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Roles of Gut Microbial Metabolites in Diabetic Kidney Disease

Qing Fang, Qing Fang, Qing Fang, Qing Fang, Qing Fang, Na Liu, Na Liu, Na Liu, Na Liu, Na Liu, Binjie Zheng, Binjie Zheng (+23 others)
2021 Frontiers in Endocrinology  
Li Y, Chen X, Kwan T, Loh Y, Singer J, Liu Y, et al.  ...  Xu Y, Gao C, Guo H, Zhang W, Huang W, Tang S, et al. Sodium butyrate supplementation ameliorates diabetic inflammation in db/db mice.  ...  Copyright © 2021 Fang, Liu, Zheng, Guo, Zeng, Huang and Ouyang. This is an openaccess article distributed under the terms of the Creative Commons Attribution License (CC BY).  ... 
doi:10.3389/fendo.2021.636175 pmid:34093430 pmcid:PMC8173181 doaj:f6960f22ef3e42c0a838e6bfe79a00f3 fatcat:y2sxtnpewnaqld6bv44ywcrxxm

Respiratory Failure, Hepatic Failure, and Hemoptysis with Thrombocytopenia in a 79-Year-Old Man

Yu-Guang Wang, Ya-Li Guo, Yi-Qing Jiao, Li-Ya Guo, Jian Liu, Qing-Quan Liu
2018 Chinese Medical Journal  
This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
doi:10.4103/0366-6999.233960 pmid:29893376 pmcid:PMC6006829 fatcat:cnqr4mm3bbfjjmazlnpz3ykf3q

Two new isoaurones derivatives fromCallistephus chinensisflower

Xiao-shu Zhang, Jia-qing Cao, Guo-hui Shi, Zhen-ting Liu, Jing-xin Liu, Yu-qing Zhao
2015 Natural Product Research  
doi:10.1080/14786419.2015.1053090 pmid:26190288 fatcat:lqsdulveyrdczm6ri7nbo7qti4

Mechanism of dexmedetomidine preventing and treating fentanyl induced hyperalgesia

Qing-qing LIU, Bi-yu WEI, Peng REN, Yong-zhe LIU, Hang GUO, Li SUN, Wen-zhi GUO, Ya-qun MA, Ming-long GAO
2018 Medical Journal of Chinese People's Liberation Army  
Objective To observe the changes in opioid induced hyperalgesia (OIH) after subcutaneous administration of dexmedetomidine, and explore the corresponding mechanism. Methods A hundred and thirty male SD rats were randomly divided into 5 groups (26 each): saline group (NS group), 5 times of subcutaneous injection of saline 1ml; fentanyl group (F group), subcutaneous injection of saline once, and 4 times injection of fentanyl 60μg/kg; dexmedetomidine + fentanyl mixture group (DF1, DF2 and DF3
more » ... ), hypodermic dexmedetomidine once with 12.5μg/kg, 25μg/kg and 50μg/kg, respectively, and then 4 times injection of fentanyl 60μg/kg, with an interval of 15min. Rats in each group were undergone the tests of tail flick threshold (TFT) and paw withdrawal latency (PWL) 30 minutes before injection and 2, 3, 4h and 1 to 5 days after injection. Twenty rats were randomly sacrificed from each group one day after drug administration to obtain the inflated spinal lumbar region. Eight samples were used to determine the expression of alpha-2A adrenergic-receptor (α2A-AR) and inducible nitric oxide synthase (iNOS) by Western blotting, 4 were measured the expression of substance P by ELISA, and 8 were used to observe the expression of astrocytes and microglia markers glial fibrillary acidic protein (GFAP) and Iba-1 by immunofluorescence. Results The behavioral results showed that the TFT and PWL were higher at 2h to 4h after injection in F group and DF groups than in NS group, but were lower at 1 to 3 days in F group and DF1 group than in NS group, the most significant difference appeared in the 1st day and returned to the NS level at the 4th day, while no statistical difference existed when compared between NS group with DF2 and DF3 groups at 1 to 5 days. Western blotting showed that compared with NS group, the expression of α2A-AR decreased and iNOS increased in F and DF1 groups;compared with F group, the expression of α2A-AR increased and iNOS decreased in DF2 and DF3 groups; ELISA results showed that compared with the F group, t [...]
doaj:44fee1d3af4f422caa89569407a89f7d fatcat:xxemz5v55vaphc2p4yg6jasgmm

Impact of charge carrier recombination and energy disorder on the open-circuit voltage of polymer solar cells

Qing-Zhong Zhou, Feng Guo, Ming-Rui Zhang, Qing-Liang You, Biao Xiao, Ji-Yan Liu, Cui Liu, Xue-Qing Liu, Liang Wang
2020 Wuli xuebao  
doi:10.7498/aps.69.20191699 fatcat:475fktywwjcxrhmjyngmnwtraq

Optimal teaching strategy in periodic impulsive knowledge dissemination system

Dan-Qing Liu, Zhen-Qiang Wu, Yu-Xin Wang, Qiang Guo, Jian-Guo Liu, Wen-Bo Du
2017 PLoS ONE  
Accurately describing the knowledge dissemination process is significant to enhance the performance of personalized education. In this study, considering the effect of periodic teaching activities on the learning process, we propose a periodic impulsive knowledge dissemination system to regenerate the knowledge dissemination process. Meanwhile, we put forward learning effectiveness which is an outcome of a trade-off between the benefits and costs raised by knowledge dissemination as objective
more » ... nction. Further, we investigate the optimal teaching strategy which can maximize learning effectiveness, to obtain the optimal effect of knowledge dissemination affected by the teaching activities. We solve this dynamic optimization problem by optimal control theory and get the optimization system. At last we numerically solve this system in several practical examples to make the conclusions intuitive and specific. The optimal teaching strategy proposed in this paper can be applied widely in the optimization problem of personal education and beneficial for enhancing the effect of knowledge dissemination.
doi:10.1371/journal.pone.0178024 pmid:28665961 pmcid:PMC5493297 fatcat:xyvoccktpbdqzbjxfse6epzm64

ABO blood type correlates with survival in hepatocellular carcinoma following hepatectomy

Tao Wu, Xiao-An Ma, Guo-Qing Wang, Qing Li, Miao-Jing Li, Jin-Yue Guo, Xuan Liang, Zhi-Ping Ruan, Tao Tian, Ke-Jun Nan, Li-Na Liu, Hui Guo
2017 Scientific Reports  
ABO blood types are associated with the prognosis of several malignancies. However, the role of the ABO blood type in hepatocellular carcinoma (HCC) remains elusive. Here, we evaluated the prognostic role of the ABO blood group in 691 HCC patients after hepatectomy by Cox regression analysis. A prognostic nomogram was generated to predict the 3 and 5-year overall survival (OS). A total of 262 HCC patients (37.9%) had blood group O, 199 (28.8%) had blood group A, 165 (23.9%) had blood group B,
more » ... d 65 (9.4%) had blood group AB. The median OS was 55 months in patients with blood group O, 39 months for blood group A, 34 months for blood group B, and 34 months for blood group AB patients (P = 0.001, log-rank test). There were significant differences in OS between patients with blood groups O and A [hazard ratio (HR) = 1.416; 95% CI, 1.101-1.820; P = 0.007], blood group B (HR = 1.736; 95% CI, 1.333-2.262; P < 0.001), blood group AB (HR = 1.739; 95% CI, 1.210-2.499; P = 0.003) and non-O blood groups (HR = 1.485; 95% CI, 1.204-1.830; P < 0.001). Our constructed nomogram (c-index = 0.687) predicted the prognosis more accurately than the TNM stage alone(c-index = 0.601). In conclusion, non-O blood groups are poor prognostic indicators for HCC following hepatectomy. Our findings justify further external validation in larger cohorts. Liver cancer is a frequent and highly aggressive malignancy. It is the third cause of cancer-related deaths worldwide 1 . Over 80% of liver cancers occur in less developed regions and 50% of all cases occur in China because of endemic hepatitis B virus (HBV) infection 2 . Notably, the incidence of liver cancer has increased in the United States and European countries over the past two decades 3, 4 . Hepatocellular carcinoma (HCC) represents the most common histological subtype of primary liver cancer, accounting for approximately 90% of cases 4 . HCC does not respond well to chemotherapy and is characterized by rapid progression and early vascular invasion. The long-term survival of patients with localized stage HCC can be improved by resection, transplantation and loco-regional therapies 5 . However, recurrence or distant metastases occur in most HCC patients and the 5-year survival rate is just 16% 6, 7 . Prognostic factors are crucial for optimal therapy and disease surveillance. Established prognostic parameters such as stage, histological grade, and α-Fetoprotein (AFP) levels have been used in clinical practice 8 . However, the prognosis of HCC is often heterogeneous and therefore unsatisfactory 9 . Despite similar clinicopathological characteristics, HCC survival can be variable 10 . Therefore, new additional prognostic indicators should be identified to improve the outcome of surgically managed HCC patients. Recently, the clinical implications of identifying the ABO blood type have extended beyond transfusion medicine 11 . The prognosis of HCC has been predicted using ABO blood typing, because this can be performed in every individual. Studies have shown that the ABO blood type is linked to the oncological outcome of various malignancies, including gastric cancer 12 , cervical cancer 13 , ovarian cancer 14 and breast cancer 15 . A recent study reported that non-O blood groups increased the risk of HCC 16 . Another study indicated that blood group A increased the risk of developing HCC in a Korean population 17 . Although ABO blood type has been associated with the risk of HCC, its prognostic role in patients receiving hepatectomy for HCC is unclear. Published: xx xx xxxx OPEN www.nature.com/scientificreports/ 2 Scientific RepoRts | 7: 4412 | In this study, we retrospectively evaluated the correlation of ABO blood type with prognosis in patients receiving hepatic resection as an initial treatment for HCC in a Chinese population. The results of this study showed that non-O blood groups (A, B, and AB) are poor prognostic indicators for HCC patients, suggesting that ABO blood typing status might represent a refined approach to prognostic stratification and individualized surveillance. Results Demographic data. A final total of 691 patients (564 males and 127 females) who received hepatic resection were included and completed follow-up. As shown in Table 1 , the basic characteristics of patients were stratified by ABO blood type. The median age of participants was 54 years[interquartile range (IQR),25-75 years)]. The ABO blood types were as follows: O in 262 (37.9%) patients, A in 199 (28.8%) patients, B in 165 (23.9%) patients, Variable, no (%) Over cohort Blood group P-value Blood group P-value O A B AB O Non-O Total case 691
doi:10.1038/s41598-017-04046-4 pmid:28667286 pmcid:PMC5493683 fatcat:yu4yphovcjfb5ognyiizsx2piy

Asynchronous Stochastic Composition Optimization with Variance Reduction [article]

Shuheng Shen, Linli Xu, Jingchang Liu, Junliang Guo, Qing Ling
2018 arXiv   pre-print
Composition optimization has drawn a lot of attention in a wide variety of machine learning domains from risk management to reinforcement learning. Existing methods solving the composition optimization problem often work in a sequential and single-machine manner, which limits their applications in large-scale problems. To address this issue, this paper proposes two asynchronous parallel variance reduced stochastic compositional gradient (AsyVRSC) algorithms that are suitable to handle
more » ... e data sets. The two algorithms are AsyVRSC-Shared for the shared-memory architecture and AsyVRSC-Distributed for the master-worker architecture. The embedded variance reduction techniques enable the algorithms to achieve linear convergence rates. Furthermore, AsyVRSC-Shared and AsyVRSC-Distributed enjoy provable linear speedup, when the time delays are bounded by the data dimensionality or the sparsity ratio of the partial gradients, respectively. Extensive experiments are conducted to verify the effectiveness of the proposed algorithms.
arXiv:1811.06396v1 fatcat:gophcoez6befbccofx6s55nere

Sparta: Spatially Attentive and Adversarially Robust Activation [article]

Qing Guo, Felix Juefei-Xu, Changqing Zhou, Yang Liu, Song Wang
2021 arXiv   pre-print
Liu are with Nanyang Technological University, Singapore. F. Juefei-Xu is with Alibaba Group, Sunnyvale, CA 94085, USA. S.  ...  To address such chal- Guo lenges, we design a novel activation function, i.e., SPARTA: spatially-attentional activation for adversarial robustness, by allowing the activation to allocate different amounts  ... 
arXiv:2105.08269v1 fatcat:czpzfniwxndgxb5bwivy2nqvee

SPC-P1: a pathogenicity-associated prophage of Salmonella paratyphi C

Qing-Hua Zou, Qing-Hai Li, Hong-Yun Zhu, Ye Feng, Yong-Guo Li, Randal N Johnston, Gui-Rong Liu, Shu-Lin Liu
2010 BMC Genomics  
Salmonella paratyphi C is one of the few human-adapted pathogens along with S. typhi, S. paratyphi A and S. paratyphi B that cause typhoid, but it is not clear whether these bacteria cause the disease by the same or different pathogenic mechanisms. Notably, these typhoid agents have distinct sets of large genomic insertions, which may encode different pathogenicity factors. Previously we identified a novel prophage, SPC-P1, in S. paratyphi C RKS4594 and wondered whether it might be involved in
more » ... athogenicity of the bacteria. We analyzed the sequence of SPC-P1 and found that it is an inducible phage with an overall G+C content of 47.24%, similar to that of most Salmonella phages such as P22 and ST64T but significantly lower than the 52.16% average of the RKS4594 chromosome. Electron microscopy showed short-tailed phage particles very similar to the lambdoid phage CUS-3. To evaluate its roles in pathogenicity, we lysogenized S. paratyphi C strain CN13/87, which did not have this prophage, and infected mice with the lysogenized CN13/87. Compared to the phage-free wild type CN13/87, the lysogenized CN13/87 exhibited significantly increased virulence and caused multi-organ damages in mice at considerably lower infection doses. SPC-P1 contributes pathogenicity to S. paratyphi C in animal infection models, so it is possible that this prophage is involved in typhoid pathogenesis in humans. Genetic and functional analyses of SPC-P1 may facilitate the study of pathogenic evolution of the extant typhoid agents, providing particular help in elucidating the pathogenic determinants of the typhoid agents.
doi:10.1186/1471-2164-11-729 pmid:21192789 pmcid:PMC3022927 fatcat:bncnzg2a4jaddikso6425nt5ie

Fault Analysis and Diagnosis of Aeroengine Fuel Metering Device

Kai Yin, Guo-long Jiang, Guo-jian Liu, Ying-qing Guo
2017 DEStech Transactions on Engineering and Technology Research  
In this _____________ Kai Yin, Guo-jian Liu, AVIC Commercial Aircraft Engine Corporation Limited, Shanghai, China.  ...  Guo-long Jiang, Ying-Qing Guo, School of Power and Energy, Northwestern Polytechnical University, Xi'an, China. paper, with a high bypass ratio turbofan engine as the object, typical faults of its FMD  ... 
doi:10.12783/dtetr/mcemic2016/9533 fatcat:nipt7zvqlfg6nibb5t2hnzp5lm

Hypertriglyceridemia: A Neglected Risk Factor for Ischemic Stroke?

Hai-jie Liang, Qing-yi Zhang, Yi-tong Hu, Guo-qing Liu, Rong Qi
2022 Journal of Stroke  
Hypertriglyceridemia is caused by defects in triglyceride metabolism and generally manifests as abnormally high plasma triglyceride levels. Although the role of hypertriglyceridemia may not draw as much attention as that of plasma cholesterol in stroke, plasma triglycerides, especially nonfasting triglycerides, are thought to be correlated with the risk of ischemic stroke. Hypertriglyceridemia may increase the risk of ischemic stroke by promoting atherosclerosis and thrombosis and increasing
more » ... od viscosity. Moreover, hypertriglyceridemia may have some protective effects in patients who have already suffered a stroke via unclear mechanisms. Therefore, further studies are needed to elucidate the role of hypertriglyceridemia in the development and prognosis of ischemic stroke.
doi:10.5853/jos.2021.02831 pmid:35135057 pmcid:PMC8829486 fatcat:rq5x2hforfgn5k2r7c6s7oe4xi

Adversarial Attack on DL-based Massive MIMO CSI Feedback [article]

Qing Liu, Jiajia Guo, Chao-Kai Wen, Shi Jin
2020 arXiv   pre-print
With the increasing application of deep learning (DL) algorithms in wireless communications, the physical layer faces new challenges caused by adversarial attack. Such attack has significantly affected the neural network in computer vision. We chose DL-based analog channel state information (CSI) to show the effect of adversarial attack on DL-based communication system. We present a practical method to craft white-box adversarial attack on DL-based CSI feedback process. Our simulation results
more » ... owed the destructive effect adversarial attack caused on DL-based CSI feedback by analyzing the performance of normalized mean square error. We also launched a jamming attack for comparison and found that the jamming attack could be prevented with certain precautions. As DL algorithm becomes the trend in developing wireless communication, this work raises concerns regarding the security in the use of DL-based algorithms.
arXiv:2002.09896v1 fatcat:ijycw36btfhejkcd4fxbwcnase

Theoretical study on influence of photon reabsorption on photocarrier radiometric characteristics of silicon wafers

Qian Wang, Wei-Guo Liu, Lei Gong, Li-Guo Wang, Ya-Qing Li, Rong Liu
2019 Wuli xuebao  
Theoretical study on influence of photon reabsorption on photocarrier radiometric characteristics of silicon wafers * Wang Qian † Liu Wei-Guo Gong Lei Wang Li Abstract τ τ In microelectronic and photovoltaic  ... 
doi:10.7498/aps.68.20181889 fatcat:of5gdjno6bbgdhs45fpiwukira

Interleukin-1β Protection Against Experimental Sepsis in Mice

Hai-Lei Guo, Fu-Dong Shi, Qi Zhou, Qing-Yang Liu, Yue-Xin Wang, Yang Song, Zong-Sheng Wu, Yu-Hao Shi, Liu Zhang, Kai-Zhi Xu, Guo-Dong Song
2020 Inflammation  
The inflammatory response involving interleukin-1β (IL-1β) has been thought to play an important role in the development of late-phase sepsis. However, in this study, we wanted to explore the possibility of using IL-1β to improve the prognosis of sepsis by triggering local differentiation of bone marrow cells (BMCs) into regulatory dendritic cells (DCs) in vivo, thereby reversing the immune paralysis in late-phase sepsis. Sepsis mouse models were induced by cecal ligation and puncture (CLP) and
more » ... lethal Escherichia coli O18 infection. Mice were injected intraperitoneally with IL-1β after CLP and after the lethal infection. Septic BMCs and liver immune cells were isolated at 0, 3, 6, 9, and 14 days post-CLP. BMCs and liver cells isolated from septic mice treated with IL-1β were adoptively transferred into CLP mice. GFP+-C57BL/6 parabiosis models were established. Serum IL-1β levels were determined by enzyme-linked immunosorbent assay (ELISA) kit, and the number, ratio, and phenotype of immune cells were observed by flow cytometry. IL-1β treatment improved the survival of sepsis and increased the numbers of BMCs and liver immune cells in septic mice. Moreover, IL-1β stimulation increased the number and the percentage of CD11c-CD45RBhigh DCs in septic BM and liver. Adoptive transfer of septic BMCs, liver immune cells, and CD11c-CD45RBhigh DCs treated with IL-1β into CLP mice attenuated sepsis. IL-1β triggered the redistribution of CD11c-CD45RBhigh DCs as well as BMCs in parabiosis models. IL-1β protects against sepsis by stimulating local proliferation and differentiation of BMCs into CD11c-CD45RBhigh DCs at immune organs and non-immune organs.
doi:10.1007/s10753-020-01341-7 pmid:33044666 pmcid:PMC7548415 fatcat:tf7rtt7n4jha5egb4vqyx2fhyi
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