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Formation of ring-banded spherulites of α and β modifications in Poly(butylene adipate)
2011
Polymer
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The morphology and crystalline structure of banded spherulites of poly(butylene adipate) (PBA) were investigated by polarized optical microscopy (POM), wide-angle X-ray diffraction (WAXD), atomic force microscopy (AFM) and scanning electronic microscopy (SEM). It was found that after purification and fractionation, the obtained PBA fractions with different molecular weight formed ring-banded spherulites at different temperature ranges. Pure a and b form of PBA can form regular ring-banded
doi:10.1016/j.polymer.2011.08.001
fatcat:vogmxgidcfclxlyy2cbnxlo36e
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... lites. AFM and SEM observations of the thin film revealed that the alternative ridges and valleys along the radial direction consisted of edge-on and flat-on lamellae, respectively, indicating the ring-bands in PBA spherulites are the consequence of lamellar twisting. In addition, sequential growth of a and b form in one PBA spherulite at the same temperature is reported and interpreted by competition of primary nucleation and radial growth of the two crystalline modifications. At a certain temperature range, the a form PBA has larger primary nucleation rate but lower radial growth rate than the b form PBA, leading to formation of spherulites consisted of a form at center and b form at the outer region. But finally, a layer of a form ringless region appears at the outside of the b form ring-banded region before impingement of the neighboring spherulites. These results suggest that besides crystallization temperature, molecular weight has considerable effect on the formation of crystal modification of PBA and the corresponding banded spherulites.
Design, Synthesis, DFT Study and Antifungal Activity of Pyrazolecarboxamide Derivatives
2016
Molecules
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A series of novel pyrazole amide derivatives were designed and synthesized by multi-step reactions from phenylhydrazine and ethyl 3-oxobutanoate as starting materials, and their structures were characterized by NMR, MS and elemental analysis. The antifungal activity of the title compounds was determined. The results indicated that some of title compounds exhibited moderate antifungal activity. Furthermore, DFT calculations were used to study the structure-activity relationships (SAR).
doi:10.3390/molecules21010068
pmid:26760990
fatcat:wfluob2flvdvndygty4tryjjda
Simulational study on streamer discharge in transformer oil under positive nanosecond pulse voltage
2013
Wuli xuebao
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In this paper, we investigate the streamer discharge process in transformer oil under positive nanosecond pulse voltage through developing a two-dimensional axially symmetric fluid model and simulating the physics of discharge inception and propagation. The streamer discharge profile and distributions of electric field and space charge density are obtained under different conditions such as the amplitude of applied voltage, rise time and gap distance. Simulation results show that space charges
doi:10.7498/aps.62.124703
fatcat:pdsamyclzbfghcf663nph5zftm
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... nhance the front field of streamer head, which is conducive to the longer propagation of discharge channel, therefore "ionization wave" is formed. The magnitude and rise time of applied voltage have evident influences on the average speed of streamer propagation. It can be observed that the higher the applied impulse voltage, the faster the streamer propagates, and the steeper the rise time of applied impulse, when streamer arrives at the same position, the larger the discharging radius will be and the smaller maximal electric field will be. The cases of different gap distances indicate that longer gap distance corresponds to a faster average speed of streamer. It is considered that fielddependent molecular ionization predominates the charge generation mechanism of streamer discharge process in transformer oil, and space charge effect contributes to further developing ionization until the whole gap eventually breakdowns. The study is dedicated to the better understanding of the process from inception to breakdown of discharging in transformer oil, as well as ionization mechanism in liquid dielectric.
Practical Security of High-Dimensional Quantum Key Distribution with Intensity Modulator Extinction
2022
Entropy
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Quantum key distribution (QKD) has attracted much attention due to its unconditional security. High-dimensional quantum key distribution (HD-QKD) is a brand-new type of QKD protocol that has many excellent advantages. Nonetheless, practical imperfections in realistic devices that are not considered in the theoretical security proof may have an impact on the practical security of realistic HD-QKD systems. In this paper, we research the influence of a realistic intensity modulator on the
doi:10.3390/e24040460
pmid:35455123
pmcid:PMC9026895
fatcat:fc7iaghfv5ecpiygssssvcy42u
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... security of HD-QKD systems with the decoy-state method and finite-key effects. We demonstrate that there is a certain impact in the secret key rate and the transmission distance when taking practical factors into security analysis.
A new quinolinone and its natural/artificial derivatives from a shark gill-derived fungus Penicillium crustosum AP2T1
2015
Figshare
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Zhang Y, Mu J, Han J, Gu X. 2012. An improved brine shrimp larvae lethality microwell test method. Toxicol Mech Methods 22(1):23−30. ...
doi:10.6084/m9.figshare.1486380.v1
fatcat:z44szvebuvhnlfe46t5cwtgdlu
A new quinolinone and its natural/artificial derivatives from a shark gill-derived fungus Penicillium polonicum AP2T1
2016
Figshare
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Zhang Y, Mu J, Han J, Gu X. 2012. An improved brine shrimp larvae lethality microwell test method. Toxicol Mech Methods 22(1):23−30. ...
doi:10.6084/m9.figshare.1486380.v2
fatcat:dqyilsue3fgzlkmacpusfdsh6i
Reversible Structural Modulation of Fe-Pt Bimetallic Surfaces and Its Effect on Reactivity
2009
ChemPhysChem
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Magnolol, a Natural Polyphenol, Attenuates Dextran Sulfate Sodium-Induced Colitis in Mice
2017
Molecules
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Magnolol is a lignan with anti-inflammatory activity identified in Magnolia officinalis. Ulcerative colitis (UC), one of the types of inflammatory bowel disease (IBD), is a disease that causes inflammation and ulcers in the colon. To investigate the effect of magnolol in dextran sulfate sodium (DSS)-induced experimental UC model, male C57 mice were treated with 2% DSS drinking water for 5 consecutive days followed by intragastric administration with magnolol (5, 10 and 15 mg/kg) daily for 7
doi:10.3390/molecules22071218
pmid:28726741
fatcat:ac7tr7wbgbfffhq7nbvvuu2fum
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... . The results showed that magnolol significantly attenuated disease activity index, inhibited colonic shortening, reduced colonic lesions and suppressed myeloperoxidase (MPO) activity. Moreover, colonic pro-inflammatory cytokines (TNF-α, IL-6, and IL-1β) induced by colitis were dramatically decreased by magnolol. To further unveil the metabolic signatures upon magnolol treatment, mass spectrometry-based metabolomic analysis of the small molecular metabolites in mice serum were performed. Compared with controls, abnormality of serum metabolic phenotypes in DSS-treated mice were effectively reversed by different doses of magnolol. In particular, magnolol treatment effectively elevated the serum levels of tryptophan metabolites including kynurenic acid (KA), 5-hydroxyindoleacetic acid, indoleacetic acid (IAA), indolelactic acid and indoxylsulfuric acid, which are potential aryl hydrocarbon receptor (AHR) ligands to impact colitis. These findings suggest that magnolol exerts anti-inflammatory effect on DSS-induced colitis and its underlying mechanisms are associated with the restoring of tryptophan metabolites that inhibit the colonic inflammation. Molecules 2017, 22, 1218 2 of 15 while long-term treatment with these drugs are not quite effective [3, 4] . Other steroid drugs such as azathioprine and 6-mercaptopurine exist non-negligible side effects [5, 6] . Infliximab is the most often used biological agent for IBD, while the clinical response is only around 65% [7]. To date, the underlying cause of IBD is not well-understood and alarmingly, in light of the soaring numbers of IBD cases, promising therapeutics have yet to be developed. Magnolol (5,5 -di-2-propen-1-yl-2,2 -Bichavicol) is a lignan exacted from the bark of Magnolia officinalis, the compounds of which demonstrating anti-cancer, anti-stress, anti-anxiety, anti-depressant, anti-oxidant and anti-inflammatory effects [8] . The anti-inflammatory effect of magnolol has been reported in the animal models of ischemic stroke [9], oxygen-induced retinopathy [10], acute lung injury [11, 12] , mastitis [13] , and arthritis [14] . In RAW264.7 cells, magnolol can inhibit lipopolysaccharide (LPS)-induced NF-κB activation, IKBα degradation and pro-inflammatory cytokines production [15, 16] . Similar mechanisms of magnolol can also be found in LPS-induced acute lung injury mice models by inhibiting the tumor necrosis factor-alpha (TNF-α), IL-1β, phosphorylation of IκB-α and NF-κB, and expression of toll-like receptor 4 (TLR4) [17] . In human aortic endothelial cells, magnolol inhibits TNF-α-induced JNK/p38 phosphorylation and NF-κB activation, thereby reducing leukocyte adhesion [18] . Furthermore, magnolol was demonstrated to suppress colonic smooth muscle contraction through downregulation of L-type Ca(2+) channels in rats [19, 20] . Magnolol treatment prevents sepsis-induced rat intestinal dysmotility by regulating stem cell factor (SCF)/c-kit and NO signaling to maintain functional interstitial cells of Cajal (ICCs) [21] , reducing TNF-α and inducible nitric oxide synthase (iNOS), while stimulating IL-10 mRNA expression in septic rat ileum [22] . These findings suggest that magnolol is a potential therapeutic compound for inflammatory gastrointestinal diseases yet to be examined. The present study aims to investigate the effect of magnolol on Dextran sulfate sodium (DSS)-induced colitis, and to explore the possible mechanisms in the levels of metabolites by UPLC/MS-based metabolomic analysis.
Simulations of the cathode falling characteristics and its influence factors in atmospheric pressure dielectric barrier glow discharge pulse
2017
Wuli xuebao
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Technol. 174-175 08 [7] Yao C W, Chang Z S, Ma H C, Xu G M, Mu H B, Zhang 降至 14% 位置 (定义 2) 两种方式分别定义了大气 多可能抑制 He 放电的过程本文暂不考虑. N 2 含 G J 2016 IEEE Trans. ...
doi:10.7498/aps.66.025203
fatcat:grvg44xakzbf3ckytxanjzb234
The management of retroperitoneal giant schwannomas in AIDS patients: A case report
2013
Oncology Letters
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Retroperitoneal schwannomas are a rare disease. During the potent antiretroviral therapy era, the incidence of AIDS-defining cancers has decreased, while the incidence of non-AIDS defining cancers has increased; however, the existence of a relationship between benign or malignant schwannomas and AIDS remains unclear. Although a case of ethmoid malignant schwannoma in an AIDS patient was first reported in 1993, no additional reports of schwannomas associated with AIDS have been published since.
doi:10.3892/ol.2013.1191
pmid:23599808
pmcid:PMC3629187
fatcat:nfwkriw2iffdpaicx4tsqe5ob4
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... n the current study, the case of a 30-year-old male AIDS patient with a large benign retroperitoneal schwannoma is presented. The ideal treatment of retroperitoneal schwannomas is complete excision. However, controversy exists over the necessity of negative soft tissue margins, particularly when adjacent tissue or viscera must also be removed. In the current case study, due to the immune dysfunction in AIDS patients, the incidence of malignancy could not be completely excluded prior to surgery and a significant risk of short-term relapse or malignancy following partial tumor resection was present. The patient underwent complete resection with partial superior mesenteric artery excision in order to attain negative margins, and recovered well. A follow-up was performed 1 year after the procedure and the patient was well and a CT scan demonstrated no evidence of recurrence. However, the long term efficacy of this procedure requires continued observation in this patient.
circAFF1 Aggravates Vascular Endothelial Cell Dysfunction Mediated by miR-516b/SAV1/YAP1 Axis
2020
Frontiers in Physiology
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Copyright © 2020 Wang, Yan, Wang, Li, Lv, Wu, Fang, Mo, Zhang, Liang, Lai, Bao, Yang, Zhao, Chen, Fan and Tong. ...
doi:10.3389/fphys.2020.00899
pmid:32848851
pmcid:PMC7425207
fatcat:ymh2fegymvgi3hyo7u4pmq3oci
Centromere Protein H Is a Novel Prognostic Marker for Nasopharyngeal Carcinoma Progression and Overall Patient Survival
2007
Clinical Cancer Research
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Purpose: The aim of the present study was to analyze the expression of Centromere protein H (CENP-H), one of the fundamental components of the human active kinetochore, in nasopharyngeal carcinoma (NPC) and to correlate it with clinicopathologic data, including patient survival. Experimental Design: Using reverse transcription-PCR and Western blot, we detected the expression of CENP-H in normal nasopharyngeal epithelial cells, immortalized nasopharyngeal epithelial cell lines, and NPC cell
doi:10.1158/1078-0432.ccr-06-1512
pmid:17255272
fatcat:hcfnqxytqjbslky5p7yawh6zta
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... . Using immunohistochemistry, we analyzed CENP-H protein expression in160 clinicopathologically characterized NPC cases. Statistical analyses were applied to test for prognostic and diagnostic associations. Results: Reverse transcription-PCR and Western blot showed that the expression level of CENP-H was higher in NPC cell lines and in immortalized nasopharyngeal epithelial cells than in the normal nasopharyngeal epithelial cell line at both transcriptional and translational levels. By immunohistochemical analysis, we found that 76 of 160 (47.5%) paraffin-embedded archival NPC biopsies showed high expression of CENP-H. Statistical analysis showed that there was a significant difference of CENP-H expression in patients categorized according to clinical stage (P = 0.024) and Tclassification (P = 0.027). Patients with higher CENP-H expression had shorter overall survival time, whereas patients with lower CENP-H expression had better survival. A prognostic value of CENP-H was also found of the subgroup of N 0 -N 1 tumor classification. Multivariate analysis showed that CENP-H expression was an independent prognostic indicator for patient's survival. Conclusions: Our results suggest that CENP-H protein is a valuable marker of NPC progression. High CENP-H expression is associated with poor overall survival in NPC patients.
CD68 and interleukin 13, prospective immune markers for esophageal squamous cell carcinoma prognosis prediction
2016
OncoTarget
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Purpose: Oncology immunity was reported to play a key role in cancer development and progression, so we investigated the prediction role of several immune markers in esophageal squamous cell carcinoma (ESCC) patients after operation in this study. Patients and Methods: 66 primary ESCC tumor tissues and four sets of tissue microarrays including 705 primary ESCC tumor tissues from four centers were collected and analyzed. Expressions of several immune markers in ESCC tumor tissue were detected
doi:10.18632/oncotarget.6900
pmid:26771842
pmcid:PMC4941258
fatcat:rh3lzqfkozdivbjn26o5gtbire
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... h immunohistochemistry staining. Their distribution densities were analyzed with InForm ™ 2.0.1 software. All statistic analyses were performed with SPSS16.0 and Stata version 10.0. Results: Survival analyses assessed by Kaplan-Meier plots and log-rank tests demonstrated that densities of CD68 and interleukin 13 (IL-13) in tumor stroma were positively correlated with the overall survival of ESCC patients after operation (p < 0.01 for CD68, p < 0.001 for IL-13). Further, a model based on tumor stroma densities of CD68 and IL-13 was constructed and it could significantly classify patients with poor or good prognosis. This model could further identify high-risk group and low-risk group at the same Tumor lymph Nodes Metastases (TNM) stage. Lastly, a more accuracy model based on TNM stage, densities of CD68 and IL-13 was constructed to predict the prognosis of ESCC patient after operation. Conclusion: Combining the TNM staging system and densities of CD68 and IL-13 could substantially improve the prognosis prediction accuracy of ESCC patient after operation, which might be an excellent tool for selecting patients for individualized therapy in future.
Partial discharge localisation methodology for power transformers based on improved acoustic propagation route search algorithm
2018
IET Science, Measurement & Technology
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The localisation of partial discharge (PD) sources using the acoustic emission (AE) technique has attracted increasing research attention. The complicated propagation routes and wave-type conversion in power transformer can induce considerable localisation error. In this paper, the catadioptric phenomenon of AE wave propagation is explained in detail. With the incident angle varying, the wave type of the direct wave in tank wall could convert and the velocity will change accordingly. A
doi:10.1049/iet-smt.2018.5092
fatcat:pwhpggwkr5ebbcafntfhrovo4m
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... er model is established in which each node refers to a suspected PD position and a shortest route search algorithm is proposed to calculate the shortest path between two nodes in this model. However, the fastest route is most significant to PD localisation rather than the shortest route when TDOA method is used. As a result, an improved propagation route search (IPRS) algorithm, which can recreate the propagation process and calculate the fastest AE routes, is proposed to localise the PD origin. To verify the feasibility of the IPRS algorithm, localisation experiments were performed in 35 and 110 kV transformers, respectively. Compared with other present localisation methods, such as the Chan algorithm, the genetic algorithm and the imperial competitive algorithm, the proposed algorithm can effectively reduce localisation error.
Association between Self-reported Snoring and Prediabetes among Adults Aged 40 Years and Older without Diabetes
2017
Chinese Medical Journal
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