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MERT - a multi-environment real-time operating system

D. L. Bayer, H. Lycklama
1975 Proceedings of the fifth symposium on Operating systems principles - SOSP '75  
Roberts and one of the authors (H. Lycklama). The authors are pleased to acknowledge Mr. C. S. Ro-ber£s for many fruitful discussions during the design stage of the current operating system.  ... 
doi:10.1145/800213.806519 dblp:conf/sosp/BayerL75 fatcat:77nrdgl6cjg6rfrrygw7qjwh7y

Hypointense Lesions on T1-Weighted Spin-Echo Magnetic Resonance Imaging

Marianne A. A. van Walderveen, Geert J. Lycklama à Nijeholt, Herman J. Adèr, Peter J. H. Jongen, Chris H. Polman, Jonas A. Castelijns, Frederik Barkhof
2001 Archives of Neurology  
Context: Hypointense lesions on T1-weighted spinecho magnetic resonance images (T1 lesions) represent destructive multiple sclerosis (MS) lesions, consisting of axonal loss and matrix destruction. These lesions are being used as a secondary outcome measure in phase III clinical trials. Clinical determinants of T1 lesions may differ between subgroups of patients with MS and subsequently may have implications for the selection of patients for clinical trials. Objective: To determine if clinical
more » ... aracteristics of patients with MS are related to T1 lesion volume. Design: A survey of 138 patients with MS (52 with relapsing-remitting MS, 44 with secondary progressive MS, and 42 with primary progressive MS).
doi:10.1001/archneur.58.1.76 pmid:11176939 fatcat:mdng4rw4fvbdhghwjbpa7kcjjm

Acute Spinal-Cord Ischemia: Evolution of MRI Findings

Cornelis L. Alblas, Willem H. Bouvy, Geert J. Lycklama à Nijeholt, Jelis Boiten
2012 Journal of Clinical Neurology  
E F G H Fig. 1.  ...  G and H: MRI performed 6 days after symptom onset: axial (G) DWI showing right-sided high signal at the C2 level and axial (H) low apparent diffusion co- efficient values showing diffusion re- striction  ... 
doi:10.3988/jcn.2012.8.3.218 pmid:23091532 pmcid:PMC3469803 fatcat:mzvxtz7ghvh4pm43ca634vx2cy

European supercritical water cooled reactor

T. Schulenberg, J. Starflinger, P. Marsault, D. Bittermann, C. Maráczy, E. Laurien, J.A. Lycklama à Nijeholt, H. Anglart, M. Andreani, M. Ruzickova, A. Toivonen
2011 Nuclear Engineering and Design  
Fig. 8 . 8 Oxide thick nesses after 600 h exposure to BWR NWC at 650 • C. data from Fig. 11 . 11 Predicted fuel rod surface temperature in a four rod bundle at hot-channel conditions.  ... 
doi:10.1016/j.nucengdes.2010.09.039 fatcat:xat7z6vmcvek3j2my6hxvpp7ie

Post-mortem high-resolution MRI of the spinal cord in multiple sclerosis

G. J. Lycklama à Nijeholt, E. Bergers, W. Kamphorst, J. Bot, K. Nicolay, J. A. Castelijns, J. H. T. M. van Waesberghe, R. Ravid, C. H. Polman, F. Barkhof
2001 Brain  
In-plane resolution was 80 µm and acquisition time was 1 h.  ...  Differences in the appearance of spinal cord abnormalities reflect disease type and symptomatology (Lycklama à Nijeholt et al., 1998) .  ... 
doi:10.1093/brain/124.1.154 pmid:11133795 fatcat:qejhjcpj5bc3dpp2xra6a2t3le

Duplex ultrasonography for the detection of vertebral artery stenosis

Anouk D. Rozeman, Hajo Hund, Michel Westein, Marieke J. H. Wermer, Geert J. Lycklama à Nijeholt, Jelis Boiten, Robert-Jan Schimsheimer, Ale Algra
2017 Brain and Behavior  
Sensitivity (%) Specificity (%) Stenosis ≥ 50% 140 39 88 130 48 85 120 61 78 110 68 69 100 71 57 90 84 47 80 84 37 70 87 25 How to cite this article: Rozeman AD, Hund H,  ... 
doi:10.1002/brb3.750 pmid:28828211 pmcid:PMC5561311 fatcat:jgbhqjnwevfctdjkhw4shzvrei

Simulation of a traveling-wave thermoacoustic engine using computational fluid dynamics

J. A. Lycklama à Nijeholt, M. E. H. Tijani, S. Spoelstra
2005 Journal of the Acoustical Society of America  
The heat source has the following form ( ) ) s g H T T S − − = α (7) where α is the heat transfer coefficient, T g and T s are the gas and solid matrix temperatures, respectively.  ... 
doi:10.1121/1.2035567 fatcat:qs7nfhit3nejdnpr6rppu2dfsq

Intravenous Thrombolysis Is Not Associated with Increased Time to Endovascular Treatment

Wouter H. Hinsenveld, Inger R. de Ridder, Robert J. van Oostenbrugge, Wim H. van Zwam, Jan Albert Vos, Jonathan M. Coutinho, Geert J. Lycklama à Nijeholt, Jelis Boiten, Wouter J. Schonewille, MR CLEAN Registry Investigators
2020 Cerebrovascular Diseases  
Van Oostenbrugge, Van Zwam, Vos, Coutinho, Lycklama à Nijeholt, Boiten, and Schonewille contributed in patient enrollment, data collection, and critical review of the manuscript.  ... 
doi:10.1159/000508898 pmid:32615562 fatcat:ppv6rdvynzajvj45uzup42yom4

Transurethral mesh resection after urethral erosion of tension-free vaginal tape: report of three cases and review of literature

S. A. M. Wijffels, H. W. Elzevier, A. A. B. Lycklama a Nijeholt
2008 International Urogynecology Journal  
A rare complication after tension-free vaginal tape (TVT; including TVT-O) procedure is erosion of the tape through the urethral wall. In the literature, different methods to remove this intra-urethral tape are described. Most authors used the transvaginal approach with urethrotomy. In the cases described in this article, the transurethral approach is applied and proposed as the optimal method, being minimally invasive and less damaging to the urethral wall A transurethral catheter can be
more » ... d shortly after surgery to enable optimal tissue healing of the urethral mucosa.
doi:10.1007/s00192-008-0705-9 pmid:18716705 fatcat:6krrellhhbasjmvn5b5e3sjjmu

Impact of various questionnaires on the prevalence of erectile dysfunction. The ENIGMA-study

B J de Boer, M L Bots, A A B Lycklama a Nijeholt, J P C Moors, H M Pieters, Th J M Verheij
2004 International journal of impotence research  
The prevalence estimates of erectile dysfunction (ED) vary considerably across studies. These differences may be attributed to used definitions of ED. Quantitative data on the effect of different definitions of ED on the prevalence are lacking, because precise information on the used definition and questionnaire is often absent. Aim of this study was to quantify the effect of using different questionnaires for ED on the prevalence estimates. In all, 5721 mail surveys on sexual problems and ED
more » ... re sent to all men (aged418 y) in 12 general practices in the middle of the Netherlands of which 2117 were completed. The questionnaire contained Enigma (WHO), International Index of Erectile Function (IIEF), Cologne Erectile Inventory (KEED) and one question (Boxmeer, Krimpen). The prevalence of ED based on the various questionnaires and the effect of these questionnaires on risk factor relationships was compared. IIEF gave the highest age specific and overall ED prevalence, KEED the lowest. The difference in prevalence was 16.8%. The agreement (kappa coefficient) between the various ED definitions varied from 0.52 (IIEF & KEED) to 0.95 (Enigma & Boxmeer). The number of risk factor relations were similar for the Dutch studies, reduced for the IIEF and KEED. This study provides evidence that differences in questionnaires to assess ED have a considerable effect on the (age specific) prevalence estimates and little on the risk factor relations. The number of questions of the survey appears not to be responsible for differences in the prevalence of ED and risk factor relations, however they affect the response rate. Uniform use is strongly recommended, since a 'golden standard' for ED assessment (by questionnaire) is lacking. A short questionnaire with one or two questions is recommended for example the one from the Boxmeer-study. These data may be used to adjust (age-specific) prevalence rates comparing ED prevalence in the open population across studies.
doi:10.1038/sj.ijir.3901053 pmid:14973534 fatcat:gwautdlicfhiniieqceh5n5fvu

Erectile dysfunction in primary care: prevalence and patient characteristics. The ENIGMA study

B J de Boer, M L Bots, A A B Lycklama a Nijeholt, J P C Moors, H M Pieters, Th J M Verheij
2004 International journal of impotence research  
The availability of adequate treatment for erectile dysfunction (ED) triggers studies into the prevalence of ED in the general population. Yet, previous studies showed different prevalence estimates partly due to differences in patient selection, in (unclear) definitions of ED and in assessment. ENIGMA has been designed to study the prevalence of ED in the general population of The Netherlands, using the WHO definition with a description of the way of assessment. In all, 5721 mail surveys were
more » ... ent to all men, aged 18 y and older in 12 general practices in The Netherlands. A total of 5601 were included in the study and 2117 (38%) were completed. A total of 38% of the men reported to have ever had some kind of erectile problem. The prevalence of ED was 17% (6% mild, 4% moderate and 7% complete). Age, diabetes, cardiovascular diseases, penile disorders, irradiation in the pelvic region, relational problems, fear for failure, surmenage, medication use and regular consumption of alcohol were independently related to ED. Men with ED were less content with their (sexual) life and had less confidence in sexual performance. Presence of ED was negatively related to affected happiness in life. ED is commonly found in men and is related to age, medication, comorbidity and lifestyle factors. Men with ED perceive a lower quality of (sex)life. Doctors should be aware of the presence of ED and its consequences in patients.
doi:10.1038/sj.ijir.3901155 pmid:14961062 fatcat:i3idi2kahrhlxpkbhbetedvwhe

Peripheral Artery Disease in Acute Ischemic Stroke Patients Treated With Endovascular Thrombectomy; Results From the MR CLEAN Registry

France A. V. Pirson, Wouter H. Hinsenveld, Julie Staals, Inger R. de Ridder, Wim H. van Zwam, Tobien H. C. M. L. Schreuder, Yvo B. W. E. M. Roos, Charles B. L. M. Majoie, H. Bart van der Worp, Maarten Uyttenboogaart, Geert J. Lycklama à Nijeholt, Wouter J. Schonewille (+1 others)
2020 Frontiers in Neurology  
Secondary outcomes included functional independence, neurological deficit measured by the National Institute of Health Stroke Scale (NIHSS) at 24-48 h (18) , and collateral grades.  ...  There was no association between PAD and all other secondary outcomes: 90-days mortality (aOR 1.24, 95% CI 0.9-1.7), 24 h NIHSS (β 0.15, 95% CI −0.9-1.2), sICH (aOR 0.85, 95% CI 0.5-1.6), or stroke progression  ... 
doi:10.3389/fneur.2020.560300 pmid:33133007 pmcid:PMC7579421 fatcat:gaflj7fhxzf43kremaoybj5l3a

Diagnostic performance of an algorithm for automated large vessel occlusion detection on CT angiography

Sven P R Luijten, Lennard Wolff, Martijne H C Duvekot, Pieter-Jan van Doormaal, Walid Moudrous, Henk Kerkhoff, Geert J Lycklama a Nijeholt, Reinoud P H Bokkers, Lonneke S F Yo, Jeannette Hofmeijer, Wim H van Zwam, Adriaan C G M van Es (+3 others)
2021 Journal of NeuroInterventional Surgery  
BackgroundMachine learning algorithms hold the potential to contribute to fast and accurate detection of large vessel occlusion (LVO) in patients with suspected acute ischemic stroke. We assessed the diagnostic performance of an automated LVO detection algorithm on CT angiography (CTA).MethodsData from the MR CLEAN Registry and PRESTO were used including patients with and without LVO. CTA data were analyzed by the algorithm for detection and localization of LVO (intracranial internal carotid
more » ... ery (ICA)/ICA terminus (ICA-T), M1, or M2). Assessments done by expert neuroradiologists were used as reference. Diagnostic performance was assessed for detection of LVO and per occlusion location by means of sensitivity, specificity, and area under the curve (AUC).ResultsWe analyzed CTAs of 1110 patients from the MR CLEAN Registry (median age (IQR) 71 years (60–80); 584 men; 1110 with LVO) and of 646 patients from PRESTO (median age (IQR) 73 years (62–82); 358 men; 141 with and 505 without LVO). For detection of LVO, the algorithm yielded a sensitivity of 89% in the MR CLEAN Registry and a sensitivity of 72%, specificity of 78%, and AUC of 0.75 in PRESTO. Sensitivity per occlusion location was 88% for ICA/ICA-T, 94% for M1, and 72% for M2 occlusion in the MR CLEAN Registry, and 80% for ICA/ICA-T, 95% for M1, and 49% for M2 occlusion in PRESTO.ConclusionThe algorithm provided a high detection rate for proximal LVO, but performance varied significantly by occlusion location. Detection of M2 occlusion needs further improvement.
doi:10.1136/neurintsurg-2021-017842 pmid:34413245 pmcid:PMC9304092 fatcat:qq7ni4ztqzfphmmcura7m4gk5a

Dissemination of Rat Cytomegalovirus through Infected Granulocytes and Monocytes In Vitro and In Vivo

B. W. A. van der Strate, J. L. Hillebrands, S. S. Lycklama a Nijeholt, L. Beljaars, C. A. Bruggeman, M. J. A. van Luyn, J. Rozing, T. H. The, D. K. F. Meijer, G. Molema, M. C. Harmsen
2003 Journal of Virology  
Louis, Mo.) or 1.0 M histamine (Sigma), respectively, for 16 h.  ...  Purified PMN and MNC, obtained from uninfected rats (Harlan), were cocultivated with RCMV-infected RFL-6 cells for 2 h.  ... 
doi:10.1128/jvi.77.20.11274-11278.2003 pmid:14512575 pmcid:PMC224975 fatcat:4qwhx65epbgwhaxt65og3stw4q

Magnetic Resonance Imaging Interpretation in Patients with Sciatica Who Are Potential Candidates for Lumbar Disc Surgery

Abdelilah el Barzouhi, Carmen L. A. M. Vleggeert-Lankamp, Geert J. Lycklama à Nijeholt, Bas F. Van der Kallen, Wilbert B. van den Hout, Annemieke J. H. Verwoerd, Bart W. Koes, Wilco C. Peul, Friedemann Paul
2013 PLoS ONE  
H Categories were: 1) Disc level 2) Folded upwards 3) Folded downwards.  ...  83.3 0.52 71.4 0.30 Characteristics the disc herniation Side of disc herniation 100.0 1.00 94.3 0.89 100.0 1.00 Location axial view V 92.3 * 82.9 * 85.7 * Location sagittal view H  ... 
doi:10.1371/journal.pone.0068411 pmid:23874616 pmcid:PMC3707920 fatcat:f6c4zv33zrextm5ztkxpdyfix4
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