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HAPSIMU: a genetic simulation platform for population-based association studies

Feng Zhang, Jianfeng Liu, Jie Chen, Hong-Wen Deng
2008 BMC Bioinformatics  
Results: We developed a genetic simulation platform, HAPSIMU, based on real haplotype data from the HapMap ENCODE project.  ...  Population structure is an important cause leading to inconsistent results in population-based association studies (PBAS) of human diseases.  ...  Acknowledgements The study was partially supported by Xi'an Jiaotong University.  ... 
doi:10.1186/1471-2105-9-331 pmid:18681963 pmcid:PMC2518933 fatcat:rqjdlzlfhjdspdnrj7gprtf52u

Genetic Data Simulators and their Applications: An Overview

Bo Peng, Huann-Sheng Chen, Leah E. Mechanic, Ben Racine, John Clarke, Elizabeth Gillanders, Eric J. Feuer
2014 Genetic Epidemiology  
Computer simulations have played an indispensable role in the development and application of statistical models and methods for genetic studies across multiple disciplines.  ...  To help researchers compare and choose the most appropriate simulators for their studies, we have created the Genetic Simulation Resources (GSR) website, which allows authors of simulation software to  ...  Acknowledgments The development of GSR is supported by a contract HHSN261201100558P from the National Cancer Institute.  ... 
doi:10.1002/gepi.21876 pmid:25504286 pmcid:PMC4804465 fatcat:exqgstend5hjdfeyemgzpcvoze