-oxidant and anti-inflammatory effects [8] . The anti-inflammatory effect of magnolol has been reported in the animal models of ischemic stroke [9], oxygen-induced retinopathy [10], acute lung injury [11, 12] , mastitis [13] , and arthritis [14] . In RAW264.7 cells, magnolol can inhibit lipopolysaccharide (LPS)-induced NF-κB activation, IKBα degradation and pro-inflammatory cytokines production [15, 16] . Similar mechanisms of magnolol can also be found in LPS-induced acute lung injury mice models by inhibiting the tumor necrosis factor-alpha (TNF-α), IL-1β, phosphorylation of IκB-α and NF-κB, and expression of toll-like receptor 4 (TLR4) [17] . In human aortic endothelial cells, magnolol inhibits TNF-α-induced JNK/p38 phosphorylation and NF-κB activation, thereby reducing leukocyte adhesion [18] . Furthermore, magnolol was demonstrated to suppress colonic smooth muscle contraction through downregulation of L-type Ca(2+) channels in rats [19, 20] . Magnolol treatment prevents sepsis-induced rat intestinal dysmotility by regulating stem cell factor (SCF)/c-kit and NO signaling to maintain functional interstitial cells of Cajal (ICCs) [21] , reducing TNF-α and inducible nitric oxide synthase (iNOS), while stimulating IL-10 mRNA expression in septic rat ileum [22] . These findings suggest that magnolol is a potential therapeutic compound for inflammatory gastrointestinal diseases yet to be examined. The present study aims to investigate the effect of magnolol on Dextran sulfate sodium (DSS)-induced colitis, and to explore the possible mechanisms in the levels of metabolites by UPLC/MS-based metabolomic analysis.
doi:10.3390/molecules22071218 pmid:28726741 fatcat:ac7tr7wbgbfffhq7nbvvuu2fum

Simulations of the cathode falling characteristics and its influence factors in atmospheric pressure dielectric barrier glow discharge pulse

Yao Cong-Wei, Ma Heng-Chi, Chang Zheng-Shi, Li Ping, Mu Hai-Bao, Zhang Guan-Jun
2017 Wuli xuebao  
Technol. 174-175 08 [7] Yao C W, Chang Z S, Ma H C, Xu G M, Mu H B, Zhang 降至 14% 位置 (定义 2) 两种方式分别定义了大气 多可能抑制 He 放电的过程本文暂不考虑. N 2 含 G J 2016 IEEE Trans.  ... 
doi:10.7498/aps.66.025203 fatcat:grvg44xakzbf3ckytxanjzb234

The management of retroperitoneal giant schwannomas in AIDS patients: A case report

2013 Oncology Letters  
Retroperitoneal schwannomas are a rare disease. During the potent antiretroviral therapy era, the incidence of AIDS-defining cancers has decreased, while the incidence of non-AIDS defining cancers has increased; however, the existence of a relationship between benign or malignant schwannomas and AIDS remains unclear. Although a case of ethmoid malignant schwannoma in an AIDS patient was first reported in 1993, no additional reports of schwannomas associated with AIDS have been published since.
more » ... n the current study, the case of a 30-year-old male AIDS patient with a large benign retroperitoneal schwannoma is presented. The ideal treatment of retroperitoneal schwannomas is complete excision. However, controversy exists over the necessity of negative soft tissue margins, particularly when adjacent tissue or viscera must also be removed. In the current case study, due to the immune dysfunction in AIDS patients, the incidence of malignancy could not be completely excluded prior to surgery and a significant risk of short-term relapse or malignancy following partial tumor resection was present. The patient underwent complete resection with partial superior mesenteric artery excision in order to attain negative margins, and recovered well. A follow-up was performed 1 year after the procedure and the patient was well and a CT scan demonstrated no evidence of recurrence. However, the long term efficacy of this procedure requires continued observation in this patient.
doi:10.3892/ol.2013.1191 pmid:23599808 pmcid:PMC3629187 fatcat:nfwkriw2iffdpaicx4tsqe5ob4

circAFF1 Aggravates Vascular Endothelial Cell Dysfunction Mediated by miR-516b/SAV1/YAP1 Axis

Hong-guang Wang, Hua Yan, Chen Wang, Mi-mi Li, Xin-ze Lv, Hai-dong Wu, Zhan-hai Fang, Dong-li Mo, Zhi-yuan Zhang, Bin Liang, Ke-guan Lai, Jing-yu Bao (+5 others)
2020 Frontiers in Physiology  
Copyright © 2020 Wang, Yan, Wang, Li, Lv, Wu, Fang, Mo, Zhang, Liang, Lai, Bao, Yang, Zhao, Chen, Fan and Tong.  ... 
doi:10.3389/fphys.2020.00899 pmid:32848851 pmcid:PMC7425207 fatcat:ymh2fegymvgi3hyo7u4pmq3oci

Centromere Protein H Is a Novel Prognostic Marker for Nasopharyngeal Carcinoma Progression and Overall Patient Survival

Wen-Ting Liao, Li-Bing Song, Hui-Zhong Zhang, Xing Zhang, Ling Zhang, Wan-Li Liu, Yan Feng, Bao-Hong Guo, Hai-Qiang Mai, Su-Mei Cao, Man-Zhi Li, Hai-De Qin (+2 others)
2007 Clinical Cancer Research  
Purpose: The aim of the present study was to analyze the expression of Centromere protein H (CENP-H), one of the fundamental components of the human active kinetochore, in nasopharyngeal carcinoma (NPC) and to correlate it with clinicopathologic data, including patient survival. Experimental Design: Using reverse transcription-PCR and Western blot, we detected the expression of CENP-H in normal nasopharyngeal epithelial cells, immortalized nasopharyngeal epithelial cell lines, and NPC cell
more » ... . Using immunohistochemistry, we analyzed CENP-H protein expression in160 clinicopathologically characterized NPC cases. Statistical analyses were applied to test for prognostic and diagnostic associations. Results: Reverse transcription-PCR and Western blot showed that the expression level of CENP-H was higher in NPC cell lines and in immortalized nasopharyngeal epithelial cells than in the normal nasopharyngeal epithelial cell line at both transcriptional and translational levels. By immunohistochemical analysis, we found that 76 of 160 (47.5%) paraffin-embedded archival NPC biopsies showed high expression of CENP-H. Statistical analysis showed that there was a significant difference of CENP-H expression in patients categorized according to clinical stage (P = 0.024) and Tclassification (P = 0.027). Patients with higher CENP-H expression had shorter overall survival time, whereas patients with lower CENP-H expression had better survival. A prognostic value of CENP-H was also found of the subgroup of N 0 -N 1 tumor classification. Multivariate analysis showed that CENP-H expression was an independent prognostic indicator for patient's survival. Conclusions: Our results suggest that CENP-H protein is a valuable marker of NPC progression. High CENP-H expression is associated with poor overall survival in NPC patients.
doi:10.1158/1078-0432.ccr-06-1512 pmid:17255272 fatcat:hcfnqxytqjbslky5p7yawh6zta

CD68 and interleukin 13, prospective immune markers for esophageal squamous cell carcinoma prognosis prediction

Jian Li, Bao-Zhu Zhang, Yan-Ru Qin, Jiong Bi, Hai-Bo Liu, Yan Li, Mu-Yan Cai, Stephanie Ma, Kwok Wah Chan, Dan Xie, Xin-Yuan Guan
2016 OncoTarget  
Purpose: Oncology immunity was reported to play a key role in cancer development and progression, so we investigated the prediction role of several immune markers in esophageal squamous cell carcinoma (ESCC) patients after operation in this study. Patients and Methods: 66 primary ESCC tumor tissues and four sets of tissue microarrays including 705 primary ESCC tumor tissues from four centers were collected and analyzed. Expressions of several immune markers in ESCC tumor tissue were detected
more » ... h immunohistochemistry staining. Their distribution densities were analyzed with InForm ™ 2.0.1 software. All statistic analyses were performed with SPSS16.0 and Stata version 10.0. Results: Survival analyses assessed by Kaplan-Meier plots and log-rank tests demonstrated that densities of CD68 and interleukin 13 (IL-13) in tumor stroma were positively correlated with the overall survival of ESCC patients after operation (p < 0.01 for CD68, p < 0.001 for IL-13). Further, a model based on tumor stroma densities of CD68 and IL-13 was constructed and it could significantly classify patients with poor or good prognosis. This model could further identify high-risk group and low-risk group at the same Tumor lymph Nodes Metastases (TNM) stage. Lastly, a more accuracy model based on TNM stage, densities of CD68 and IL-13 was constructed to predict the prognosis of ESCC patient after operation. Conclusion: Combining the TNM staging system and densities of CD68 and IL-13 could substantially improve the prognosis prediction accuracy of ESCC patient after operation, which might be an excellent tool for selecting patients for individualized therapy in future.
doi:10.18632/oncotarget.6900 pmid:26771842 pmcid:PMC4941258 fatcat:rh3lzqfkozdivbjn26o5gtbire

Partial discharge localisation methodology for power transformers based on improved acoustic propagation route search algorithm

Yan-Bo Wang, Yu-Hang Fan, Shao-Rui Qin, Ding-Ge Chang, Xian-Jun Shao, Hai-Bao Mu, Guan-Jun Zhang
2018 IET Science, Measurement & Technology  
The localisation of partial discharge (PD) sources using the acoustic emission (AE) technique has attracted increasing research attention. The complicated propagation routes and wave-type conversion in power transformer can induce considerable localisation error. In this paper, the catadioptric phenomenon of AE wave propagation is explained in detail. With the incident angle varying, the wave type of the direct wave in tank wall could convert and the velocity will change accordingly. A
more » ... er model is established in which each node refers to a suspected PD position and a shortest route search algorithm is proposed to calculate the shortest path between two nodes in this model. However, the fastest route is most significant to PD localisation rather than the shortest route when TDOA method is used. As a result, an improved propagation route search (IPRS) algorithm, which can recreate the propagation process and calculate the fastest AE routes, is proposed to localise the PD origin. To verify the feasibility of the IPRS algorithm, localisation experiments were performed in 35 and 110 kV transformers, respectively. Compared with other present localisation methods, such as the Chan algorithm, the genetic algorithm and the imperial competitive algorithm, the proposed algorithm can effectively reduce localisation error.
doi:10.1049/iet-smt.2018.5092 fatcat:pwhpggwkr5ebbcafntfhrovo4m

Association between Self-reported Snoring and Prediabetes among Adults Aged 40 Years and Older without Diabetes

Yi-Ming Mu, Hai-Bin Wang, Wen-Hua Yan, Jing-Tao Dou, Zhao-Hui Lu, Bao-An Wang
2017 Chinese Medical Journal  
doi:10.4103/0366-6999.202741 pmid:28345542 pmcid:PMC5381312 fatcat:yoexej7pozfrvi6c4g5xed2mzi
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