Filters








37 Hits in 0.92 sec

Augmenting Anchors by the Detector Itself [article]

Xiaopei Wan, Guoqiu Li, Yujiu Yang, Zhenhua Guo
2022 arXiv   pre-print
Zhang, Cheng Chi, Yongqiang Yao, Zhen Lei, and Stan Z Li. 2020. Bridging the gap between anchor-based and anchor-free detection via adaptive training sample selection.  ... 
arXiv:2105.14086v2 fatcat:gitxljrhmvfhdayk4e3y47kodm

Some Sufficient Conditions for Heegaard Genera to Be Additive Under Annulus Sum

Fengling Li, Fengchun Lei, Guoqiu Yang
2014 Mathematica Scandinavica  
Let H P 1 denote the closure of the region that lies between P and P + and similarly define H P 2 to denote the closure of the region that lies between P and P − .  ...  Suppose A i = A lies in an incompressible boundary component F i of M i for i = 1, 2, and A 1 is separating on F 1 and A 2 is non-separating on F 2 .  ... 
doi:10.7146/math.scand.a-19221 fatcat:imnjp4t2xjep5gcpngocl66ica

Heegaard genera of high distance are additive under annulus sum

Fengling Li, Guoqiu Yang, Fengchun Lei
2010 Topology and its Applications  
Let H P 1 denote the closure of the region that lies between P and P + and similarly define H P 2 to denote the closure of the region that lies between P and P − .  ...  If β 2 lies in Λ 1 or Λ 3 , and the component of H ∩ M 1 which has β 2 as a boundary component is essential in M 1 , then M 0 contains an essential closed surface, a contradiction.  ... 
doi:10.1016/j.topol.2010.02.009 fatcat:howeybjm2vcovp3umexnmd5b4u

Sparse Nonlinear Feature Selection Algorithm via Local Structure Learning

Jiaye Li, Guoqiu Wen, Jiangzhang Gan, Leyuan Zhang, Shanwen Zhang
2019 Emerging Science Journal  
Li et al. proposed a stable feature selection algorithm [12] . The algorithm is a stable feature selection algorithm based on energy learning.  ... 
doi:10.28991/esj-2019-01175 fatcat:sdicjem7rnc7tky36wqjrqnvze

Theoretical Development of Plant Root Diameter Estimation Based on GprMax Data and Neural Network Modelling

Hao Liang, Guoqiu Fan, Yinghang Li, Yandong Zhao
2021 Forests  
The in situ non-destructive quantitative observation of plant roots is difficult. Traditional detection methods are not only time-consuming and labor-intensive, but also destroy the root environment. Ground penetrating radar (GPR), as a non-destructive detection method, has great potential in the estimation of root parameters. In this paper, we use GprMax software to perform forward modeling of plant roots under different soil dielectric constants, and analyze the situation of plant roots with
more » ... ifferent dielectric constants and different root diameters under 1.5 GHz frequency antenna detection. Firstly, root systems with increasing diameter under different values of root and soil dielectric constant were scanned. Secondly, from the scanning results, two time points T1 and T2 of radar wave entering and penetrating the root system were defined, and the correlation between root diameter D and time interval ∆T between T1 and T2 was analyzed. Finally, the least square regression model and back propagation (BP) neural network model for root diameter parameter estimation were established, and the estimation effects of the two models were compared and evaluated. The research results show that the root diameter (12–48 mm) is highly correlated with the time interval. Given the dielectric constants of the root and soil, the prediction results of the two models are accurate, but the prediction result of the neural network model is more stable, and the residual between the predicted value and the actual value is mainly concentrated in the [−1.5 mm, 1.5 mm] range, as well as the average of prediction error percentage being 3.62%. When the dielectric constants of the root and soil are unknown, the accuracy of the prediction results of the two models is decreased, but the stability of the neural network model is still superior to the least squares model, and the residual error is mainly concentrated in the range of [−5.3 mm, 5.0 mm], the average of prediction error percentage is 10.19%. This study uses GprMax to simulate root system detection and reveals the theoretical potential of GPR technology for non-destructive estimation of root diameter parameters. It is also pointed out that in the field exploration process, if the dielectric constants of the root and soil in the experimental site are sampled and measured first, the prediction accuracy of the model for root diameter would be effectively improved. This research is based on simulation experiments, so further simulation followed by laboratory and field testing is warranted using non-uniform roots and soil.
doi:10.3390/f12050615 fatcat:7qk3slbelramncfvu7xzdlqd64

Prevalence study of brucellosis among high-risk people in xinjiang region, China

Guoqiu Wu, Chengxin Yang, jing Li, Nannan Liu, Wenhai Yao, Rui Zhang, Zhiqiang Lin
2013 Microbiology Discovery  
Brucellosis was a zoonotic disease causing serious public health and economic problems. Methods: Total 2,648 samples were collected between July 2011 and August 2012 from high-risk individuals, who were outpatients at Infectious Disease Hospital of Xinjiang Uygur Autonomous Region. The diagnosis was based upon clinical symptoms and serological or bacteriological test. Results: 1080 individuals (40.8%) were diagnosed as having been infected with brucellosis. The positive rate of brucellosis
more » ... osis was correlated with gender, ethnic group and clinical symptoms. All isolates from blood culture were identified as Brucella melitensis biotype 3. Conclusions: High prevalence of brucellosis exists in Xinjiang, China. An improved healthcare system and preventive measures is needed to minimize the infection of brucellosis.
doi:10.7243/2052-6180-1-2 fatcat:efejhhrlqvfa7klh4x3z6jvwvu

Elevated Gab2 induces tumor growth and angiogenesis in colorectal cancer through upregulating VEGF levels

Chenbo Ding, Junmin Luo, Xiaobo Fan, Longmei Li, Shanshan Li, Kunming Wen, Jihong Feng, Guoqiu Wu
2017 Journal of Experimental & Clinical Cancer Research  
Grb2-associated binder 2 (Gab2) is a scaffolding protein that serves as a critical signaling amplifier downstream of tyrosine kinase receptors. Our previous study has shown that Gab2 induces epithelial-to-mesenchymal transition (EMT) and promotes metastasis in colorectal cancer (CRC). However, the role of Gab2 in CRC growth and angiogenesis remains unclear. Methods: The expression of vascular endothelial growth factor (VEGF) in different colorectal tissues was detected by immunohistochemistry
more » ... d qRT-PCR to evaluate its correlation with Gab2. Lentiviral vectors bearing Gab2 gene and its small interfering RNAs were constructed and transfected into CRC cell lines. The effects of Gab2 on the cell proliferation in vitro and tumorigenesis in vivo, were examined via CCK-8 assay, colony formation assay as well as tumorigenicity assay respectively. Moreover, to assess its potential role in tumor growth and angiogenesis, the expression of Ki67, CD34 and vascular endothelial growth factor receptor-2 (VEGFR2) were detected by immunohistochemistry in CRC cells tumors. Finally, we evaluated the impact of Gab2 on the expression of c-Myc and VEGF, and the probable effect of mechanistic targeted extracellular signal-regulated kinase (ERK) pathway in suppressing tumor growth and angiogenesis.
doi:10.1186/s13046-017-0524-2 pmid:28420432 pmcid:PMC5395829 fatcat:3cvbdwwk6rczfpa4ufx32c52ui

Effects of Cations and PH on Antimicrobial Activity of Thanatin and s-Thanatin against _Escherichia coli_ ATCC25922 and _B. subtilis_ ATCC 21332

Guoqiu Wu, Jiaxuan Ding, Hui Li, Linxian Li, Rui Zhao, Xiaobo Fan, Zilong Shen
2008 Nature Precedings  
Thanatin and s-thanatin were insect antimicrobial peptides which have shown potent antimicrobial activities on a variety of microbes. In order to investigate the effect of cations and pH on the activity of these peptides against Gram-negative bacteria and Gram-positive bacteria, the antimicrobial activities of both peptides were studied in increasing concentrations of monovalent cations (K + and Na + ), divalent cations (Ca 2+ and Mg 2+ ) and H + . The NCCLS broth microdilution method showed
more » ... t both peptides were sensitive to the presence of cations. The divalent cations showed more antagonized effect on the activity against Gram-negative bacteria than the monovalent cations, since the two peptides lost the ability to inhibit bacterial growth at a very low concentration. In addition, the activities of both peptides tested were not significantly affected by pH. Comparing to studies of other antibacterial peptide activities, our data support a hypothesis that positive ions affect the sensitivity to cation peptides.
doi:10.1038/npre.2008.2006.1 fatcat:yobpxcpoyre4zgp45l72yxcc64

Effects of Cations and PH on Antimicrobial Activity of Thanatin and s-Thanatin Against Escherichia coli ATCC25922 and B. subtilis ATCC 21332

Guoqiu Wu, Jiaxuan Ding, Hui Li, Linxian Li, Rui Zhao, Zilong Shen, Xiaobo Fan, Tao Xi
2008 Current Microbiology  
Thanatin and s-thanatin were insect antimicrobial peptides which have shown potent antimicrobial activities on a variety of microbes. In order to investigate the effect of cations and pH on the activity of these peptides against Gram-negative bacteria and Gram-positive bacteria, the antimicrobial activities of both peptides were studied in increasing concentrations of monovalent cations (K + and Na + ), divalent cations (Ca 2+ and Mg 2+ ) and H + . The NCCLS broth microdilution method showed
more » ... t both peptides were sensitive to the presence of cations. The divalent cations showed more antagonized effect on the activity against Gram-negative bacteria than the monovalent cations, since the two peptides lost the ability to inhibit bacterial growth at a very low concentration. In addition, the activities of both peptides tested were not significantly affected by pH. Comparing to studies of other antibacterial peptide activities, our data support a hypothesis that positive ions affect the sensitivity to cation peptides.
doi:10.1007/s00284-008-9241-6 pmid:18810542 fatcat:mpfr7sojvzhq3mgnhnq7prqwxm

Environmental connections of novel avian-origin H7N9 influenza virus infection and virus adaptation to the human

Jun Li, XinFen Yu, XiaoYing Pu, Li Xie, YongXiang Sun, HaiXia Xiao, FenJuan Wang, Hua Din, Ying Wu, Di Liu, GuoQiu Zhao, Jun Liu (+1 others)
2013 Science China Life Sciences  
H7N9 influenza A virus, human adaptation, epidemiology, substitution Citation: Li J, Yu X F, Pu X Y, et al.  ... 
doi:10.1007/s11427-013-4491-3 pmid:23657795 fatcat:nu52gslyzbb3nhvn63bpsi2pam

Clopidogrel-Induced Gastric Injury in Rats is Attenuated by Stable Gastric Pentadecapeptide BPC 157

Hailu Wu, Ming Wei, Nan Li, Qin Lu, Sachin Mulmi Shrestha, Jiacheng Tan, Zhenyu Zhang, Guoqiu Wu, Ruihua Shi
2020 Drug Design, Development and Therapy  
Although Clopidogrel is safe in healthy volunteers, it can induce recurrence of gastric ulcers in high-risk patients. Here, we investigated the protective effect of the natural product, stable gastric pentadecapeptide 157 (BPC 157) on Clopidogrel-induced gastric injury. We used acetic acid to induce gastric ulcer in Sprague Dawley rats. Clopidogrel alone or in combination with BPC 157 or L-NAME (nitric oxide system blockade) were administered after healing of acetic acid-induced ulcer. One
more » ... nt methylcellulose solution was used as control. Ulcer recurrence rate and the ulcer index were compared between these groups. Gastric mucosal apoptosis rate, microscopic inflammation activity and angiogenesis markers vascular endothelial growth factor A (VEGF-A) and CD34 were examined by TUNEL, histological evaluations (HE) and immunohistochemistry (IHC). Pathways involved, expressions of endoplasmic reticulum (ER) stress apoptosis marker CHOP, angiogenic markers VEGF-A and its receptor VEGFR1, and endothelial NO synthase (eNOS) were all analyzed by Western blot. This study indicated that Clopidogrel significantly induced the gastric ulcers recurrence, severe inflammation and ER stress related apoptosis of the gastric mucosa, suppressed the synthesis of angiogenic markers and eNOS. Furthermore, Clopidrogel intervention resulted in the activation of protein kinase B (AKT) and p38 mitogen-activated protein kinase (p38/MAPK). BPC 157 attenuated the gastric mucosal damage caused by Clopidogrel and reversed these molecular effects. However, NO blockade L-NAME weakened the protective effect and thus the molecular effects of BPC 157 on gastric mucosa. In conclusion, these results suggest that BPC 157 inhibited Clopidogrel-induced gastric mucosa injury partially by inhibition of gastric mucosa cell ER stress-mediated apoptosis and inflammation, and promoting gastric mucosa angiogenesis via VEGF-A/VEGFR1 mediated-AKT/p38/MAPK signaling pathways.
doi:10.2147/dddt.s284163 pmid:33376304 pmcid:PMC7763470 fatcat:nqpydfum65bgdmu2ubnv356jr4

A Method for Fuzzy Soft Sets in Decision Making Based on Grey Relational Analysis and D-S Theory of Evidence: Application to Medical Diagnosis

Ningxin Xie, Guoqiu Wen, Zhaowen Li
2014 Computational and Mathematical Methods in Medicine  
Recently, Feng and Li [12] ascertained the relationships among five different types of soft subsets and considered the free soft algebras associated with soft product operations.  ...  Inspired by the work of Wu [34] and Li and Liu [35] , we introduce a method for fuzzy soft sets in decision making based on grey relational analysis and D-S theory of evidence.  ... 
doi:10.1155/2014/581316 pmid:24982687 pmcid:PMC4055226 fatcat:rz6tfdluozfdfkk3hhyifhifki

Retargeted human avidin-CAR T cells for adoptive immunotherapy of EGFRvIII expressing gliomas and their evaluation via optical imaging

Kaiyu Liu, Xujie Liu, Zhiping Peng, Haojie Sun, Mingzhi Zhang, Jianning Zhang, Shuang Liu, Limin Hao, Guoqiu Lu, Kangcheng Zheng, Xikui Gong, Di Wu (+2 others)
2015 OncoTarget  
There has been significant progress in the design of chimeric antigen receptors (CAR) for adoptive immunotherapy targeting tumor-associated antigens. However, the challenge of monitoring the therapy in real time has been continually ignored. To address this issue, we developed optical molecular imaging approaches to evaluate a recently reported novel CAR strategy for adoptive immunotherapy against glioma xenografts expressing EGFRvIII. We initially biotinylated a novel anti-EGFRvIII monoclonal
more » ... ntibody (biotin-4G1) to pre-target EGFRvIII + gliomas and then redirect activated avidin-CAR expressing T cells against the pre-targeted biotin-4G1. By optical imaging study and bio-distribution analysis, we confirmed the specificity of pre-target and target and determined the optimal time for T cells adoptive transfer in vivo. The results showed this therapeutic strategy offered efficient therapy effect to EGFRvIII + glioma-bearing mice and implied that optical imaging is a highly useful tool in aiding in the instruction of clinical CAR-T cells adoptive transfer in future.
doi:10.18632/oncotarget.4362 pmid:26124178 pmcid:PMC4695148 fatcat:eqezagrwn5bonbcm2gwrawj3pa

Combined application of anti-VEGF and anti-EGFR attenuates the growth and angiogenesis of colorectal cancer mainly through suppressing AKT and ERK signaling in mice model

Chenbo Ding, Longmei Li, Taoyu Yang, Xiaobo Fan, Guoqiu Wu
2016 BMC Cancer  
Angiogenesis is generally involved during the cancer development and hematogenous metastasis. Vascular endothelial growth factor (VEGF) and epidermal growth factor receptor (EGFR) are considered to have an important role in tumor-associated angiogenesis. However, the effects of simultaneously targeting on VEGF and EGFR on the growth and angiogenesis of colorectal cancer (CRC), and its underlying mechanisms remain unknown. Methods: Immunohistochemical staining was used to detect the VEGF and
more » ... expression in different CRC tissue specimens, and the correlation between VEGF/EGFR expression with the clinicopathologic features was analyzed. Cell counting kit-8 (CCK-8) and transwell assays were used to assess the cellular proliferation and invasion of CRC cells after treated with anti-VEGF antibody and/or anti-EGFR antibody in vitro, respectively. Moreover, in vivo tumor formation was performed on nude mice model, and the tumor microvessel density (MVD) was determined by anti-CD34 staining in different groups. Finally, we evaluated the impact of anti-VEGF antibody and/or anti-EGFR antibody on the activation of downstream signaling effectors using western blot. Results: VEGF and EGFR were upregulated in CRC tissues, and their expression levels were correlated with hepatic metastasis. Blockage on VEGF or EGFR alone could inhibit the cellular proliferation and metastasis while their combination could reach a good synergism in vitro. In addition, in vivo xenograft mice model demonstrated that the tumor formation and angiogenesis were strongly suppressed by combination treatment of anti-VEGF and anti-EGFR antibodies. Besides, the combination treatment significantly reduced the activation of AKT and ERK1/2, but barely affected the activation of c-Myc, NF-κB/p65 and IκBα in CRC cells tumors. Interestingly, anti-VEGF antibody or anti-EGFR antibody alone could attenuate the phosphorylation of STAT3 as compared with negative control group, whereas the combined application not further suppressed but at least partially restored the activation of STAT3 in vivo. Conclusions: Simultaneous targeting on VEGF and EGFR does show significant inhibition on CRC tumor growth and angiogenesis in mice model, and these effects are mainly attributed to suppression of the AKT and ERK signaling pathways.
doi:10.1186/s12885-016-2834-8 pmid:27729020 pmcid:PMC5059930 fatcat:4hzmlxyx5fgkhl4jw3e23kfhhi

Unrestricted Adversarial Attacks on ImageNet Competition [article]

Yuefeng Chen, Xiaofeng Mao, Yuan He, Hui Xue, Chao Li, Yinpeng Dong, Qi-An Fu, Xiao Yang, Wenzhao Xiang, Tianyu Pang, Hang Su, Jun Zhu (+26 others)
2021 arXiv   pre-print
They are effective but not ideal for the competition. 4th place: team Advers Team members: Guoqiu Wang, Huanqian Yan, Ying Guo, Chaoning Zhang.  ...  The final score of our method is 10567.8. 3rd place: team DemiguiseWoo Team members: Yajie Wang, Huipeng Zhou, Haoran Lyu, Yidan Xu, Zixuan Xu, Taoyu Zhu, Wenjun Li, Xianfeng Gao In this section, we  ... 
arXiv:2110.09903v2 fatcat:leufdo6h3zdxvoh5kjfldlqqta
« Previous Showing results 1 — 15 out of 37 results